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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase显示文摘 | RALF T TANJA S BRIGITTE D | 2004 | Nature2004，432，7013： | 1 |
| 4 | Genetic clustering of Borna disease virus natural animal isolates, laboratory and vaccine strains strongly reflects their regional geographical origin 显示文摘 | Jolanta Kolodziejek Ralf D rrwald Sibylle Herzog | 2005 | J Gen Virol2005，86，2： | 1 |
| 5 | Association of subjective well--be ing,symptoms,and side effects with compliance after 12 months of treatment in schizophrenia显示文摘 | Karow A Joerg C Ralf D | 2007 | Clin Psychiatry2007，68，： | 1 |
| 6 | Ruthenium - modified zinc oxide, a highly activevis - photocatalyst: the nature and reactivity of photoactive centres 显示文摘 | Jonathan Z B Ralf D Detlef W B | 2014 | View Article Ordine2014，，16： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | BerlinMOD: a benchmark for moving object databases 显示文摘 | CHRISTIAN D THOMAS B RALF H G | 2009 | The VLDB Journal2009，，18： | 1 |
| 9 | Bromelain Ameliorates Hepatic Microcirculation After Warm Ischemia显示文摘 | Ralf Bahde M D Daniel Palme M D Evgeni Minin M D | 2007 | Journal of Surgical Research2007，139，1： | 1 |
| 10 | Mobile number portability in Europe 显示文摘 | Stefan B Ralf D Justus H | 2006 | Telecommunications Policy2006，30，7： | 1 |
| 11 | Cloning,purification and characterization of Staphylococcus warneri lipase 2显示文摘 | Van D Ralf R Gotz F | 2001 | Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology2001，1544，： | 1 |
| 12 | Effect of SOCl2treatment on electrical and mechanical properties of single-wall carbon nanotube networks显示文摘 | Urszula D W Viera S Ralf G | 2005 | J Am Chem Soc2005，127，14： | 1 |
| 13 | MYB transcription factors in Arabidopsis显示文摘 | CHRISTIAN D RALF S ERICH G | 2010 | Trends in Plant Science2010，15，10： | 1 |
| 14 | Status of Zerodur mirror blank production at Schott显示文摘 | THORSTEN D PETER H RALF J | 2005 | SPIE2005，5869，58： | 1 |
| 15 | UHF PD Detection in Gas-insulated Switchgear-Suitability and Sensitivity of the UHF Method in Comparison with the IEC 270 Method显示文摘 | NICHOLAS D BRANKO C RALF P | 1996 | IEEE Electrical Insulation Magazine1996，12，6： | 1 |
| 16 | Making friends in Zurich's urban forests and parks: The role of public green space for social inclusion of youths from differnt cultures显示文摘 | KLAUS S SABINE D RALF H | 2009 | Forest Poliey and Economics2009，11，： | 1 |
| 17 | Photocatalytic degradation of azo dyes by BiOX (X =Cl,Br)显示文摘 | Yu Z Y Detlef B Ralf D | 2012 | Journal of Molecular Catalysis A:Chemical2012，，365： | 1 |
| 18 | The past, present and future of HIV-vaccine development: a critical view 显示文摘 | Alexandra B Ludwig D Ralf W | 2002 | DTT2002，7，1： | 1 |
| 19 | Morning and evening behavior in children and adolescents treated with atomoxetine once daily for Attention-Deficit/Hyperactivity Disorder(ADHD):Findings from two 24-week,open-label studies显示文摘 | PETER M W RALF W D ALEXANDERR S | 2009 | Child and Adolescent Psychiatry and Mental Health2009，3，5： | 1 |
| 20 | Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow 显示文摘 | Ralf L S Christine K Christoph D | 2001 | Fertil Steril2001，75，2： | 1 |
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