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| 1 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 2 | Relationship between corneal biomechanical parameters and corneal sublayer thickness measured by Corvis ST and UHR-OCT in keratoconus and normal eyes显示文摘Background:To explore the relationship between corneal biomechanical parameters and corneal sublayer thickness using corneal visualization Scheimpflug technology(Corvis ST)and ultrahigh-resolution optical coherence tomography(UHR-OCT)in clinical and suspected keratoconus and normal eyes.Methods:Cross-sectional prospective study.A total of 94 eyes of 70 participants were recruited.Twenty five eyes of 19 keratoconus patients,52 eyes of 34 patients showing high risk of developing keratoconus according to the Belin/Ambrosio Enhanced Ectasia Display,and each eye of 17 normal subjects were enrolled.All participants underwent Corvis ST,Pentacam,and UHR-OCT examinations at the same time.Stiffness parameter A1(SP-A1),deformation amplitude ratio(DA ratio),and other biomechanical parameters were recorded using Corvis ST.The vertical and horizontal thickness profiles of central 3mm corneal epithelium,Bowman’s layer,and stroma as measured by the perpendicular distance between the neighboring interfaces were generated using UHR-OCT.The flat keratometry and steep keratometry were obtained using Pentacam.Analysis of correlation was applied to explore the association between variables.Results:Most of the biomechanical parameters and corneal sublayer thickness profiles showed statistical differences among three groups.A statistically significant linear relationship was noted between SP-A1 and DA ratio in all three groups.SP-A1 was found to be positively correlated with epithelial and Bowman’s layer thickness in the keratoconus(KC)group,and with stromal thickness in all three groups.In the normal and suspected keratoconus(SKC)groups,only stromal thickness was included in the stepwise linear regression to predict SP-A1,whereas in the KC group,steep keratometry and Bowman’s layer thickness were included.Conclusions:Significant and different correlations were noted between corneal stiffness and corneal sublayer thickness in different groups,indicating that corneal sublayers may play different roles in maintaining corneal biomechanical stability between keratoconus and normal eyes. | Yong Li Zhiqiang Xu Qiaoli Liu Yuzhou Wang Kan Lin Jiahui Xia Shihao Chen Liang Hu | 2021 | Eye and Vision2021，8，1： | 2 |
| 3 | Electronic structure and phase stability during martensitic transformation in Al-doped ZrCu intermetallics显示文摘 | Feng Qiu Ping Shen Tao Liu Qiaoli Lin Qichuan Jiang | 2009 | Journal of Alloys and Compounds2009，，1： | 1 |
| 4 | Wetting and evaporation behaviors of molten Mg on partially oxidized SiC substrates显示文摘 | Dan Zhang Ping Shen Laixin Shi Qiaoli Lin Qichuan Jiang | 2010 | Applied Surface Science2010，，23： | 1 |
| 5 | Effect and mechanism of CyPA in radiosensitization of lung adenocarcinoma using CRISPR/Cas9 technology显示文摘Objective:To explore the role of cyclophilin A(CyPA)in sensitization of lung adenocarcinoma to radiotherapy using CRISPR/Cas9 technology.Methods:A CyPA knockout human lung adenocarcinoma cell line H1975 was established by CRISPR/Cas9 technology.Groups included a control group(wildtype),CyPA knockout group,traditional Chinese medicine(TCM)extract with Fuzhengzengxiao decoction group,and TCM extract with Fuzhengzengxiao decoction t CyPA knockout group.Each group was exposed to radiation at doses of 0,2,4,6,and 8 Gy.After 24 h,MTT assays were used to determine the survival rate of lung cancer cells and calculate radiosensitivity.The qPCR was used to measure mRNA expression of DDIT3,CDKN1A,and CDC25A associated with DNA damage repair.Results:Without irradiation,Fuzhengzengxiao decoction reduced the survival rate of lung adenocarcinoma cells(P<.0001).After irradiation,TCM extract with Fuzhengzengxiao decoction,CyPA knockout,and TCM extract with Fuzhengzengxiao decoction t CyPA knockout groups had reduced survival rates(P<.0001)and radiosensitivity was increased significantly.Expression of DDIT3,CDKN1A,and CDC25A was upregulated after knockout of CyPA(P<.0001).Expression of DDIT3 and CDC25A was increased after irradiation in wildtype cells treated with TCM extract with Fuzhengzengxiao decoction(DDIT3,P<.0001;CDC25A,P紏.0059).The TCM extract with Fuzhengzengxiao decoction t CyPA knockout group also had increased expression of DDIT3 and CDC25A after irradiation(P<.0001).Conclusion:Fuzhengzengxiao decoction significantly decreases the survival rate of lung cancer cells,and its mechanism may be related to radiosensitization by decreasing expression of CyPA and inducing G1/S cell cycle arrest. | Jinkun Ma Lin Xu Jinchang Huang Qiaoli Zhang Yuqin Qiu Xuewei Qi Lina Wang Yuchan Cao Zeyu Liu Shiyun Liu | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 1 |
| 6 | The research progress of placenta implantation 显示文摘 | Qiaoli Song Xiaochun Zheng Lin Ya | 2010 | Chinese Nursing Research2010，24，12： | 1 |
| 7 | 大型水库消落带中西来稗种子耐淹性沿高程梯度的种内分化显示文摘在水文节律稳定、每年蓄水时间很长且水位涨落落差很大的水库中,生长在水库库岸消落带不同高程区域中的植物每年要面对长时间的不同强度的水淹,这种每年发生持续的水淹胁迫可能会导致水库库岸消落带中生长的植物的种子耐淹能力发生种内分化。西来稗(Echinochloa crusgalli var.zelayensis)是在三峡水库消落带中自然生长的优势一年生植物,在三峡水库消落带植被及消落带生态环境保护中发挥着重要作用。本研究的目的在于探究三峡水库消落带中生长的西来稗种子的耐淹能力是否已发生种内分化,以及此分化的发生是否与较弱的种子扩散能力有关。在本研究中,采集来自三峡水库消落带不同高程区域中生长的西来稗种子,在三峡水库即将蓄水时将所有采集的种子放置于三峡水库消落带中4个不同高程位置接受不同深度不同时长的水库蓄水水淹,同时把所有采集的种子也放置于不会被水库蓄水淹没的非消落带河岸上作为对照处理;测定种子在水中的漂浮持续时间和蓄水期间水库水位上涨速度以量化在水库蓄水水位上涨时种子的扩散能力,水库蓄水结束水退后检测放置于水库消落带和非消落带河岸上的种子的种子完好率、种子萌发能力和成苗率。研究结果发现,在经历三峡水库蓄水水淹后,西来稗种子的完好率和最终成苗率随种子母株在消落带中所处的高程的增加而显著降低,表明在三峡水库成库运行七年后,在三峡水库消落带中生长的西来稗的种子耐淹能力已发生了种内分化。三峡水库蓄水水位上涨时西来稗种子在水中较短的漂浮持续时间和水库蓄水时较慢的水位上升速度限制了西来稗种子的水媒传播和扩散距离,从而有利于西来稗种子的耐淹能力发生种内分化。 | Songping Liu Feng Lin Xiaolei Su Qiaoli Ayi Hangang Niu Shaohua Shi Binna Wan Bo Zeng Xiaoping Zhang | 2021 | Journal of Plant Ecology2021，14，1： | 0 |
| 8 | Growth mechanisms of interfacial carbides in solid-state reaction between single-crystal diamond and chromium显示文摘Interfacial bonding is one of the most challenging issues in the fabrication,and hence comprehensively influences the properties of diamond-based metal matrix composites(MMCs)materials.In this work,solid-state(S/S)interface reaction between single-crystal synthetic diamond and chromium(Cr)metal was critically examined with special attention given to unveil the role of crystal orientation in the for-mation and growth of interfacial products.It has been revealed that catalytically converted carbon(CCC)was formed prior to chromium carbides,which is counterintuitive to previous studies.Cr 7 C 3 was the first carbide formed in the S/S interface reaction,aided by the relaxation of diamond lattices that re-duces the interfacial mismatch.Interfacial Cr 7 C 3 and Cr 3 C 2 carbides were formed at 600 and 800℃,respectively,with the growth preferred on diamond(100)plane,because of its higher density of surface defects than(111)plane.Interfacial strain distribution was quasi-quantitively measured using windowed Fourier Transform-Geometric Phase Analysis(WFT-GPA)analysis and an ameliorated strain concentration was found after the ripening of interfacial carbides.Textured morphologies of Cr_(3)C_(2) grown on diamond(100)and(111)planes were perceived after S/S interface reaction at 1000℃,which is reported for the first time.The underlying mechanisms of Cr-induced phase transformation on diamond surface,as well as the crystal orientation dependent growth of interfacial carbides were unveiled using the first-principles calculation.The formation and growth mechanisms of Cr_(3)C_(2) were elucidated using SEM,TEM and XRD analyses.Finally,an approach for tailoring the interfacial microstructure between synthetic diamond and bonding metals was proposed. | Zhuo Liu Wei Cheng Dekui Mu Qiaoli Lin Xipeng Xu Han Huang | 2023 | Journal of Materials Science & Technology2023，，13： | 0 |
| 9 | Wetting of Laser Textured Cu Surface by Ethylene Glycol and Sn显示文摘The effect of microcosmic morphologies of textured Cu surface by nanosecond laser on the inert wetting and reactive wetting,i.e.,ethylene glycol/copper and tin/copper wetting systems,was studied by using modified sessile drop methods.To create different surface roughness,the microcosmic morphologies with different spacing of grooves were constructed by nanosecond laser.The results showed that the inert wetting(ethylene glycol/copper)was consistent with Wenzel model,while the reactive wetting results deviated from the model.In Sn/Cu reactive wetting system,the interfacial evolution in the early stage and the pinning of triple line by the precipitated η-Cu_(6)Sn_(5) caused the rougher surface and the worse final wettability.When the scale of artificial roughness exceeded the roughness that was caused by interfacial reaction after reaching the quasi-equilibrium state at interface,the final wettability could be improved. | Kaibin Xie Yujie Ge Qiaoli Lin | 2021 | Journal of Metallic Material Research2021，4，1： | 0 |
| 10 | Formation Mechanism of Precursor Films at High Temperatures:A Review显示文摘The formation of a precursor flm(PF)is always coupled with better wettability;thus,clarifying the formation mechanism is required to optimize the interfacial structures.However,recent research focuses on inert wetting systems at room temperature,which cannot guide practical material processing at high temperatures.In this review,PF formation mechanisms at high temperatures were reviewed.The mechanisms are surface difusion,evaporation–condensation,subcutaneous infltration,and rapid absorption and flm overfow.In experimental metal/metal systems,the most probable mechanism is subcutaneous infltration,related to the apparent contact angle,radius,and height of the gap between the substrate metal and the oxide flm.The rapid absorption and flm overfow mechanism usually occurs in metal/ceramic systems.The PF appearance for the adsorption mechanism must satisfy the paradox,that is,the relative inertial and high-afnity liquid/solid interface.Finally,another possible mechanism of PF appearance for the reactive wetting system at high temperatures was proposed,that is,the thin-surface transport mechanism.The PF formation is sensitive to external conditions.Therefore,it is necessary to develop thermodynamic and dynamic models for predicting and simulating PFs. | Qiaoli Lin Lu Liu Wenqi Zhu | 2022 | Chinese Journal of Mechanical Engineering2022，35，4： | 0 |
| 11 | Wetting of molten cerium on typical carbon materials(graphite,CVD-diamond and NWCNT) and molten Cu-Ce alloys on graphite at 950℃显示文摘A series of experiments were conducted to investigate the wettability of graphite plate,graphite paper,NWCNTs Buckypaper,CVD-diamond by molten Ce and graphite plate by Cu-Ce binary alloy using a modified sessile drop method at 950℃.The remarkable apparent equilibrium contact angles(graphite plate(0°) | Ran Sui Qiaoli Lin Le Wang Fan Yang | 2021 | Journal of Rare Earths2021，39，3： | 0 |
| 12 | Surface Tension of GaInSnBiZn Liquid High-entropy Allo显示文摘As an emerging alloy material,high-entropy alloy has potential applications that distinguish it from traditional alloys due to its special physicochemical properties.In this work,a low melting point GaInSnBiZn high-entropy alloy was designed based on Miedema model,and its surface tension was measured by the continuous pendant-drop method.The results show that the intrinsic surface tension of GaInSnBiZn high-entropy alloy at 80°C is 545±5 mN/m,and the surface tension of the liquid alloy is significantly reduced by the formation of surface oxide film.The surface tension of GaInSnBiZn high-entropy alloy was analyzed by using theoretical models(Guggenheim model,GSM(general solution)model and Butler model),and the thermodynamic characteristics of the surface tension formation were further verified by combining with thermodynamic calculations,among which the calculated results of Butler model were in good agreement with the experimental data.Meanwhile,it is found that the surface concentration of Bi in the alloy is much larger than the nominal concentration of its bulk phase,which contributes the most to the surface tension of the alloy,however,it contributes the least to the entropy of the alloy formation in combination with the Butler model. | Shirong Zhu Lu Liu Qiaoli Lin | 2021 | Journal of Metallic Material Research2021，4，2： | 0 |
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