|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 2 | 藜芦属植物甾体生物碱及其药理活性研究进展显示文摘藜芦属植物含有多种甾体生物碱成分,目前从该属植物中分离鉴定了至少184个甾体生物碱,其中西藜芦碱型69个(A-1~A-69),藜芦胺型21个(B-1~B-21),介藜芦碱型31个(C-1~C-31),茄次碱型10个(D-1~D-10)和维藜芦碱型53个(E-1~E-53)。研究表明这些甾体生物碱具有多种药理活性,主要包括降血压、抗血小板聚集和抗血栓形成、抗炎镇痛和抗肿瘤作用。该文对藜芦属植物中184个甾体生物碱进行分类归纳,并概述了其主要的药理活性,为藜芦属生物碱成分的开发和利用提供科学依据。 | 张蒙珍 高丽娟 徐世芳 黄文康 李晓誉 叶益萍 | 2020 | 中国中药杂志2020，45，21： | 7 |
| 3 | Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas显示文摘The majority of non-melanoma skin cancer(NMSC)is cutaneous basal cell carcinoma(BCC)or squamous cell carcinoma(SCC),which are also called keratinocyte carcinomas,as both of them originate from keratinocytes.The incidence of keratinocyte carcinomas is over 5 million per year in the US,three-fold higher than the total incidence of all other types of cancer combined.While there are several reports on gene expression profiling of BCC and SCC,there are significant variations in the reported gene expression changes in different studies.One reason is that tumor-adjacent normal skin specimens were not included in many studies as matched controls.Furthermore,while numerous studies of skin stem cells in mouse models have been reported,their relevance to human skin cancer remains unknown.In this report,we analyzed gene expression profiles of paired specimens of keratinocyte carcinomas with their matched normal skin tissues as the control.Among several novel findings,we discovered a significant number of zinc finger encoding genes up-regulated in human BCC.In BCC,a novel link was found between hedgehog signaling,Wnt signaling,and the cilium.While the SCC cancerstem-cell gene signature is shared between human and mouse SCCs,the hair follicle stem-cell signature of mice was not highly represented in human SCC.Differential gene expression(DEG)in human BCC shares gene signature with both bulge and epidermal stem cells.We have also determined that human BCCs and SCCs have distinct gene expression patterns,and some of them are not fully reflected in current mouse models. | Jun Wan Hongji Dai Xiaoli Zhang Sheng Liu Yuan Lin Ally-Khan Somani Jingwu Xie Jiali Han | 2021 | Genes & Diseases2021，8，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员