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| 1 | 食物过敏的定义、流行性、诊断及治疗显示文摘食物过敏是异质性群体相关疾病,会通过一种或多种方式对多个器官造成影响。其反应的严重程度可从轻度的局部反应到全身性的过敏反应。从机制上来看,食物过敏是Th2细胞驱动的免疫紊乱疾病,食物特异性IgE是这种速发型不良反应的基础。过敏的部位和症状并不一定相同。食物过敏常会与自身免疫性(如乳糜泻)和非免疫性(如乳糖不耐受)的其他食物不良反应相混淆。为了正确诊断食物过敏,需要详细了解患者病史,检测特异性IgE,并进行经口激发试验来确诊。一些辅助因素(如运动、药物和酒精)有助于诱发食物过敏,会进一步增加诊断的复杂性。以食物提取物为基础的诊断试验并不能反映症状的严重程度,而检测单个食物致敏原IgE的新一代分子诊断技术,则能够为临床医生和患者提供可靠的症状严重程度依据。分子诊断还有助于确定食物过敏是直接源于对食物的暴露还是间接源于花粉过敏(交叉反应)。流行病学调查表明,桃过敏在欧洲主要是源于对桃的食用,而在中国则是源于对艾蒿花粉的初级致敏。但这两种情况都是由来自同一家族的致敏原分子介导的。流行病学调查深入揭示了食物过敏的病因、流行性及其所包含的风险因素,为预防食物过敏提供了循证策略。过去的十年中,食物过敏在发达国家盛行。经济发展和城市化进程都被认为会导致食物过敏流行性的增加,而且饮食习惯不同,过敏的食物也不同。目前,分子变态反应学和生物技术正在开发安全的免疫治疗方法,有望能够减轻日益加重的食物过敏负担。一种使用低致敏性突变重组分子的免疫疗法已经开始进行第一阶段临床试验的评估。食物致敏原名单的不断完善为转基因食品致敏性的评估提供了坚实基础。 | Ronald van Ree Lars K. Poulsen Gary WK Wong Barbara K. Ballmer-Weber 高中山 贾旭东 | 2015 | 中华预防医学杂志2015，49，1： | 28 |
| 2 | 纳秒脉冲在普通单模光纤中产生超连续谱的实验研究显示文摘利用中心波长1064 nm的纳秒激光脉冲入射到普通单模光纤中,获得了从700 nm到超过1750 nm的超连续谱输出。在正常色散区抽运下,光谱首先出现多级拉曼斯托克斯线,随着抽运功率或光纤长度的增加,斯托克斯能量将进入光纤反常色散区,形成光孤子,随后与孤子相关的非线性效应将使光谱进一步展宽。实验结果表明,当单模光纤长度为28 m时,产生的光谱在1260~1750 nm范围内,有较好的光谱平坦度(小于3.8 dB)、较强的光谱光功率密度(平均约为0.4 mW/nm)并且单模输出。 | 刘楚 Eric Rees Toni Laurila 简水生 Clemens Kaminski | 2011 | 中国激光2011，38，7： | 10 |
| 3 | The Global boundary Stratotype Section and Point (GSSP) of the Drumian Stage (Cambrian) in the Drum Mountains, Utah, USA显示文摘 | Loren E. Babcock Richard A. Robison Margaret N. Rees Shanchi Peng Matthew R. Saltzman | 2007 | Episodes2007，30，2： | 9 |
| 4 | Low-grade gliomas:do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation?显示文摘Radiology. 2008 Apr;247(1):170-8.PURPOSE: To prospectively perform longitudinal magnetic resonance (MR) perfusion imaging of conservatively treated low-gradegliomas to determine whether relative cerebral blood volume (rCBV) changes precede malignant transformation as defined | Danchaivijitr N Waldman AD Tozer DJ Benton CE Brasil Caseiras G Tofts PS Rees JH J?ger HR | 2008 | 中国神经肿瘤杂志2008，6，2： | 7 |
| 5 | Molecular phylogeny of Solms-laubachia(Brassicaceae) s.l.,based on multiple nuclear and plastid DNA sequences,and its biogeographic implications显示文摘The Hengduan Mountains region of south-west China is a noted biodiversity hotspot,but the geographic origins and historical assembly of its rich endemic flora,including the sky-island species of Solms-laubachia Muschl.(Brassicaceae),have been little studied.Previous molecular studies on the phylogeny of Solms-laubachia showed it to be paraphyletic,leading to considerable expansion not only of its taxonomic limits,but also its geographic range,with the inclusion of taxa from outside the Hengduan region.However,these studies provided little resolution of interspecific relationships,preventing inferences about historical biogeography within the clade.In the present study,new sequence data from two nuclear genes(LEAFY and G3pdh) and two chloroplast intergenic spacers(petN-psbM and psbM-trnD) were combined with existing markers to increase phylogenetic signals.Phaeonychium villosum(Maxim.) Al-Shehbaz was found to be nested within Solms-laubachia s.l.In general,phylogenetic relationships appear to be a good predictor of geography,with the Hengduan Mountain endemics embedded in a paraphyletic grade of species from the western Himalayas and central Asia,but they also imply morphological homoplasy.Incongruence was detected between the nuclear and chloroplast gene trees,perhaps resulting from incomplete lineage sorting of ancestral polymorphisms.The crown age of Solms-laubachia s.l.was estimated to be approximately 1.42-3.68 mya,using Bayesian relaxed molecular clock analysis.Historical biogeographic analysis using a parametric dispersal-extinction-cladogenesis model inferred central Asia and the western Himalayas as most probable ancestral range of Solms-laubachia s.l.,and estimated higher rates of eastward expansion than westward during the diversification of descendant lineages.In summary,our results suggest that Solms-laubachia s.l.originated during the Pliocene in central Asia,and subsequently migrated eastward into the Hengduan Mountains,colonizing sky-island,alpine scree-slope habitats that may have provided novel ecological opportunity and accelerated speciation,ultimately establishing this region as the present center of diversity of the genus. | Ji-Pei YUE Hang SUN David A. BAUM jian-Hua LI Ihsan A. AL-SHEHBAZ Richard REE | 2009 | Journal of Systematics and Evolution2009，47，5： | 6 |
| 6 | 修补性政策、适应性政策及改造性政策[J]显示文摘 | Teresa Rees | 2000 | 妇女研究论丛2000，，2： | 5 |
| 7 | Coulometric sizing of nanoparticles: Cathodic and anodic impact experiments open two independent routes to electrochemical sizing of Fez04 nanoparticles显示文摘 | Kristina Tschulik Baptiste Haddou Dario Omanovi Neil V. Rees Richard G. Compton | 2013 | Nano Research2013，6，11： | 5 |
| 8 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 9 | 温度限制串联相关神经网络及其在细菌辨识中的应用显示文摘蛋白质在微生物研究中可用作生物标记物, 故在生物技术中其表征工作很重要. 各种质谱技术已被用于细菌的表征[1~3]. 1994年, Cain等[4]首先报道了将色谱和基体辅助激光解离/电离飞行时间质谱(MALDI-TOF-MS)用于细菌的辨识. Holland等[5]采用高质量离子MALDI-TOF-MS对细菌全细胞进行辨识. 最近, Lay[6]对该技术的细菌辨识做了综述. MALDI-TOF-MS是目前对细菌全细胞分析的最佳手段. | 张卓勇 Aaron Urbas Peter de B Harrington Kent J.Voorhees Jon Rees | 2002 | 高等学校化学学报2002，23，4： | 4 |
| 10 | 环戊烷在Silicalite-1上吸附的热力学研究显示文摘 用智能重量分析仪测定了环戊烷在Silicalite-1上的吸附等温线,根据吸附等温线数据计算了热力学参数(吸附热Qst、熵变ΔS、Gibbs自由能变ΔG)。423K时,吸附等温线符合Langmuir方程。254,274K时,吸附等温线出现了滞后环。与分子构型相近的苯与环己烷相比,环戊烷的饱和吸附量超乎寻常,Qst、ΔG、ΔS随吸附量的变化较大,表明环戊烷在Silicalite-1上的吸附机理相当复杂。在吸附过程中,吸附质分子之间、吸附质和Silicalite-1之间的相互作用较强,环戊烷分子发生了重排。当吸附量达到1.5mmol/g时,吸附相开始凝聚,吸附热逐渐达到了凝聚热值。 | 段林海 蒋施 孙兆林 张晓彤 宋丽娟 Rees L V C | 2003 | 石油化工高等学校学报2003，16，3： | 4 |
| 11 | Urban ecological footprints: Why cities cannot be sustainable—And why they are a key to sustainability显示文摘 | William Rees | 1996 | Environmental Impact Assessment Review1996，，4： | 4 |
| 12 | 环戊烷在Silicalite-1分子筛上吸附的动力学研究显示文摘为了探究环戊烷在Silicalite—1分子筛上扩散过程的动力学特性,以及温度、压力等环境因素和吸附质的性质是如何对动力学过程的影响,实验采用重量法测定了环戊烷不同压力下扩散的动力学数据,绘制其在Silicalite—1上的吸附等温线,计算了扩散系数、扩散活化能和活化熵变等动力学参数。结果表明,环戊烷在Silicalite—1上的扩散过程符合Fick第二定律,吸附剂Silicalite—1的特殊孔道结构和吸附质分子的尺寸大小、及分子间的作用,影响着扩散的动力学过程。扩散的活化能、活化熵变和吸附热的变化决定了扩散系数的变化。随着吸附质在沸石上的吸附量增大,吸附热增大,而环戊烷的扩散速率随之降低,并且温度越高,扩散速率越大。 | 蒋施 段林海 张晓彤 孙兆林 宋丽娟 Rees L VC | 2003 | 石油化工高等学校学报2003，16，4： | 3 |
| 13 | 快速报告标准之二:严重性及因果关系评价显示文摘1引言按照明确的、国际公认的管理规定,制药公司必须收集药品安全性信息以便进行安全性评估并向上级主管部门报告。虽然不同国家的管理部门有不同的报告标准及时限要求,但共同要求严重的及存在因果关系的不良事件报告应通过速报形式提交行政管理部门。本文的目的是提供如何在个案病例回顾中进行严重性及因果关系评价的实用性指导。 | Manel De Silva Wijayasinghe Inna Pendrak Nicholas Rees 西安杨森药品安全部(译) | 2009 | 中国药物警戒2009，6，5： | 3 |
| 14 | DNA barcoding of Pedicularis L.(Orobanchaceae):Evaluating four universal barcode loci in a large and hemiparasitic genus显示文摘One application of DNA barcoding is species identification based on sequences of a short and standardized DNA region.In plants,various DNA regions,alone or in combination,have been proposed and investigated,but consensus on a universal plant barcode remains elusive.In this study,we tested the utility of four candidate barcoding regions(rbcL,matK,trnH-psbA,and internal transcribed spacer(ITS)) as DNA barcodes for discriminating species in a large and hemiparasitic genus Pedicularis(Orobanchaceae).Amplification and sequencing was successful using single primer pairs for rbcL,trnH-psbA,and ITS,whereas two primer pairs were required for matK.Patterns of sequence divergence commonly showed a 'barcoding gap',that is,a bimodal frequency distribution of pairwise distances representing genetic diversity within and between species,respectively.Considering primer universality,ease of amplification and sequencing,and performance in discriminating species,we found the most effective single-region barcode for Pedicularis to be ITS,and the most effective two-region barcode to be rbcL + ITS.Both discriminated at least 78% of the 88 species and correctly identified at least 89% of the sequences in our sample,and were effective in placing unidentified samples in known species groups.Our results suggest that DNA barcoding has the potential to aid taxonomic research in Pedicularis,a species-rich cosmopolitan clade much in need of revision,as well as ecological studies in its center of diversity,the Hengduan Mountains region of China. | Wen-Bin YU Pan-Hui HUANG Richard H. REE Min-Lu LIU De-Zhu LI Hong WANG | 2011 | Journal of Systematics and Evolution2011，49，5： | 3 |
| 15 | 径向基函数网络用于细菌的MALDI-TOF-MS分类显示文摘径向基函数(RBF)网络被用于根据基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF-MS)对细菌的分类辨识。为了加速网络训练和减少网络的复杂性,本文采用小波变换对原始质谱数据进行压缩,将原来的13828个数据点压缩至328个,且保持了原来的特征谱峰。本文研究了在不同培养时间(24、48和72小时)的5种细菌分类,并对RBF网络参数的影响做了详细地研究,为生物学研究提供了有用的信息。结果表明,约60%以上的细菌样本能够被正确地分类辨识。由于细菌培养的生物学影响因素复杂,因而进一步严格控制细菌的培养条件是改善细菌分类正确率的关键。 | 张卓勇 王丹 Peter de B.Harrington Kent J.Voorhees Jon Rees | 2002 | 计算机与应用化学2002，19，1： | 3 |
| 16 | 正己烷在ZnNi/HZSM-5上微波芳构化显示文摘 研究了常规加热和微波辐射两种加热方法对正己烷在ZnNi/HZSM-5催化剂上的芳构化反应的影响。考察了温度、空速对反应性能的影响,并利用XRD对ZnNi/HZSM-5催化剂作了表征。结果表明,金属锌和镍高度分散于HZSM-5沸石中,微波辐射对分子筛结构的影响很小。与常规加热反应相比,要达到相同的芳烃收率,在微波加热条件下能使反应温度降低约100℃左右。在一定程度上提高反应温度可以获得较高的总芳烃收率和BTX收率,亦能明显地改变BTX中各组分的相对选择性。改变空速能显著影响总芳烃收率和BTX收率,在常规加热和微波加热条件下的最佳空速分别为1.5h-1和1.0h-1。讨论了正己烷在微波辐射下ZnNi/HZSM-5上的芳构化反应机理。正己烷首先裂解为C03+C=3,一部分烯烃齐聚、环化生成芳烃,另一部分烯烃则经氢转移或加氢生成烷烃,C03和C04在锌和镍活性中心上直接脱氢二聚环化生成芳烃。 | 许健 张晓彤 桂建舟 罗有训 孙兆林 Rees L V C | 2003 | 石油化工高等学校学报2003，16，2： | 3 |
| 17 | Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer显示文摘 | Gareth Betts Emma Jones Syed Junaid Tariq El-Shanawany Martin Scurr Paul Mizen Mayur Kumar Sion Jones Brian Rees Geraint Williams Awen Gallimore Andrew Godkin | 2012 | Gut2012，，8： | 3 |
| 18 | Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit显示文摘Chinese bayberry Myrica rubra is a very popular fruit in southeastern China.In spite of its wide consumption,no allergies to this fruit have been reported previously.Here we report on a 40-year-old woman suffering from anaphylaxis to Chinese bayberry fruit.Prick-prick skin tests revealed strong reactions to fresh Chinese bayberry fruits as well as to peach,and weaker reactions to some other fruits including apple,melon,and banana.ImmunoCAP analysis revealed identical titers of specific IgE(4.3 kU A /L) to peach extract and its lipid transfer protein(LTP,rPru p 3),which was confirmed by detection of a 9 kD band following immunoblotting.Immunoblot analysis with Chinese bayberry extract gave bands of 22,45,and 90 kD,but no 9 kD band was recognized.There was also no evidence of LTP recognition for loquat(36 kD) or melon(24 kD).This first report of a severe allergic reaction to Chinese bayberry fruit in a patient with LTP-mediated peach allergy indicates that other as yet unidentified non-pollen related fruit allergens are involved in this new severe fruit allergy. | Hui-ying WANG Zhong-shan GAO Zhao-wei YANG Jing-xin SHAO Xiu-zhen ZHAO Yu DAI Ronald VAN REE | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，10： | 3 |
| 19 | LONG-TERM OUTCOME OF TRANSCATHETER EMBOLIZATION OF RENAL ANGIOMYOLIPOMAS DUE TO TUBEROUS SCLEROSIS COMPLEX显示文摘 | DAVID H. EWALT NORMAN DIAMOND CHET REES STEVEN P. SPARAGANA MAURICIO DELGADO LORI BATCHELOR E. STEVE ROACH | 2005 | The Journal of Urology2005，，5： | 2 |
| 20 | Perceptual and structural barriers to investing in natural capital: economics from an ecological footprint perspective 显示文摘 | Wackernagel M Rees W E | 1997 | Ecological Economics1997，20，1： | 2 |
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