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| 1 | Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs显示文摘AIM To study the effect of cholecystokinin-octapeptide(CCK-8)and secretin on contractileactivity of isolated gastric muscle strips inguinea pigs.METHODS Each isolated gastric muscle stripwas suspended in a tissue chamber containing5 mL Krebs solution constantly warmed by waterjacked at 37℃ and supplied with a mixed gas of95% O2 and 5% CO2 After incubating for lhunder 1 g tension,varied concentrations of CCK-8 and secretin were added respectively in thetissue chamber and the contractile response wasmeasured isometrically on ink-writing recorders.RESULTS CCK-8 could increase①all regionalcircular and longitudinal muscular tension at rest(fundus LM 19.7%±2.1%,P<0.01;fundus CM16.7%±2.2%,P<0.01;gastric body LM 16.8%±2.3%,P<0.01;body CM 12.7%±2.6%,P<0.01;antrum LM 12.3%±1.3%,P<0.01;antrum CM 16.7%±4.5%,P<0.01;pylous CM12.7%±5.0%,P<0.05);②contractilefrequencies of body LM,both LM and CM ofantrum and pylorus CM(5.1/min±0.2/min to5.6/min±0.2/min,5.9/min±0.2/min to 6.6/min±0.l/min,5.4/min±0.3/min to 6.3/min±0.4/rain,1.3/min±0.2/min to 2.3/min±0.3/min,respectively,P<0.05);③the mean contractileamplitude of antral circular muscle(58.6%±18.4%,P<0.05)and ④the motility index ofpylorus CM(145.0%±23.8%,P<0.01),butdecrease the mean contractile amplitude ofgastric body and antral LM(-10.3%±3.3%,-10.5%±4.6%,respectively,P<0.05).All the CCK-8 effects were not blocked by atropine orindomethacin.Secretin had no effect on gastricsmooth muscle activity.CONCLUSION CCK-8 possessed bothexcitatory and inhibitory action on contractileactivity of different regions of stomach in guineapigs.Its action was not mediated via cholinergicM receptor and endogenous prostagiandinreceptor, | Li W Zheng TZ Qu SY | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 2 | Investigating the Effectiveness of Road-related Mitigation Measures under Semi-controlled Conditions:A Case Study on Asian Amphibians显示文摘Road traffic is the main factor causing the decline in amphibian populations worldwide. The proper design of an amphibian tunnel is one of the most efficient measures to mitigate the negative impacts of road traffic on amphibians. However, no study has investigated the effectiveness of amphibian tunnels under semi-controlled conditions in Asian amphibians. Here, we selected two representative amphibian species, the Chinese brown frog, Rana chensinensis, and the Asiatic toad, Bufo gargarizans, which suffer the most severe road mortality along the roads in Northeast China. We placed experimental arrays of culverts of various sizes(diameters of 1.5, 1, and 0.5 m for circular culverts; side lengths of 1.5, 1, and 0.5 m for box culverts), and substrate type(soil, concrete, and metal) to examine the preferences of both species during the migratory season between May and September in 2016 and 2017. The results revealed that the Chinese brown frog preferred mid-and large-sized culverts as well as soil culverts. We concluded that culverts with a side length ≥ 1 m, lined with soil, and accompanied by a ≥ 0.4 m high guide drift fence and ≤ 45° gradient on the roadside ditch wall would best facilitate road crossings for both species and likely for other amphibian species in Northeast China. | Yun WANG Jiayu LAN Hongping ZHOU Lei GUAN Yudi WANG Yongshun HAN Jiapeng QU Syed Asifullah SHAH Yaping KONG | 2019 | Asian Herpetological Research2019，10，1： | 4 |
| 3 | Cyclic bisbibenzyls induce growth arrest and apoptosis of human prostate cancer PC3 cells显示文摘 | Ai-hui XU Zhi-min HU Jian-bo QU Shang-ming LIU Ali Kazim Abbas SYED Hui-qing YUAN Hong-xiang LOU | 2010 | Acta Pharmacologica Sinica2010，31，5： | 4 |
| 4 | Impact and risk factors of post-stroke bone fracture显示文摘Bone fracture occurs in stroke patients at different times during the recovery phase, prolonging recovery time and increasing medical costs. In this review, we discuss the potential risk factors for post-stroke bone fracture and preventive methods. Most post-stroke bone fractures occur in the lower extremities, indicating fragile bones are a risk factor. Motor changes, including posture, mobility, and balance post-stroke contribute to bone loss and thus increase risk of bone fracture. Bone mineral density is a useful indicator for bone resorption, useful to identify patients at risk of post-stroke bone fracture. Calcium supplementation was previously regarded as a useful treatment during physical rehabilitation. However, recent data suggests calcium supplementation has a negative impact on atherosclerotic conditions. Vitamin D intake may prevent osteoporosis and fractures in patients with stroke. Although drugs such as teriparatide show some benefits in preventing osteoporosis, additional clinical trials are needed to determine the most effective conditions for post-stroke applications. | Kang Huo Syed I Hashim Kimberley LY Yong Hua Su Qiu-Min Qu | 2016 | World Journal of Experimental Medicine2016，6，1： | 2 |
| 5 | Inhibin production and secretion in human placental cells cultured in vitro显示文摘 | Qu JP Ying SY Thomas K | 1992 | Obstet Gynecol1992，79，5： | 1 |
| 6 | Difference in receptor usage be- tween severe acute respiratory syndrome (SARS) coronavir- us and SARS-like coronavirus of bat origin显示文摘 | Ren W Qu X Li W Han Z Yu M Zhou P Zhang SY Wang LF Deng H Shi Z | 2008 | J Virol2008，82，4： | 1 |
| 7 | Overexpression of osteopotin is associated with intrahepatic matastasis,early recurrence,and poorer prognosis of surgically resected hepatocellular careinoma显示文摘 | Pan HW Qu YH Peng SY | 2003 | Cancer2003，98，1： | 1 |
| 8 | Identification of two critical amino acid res- idues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy 显示文摘 | Qu XX Hao P Song XJ Jiang SM Liu YX Wang PG Rao X Song HD Wang SY Zuo Y Zheng AH Luo M Wang HL Deng F Wang HZ Hu ZH Ding MX Zhao GP Deng HK | 2005 | J Biol Chem2005，280，29： | 1 |
| 9 | Advances in research of depression effection on cardiovascular diseases显示文摘 | Gong JM Qu HD Cheng SY | 2001 | Adv ances in Cardiovascular2001，22，2： | 1 |
| 10 | Aryl hydrocarbon receptor exogenous ligand 3-methylchoranthrene inhibited endometrial cancer cell proliferation显示文摘 | Qu XL Wang SY Jia Y J | 2014 | Eur Rev Med Pharmaeol Sci2014，18，： | 1 |
| 11 | Overexpression of osteopontinis associated with intrahepatic metastasis, early recurrence, andpoorer prognosis of resected hepatocellular carcinoma显示文摘 | Pan HW Qu YH Peng SY | 2003 | Cancer2003，98，1： | 1 |
| 12 | Der p 2 recombinant bacille Calmette-Guerin targets dendritic cells to inhibit allergic airway inflammation in a mouse model of asthma 显示文摘 | Qu SY Ou Yang HF He YL | 2013 | Respiration2013，85，1： | 1 |
| 13 | Preparation of biodiesel from waste cooking oil via two-step catalyzed process显示文摘 | WANG Y QU SY LIU PZ | 2007 | Energ Convers Manage2007，48，： | 1 |
| 14 | The GUS reporter-aided analysis of the promoter activities of a rice metallothionein gene reveals different regulatory regions responsible for tissue-specific and inducible expression in transgenic Arabidops/s 显示文摘 | Lu SY Gu HY Yuan X J Wang XM Wu AM Qu L J Liu JY | 2007 | Transgenic Res2007，16，2： | 1 |
| 15 | Effect of Dan Shen on isolated gastric muscle strips in rats 显示文摘 | Zheng TZ Li W Qu Sy | 1992 | WJG1992，，4： | 1 |
| 16 | Downregulation of Cdkl and cy- clinB1 expression contributes to oridonin-induced cell cycle arrest at G2/M phase and growth inhibition in SGC-7901 gastric cancer cells显示文摘 | Gao SY Li J Qu XY | 2014 | AsianPacJ Cancer Prev2014，15，15： | 1 |
| 17 | lnhibin production and secretion in human placental cells cuhured in vitro 显示文摘 | Qu JP Ying SY Thomas K | 1992 | Obstet Gynecol1992，79，5： | 1 |
| 18 | Inhibin production and secretion in human placental cells cultured in vitro 显示文摘 | Qu J Ying SY Thomas K | 1992 | Obstet Gynecol1992，79，1： | 1 |
| 19 | Static magnetic fields promote osteoblast-like cells differentiation via increasing thmembrane rigidity显示文摘 | Chiu KH Qu KL Lee SY | 2007 | J Ann Biomed Eng2007，35，11： | 1 |
| 20 | A study of the mechanisms involved in relaxation induced by 17-beta-estradiol in the isolated rabbit aorta显示文摘 | Li HF Li W Zheng TZ Qu SY Zhang CL | 2002 | Arch Gynecol Obstet2002，266，2： | 1 |
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