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| 1 | Major osteoporotic fragility fractures: Risk factor updates and societal impact显示文摘Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders(for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence. | Paola Pisani Maria Daniela Renna Francesco Conversano Ernesto Casciaro Marco Di Paola Eugenio Quarta Maurizio Muratore Sergio Casciaro | 2016 | World Journal of Orthopedics2016，7，3： | 39 |
| 2 | 屏蔽并且通过 X 光检查和超声的骨质疏松症的早诊断基于技术显示文摘 Effective prevention and management of osteoporosis would require suitable methods for population screenings and early diagnosis. Current clinicallyavailable diagnostic methods are mainly based on the use of either X-rays or ultrasound(US). All X-ray based methods provide a measure of bone mineral density(BMD), but it has been demonstrated that other structural aspects of the bone are important in determining fracture risk, such as mechanical features and elastic properties, which cannot be assessed using densitometric techniques. Among the most commonly used techniques, dual X-ray absorptiometry(DXA) is considered the current 'gold standard' for osteoporosis diagnosis and fracture risk prediction. Unfortunately, as other X-ray based techniques, DXA has specific limitations(e.g., use of ionizing radiation, large size of the equipment, high costs, limited availability) that hinder its application for population screenings and primary care diagnosis. This has resulted in an increasing interest in developing reliable pre-screening tools for osteoporosis such as quantitative ultrasound(QUS) scanners, which do not involve ionizing radiation exposure and represent a cheaper solution exploiting portable and widely available devices. Furthermore, the usefulness of QUS techniques in fracture risk prediction has been proven and, with the last developments, they are also becoming a more and more reliable approach for assessing bone quality. However, the US assessment of osteoporosis is currently used only as a pre-screening tool, requiring a subsequent diagnosis confirmation by means of a DXA evaluation. Here we illustrate the state of art in the early diagnosis of this 'silent disease' and show up recent advances for its prevention and improved management through early diagnosis. | Paola Pisani Maria Daniela Renna Francesco Conversano Ernesto Casciaro Maurizio Muratore Eugenio Quarta Marco Di Paola Sergio Casciaro | 2013 | World Journal of Radiology2013，5，11： | 4 |
| 3 | Ten years of hip fractures in Italy: For the first time a decreasing trend in elderly women显示文摘AIM:To evaluate the hospitalization rate of femoralneck fractures in the elderly Italian population over ten years.METHODS:We analyzed national hospitalizations records collected at central level by the Ministry of Health from 2000 to 2009.Age-and sex-specific rates of fractures occurred at femoral neck in people≥65 years old.We performed a sub-analysis over a three-year period(2007-2009),presenting data per five-year age groups,in order to evaluate the incidence of the hip fracture in the oldest population.RESULTS:We estimated a total of 839008 hospitalizations due to femoral neck fractures between 2000 and2009 in people≥65,with an overall increase of 29.8%over 10 years.The incidence per 10000 inhabitants remarkably increased in people≥75,passing from158.5 to 166.8(+5.2%)and from 72.6 to 77.5(+6.8%)over the ten-year period in women and men,respectively.The oldest age group(people>85 years old)accounted for more than 42%of total hospital admissions in 2009(n=39000),despite representing only 2.5%of the Italian population.Particularly,women aged>85accounted for 30.8%of total fractures,although they represented just 1.8%of the general population.The results of this analysis indicate that the incidence of hip fractures progressively increased from 2000 to 2009,but a reduction can be observed for the first time in women≤75(-7.9%between 2004 and 2009).CONCLUSION:Incidence of hip fractures in Italy are continuously increasing,although women aged 65-74years old started showing a decreasing trend. | Prisco Piscitelli Maurizio Feola Cecilia Rao Monica Celi Elena Gasbarra Cosimo Neglia Giuseppe Quarta Federico Maria Liuni Simone Parri Giovanni Iolascon Maria Luisa Brandi Alessandro Distante Umberto Tarantino | 2014 | World Journal of Orthopedics2014，5，3： | 2 |
| 4 | The long-term survival and the risks and benefits of implantable cardioverter defibrillators in patients with hypertrophic cardiomyopathy显示文摘 | O' Mahony C Lambiase PD Quarta G | | 0，，2： | 1 |
| 5 | Rewarding, reinforcingand incentive salient events involve orexigenic hypo-thalamic neuropeptides regulating mesolimbic dopam-inergic neurotransmission 显示文摘 | QUARTA D SMOLDERS I | 2014 | European Journal ofPharmaceutical Sciences2014，57，： | 1 |
| 6 | Unusual clinical presentation of infection due toFlavimonas oryzihabitans显示文摘 | A. Giacometti O. Cirioni M. Quarta A. M. Schimizzi M. S. Prete G. Scalise | 1998 | European Journal of Clinical Microbiology & Infectious Diseases1998，，9： | 1 |
| 7 | Interpolation methods comparison 显示文摘 | Caruso C Quarta F | 1998 | Computers & Mathematics with Applications1998，35，12： | 1 |
| 8 | DTI and PWI analysis of peri-enhancing tumoral brain tissue in patients treated for glioblastoma显示文摘 | Stecco A Pisani C Quarta R | | 0，，2： | 1 |
| 9 | Partial androgen deficiency,depression and testosterone treatment in aging men显示文摘 | Amore M Scarlatti F Quarta AL | | 0，，： | 1 |
| 10 | Osteoporosis and diabetesReumatismo 显示文摘 | Dominguez LJ Muratore M Quarta E | 2004 | Diabetes Educ2004，56，4： | 1 |
| 11 | Escape from elliptic orbit using constant radial thrust 显示文摘 | Mengali G Quarta A | 2009 | Journal of Guidance Control and Dynamics2009，32，3： | 1 |
| 12 | A set of EST-SSRs isolated from peach fruit transcriptome and their transportability across Prunus species 显示文摘 | VENDRAMIN E DETrORI M T GIOVINAZZI J MICAH S QUARTA R VERDE I | 2007 | Molecular Ecology Notes2007，7，： | 1 |
| 13 | Porcine sclera as a model of human sclera for in vitro transport experiments:histology,SEM,and comparative permeability显示文摘 | Nicoli S Ferrari G Quarta M | 2009 | Mol Vis2009，15，： | 1 |
| 14 | Anesthetic- and heat-induced sudden death in calsequestrin-l-knockout mice 显示文摘 | Dainese M Quarta M Lyfenko AD | 2009 | FASEB J2009，23，6： | 1 |
| 15 | Interpolation methods comparison显示文摘 | CARUSO C QUARTA F | 1998 | Computers&Mathematics with Applications1998，35，12： | 1 |
| 16 | Cure monitoring of epoxy matrices for composites by ultrasonic wave propagation显示文摘 | Maffezzoli A Quarta E Luprano V A M | 1999 | Journal of Applied Polymer Science1999，73，： | 1 |
| 17 | Cure monitoring of epoxy matrices for composites by ultrasonic wave propagation显示文摘 | Maffezzoli A Quarta E Luprano V A M | 1999 | Journal of Applied Polymer Science1999，73，10： | 1 |
| 18 | Inactivation of pectic lyases by light exposure in model systems and fresh-cut apple显示文摘 | Manzocco L Dri A Quarta B | 2009 | InnovFood Sci Emerg2009，10，： | 1 |
| 19 | The Orexin-1 receptor antagonist SB-334867 reduces amphetamineevoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization显示文摘 | Quarta D Valerio E Hutcheson DM | 2010 | Neurochemistry International2010，56，1： | 1 |
| 20 | Modelling the effect of asparaginase in reducing acrylamide formation in biscuits显示文摘 | ANESE M QUARTA B FRIAS J | 2011 | Food Chemistry2011，126，： | 1 |
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