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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 4 | 14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis显示文摘 | Jonathan M Spergel Terri F Brown-Whitehorn Janet L Beausoleil James Franciosi Michele Shuker Ritu Verma Chris A Liacouras | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 2 |
| 5 | Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru:high prevalence of p53 overexpression显示文摘 | Janet L Ivonne G | 1999 | Hum Pathol1999，30，7： | 1 |
| 6 | Pharmacy residency train- ing in the future:a stakeholders' roundtable discussion显示文摘 | Janet L Teeters Mark Brueckl | 2005 | Am J Health-Syst Pharm2005，62，17： | 1 |
| 7 | Management the buyer-supplier interface for on-time performance inproduct development显示文摘 | HARTLEY JANET L ZIRGER B KAMATH J RAJAN R | 1997 | Journal of Operations Management1997，15，： | 1 |
| 8 | Experimental investigation of the combustive sound source 显示文摘 | Preston S Wilson Janet L Ellzey Thoms G Muir | 1995 | IEEE Journal of Oceanic Engineering1995，20，4： | 1 |
| 9 | Heterogeneity of human neuroblastoma cell lines in their proliferative responses to basic FGF,NGF,and EGF:correlation with expression of growth factors and growth factor receptors显示文摘 | Janet T Lüdecke G Otten U Urtsicker K | | 0，，06： | 1 |
| 10 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 11 | Modification of human immunodediciency viral replication by pine cone extracts 显示文摘 | Patrick K L Janet D Hideaki T | 1990 | Aids Res Hum Retroviruses1990，6，2： | 1 |
| 12 | Technical note:An exploration of supplier selection practices across the supply chain显示文摘 | Janet L Hartley | 1996 | Journal of operations management1996，，14： | 1 |
| 13 | Public Capital and Private Productivity显示文摘 | Vijverberg W P M Vijerberg Chu-Ping C Gamble Janet L | 1997 | The Review of Economic and Statistics1997，79，2： | 1 |
| 14 | The library for the mobile patron 显示文摘 | Janet L B | 2009 | Computers in Libraries2009，，5： | 1 |
| 15 | An exploration of supplier selection practices across the supply chain显示文摘 | CHOI Thomas Y HARTLEY Janet L | 2009 | Jour- nal of Operations Management2009，14，4： | 1 |
| 16 | An approach to electrical studies of single nanocrystals显示文摘 | David L Klein Paul L McEuen Janet E Bowen Katan | 1996 | Appl Phys Lett1996，68，18： | 1 |
| 17 | Hartley, Collaborative Value Analysis: Experiences from the Automotive Industry, The Journal of Supply Chain Management显示文摘 | Janet L | 2000 | Volume2000，，： | 1 |
| 18 | Extraction of organic pollutants from solid samplesusing microwave energy显示文摘 | VIORIA L A RICHARD Y JANET B | 1995 | Analytical Chemistry1995，67，13： | 1 |
| 19 | Cauliflower mosaic virus protein P6 is a suppressor of RNA silencing 显示文摘 | Andrew J L Janet L Justin H | 2007 | Journal of General Virology2007，88，： | 1 |
| 20 | A comparison of in situ hybridisation, reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ-RT-PCR for the detection of canine distemper virus RNA in Paget’s disease显示文摘 | Judith A Hoyland Janet A Dixon Jacqueline L Berry Michael Davies Peter L Selby Andrew P Mee | 2003 | Journal of Virological Methods2003，，2： | 1 |
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