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| 1 | Effect of short-term high-dose atorvastatin on systemic inflammatory response and myocardial ischemic injury in patients with unstable angina pectoris undergoing percutaneous coronary intervention显示文摘 | Sun Fei Yin Zhao Shi Quanxing Zhao Bei Wang Shouli | 2014 | Chinese Medical Journal2014，，21： | 27 |
| 2 | Dendritic Cells Transduced with SOCS1 Gene Exhibit Regulatory DC Properties and Prolong Allograft Survival显示文摘SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. It is thought to participate in negative feedback loops in cytokine signaling and may be an important signal for the regulation of dendritic cell (DC) maturation. However, it remains unclear whether DCs transduced with SOCS1 exhibit characteristics of regulatory DCs and induce allogeneic T-cell hyporesponsiveness. In this study, we constructed adenoviral vector coding SOCS1 (Ad-SOCS1) that can efficiently increase SOCS1 gene expression in bone marrow-derived dendritic cells. DCs transduced with Ad-SOCS1 (DC-SOCS1) expressed low levels of costimulatory and MHC molecules, were resistant to maturation and activation stimulation, induced allogeneic T-cell hyporesponsiveness, and promoted the generation of regulatory-like T cells in vitro. DC-SOCS1 pretreatment significantly prolonged the survival of allografts and led to a substantial increase in the generation of regulatory T cells. Our data suggest that SOCS1 inhibits DC maturation and induces regulatory DC generation, therefore possessing therapeutic potential to prevent rejection in organ transplantation. | Hong Fu Shaohua Song Fang Liu Zhijia Ni Xiaoyun Shen Liang Xiao Guoshan Ding Quanxing Wang | 2009 | Cellular & Molecular Immunology2009，6，2： | 20 |
| 3 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 4 | Effect of Mg/Al atom ratio of support on catalytic performance of Co-Mo/MgO-Al_2O_3 catalyst for water gas shift reaction显示文摘Co-Mo-based catalysts supported on mixed oxide supports MgO-Al2O3 with different Mg/Al atom ratios for water gas shift reaction were studied by means of TPR, Raman, XPS and ESR. It was found that the octahedral Mo species in oxidized Co-Mo/MgO(x)-Al2O3 catalyst and the contents of Mo5+, Mo4+, S2- and S22- species in the functioning catalysts increased with increasing the Mg/Al atom ratio of the support under the studied experimental conditions. This is favorable for the formation of the active Co-Mo-S phase of the catalysts. Catalytic performance testing results showed that the catalysts Co-Mo/MgO-Al2O3 with the Mg/Al atom ratio of the support in the range of 0.475-0.525 exhibited optimal catalytic activity for the reaction. | Yixin Lian Huifang Wang Quanxing Zheng Weiping Fang Yiquan Yang | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 6 |
| 5 | Human BDCA2^+CD123^+CD56^+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset显示文摘树枝状的房间(DC ) 包括二个机能上地不同的子集:plasmacytoid DC (pDCs ) 和 myeloid DC (mDCs ) 。pDCs 被专攻类型的快速、巨大的分泌物我响应通过使用费的 nucleic 酸的干扰素(IFN-I ) 相似受体(TLR )-7 或 TLR-9。在这份报告,我们描绘了 CD56 < 啜 class= “ a-plus-plus ” >+ DC 人口包括 CD123 和 BDCA2 表示典型 pDC 标记,但是生产与 pDCs 作比较的少得多 IFN-I。另外, CD56 < 啜 class= “ a-plus-plus ” > 和由介绍的染色体宽的 transcriptional 的 mDCs 然而并非 pDCs 的 + DC 簇。因此, CD56 < 啜 class= “ a-plus-plus ” >+ DC 机能上地由在 TLR4 刺激和 priming na 之上生产 IL-12 类似于 mDCs ? 没有优先的激活的 ve T 房间。这些数据建议 CD56 < 啜 class= “ a-plus-plus ” >+ DC 代表与一些 pDC 特征混合的一个新奇 mDC 子集。CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ hematological 恶意作为 blastic plasmacytoid 被分类树枝状的房间瘤(BPDCN ) 由于它 pDCs 的典型分子的表示。然而,我们证明 BPDCN 接近 CD56 < 啜 class= “ a-plus-plus ” >+ DC 比由介绍的全球基因表示的 pDCs。因此,我们建议 CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ 瘤可以是 CD56 的一个肿瘤对应物 < 啜 class= “ a-plus-plus ” >+ mDCs 然而并非 pDCs。 | Haisheng Yu Peng Zhang Xiangyun Yin Zhao Yin QuanxinG Shi Ya Cui Guanyuan Liu Shouli Wang Pier Paolo Piccaluga Taijiao Jiang Liguo Zhang | 2015 | Protein & Cell2015，6，4： | 6 |
| 6 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 7 | Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells显示文摘Apoptotic 房间转移被发现了能便于 allograft 的嫁接。然而,内在的机制尚待充分被理解。这里,我们证明施主 apoptotic splenocytes 的静脉内的管理能由导致 tolerogenic 的产生支持胰腺的小岛嫁接树枝状的房间(Tol-DCs ) 和 CD4 + Foxp3 + 规章的 T 房间(Tregs ) 。在 vivo,树枝状的房间(DC ) 或 Tregs 的清理由 apoptotic 房间管理阻止了有免疫力的忍耐的正式就职。用 anti-CD25 的 Tregs 的短暂消除, monoclonal 抗体(mAb ) 在 apoptotic splenocytes 的管理以后废除了 Tol-DCs 的产生。相互地,在用白喉毒素(DT ) 的 CD11c 数据终端就绪老鼠以内的 DC 的弄空与 apoptotic splenocytes 的管理在接受者阻止了 Tregs 的产生。在二个房间之间的房间接触打的由直接要求,并且规划了死亡 1 ligand (PD-L1 ) 的 Tol-DCs 的 Tregs 的正式就职在 Tregs 扩大起了重要作用。Apoptotic 房间管理没能在 IL-10-deficient 和 Smad3 缺乏的老鼠导致 Tol-DCs,建议那 IL-10 和转变生长 factor-β(TGF-β) 被需要处于 tolerogenic 状态维持 DC。因此,我们证明 Tol-DCs 在他们的表面上并且相互地经由 PD-L1 支持 Tregs 的扩大 Tregs 便于 Tol-DCs 维持 apoptotic 房间经由 secreting IL-10 和 TGF-β 导致的移植忍耐;。 | Cong Wu Yi Zhang Yingnling Jiang Quanxing Wang Yao Long Chunmei Wang Xuetao Cao Guoyou Chen | 2013 | Cellular & Molecular Immunology2013，10，5： | 4 |
| 8 | ADSORPTION OF PHENOL AND Pb^(2+) FROM AQUEOUS SOLUTIONS BY A NEW DI-FUNCTION ADSORBENT WITH SULFHYDRYL GROUPS显示文摘A new di-function adsorbent (JN-3) was prepared by sulfhydryl modified. Comparing with Amberlite XAD-4 and NDA-150, the equilibrium adsorption for phenol on the JN-3 from aqueous solutions was tested, perfect adsorption capacity was shown. Pb2+ can be also removed by JN-3 because of the chelate interaction between sulfhydryl groups and metal ions. This adsorbent could be used in removal of combine pollutants such as phenolic compounds and heavy metal ions from waste streams. | WANG Jinnan LI Aimin ZHANG Bo ZHANG Quanxing | 2007 | Chinese Journal of Reactive Polymers2007，16，1： | 3 |
| 9 | TREATMENT AND RESOURSE REUSE OF INDUSTRIAL WASTEWATER FROM PRODUCTION PROCESS OF PHENYL ACETIC ACID显示文摘The effluent from phenyl acetic acid (PhCH2COOH) production process can betreated with NDA-999 macroporous polymeric adsorbent with about 100% removalefficiency of PhCH2COOK benzyl alcohol (PhCH2OH)and benzaldehyde (PhCHO) aswell as the decrease in Total Organic Carbon (TOC)from 4691mg/l to <300mg/L. 3. 7kgPhCH2COOH and 120kg NaCl will be recovered from per m3 wastewater and theadsorbent can be reused after being regenerated by NaOH aqueous solution andmethanol. Good economic, social and environmental results can be achieved with thismethod. | PAN Bingcai CHEN Jinlong ZHANG Quanxing WANG Yong(State Key Laboratory of Pollution Control & Resource Reuse, Department of EnvironmentalScience & Engineering, Nanjing University Nanjing 210093, P R. China) | 1999 | Chinese Journal of Reactive Polymers1999，8，1： | 3 |
| 10 | Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment显示文摘 | Feng Yang Chen Jin Dong Yang Yongjian Jiang Ji Li Yang Di Jianhua Hu Changchun Wang Quanxing Ni Deliang Fu | 2011 | European Journal of Cancer2011，，12： | 2 |
| 11 | Computer Simulation of Heat Transfer in Regenerative Chambers of Self- Preheating Hot Blast Stoves显示文摘 | Zhong Liangcai Liu Quanxing Wang Wenzhong | 2004 | ISIJ International2004，44，5： | 1 |
| 12 | Bioaugmentation as a tool to enhance the removal of refractory compound in coke plant wastewater显示文摘 | Wang J L QuanX C WuLB | 2002 | Process Biochemistry2002，38，5： | 1 |
| 13 | Fabrication of a TiO2/ carbon nanowall heterojunction and its photocatalytic ability显示文摘 | Wang H QuanX Yu H | 2008 | Carbon2008，46，2： | 1 |
| 14 | Dual nanocomposite multihollow polymer microspheres prepared by suspension polymerization based on a multiple pickering emulsion显示文摘 | Quanxing Gao Chaoyang Wang Hongxia Liu etal | 2010 | Polymer Chemistry2010，1，： | 1 |
| 15 | Surfactant-Free Multiple Pickering Emulsions Stabilized by Combining Hydrophobic and Hydrophilic Nanoparticles显示文摘 | Shengwen Zou Chaoyang Wang Quanxing Gao Zhen Tong | 2013 | Journal of Dispersion Science and Technology2013，，2： | 1 |
| 16 | Prehistoric damaging earthquake promoted the decline of'Heluo Ancient State'in Early China显示文摘The emergence of the'Ancient State'is considered an important stage in the discourse on human civilizations.Based on its complex and hierarchical social structure,the Shuanghuaishu site of Henan Province is regarded as an'Ancient state',specifically the'Heluo Ancient State'.The site is situated in the middle reaches of the Yellow River region and played a key role in prehistoric China.However,the reasons behind its decline are unclear.Here,we conducted an integrated investigation of the archaeological excavations and archaeoseismic analyses at the Shuanghuaishu site.We identified paleoseismic remains within paleo-artificial moats,which were formed owing to off-fault structures of soil liquefaction,hillslope landslides,and related ground fractures,along with shake-related wall disruption and building collapse in the residential zone.Charcoal dating was conducted to constrain the age for this earthquake event,which was determined to be approximately 5.0 cal kyr BP.Furthermore,based on the practical curve for earthquake-induced liquefaction,the preliminary estimate of the magnitude of this paleo seismic event is greater than M_(s)5.9-6.0.We propose that the Shuanghuaishu site experienced a recession after the earthquake event,which may have influenced the continuous development of the'Heluo Ancient State'as a regional center settlement. | Xiu HU Peng LU Youli LI Duowen MO Wanfa GU Qingri LIU Ailun GUO Panpan CHEN Hui WANG Yan TIAN Xu WANG Yayi HU Jiqin ZHANG Zhen WANG Quanxing LUO Junjie XU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 17 | Glutamine deprivation induces ferroptosis in pancreatic cancer cells显示文摘Ferroptosis is a type of programmed cell death closely related to amino acid metabolism.Pancreatic cancer cells have a strong dependence on glutamine,which serves as a carbon and nitrogen substrate to sustain rapid growth.Glutamine also aids in self-protection mechanisms.However,the effect of glutamine on ferroptosis in pancreatic cancer remains largely unknown.Here,we aim to explore the association between ferroptosis and glutamine deprivation in pancreatic cancer.The growth of pancreatic cancer cells in culture media with or without glutamine is evaluated using Cell Counting Kit-8.Reactive oxygen species(ROS)are measured by 2′,7′-dichlorodihydrofluorescein diacetate staining.Ferroptosis is assessed by BODIPY-C11 dye using confocal microscopy and flow cytometry.Amino acid concentrations are measured using ultrahigh-performance liquid chromatography-tandem mass spectrometry.Isotope-labelled metabolic flux analysis is performed to track the metabolic flow of glutamine.Additionally,RNA sequencing is performed to analyse the genetic alterations.Glutamine deprivation inhibits pancreatic cancer growth and induces ferroptosis both in vitro and in vivo.Additionally,glutamine decreases ROS formation via glutathione production in pancreatic cancer cells.Interestingly,glutamine inhibitors(diazooxonorleucine and azaserine)promotes ROS formation and ferroptosis in pancreatic cancer cells.Furthermore,ferrostatin,a ferroptosis inhibitor,rescues ferroptosis in pancreatic cancer cells.Glutamine deprivation leads to changes in molecular pathways,including cytokine-cytokine receptor interaction pathways(CCL5,CCR4,LTA,CXCR4,IL-6R,and IL-7R).Thus,exogenous glutamine is required for the detoxification of ROS in pancreatic cancer cells,thereby preventing ferroptosis. | Zhiwen Xiao Shengming Deng He Liu Ruijie Wang Yu Liu Zhengjie Dai Wenchao Gu Quanxing Ni Xianjun Yu Chen Liu Guopei Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 18 | ICOS-Ig combined with CsA induces long term survival of cardiac allografts in mouse显示文摘Objective: To study the synergistic effect of ICOS-Ig combined with cyclosporine (CsA) on mouse heart transplantation and explore its therapeutic potential. Methods: ICOS-Ig fusion protein was generated by fusing the extracellular portion of human ICOS and Fc portion of human IgG. To investigate the effect of ICOS-Ig on T-cell proliferation in vitro, ICOS-Ig or IgG was added to the primary MLR cultures (BALB/c spleen T cells as responder cells and irradiated C57BL/6 spleen cells as stimulator cells). The cells responsiveness rates were detected by 3H-TdR methods. Then the T cells of each group in primary MLR were cultured as responder cells for secondary MLR, and irradiated C57BL/6 (donor) or C3H (third party) spleen cells as stimulator cells. To study the effect of ICOS-Ig on T-cell proliferation in vivo, CFSE-labeled C57BL/6 spleen cells were transferred to irradiated BALB/c mice. Mice were then treated with IgG, ICOS-Ig or CsA. Seventy two hours after transfer, the spleen cells of the mice were harvested for the detection of CD4+CFSE+ and CD8+CFSE+ by FACS. C57BL/6 mouse underwent transplantation of the hearts of BALB/c mouse and were then randomly divided into five equal groups: no treatment group, control IgG treated group (250 μg i.p. d2, 4, 6), ICOS-Ig treated group (250 μg i.p. d2, 4, 6), CsA treated group (10 mg/kg i.p. d0-6), ICOS-Ig combined with CsA group. The cardiac allograft survival was monitored by daily palpation. Results: In primary MLR, ICOS-Ig inhibited T-cell proliferation, (inhibition ratio 58±8.2% in 50 μg/ml). In secondary MLR, ICOS-Ig specifically inhibited donor spleen cells, which suggested ICOS-Ig could induce donor-specific hyporesponsiveness. In the CFSE dye assay, CD4+CFSE+ and CD8+CFSE+ in ICOS-Ig and CsA group was stronger than those in control group, which showed ICOS-Ig and CsA could inhibit the proliferation of allo-reactive T cells in vivo. In mouse heart transplantation model, survival was significantly prolonged in animals treated with ICOS-Ig or CsA as compared with controls. Moreover, ICOS-Ig combined with CsA group had even longer engraftment (>100 d) than ICOS-Ig or CsA used alone. In histological examination, it was found that there were congestions and edemas in no treatment and IgG treated recipients, together with a lot of inflammatory cells infiltrated. Allogeneic hearts from ICOS-Ig and/or CsA immunized recipients revealed milder histological changes. It was revealed in mechanical analysis that splenic T cells from recipients also exhibited depressed mixed leukocyte reactions (MLR) and cytotoxic lymphocyte reactions (CTL). Conclusion: These data suggest that ICOS-Ig combined with CsA induces a long-term survival of mouse cardiac allografts, whereas monotherapy is less effective in this regard. Thus, ICOS-Ig combined with CsA treatment may be a novel regimen to combat allograft rejection. | Zhang Peng Wang Zhenmeng Qin Qin Tang Yi Wang Quanxing Shen Qian | 2009 | Journal of Medical Colleges of PLA(China)2009，24，5： | 0 |
| 19 | Augmentation of antitumor effects by fibroblast-mediated IL-2 and IL-3 gene therapy in mice treated with chemotherapy and BMT显示文摘Effects of fibroblast-mediated IL-2 and IL-3 genetherapy on recovery of bone marrow depression in tumor-bearing mice treated with cyclophosphamide (300 mg/kg) and syngeneic BMT were investigated in the presentreport. BALB/c mice were inoculated with J558Lplasmacytoma cells s. c. and 3 days later IL-2 secretingNIH3T3-IL-2, IL-3 secreting NIH3T3-IL-3 fibroblastcells were implanted into the tumor-bearing mice | Xuetao Cao, Qing Li, Dianwen Ju, Quanxing Wang, Weiping Zhang, Qun TaoDepartment of Immunology, The Second Military Medical University, Shanghai 200433 | 1997 | 中国实验血液学杂志1997，5，3： | 0 |
| 20 | Mini-biography for Mr. Xitao Cai: the pioneer botanist of the plant kingdom显示文摘 | Gaibian Wang Quanxing Zhang Yongping Yang | 2018 | Protein & Cell2018，9，11： | 0 |
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