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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 3 | Enhanced Photocatalytic Activity of Nanoparticle-Aggregated Ag–AgX(X=Cl, Br)@TiO_2 Microspheres Under Visible Light显示文摘Ag–AgX(X = Cl, Br)@TiO_2 nanoparticle-aggregated spheres with different mass ratio of R = TiO2/Ag(X) from 35:1 to 5:1 were synthesized by a facile sol–gel technique with post-photoreduction. The photocatalytic activities of both Ag–Ag Cl@TiO_2 and Ag–Ag Br@TiO_2 under visible light are effectively improved by ~3 times relative to TiO_2 NPAS under the simulated sunlight for the decomposition of methyl orange(MO). Ag–AgBr@TiO_2 showed 30% improvement and less stable in photocatalytic activity than that of AgCl@TiO_2. The role of Ag and Ag X nanoparticles on the surface of Ag–Ag X(X = Cl,Br)@TiO_2 was discussed. Ag on these samples not onlycan efficiently harvest visible light especially for Ag Cl, but also efficiently separate excited electrons and holes via the fast electron transfer from Ag X(X = Cl, Br) to metal Ag nanoparticles and then to TiO_2-aggregated spheres on the surface of heterostructure. On the basis of their efficient and stable photocatalytic activities under visible-light irradiation, these photocatalysts could be widely used for degradation of organic pollutants in aqueous solution. | Cuiling Zhang Hao Hua Jianlin Liu Xiangyu Han Qipeng Liu Zidong Wei Chengbin Shao Chenguo Hu | 2017 | Nano-Micro Letters2017，9，4： | 5 |
| 4 | Triple Medium Physical Model of Post Fracturing High-Rank Coal Reservoir in Southern Qinshui Basin显示文摘In this paper, influences on the reservoir permeability, the reservoir architecture and the fluid flow pattern caused by hydraulic fracturing are analyzed. Based on the structure and production fluid flow model of post fracturing high-rank coal reservoir, Warren-Root Model is improved. A new physical model that is more suitable for post fracturing high-rank coal reservoir is established. The results show that the width, the flow conductivity and the permeability of hydraulic fractures are much larger than natural fractures in coal bed reservoir. Hydraulic fracture changes the flow pattern of gas and flow channel to wellbore, thus should be treated as an independent medium. Warrant-Root Model has some limitations and can't give a comprehensive interpretation of seepage mechanism in post fracturing high-rank coal reservoir. Modified Warrant-Root Model simplifies coal bed reservoir to an ideal system with hydraulic fracture, orthogonal macroscopic fracture and cuboid matrix. Hydraulic fracture is double wing, vertical and symmetric to wellbore. Coal bed reservoir is divided into cuboids by hydraulic fracture and further by macroscopic fractures. Flow behaviors in coal bed reservoir are simplified to three step flows of gas and two step flows of water. The swap mode of methane between coal matrix and macroscopic fractures is pseudo steady fluid channeling. The flow behaviors of methane to wellbore no longer follow Darcy's Law and are mainly affected by inertia force. The flow pattern of water follows Darcy's Law. The new physical model is more suitable for post fracturing high-rank coal reservoir. | Shiqi Liu Shuxun Sang Qipeng Zhu Jiefang Zhang Hefeng Gao Huihu Liu Lixing Lin | 2015 | Journal of Earth Science2015，26，3： | 3 |
| 5 | Synthesis of MoX2 (X =Se or S) monolayers with high-concentration 1T'phase on 4H/fcc-Au nanorods for hydrogen evolution显示文摘Controlled synthesis of transition metal dichalcogenide (TMD) monolayers with unusual crystal phases has attracted increasing attention due to their promising applications in electrocatalysis.However,the facile and large-scale preparation of TMD monolayers with high-concentration unusual crystal phase still remains a challenge.Herein,we report the synthesis of MoX2 (X =Se or S) monolayers with high-concentration semimetallic 1T'phase by using the 4H/face-centered cubic (fcc)-Au nanorod as template to form the 4H/fcc-Au@MoX2 nanocomposite.The concentrations of 1T'phase in the prepared MoSe2 and MoS2 monolayers are up to 86% and 81%,respectively.As a proof-of-concept application,the obtained Au@MoS2 nanocomposite is used for the electrocatalytic hydrogen evolution reaction (HER) in acid medium,exhibiting excellent performance with a low overpotential of 178 mV at the current density of 10 mNcm^2,a small Tafel slope of 43.3 mV/dec,and excellent HER stability.This work paves a way for direct synthesis of TMD monolayers with high-concentration of unusual crystal phase for the electrocatalytic application. | Zhengqing Liu Xiao Zhang Yue Gong Qipeng Lu Zhicheng Zhang Hongfei Cheng Qinglang Ma Junze Chen Meiting Zhao Bo Chen Ye Chen Xue-Jun Wu Pengfei Yin Lin Gu Yaping Du Hua Zhang | 2019 | Nano Research2019，12，6： | 3 |
| 6 | A version of Hill's lemma for Cosserat continuum显示文摘根据希尔为古典 Cauchy 连续统的词根,希尔为异构的 Cosserat 连续统当模特儿的微宏 homogenization 的词根的一个版本在平均地的理论的框架被介绍。要求为建模在代表性的卷元素上规定的可被考虑的边界条件被提取并且讨论了保证希尔晓东精力状况和一阶的平均领域理论的满足。 | Xikui Li Qipeng Liu | 2009 | Acta Mechanica Sinica2009，25，4： | 3 |
| 7 | Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling显示文摘The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis. | Qipeng Fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，7： | 3 |
| 8 | DISTRIBUTED QUANTIZED CONSENSUS FOR AGENTS ON DIRECTED NETWORKS显示文摘Communication bandwidth and network topology are two important factors that affect performance of distributed consensus in multi-agent systems.The available works about quantized average consensus assume that the adjacency matrices associated with the digraphs are doubly stochastic,which amounts to that the digital networks are balanced.However,this assumption may be unrealistic in practice.In this paper,without assuming double stochasticity,the authors revisit an existing quantized average consensus protocol with the logarithmic quantization scheme,and investigate the quantized consensus problem in general directed digital networks that are strongly connected but not necessarily balanced.The authors first derive an achievable upper bound of the quantization precision parameter to design suitable logarithmic quantizer,and this bound explicitly depends on network topology.Subsequently,by means of the matrix transformation and the Lyapunov techniques,the authors provide a testable condition under which the weighted average consensus can be achieved with the proposed quantized protocol. | LI Dequan LIU Qipeng WANG Xiaofan | 2013 | Journal of Systems Science & Complexity2013，26，4： | 2 |
| 9 | Fault Diagnosis Using Wavelet Neural Networks 显示文摘 | Liu Qipeng Yu Xiaoling Feng Quanke | 2003 | Nerual Processing Letters2003，18，2： | 1 |
| 10 | Surface charge of PLA microparticles in regulation of antigen loading,macrophage phagocytosis and activation,and immune effects in vitro显示文摘The use of microparticles(MPs) as adjuvants has attracted increasing interest in vaccine delivery systems.Many physiochemical characteristics of MPs including hydrodynamic size,surface properties,and morphology can regulate the immune response.Surface charge is an important characteristic of MPs,but how it affects their adjuvanticity remains unknown.In this study,we prepared uniform-sized polylactide MPs coated with various polymers of different positive charge,and investigated how the surface charge affected antigen loading and macrophage phagocytosis and activation in vitro.A higher surface charge greatly enhanced antigen loading and antigen internalization into macrophages,promoted the expression of MHC 11 and CD80,and increased the secretion level of TNF-a.Taken together,these results indicated that surface charge was an important parameter for improving the adjuvanticity of MPs. | Yuying Liu Xiaoming Chen Lianyan Wang Tingyuan Yang Qipeng Yuan Guanghui Ma | 2014 | Particuology2014，12，6： | 1 |
| 11 | Fault diagnosis using wavelet neural networks显示文摘 | Liu Qipeng Yu Xiaoling Feng Quanke | 2003 | Neural Processing Letters2003，18，2： | 1 |
| 12 | Consensus seeking over directed networks with limited information communication显示文摘 | Dequan Li Qipeng Liu Xiaofan Wang Zongli Lin | 2012 | Automatica2012，，： | 1 |
| 13 | The ~-crystalline form of wollastonite- filled polypropylene 显示文摘 | Liu Jingjiang Wei Xiufen Guo Qipeng | 2003 | Journal of Applied Polymer Science2003，41，1112： | 1 |
| 14 | Self-Assembled Complexes of Poly(4-vinylphenol) and Poly(e-caprolactone)-block-poly(2-vinylpyridine) via Competitive Hydrogen Bonding显示文摘 | Nishar Hameed Jing Liu Qipeng Guo | 2008 | Macromolecules2008，41，： | 1 |
| 15 | Cosensitization process effect of D-A-π-A featured dyes on photovoltaic performances显示文摘Cosensitization based on two or multiple dyes as 'dye cocktails' can hit the target on compensating and broadening light-harvesting region.Two indoline D-A-π-A motif sensitizers(WS-2 and WS-39) that possess similar light response area but distinctly reversed feature in photovoltaic performance are selected as the specific cosensitization couple. That is, WS-2 shows quite high photocurrent but low photovoltage, and WS-39 gives relatively low photocurrent but quite high photo voltage. Due to the obvious 'barrel effect',both dyes show medium PCE around8.50%. In contrast with the previous cosensitization strategy mostly focused on the compensation of light response region, herein we perform different cosensitization sequence, for taking insight into the balance of photocurrent and photo voltage, and achieving the synergistic improvement in power conversion efficiency(PCE). Electronic impedance spectra(EIS) indicate that exploiting dye WS-39 with high V_(OC) value as the primary sensitizer can repress the charge recombination more effectively, resulting in superior V_(OC) rather than using dye WS-2 with high J_(SC)as the primary sensitizer. As a consequence, a high PCE value of 9.48% is obtained with the delicate cosensitization using WS-39 as primary dye and WS-2 as accessory dye, which is higher than the corresponding devices sensitized by each individual dye(around 8.48-8.67%). It provides an effective optimizing strategy of cosensitization how to combine the individual dye advantages for developing highly efficient solar cells. | Bo Liu Qipeng Chai Weiwei Zhang Wenjun Wu He Tian Wei-Hong Zhu | 2016 | Green Energy & Environment2016，1，1： | 1 |
| 16 | Highly selective electrocatalytic Cl− oxidation reaction by oxygen-modified cobalt nanoparticles immobilized carbon nanofibers for coupling with brine water remediation and H2 production显示文摘Combining the H2 production with brine remediation is regarded as a sustainable approach to achieving clean H2 energy. However, designing stable Cl− oxidation reaction (COR) electrocatalyst is the key to realize this route. Herein, a type of oxygen-modified Co nanoparticles anchored graphitic carbon nanofibers catalyst (Co/GCFs) was synthesized through a two-step strategy of adsorption and pyrolysis. The Co/GCFs-2.4 exhibits high selectivity and stability for COR at neutral electrolyte. It is worth noting that unlike the water oxidation, the chemical valence of cobalt has not changed during the COR. Further results demonstrated that the oxygen-modified Co nanoparticles provide active sites for selective COR, meanwhile, the graphitic carbon gives rise to strong catalytic stability. Thanks to the superior COR and H2 production activity of Co/GCFs-2.4, a two-electrode brine electrocatalysis system employing Co/GCFs-2.4 as both cathode and anode for H2 production exhibited robust stability, efficient and high Faraday efficiency (98%-100%). We propose that this work provides a novel strategy for designing efficient and stable catalysts with electrocatalytic COR and HER activities at neutral brine water for practically coupling with H2 production by water electrolysis and brine water remediation. | Qizhong Xiong Xian Zhang Qipeng Cheng Guoqiang Liu Gang Xu Junli Li Xinxin Ye Hongjian Gao | 2021 | Nano Research2021，14，5： | 1 |
| 17 | Optimisation of enzyme assisted extraction of silybin from the seeds of Silybum marianum by Box-Behnken experimental design显示文摘 | LIU Hong DU Xueling YUAN Qipeng | 2009 | Phytochem Anal2009，20，6： | 1 |
| 18 | Optimisation of enzyme assisted extraction of silybin from the seeds of silybum marianum by box-behnken显示文摘 | Liu Hong Du Xueling Yuan Qipeng | 2009 | Exper Design Phytochem Anal2009，20，3： | 1 |
| 19 | Implementation of effective control system for variable-included angle plane-grating monochromator显示文摘The variable-included angle plane-grating monochromator is a homemade key equipment of the scanning transmission X-ray microscopy (STXM) beamline at Shanghai Synchrotron Radiation Facility (SSRF).Monochromatic light of various wavelengths is achieved by an effective control system that handles the rotation of the plane mirror and plane grating mounted in a high vacuum chamber.M511.DDB made by PI Corp.is used as motion stage which has a DC servo motor controlled by a C862 controller based on RS232 protocol.The software platform of STXM is EPICS,so the local control functions are implemented by LabVIEW program to satisfy physics control.For the remote control functions,the program is integrated into EPICS with ShareMemoryIOC.Experimental tests show that the repeat precision of motion control is less than 0.2μm,which meets the control demand. | LIU Ping WANG Yong TAI Renzhong XUE Song LU Qipeng ZHENG Lifang | 2011 | Nuclear Science and Techniques2011，22，1： | 1 |
| 20 | The β-crystalline form of wollastonite-filled polypropylene显示文摘 | Liu Jingjiang Wei Xiufan Guo Qipeng | 1990 | J Appl Polym Sci1990，41，： | 1 |
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