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| 1 | Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors显示文摘Pancreatic carcinomas with acinar differentiation are rare,accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell carcinoma(PACC),pancreatoblastoma,and carcinomas of mixed differentiation. Patients with PACC have a prognosis better than pancreatic ductal adenocarcinomas but worse than pancreatic neuroendocrine tumors. Reports of overall survival range from 18 to 47 mo. A literature review on PACCs included comprehensive genomic profiling and whole exome sequencing on a series of more than 70 patients as well as other diagnostic studies including immunohistochemistry. Surgical resection of PACC is the preferred treatment for localized and resectable tumors. The efficacy of adjuvant treatment is unclear. Metastatic PACCs are generally not curable and treated with systemic chemotherapy. They are moderately responsive to chemotherapy with different regimens showing various degrees of response in case reports/series. Most of these regimens were developed to treat patients with pancreatic ductal adenocarcinomas or colorectal adenocarcinomas. Review of PACC's molecular profiling showed a number of gene alterations such as: SMAD4,BRAF,BRCA2,TP53,RB1,MEN1,JAK-1,BRCA-1,BRCA-2,and DNA mismatch repair abnormalities. PACCs had multiple somatic mutations with some targetable with available drugs. Therefore,molecular profiling of PACC should be an option for patients with refractory PACC. | Ahmad Al-Hader Rami N Al-Rohil Haiyong Han Daniel Von Hoff | 2017 | World Journal of Gastroenterology2017，23，45： | 8 |
| 2 | Does capsule endoscopy have an added value in patients with perianal disease and a negative work up for Crohn's disease?显示文摘AIM:To investigate the role of capsule endoscopy in patients with persistent perianal disease and negative conventional work up for Crohn's disease(CD).METHODS:Patients with perianal disease(abscesses,fistulas,recurrent fissures) were evaluated for underlying CD.Patients who had a negative work up,defined as a negative colonoscopy with a normal ileoscopy or a normal small bowel series or a normal CT/MR enterography,underwent a Pillcam study of the small bowel after signing informed consent.Patients using nonsteroidal anti-inflammatory drugs or who had a history of inflammatory bowel disease or rheumatic disease were excluded.RESULTS:We recruited 26 patients aged 21-61 years(average 35.6 years),17 males and 9 females.One case could not be evaluated since the capsule did not leave the stomach.In 6 of 25(24%) patients with a negative standard work up for Crohn's disease,capsuleendoscopy(CE) findings were consistent with Crohn's disease of the small bowel.Family history of CD,white blood cell,hemoglobin,erythrocyte sedimentation rate or C-reactive protein did not predict a diagnosis of CD.Capsule endoscopy findings led to a change in treatment.CONCLUSION:In patients with perianal disease and a negative conventional work up to exclude CD,CE leads to incremental diagnostic yield of 24%. | Samuel N Adler Metzger Yoav Scapa Eitan Chowers Yehuda Rami Eliakim | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 4 |
| 3 | Bilateral same-session intravitreal injections of antivascular endothelial growth factors显示文摘AIM: To document the indications, safety and possible complications of bilateral same-session intravitreal antivascular endothelial growth factor(VEGF) injections performed in the ophthalmic operating room.METHODS: A retrospective case series study.Consecutive records of seventy four patients receiving simultaneous bilateral intravitreal injections of either ranibizumab or bevacizumab, between September 2010 and September 2013, were reviewed and the outcomes were assessed. Data collected included number of injections, indications for injections, pre-injection and post-injection visual acuity(VA), pre-injection and postinjection intraocular pressure and ocular and systemic complications/complaints after each injection.RESULTS: A total of 342 injections were administered to 74 patients, with a mean of 4.62 injections per patient.Seventy-three patients received bevacizumab(Avastin;Genentech Inc., South San Francisco, California, USA)alone, and only one patient received both bevacizumab and ranibizumab(Lucentis; Genentech Inc.) distributed between the injections. Pre- and post-injection VA follow-up measurements were available for 65 patients.Mean follow up period was 22 mo. The indications for initiating therapy were choroidal neovascular membrane from age-related macular degeneration(3 patients) and diabetic macular edema(71 patients). The mean Snellen VA before each injection was 6/22. The next post-injection follow-up mean Snellen VA was 6/20. One patient had a painful, culture-positive endophthalmitis in one eye 3d after bilateral bevacizumab. Another patient had a painless subconjunctival hemorrhage in one eye.No other ocular or systemic adverse side effects/complaints have been registered in this study group.CONCLUSION: Bilateral same-session intravitreal injections using a separate povidone-iodine preparation,speculum, needle, and syringe for each eye are well-tolerated. None of the subjects in this study requested to switch to alternating unilateral injections. Proper patient counseling as to the risk of complications with this procedure is necessary. | Nakhleh E.Abu-Yaghi Ahmed N Shokry Rami H Abu-Sbeit | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 3 |
| 4 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 5 | Peripheral interventions and antiplatelet therapy: Role in current practice显示文摘Peripheral arterial disease(PAD) is a common disorder associated with a high risk of cardiovascular mortality and continues to be under-recognized. The major risk factors for PAD are similar to those for coronary and cerebrovascular disease. Management includes exercise program, pharmacologic therapy and revascularization including endovascular and surgical approach. The optimal revascularization strategy, endovascular or surgical intervention, is often debated due to the paucity of head to head randomized controlled studies. Despite significant advances in endovascular interventions resulting in increased utilization over surgical bypass, significant challenges still remain. Platelet activation and aggregation after percutaneous transluminal angioplasty of atherosclerotic arteries are important risk factors for re-occlusion/restenosis and life-threatening thrombosis following endovascular procedures. Antiplatelet agents are commonly prescribed to reduce the risk of myocardial infarction, stroke and death from cardiovascular causes in patients with PAD. Despite an abundance of data demonstrating efficacy of antiplatelet therapy in coronary artery disease and cerebrovascular disease, there is a paucity of clinical information, clinical guidelines and randomized controlled studies in the PAD population. Hence, data on antiplatelet therapy in coronary interventions is frequently extrapolated to peripheral interventions. The aim of this review article is to elucidate the current data on revascularization and the role and duration of antiplatelet and anticoagulant therapy in re-vascularized lower limb PAD patients. | Pahul Singh Yenal Harper Carrie S Oliphant Mohamed Morsy Michelle Skelton Raza Askari Rami N Khouzam | 2017 | World Journal of Cardiology2017，9，7： | 2 |
| 6 | Real time physically-based modeling and simulation of cratering and fragmentation of terrain 显示文摘 | RAMI N PROCTOR M D | 2007 | Simulation2007，83，12： | 1 |
| 7 | A taxon- omy of botnet behavior, detection, and defense 显示文摘 | KHAq~FAK S RAMY N R KHAN K R | 2014 | Communications Surveys & Tutorials IEEE2014，16，2： | 1 |
| 8 | Reli- ability estimation of structures under stochastic load- ing A case study on nuclear piping 显示文摘 | Hari Prasad M Rami Reddy G Dubey P N | 2013 | Nuclear Engineering and Design2013，254，702： | 1 |
| 9 | Comparative study of two models that use biochemical parameters for the noninvasive diagnosis of fibrosis in patients with hepatitis C显示文摘 | Romero Gomez M Rami rez Marti n del Campo M Otero MA | 2005 | Med Clin2005，124，20： | 1 |
| 10 | Rice root genetic architecture: meta analysis from a drought QTL database显示文摘 | Courtois B Ahmadi N Khowaja F Price A H Rami J F Frouin J Hamelin C Ruiz M | 2009 | Rice2009，，2： | 1 |
| 11 | A new route for the preparation of the 22,23 - dioxocholestane side chain from diosgenin and its application to the stereocontrolled construction of the 22R ,23S -diol function 显示文摘 | RINCO'N S DEL RI'O R E SANDOVAL - RAMI'REZ J | 2006 | Tetrahedron2006，62，： | 1 |
| 12 | Enhancement of antigen uptake and antibody production in goldfish (Carassius auratus)following bath immunization and ultrasound treatment显示文摘 | Noy N Eitan K Ramy R A | 2004 | Vaccine2004，22，： | 1 |
| 13 | Corrosion protection with polyaniline and polypyrrole as anticorrosive additives for epoxy paint显示文摘 | Elaine Armelin Rosa Pla Francisco Liesa Xavier Ramis José I. Iribarren Carlos Alemán | 2007 | Corrosion Science2007，，3： | 1 |
| 14 | Jaundice,phototherapy and DNA damage in full-term neonates显示文摘 | Ramy N Ghany E A Alsharany W | 2016 | J Perinatol2016，36，2： | 1 |
| 15 | FTIR/ATR study of the copolymerization of diglycidyl ether of Bisphenol A with methyl-substituted γ-lactones catalyzed by rare earth triflate initiators显示文摘 | Arasa M Ramis X Salla J M Mantecón A Serra A | 2007 | J Polym Sci Part A Polym Chem2007，45，11： | 1 |
| 16 | Crosslinking study of mixtures of DGEBA and 1,3-dioxan-2-one catalyzed by lanthanide triflates显示文摘 | Cervellera R Ramis X Salla J M Mantecoón A Serra A | 2005 | J Polym Sci Part A:Polym Chem2005，43，23： | 1 |
| 17 | RFID management in libraries显示文摘 | Rupsingh N Venkata Rami R | | 0，，4： | 1 |
| 18 | Protective Effects of N-Acetylcysteine on Cyclosporine-A-Induced Nephrotoxicity显示文摘 | Mehmet Duru Ahmet Nacar Zafer Y?nden Güven Kuvand?k Mehmet Rami Helvac? Ahmet Ko? Ye?im Akayd?n Hüseyin ?ksüz Sad?k S??üt | 2008 | Renal Failure2008，，4： | 1 |
| 19 | Interleukin 1 β (IL-1B) and IL-1 Antagonist Receptor (IL-1RN) Gene Polymorphisms are Associated With the Genetic Susceptibility and Steroid Dependence in Patients With Ulcerative Colitis显示文摘 | Jesús K. Yamamoto-Furusho Jean J. Santiago-Hernández Nonanzit Pérez-Hernández Silvestre Rami′rez-Fuentes José Manuel Fragoso Gilberto Vargas-Alarcón | 2011 | Journal of Clinical Gastroenterology2011，，6： | 1 |
| 20 | A rare rumor of the lung: inflammatory myofibroblastic tumor显示文摘 | Hammas N Chbani L Rami M | 2012 | Diagn Pathol2012，7，： | 1 |
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