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| 1 | Severe cyclophosphamide-related hyponatremia in a patient with acute glomerulonephritis显示文摘Cyclophosphamide is frequently used to treat cancer,autoimmune and renal diseases,such as rapidly progressive glomerulonephritis.Its side effects are well-known,including bone marrow depression,infections,alopecia,sterility,bladder malignancy and hemorrhagic cystitis.Moreover,in some cases cyclophosphamide use has been related to the onset of hyponatremia,by development of a syndrome of inappropriate antidiuresis.Indeed,severe hyponatremia has been previously reported in patients treated with high-dose or moderate-dose of intravenous cyclophosphamide,while only few cases have been reported in patients treated with low dose.Here,we discuss a case of a syndrome of inappropriate antidiuresis followed to a single low-dose of intravenous cyclophosphamide in a patient with a histological diagnosis of acute glomerulonephritis,presenting as acute kidney injury.After cyclophosphamide administration(500 mg IV),while renal function gradually improved,the patient developed confusion and headache.Laboratory examinations showed serum sodium concentration dropped to 122 mmol per liter associated with an elevated urinary osmolality of 199 mO sm/kg,while common causes of acute hyponatremia were excluded.He was successfully treated with water restriction and hypertonic saline solution infusion with the resolution of the electrolyte disorder.This case,together with the previous ones already reported,highlights that electrolyte profile should be strictly monitored in patients undergoing cyclophosphamide therapy in order to early recognize the potentially lifethreatening complications of acute water retention. | Pasquale Esposito Maria Valentina Domenech Nicoletta Serpieri Marta Calatroni Ilaria Massa Alessandro Avella Edoardo La Porta Luca Estienne Elena Caramella Teresa Rampino | 2017 | World Journal of Nephrology2017，6，4： | 2 |
| 2 | Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain显示文摘 | Bertolino A Blasi G Latorre V Rubino V Rampino A Sinibaldi L | | 0，，15： | 1 |
| 3 | Flood basalt volcanism during the past 250 million years显示文摘 | Rampino M R Stothers R B | 1988 | Science1988，241，： | 1 |
| 4 | Scleromyxedema: treatment of widespread cutaneous involvement by total skin electro-beam therapy显示文摘 | Rampino M Garibaldi E Ragona R | 2007 | Int J Dermatol2007，46，6： | 1 |
| 5 | Efficacy and feasibility of induction chemotherapy and radiotherapy plus cetuximab in head and neck cancer 显示文摘 | Rampino M Bacigalupo A Russi E | 2012 | Anticancer Res2012，32，1： | 1 |
| 6 | The Mid-Cretaceous super plume,carbon dioxide,and global warming显示文摘 | Calderia K Rampino M R | 1991 | Geophysical Research Letters1991，18，6： | 1 |
| 7 | The effect of heat stress and cadmium ions on the expression of a small hsp gene in barley and maize显示文摘 | GULLI M RAMPINO P LUPOTTO E | 2005 | Journal of Cereal Science2005，42，1： | 1 |
| 8 | Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype显示文摘 | RAMPINO N YAMAMOTO H IONOV Y | 1997 | Science1997，275，： | 1 |
| 9 | Applicability of palladium synthetic high polymer catalysts显示文摘 | Rampino L D Nord F F | 1941 | J Am Chem Soc1941，63，12： | 1 |
| 10 | DNA damage and repair in telomeres: relation to aging显示文摘 | Kruk P A Rampino N J Bohr V A | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 11 | The mid-Cretaceous super plume, carbon dioxide, and global warming 显示文摘 | Ken Caldeira Michael R Rampino | 1991 | Geophysical Research Letters1991，18，6： | 1 |
| 12 | Frameshift mutator mutation显示文摘 | Rampino N Yamamoto H | 1996 | Nature1996，，： | 1 |
| 13 | Molecular analysis of a durum wheat ' stay green' mutant:expression pattern of photosynthesis-related genes显示文摘 | RAMPINO P SPANO G PATALEO S | 2006 | Journal of Cereal Science2006，，43： | 1 |
| 14 | Polarization of T-helper lymphocytes toward the Th2 phenotype in uremic patients显示文摘 | Libetta C Rampino T Dal Canton A | 2001 | Am J Kidney Dis2001，38，2： | 1 |
| 15 | Polarization of T-helper lymphocytes toward the Th2 phenotype in uremic patients显示文摘 | Rampino T Dal Canton A | 2001 | Am J Kidney Dis2001，38，2： | 1 |
| 16 | “The Shiva Hypothesis”: Impacts, mass extinctions, and galaxy显示文摘 | RAMPINO M R HAGGERTY B M | 1996 | Earth Moon Planets1996，72，： | 1 |
| 17 | COMT Val 158 Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophrenia显示文摘 | Alessandro Bertolino Grazia Caforio Giuseppe Blasi Antonio Rampino Lorenzo Sinibaldi Sophia Douzgou Marcello Nardini Daniel R. Weinberger Bruno Dallapiccola | 2007 | Schizophrenia Research2007，，1： | 1 |
| 18 | Hemodialysis prevents liver disease caused by hepatitis C rirus:Role of hepatitis C rirus: Role of hepatocyte growth factor 显示文摘 | Rampino T Arbustini E Gregorini M | 1999 | Kidney Int1999，56，： | 1 |
| 19 | G-protein-mediated inhibition of the Trp channel TRPMI requires the GI33, dimer 显示文摘 | Shen Y Rampino MA Carroll RC | 2012 | PNAS2012，109，22： | 1 |
| 20 | Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma显示文摘 | Paolo GARZINO-DEMO Alessandro DELL’ACQUA Paola DALMASSO Massimo FASOLIS Gian Marco LA TERRA MAGGIORE Guglielmo RAMIERI Sid BERRONE Monica RAMPINO Marina SCHENA | 2006 | Journal of Cranio-Maxillofacial Surgery2006，，6： | 1 |
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