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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai.显示文摘 | Zhang ZX Roman GC Hong Z Wu CB Qu QM Huang JB Zhou B Geng ZP Wu JX Wen HB Zhao H Zahner GE | 2006 | 中国生物学文摘2006，20，8： | 9 |
| 3 | Black and green tea consumption and the risk of coronary artery disease, a meta-analysis显示文摘 | Wang ZM Zhou, B Wang, YS Gong, QY Wang, QM Yan, JJ Gao, W Wang, LS | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 5 |
| 4 | Hepatitis C virus RNA and antibodies among blood donors in Beijing 显示文摘 | Wang Y Tao QM Zhao HY | 1994 | J Hepatol1994，21，4： | 4 |
| 5 | 3D-QSAR STUDY ON HUPERZINE A ANALOGS WITH MOLECULAR MODELING AND COMPARATIVE MOLECULAR FIELD ANALYSIS(COMFA) METHODS显示文摘3D-QSARSTUDYONHUPERZINEAANALOGSWITHMOLECULARMODELINGANDCOMPARATIVEMOLECULARFIELDANALYSIS(COMFA)METHODS￥HuaLiangJIANG;KaiXianC... | Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, QM Li, Q Shen, X Ji, RY | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 6 | CYCLIC VOLTAMMETRY STUDY ON ANTIMALARIAL MECHANISM OF ARTEMISININ(QINGHAOSU)DERIVATIVES显示文摘CYCLICVOLTAMMETRYSTUDYONANTIMALARIALMECHANISMOFARTEMISININ(QINGHAOSU)DERIVATIVES￥HuaLiangJIANG;KaiXianCHEN;YunTANG;JianZhongC... | Jiang, HL Chen, KX Tang, Y Chen, JZ Li, Y Wang, QM Li, Q Ji, RY Zhuang, QK | 1996 | Chinese Chemical Letters1996，7，7： | 2 |
| 7 | Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru:high prevalence of p53 overexpression显示文摘 | Janet L Ivonne G | 1999 | Hum Pathol1999，30，7： | 1 |
| 8 | Autism spectrum phenotype in males and females with fragile X full mutation and premutation显示文摘 | Clifford S Dissanayake C Bui QM | 2007 | Journal of Autism and Developmental Disorders2007，37，4： | 1 |
| 9 | Studies on the hypoglycemic effect of coptis chinensis and berberine 显示文摘 | Chen QM Xie MZ | 1986 | Yao Xue Xue Bao1986，21，6： | 1 |
| 10 | Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs显示文摘 | Zhang JS Ding J Tang QM | 1999 | Bioorganic & Medicinal Chemistry Letters1999，9，18： | 1 |
| 11 | Gene therapy of bone morphogenetic protein for periodontal tissue engineering 显示文摘 | Jin QM Anusaksathien O Webb SA | 2003 | J Periodontol2003，74，2： | 1 |
| 12 | Improved cellular immune response elicited by a ubiquitin-fused ESAT-6 DNA vaccine against Mycobacterium tuberculosis显示文摘 | Wang QM Kang L Wang XH | 2009 | Microbiol Immunol2009，53，7： | 1 |
| 13 | Emergency colorectal resec- tions in Asian octogenarians: factors impacting surgical outcome 显示文摘 | Leong QM Aung MO Ho CK | 2009 | Surg Today2009，39，7： | 1 |
| 14 | Neutrophil enhancement of Pseudomonas aeruginosa biofilm development:human F-actin and DNA as targets for therapy显示文摘 | Parks QM Young RL Poch KR | | 0，，4： | 1 |
| 15 | Pulse oximetry with clini- cal assessment to screen forcongenital heart disease in neonatesin China: a prospective study显示文摘 | Zhao QM Ma X J Huang GY | 2014 | Lancet2014，384，9945： | 1 |
| 16 | Thoracic endovascular aortic repair for retrograde type A aortic dissection with an entry tear in the descending aorta 显示文摘 | Shu C Wang T Li QM | 2012 | J Vasc Interv Radiol2012，23，4： | 1 |
| 17 | Pharmacological actions of tetrandrine in inflammatory pulmonary diseases 显示文摘 | Xie QM Tang HF Chen JQ | 2002 | Acta Pharmacol Sin2002，23，12： | 1 |
| 18 | The IKK NF-kappa B system:a treasure trove for drug development显示文摘 | Karin M Yamamoto Y Wang QM | 2004 | Nat Rev Drug Discov2004，3，1： | 1 |
| 19 | Hydrogen peroxide dose dependent induction of cel death or hypertrophy in cardiomyocytcs 显示文摘 | Chen QM Tu VC Wu Y | 2000 | Arch Biochem Biophys2000，373，1： | 1 |
| 20 | New microRNAs from mouse and human显示文摘 | Lagos QM Rauhut R Meyer J | 2003 | RNA2003，9，2： | 1 |
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