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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 3 | Smart Substation Integration Technology and Its Application in Distribution Power Grid显示文摘At present,smart substations use the IEC61850 standard based on the architectural framework of three layers and two networks to realize information digitization and advanced applications.Although the smart substation offers many improvements in design,equipment manufacturing,and construction,the intelligent devices used in smart substations are costly,and are also difficult to maintain since they are dispersed within a single unit.Functionality optimization and device integration,thus,have become important issues in smart substation development.This paper presents an integrated solution and implementation process for a smart substation system.In the process layer,an integrated intelligence component is developed that functions both as an intelligent terminal and a merging unit.In the bay layer,an integrated station-area protection measurement and control master device is designed to achieve such functions as protection,monitoring,control,fault recorder,and power quality monitoring.Finally,in the station control layer,an integrated information platform is established to bring together various system functions and to promote interactive sharing.Integration technology improves the economy and practicality of the smart substation,especially in a distribution power grid. | Qipeng Song Wanxing Sheng Lingfeng Kou Dongbo Zhao Ziping Wu Hengfu Fang Xiaolong Zhao | 2016 | CSEE Journal of Power and Energy Systems2016，2，4： | 6 |
| 4 | Enhanced Photocatalytic Activity of Nanoparticle-Aggregated Ag–AgX(X=Cl, Br)@TiO_2 Microspheres Under Visible Light显示文摘Ag–AgX(X = Cl, Br)@TiO_2 nanoparticle-aggregated spheres with different mass ratio of R = TiO2/Ag(X) from 35:1 to 5:1 were synthesized by a facile sol–gel technique with post-photoreduction. The photocatalytic activities of both Ag–Ag Cl@TiO_2 and Ag–Ag Br@TiO_2 under visible light are effectively improved by ~3 times relative to TiO_2 NPAS under the simulated sunlight for the decomposition of methyl orange(MO). Ag–AgBr@TiO_2 showed 30% improvement and less stable in photocatalytic activity than that of AgCl@TiO_2. The role of Ag and Ag X nanoparticles on the surface of Ag–Ag X(X = Cl,Br)@TiO_2 was discussed. Ag on these samples not onlycan efficiently harvest visible light especially for Ag Cl, but also efficiently separate excited electrons and holes via the fast electron transfer from Ag X(X = Cl, Br) to metal Ag nanoparticles and then to TiO_2-aggregated spheres on the surface of heterostructure. On the basis of their efficient and stable photocatalytic activities under visible-light irradiation, these photocatalysts could be widely used for degradation of organic pollutants in aqueous solution. | Cuiling Zhang Hao Hua Jianlin Liu Xiangyu Han Qipeng Liu Zidong Wei Chengbin Shao Chenguo Hu | 2017 | Nano-Micro Letters2017，9，4： | 5 |
| 5 | Multi-functional forward osmosis draw solutes for seawater desalination显示文摘Forward osmosis(FO), as one of the emerging desalination technologies, has the potential to produce fresh water from a variety of water sources by utilizing the osmotic pressure gradient across a semi-permeable membrane.Draw solution, as an essential component of any FO process, can extract water molecules from seawater or wastewater. An ideal draw solution should meet three essential requirements, namely high osmotic pressure, low reverse flux, and facile regeneration mechanism. The selection of proper draw solutes is especially critical for an energy-efficient FO process since the energy consumption mostly arises from the separation or regeneration of the draw solution. Recently, we developed a few multi-functional FO draw solutes, mainly aiming to enhance the FO water flux and to explore facile re-concentration methods. This review summarizes these draw solutes,including Na^+_- functionalized carbon quantum dots, thermoresponsive copolymers, hydrophilic magnetic nanoparticles, and thermoresponsive magnetic nanoparticles. | Dieling Zhao Shucheng Chen Chun Xian Guo Qipeng Zhao Xianmao Lu | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 4 |
| 6 | Fundamental CRISPR-Cas9 tools and current applications in microbial systems显示文摘Derived from the bacterial adaptive immune system,CRISPR technology has revolutionized conventional genetic engineering methods and unprecedentedly facilitated strain engineering.In this review,we outline the fundamental CRISPR tools that have been employed for strain optimization.These tools include CRISPR editing,CRISPR interference,CRISPR activation and protein imaging.To further characterize the CRISPR technology,we present current applications of these tools in microbial systems,including model-and non-model industrial microorganisms.Specially,we point out the major challenges of the CRISPR tools when utilized for multiplex genome editing and sophisticated expression regulation.To address these challenges,we came up with strategies that place emphasis on the amelioration of DNA repair efficiency through CRISPR-Cas9-assisted recombineering.Lastly,multiple promising research directions were proposed,mainly focusing on CRISPR-based construction of microbial ecosystems toward high production of desired chemicals. | Pingfang Tian Jia Wang Xiaolin Shen Justin Forrest Rey Qipeng Yuan Yajun Yan | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 4 |
| 7 | Novel hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites for dramatically enhanced electromagnetic absorbing properties显示文摘In order to prevent the microwave leakage and mutual interference,more and more microwave absorbing devices are added into the design of electronic products to ensure its routine operation.In this work,we have successfully prepared MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) hierarchical composites by one-pot hydrothermal method and focused on the relationship between structures and electromagnetic absorbing properties.Supported by comprehensive characterizations,M0S_(2) nanosheets were proved to be anchored on the surface and interlayer of Ti_(3)C_(2)T_(x) through a hydrothermal process.Additionally,TiO_(2) nanoparticles were obtained in situ.Due to these hierarchical structures,the MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites showed greatly enhanced microwave absorbing performance.The MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites exhibit a maximum reflection loss value of -33.5 dB at 10.24 GHz and the effective absorption bandwidth covers 3.1GHz(13.9-17 GHz)at the thickness of 1.0 mm,implying the features of wide frequency and light weight.This work in the hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites opens a promising door to the exploration of constructing extraordinary electromagnetic wave absorbents. | Heng DU Qipeng ZHANG Biao ZHAO Frank MARKEN Qiancheng GAO Hongxia LU Li GUAN Hailong WANG Gang SHAO Hongliang XU Rui ZHANG Bingbing FAN | 2021 | Journal of Advanced Ceramics2021，10，5： | 4 |
| 8 | Triple Medium Physical Model of Post Fracturing High-Rank Coal Reservoir in Southern Qinshui Basin显示文摘In this paper, influences on the reservoir permeability, the reservoir architecture and the fluid flow pattern caused by hydraulic fracturing are analyzed. Based on the structure and production fluid flow model of post fracturing high-rank coal reservoir, Warren-Root Model is improved. A new physical model that is more suitable for post fracturing high-rank coal reservoir is established. The results show that the width, the flow conductivity and the permeability of hydraulic fractures are much larger than natural fractures in coal bed reservoir. Hydraulic fracture changes the flow pattern of gas and flow channel to wellbore, thus should be treated as an independent medium. Warrant-Root Model has some limitations and can't give a comprehensive interpretation of seepage mechanism in post fracturing high-rank coal reservoir. Modified Warrant-Root Model simplifies coal bed reservoir to an ideal system with hydraulic fracture, orthogonal macroscopic fracture and cuboid matrix. Hydraulic fracture is double wing, vertical and symmetric to wellbore. Coal bed reservoir is divided into cuboids by hydraulic fracture and further by macroscopic fractures. Flow behaviors in coal bed reservoir are simplified to three step flows of gas and two step flows of water. The swap mode of methane between coal matrix and macroscopic fractures is pseudo steady fluid channeling. The flow behaviors of methane to wellbore no longer follow Darcy's Law and are mainly affected by inertia force. The flow pattern of water follows Darcy's Law. The new physical model is more suitable for post fracturing high-rank coal reservoir. | Shiqi Liu Shuxun Sang Qipeng Zhu Jiefang Zhang Hefeng Gao Huihu Liu Lixing Lin | 2015 | Journal of Earth Science2015，26，3： | 3 |
| 9 | Synthesis of MoX2 (X =Se or S) monolayers with high-concentration 1T'phase on 4H/fcc-Au nanorods for hydrogen evolution显示文摘Controlled synthesis of transition metal dichalcogenide (TMD) monolayers with unusual crystal phases has attracted increasing attention due to their promising applications in electrocatalysis.However,the facile and large-scale preparation of TMD monolayers with high-concentration unusual crystal phase still remains a challenge.Herein,we report the synthesis of MoX2 (X =Se or S) monolayers with high-concentration semimetallic 1T'phase by using the 4H/face-centered cubic (fcc)-Au nanorod as template to form the 4H/fcc-Au@MoX2 nanocomposite.The concentrations of 1T'phase in the prepared MoSe2 and MoS2 monolayers are up to 86% and 81%,respectively.As a proof-of-concept application,the obtained Au@MoS2 nanocomposite is used for the electrocatalytic hydrogen evolution reaction (HER) in acid medium,exhibiting excellent performance with a low overpotential of 178 mV at the current density of 10 mNcm^2,a small Tafel slope of 43.3 mV/dec,and excellent HER stability.This work paves a way for direct synthesis of TMD monolayers with high-concentration of unusual crystal phase for the electrocatalytic application. | Zhengqing Liu Xiao Zhang Yue Gong Qipeng Lu Zhicheng Zhang Hongfei Cheng Qinglang Ma Junze Chen Meiting Zhao Bo Chen Ye Chen Xue-Jun Wu Pengfei Yin Lin Gu Yaping Du Hua Zhang | 2019 | Nano Research2019，12，6： | 3 |
| 10 | A version of Hill's lemma for Cosserat continuum显示文摘根据希尔为古典 Cauchy 连续统的词根,希尔为异构的 Cosserat 连续统当模特儿的微宏 homogenization 的词根的一个版本在平均地的理论的框架被介绍。要求为建模在代表性的卷元素上规定的可被考虑的边界条件被提取并且讨论了保证希尔晓东精力状况和一阶的平均领域理论的满足。 | Xikui Li Qipeng Liu | 2009 | Acta Mechanica Sinica2009，25，4： | 3 |
| 11 | Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling显示文摘The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis. | Qipeng Fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，7： | 3 |
| 12 | Study on the lift and propulsive force shares to improve the flight performance of a compound helicopter显示文摘To investigate the effects of lift and propulsive force shares on flight performance,a compound helicopter model is derived.The model consists of a helicopter model,a wing model and a propeller model.At a low speed of 100 km/h,the Lift-to-Drag ratio(L/D)of the compound helicopter is improved when the wing provides 20.2%of the take-off weight.At high speeds,the L/D can be improved when the propeller provides the total propulsive force.Lowering the main rotor speed increases the wing lift share,however,the maximum L/D increases first and then decreases.The maximum L/D increases with decreasing the blade twist of the main rotor.Decreasing the blade twist from-16°to-8°increases the maximum L/D by 2.3%,and the wing lift share is increased from 65.0%to 74.7%.When the main rotor torque is balanced by the rudder,the maximum L/D is increased by 2.2%without changing the wing lift share.The wing should provide more lift as increasing the take-off weight,which reduces the induced power of the main rotor and increases the L/D.When increasing the take-off weight from 9500 kg to 11000 kg,the maximum L/D is increased by 6.5%,and the wing lift share is increased from 74.7%to 80.2%. | Kelong YANG Dong HAN Qipeng SHI | 2022 | Chinese Journal of Aeronautics2022，35，1： | 2 |
| 13 | Role of chemerin/CMKLR1 in the maintenance of earlypregnancy显示文摘Chemerin is a cytokine that attracts much attention in the reproductive process. This study aimed toexplore the effects of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) on the maintenance of earlypregnancy. The expression levels of chemerin and CMKLR1 in the decidua tissues of 20 early normal pregnantwomen and 20 early spontaneous abortion women were examined by Western blot and real-time polymerase chainreaction analyses. CMKLR1 receptor antagonist (a-NETA) was then intrauterinely injected into normal pregnantmice model to assess its effect on the outcome of pregnancy and the phosphorylation rate of ERK1/2 in deciduatissues. We found that the expression level of chemerin in women who had experienced early spontaneous abortionwas lower than in those who had experienced normal early pregnancy (P 〈 0.01); conversely, CMKLR1expression was higher in the former than in the latter (P 〈 0.01). In a pregnant-mouse model, the embryoresorption rate of a-NETA group was higher than that in the negative control group (61.5% vs. 10.8%) (P 〈 0.001).Compared with the control group, ERK1/2 phosphorylation in decidua tissues decreased in the a-NETA-treatedgroup (P 〈 0.01). These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can leadto the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance ofearly pregnancy possibly by regulating ERK1/2 phosphorylation. | Xuezhou Yang Junning Yao Qipeng Wei Jinhai Ye Xiaofang Yin Xiaozhen Quan Yanli Lan Hui Xing | 2018 | Frontiers of Medicine2018，12，5： | 2 |
| 14 | DISTRIBUTED QUANTIZED CONSENSUS FOR AGENTS ON DIRECTED NETWORKS显示文摘Communication bandwidth and network topology are two important factors that affect performance of distributed consensus in multi-agent systems.The available works about quantized average consensus assume that the adjacency matrices associated with the digraphs are doubly stochastic,which amounts to that the digital networks are balanced.However,this assumption may be unrealistic in practice.In this paper,without assuming double stochasticity,the authors revisit an existing quantized average consensus protocol with the logarithmic quantization scheme,and investigate the quantized consensus problem in general directed digital networks that are strongly connected but not necessarily balanced.The authors first derive an achievable upper bound of the quantization precision parameter to design suitable logarithmic quantizer,and this bound explicitly depends on network topology.Subsequently,by means of the matrix transformation and the Lyapunov techniques,the authors provide a testable condition under which the weighted average consensus can be achieved with the proposed quantized protocol. | LI Dequan LIU Qipeng WANG Xiaofan | 2013 | Journal of Systems Science & Complexity2013，26，4： | 2 |
| 15 | Crystal facet-dependent electrocatalytic performance of metallic Cu in CO_(2)reduction reactions显示文摘Developing high-performance electrocatalysts for CO_(2) reduction reaction(CO_(2)RR)is crucial since it is beneficial for environmental protection and the resulting value-add chemical products can act as an alternative to fossil feedstocks.Nonetheless,the direct reduction of CO_(2) into long-chain hydrocarbons and oxygenated hydrocarbons with high selectivity remains challenging.Copper(Cu)shows a distinctive advantage that it is the only pure metal catalyst for reducing CO_(2) into multi-carbon(C_(2+))products and the certain facets(e.g.,(100),(111),(111))of Cu nanocrystals exhibit relatively low energy barriers for the formation of specific products(e.g.,CO,HCOOH,CH_(4),C_(2)H_(4),C_(2)H_(5)OH,and other C_(2+) products).Therefore,extensive studies have been carried out to explore the relationship between the facets of Cu nanocrystals and corresponding catalytic products.In this review,we will discuss the crystal facet-dependent electrocatalytic CO_(2)RR performance in metallic Cu catalysts,meanwhile,the detailed reaction mechanisms will be systematically summarized.In addition,we will provide a personal perspective for the future research directions in this emerging field.We believe this review is helpful to guide the design of high-selectivity Cu-based electrocatalysts for CO_(2)RR. | Hao Zhang Caihong He Sumei Han Zeyang Du Ling Wang Qinbai Yun Wenbin Cao Bowei Zhang Ya-Hui Tian Qipeng Lu | 2022 | Chinese Chemical Letters2022，33，8： | 2 |
| 16 | Selective secretion of microRNA in CNS system显示文摘EXTRACELLULAR miRNAs ARE PRESENT IN VARIOUS BODY FLUIDS MicroRNAs(miRNAs)are a diverse class of endogenous small non-coding RNAs,which posttranscriptionally regulate gene expression by interacting with their binding sites in target mRNAs.Recently,several studies have demonstrated that miRNAs are also detectable outside cells,and these miRNAs may be called extracellular miRNAs.Extracellular miRNAs are found in various body fluids,including plasma and serum(Chen et al.,2008),saliva(Park et al.,2009),amniotic fl uid(Weber et al.,2010),Bronchial lavage(Molina-Pinelo et al.,2012;Weber et al.,2010),sputum(Xie et al.,2010),tears and urine(Weber et al.,2010),bile(Shigehara et al.,2011),seminal plasma(Wang et al.,2011),breast milk(Zhou et al.,2012),peritoneal fluid(Chen et al.,2012a).Finding the extracellular miRNAs extended the research field of miRNAs,and got a lot of fruitful research fi ndings. | Qipeng Zhang Jie Xu Qun Chen Xi Chen Ke Zen Chen-Yu Zhang | 2013 | Protein & Cell2013，4，4： | 2 |
| 17 | Relationship of proprioception,cutaneous sensitivity,and muscle strength with the balance control among older adults显示文摘Background:Balance impairment is one of the strongest risk factors for falls.Proprioception,cutaneous sensitivity,and muscle strength are 3 important contributors to balance control in older adults.The relationship that dynamic and static balance control has to proprioception,cutaneous sensitivity,and muscle strength is still unclear.This study was performed to investigate the relationship these contributors have to dynamic and static balance control.Methods:A total of 164 older adults(female=89,left dominant=15,age:73.5±7.8 years,height:161.6±7.1 cm,weight:63.7±8.9 kg,mean±SD)participated in this study.It tested the proprioception of their knee flexion/extension and ankle dorsi/plantarflexion,along with cutaneous sensitivity at the great toe,first and fifth metatarsals,arch,and heel,and the muscle strength of their ankle dorsi/plantarflexion and hip abduction.The Berg Balance Scale(BBS)and the root mean square(RMS)of the center of pressure(CoP)were collected as indications of dynamic and static balance control.A partial correlation was used to determine the relationship between the measured outcomes variables(BBS and CoPRMS)and the proprioception,cutaneous sensitivity,and muscle strength variables.Results:Proprioception of ankle plantarflexion(r=-0.306,p=0.002)and dorsiflexion(r=-0.217,p=0.030),and muscle strength of ankle plantarflexion(r=0.275,p=0.004),dorsiflexion(r=0.369,p<0.001),and hip abduction(r=0.342,p<0.001)were weakly to moderately correlated with BBS.Proprioception of ankle dorsiflexion(r=0.218,p=0.020)and cutaneous sensitivity at the great toe(r=0.231,p=0.041)and arch(r=0.285,p=0.002)were weakly correlated with CoP-RMS in the anteroposterior direction.Proprioception of ankle dorsiflexion(r=0.220,p=0.035),knee flexion(r=0.308,p=0.001)and extension(r=0.193,p=0.040),and cutaneous sensitivity at the arch(r=0.206,p=0.028)were weakly to moderately correlated with CoP-RMS in the mediolateral direction.Conclusion:There is a weak-to-moderate relationship between proprioception and dynamic and static balance control,a weak relationship between cutaneous sensitivity and static balance control,and a weak-to-moderate relationship between muscle strength and dynamic balance control. | Qipeng Song Xinyan Zhang Min Mao Wei Sun Cui Zhang Yan Chen Li Li | 2021 | Journal of Sport and Health Science2021，10，5： | 2 |
| 18 | Preparative isolation and purification of purification from pomegranate husk by high-speed countercurrent chromatography显示文摘 | LU Jingjing WEI Yun YUAN Qipeng | 2007 | J Chromatogr B: Analyt Technol Biomed Life Sei2007，857，1： | 1 |
| 19 | Adsorption of phenol by oil-palm-shell activated carbons in a fixed bed 显示文摘 | Lua Aik Chong Jia Qipeng | 2009 | Chemical Engineering Journal2009，150，23： | 1 |
| 20 | Microbi- al biosynthesis of the anticoagulant precursor 4-hydroxy- coumarin 显示文摘 | Lin Yuheng Shen Xiaolin Yuan Qipeng | 2013 | Nature Communications2013，，4： | 1 |
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