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| 1 | Mercury Emission From Coal-fired Power Plants in China显示文摘燃煤是最大的人为汞排放源之一,燃煤电厂的汞排放控制问题也越来越为人们所关注。该文将目前公布的中国电厂的汞排放数据进行筛选汇总,得到18个电厂的汞排放数据,通过对比和分析,总结出了符合我国燃煤电厂特点的一般性汞排放规律。结果表明:与美国煤种相比,我国的燃煤具有低氯、高灰的特性,这不利于汞的排放控制;循环流化床燃烧可能会因燃尽率的不同而较煤粉炉燃烧易获得较高的Hgp;空气污染控制设备的使用能够有效地减少汞排放,选择性催化还原+静电除尘器/布袋除尘器+石灰石-石膏湿法脱硫(SCR+ESP/FF+WFGD)组合的平均脱汞率可达71.48%;SCR的大规模应用可能会将汞大量转移到飞灰和脱硫石膏中,带来二次污染的问题。 | YIN Libao ZHUO Yuqun XU Qisheng ZHU Zhenwu DU Wen AN Zhongyi | 2013 | 中国电机工程学报2013，33，29： | 29 |
| 2 | Changes in global potential vegetation distributions from 1911 to 2000 as simulated by the Comprehensive Sequential Classification System approach显示文摘Vegetation classification models play an important role in studying the response of the terrestrial ecosystem to global climate change. In this paper, we study changes in global Potential Natural Vegetation (PNV) distributions using the Comprehensive Sequential Classification System (CSCS) approach, a technique that combines geographic information systems. Results indicate that on a global scale there are good agreements among maps produced by the CSCS method and the globally well-accepted Holdridge Life Zone (HLZ) and BIOME4 PNV models. The potential vegetation simulated by the CSCS approach has 6 major latitudinal zones in the northern hemisphere and 2 in the southern hemisphere. In mountainous areas it has obvious altitudinal distribution characteristics due to topographic effects. The distribution extent for different PNV classes at various periods has different characteristics. It had a decreasing trend for the tundra and alpine steppe, desert, sub-tropical forest and tropical forest categories, and an increasing trend for the temperate forest and grassland vegetation categories. The simulation of global CSCS-based PNV classes helps to understand climate-vegetation relationships and reveals the dynamics of potential vegetation distributions induced by global changes. Compared with existing statistical and equilibrium models, the CSCS approach provides similar mapping results for global PNV and has the advantage of improved simulation of grassland classes. | LIANG TianGang FENG QiSheng CAO JianJun XIE HongJie LIN HuiLong ZHAO Jun REN JiZhou | 2012 | Chinese Science Bulletin2012，57，11： | 23 |
| 3 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 4 | Late Jurassic-Early Cretaceous Plutonism in the Northern Part of the Precambrian North China Craton:SHRIMP Zircon U-Pb Dating of Diorites and Granites from the Yunmengshan Geopark,Beijing显示文摘The Yunmengshan Geopark in northern Beijing is located within the Yanshan range.It contains the Yunmengshan batholith,which is dominated by two plutons:the Yunmengshan gneissic granite and the Shicheng gneissic diorite.Four samples of the Yunmengshan gneissic granite give SHRIMP zircon U-Pb ages from 145 to 141 Ma,whereas four samples of the Shicheng gneissic diorite have ages from 159 Ma to 151 Ma.Dikes that cut the Yunmengshan diorite record SHRIMP zircon UPb age of 162±2 and 156±4 Ma.The cumulative plots of zircons from the diorites show a peak age of 155 Ma,without inherited zircon cores,and the peak age of 142 Ma for granite is interpreted as the emplacement age of the Yunmengshan granitic pluton,whose igneous zircons contain inherited zircon cores.The data presented here show that there were two pulses of magmatism:early diorites,followed c13 Ma later by true granites,which incorporated material from an older continental crust. | SHI Yuruo ZHAO Xitao MA Yinsheng HU Daogong LIU Qisheng WU Zhenhan ZHAO Yuanyi LIU Dunyi | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 17 |
| 5 | A versatile cooperative template-directed coating method to synthesize hollow and yolk-shell mesoporous zirconium titanium oxide nanospheres as catalytic reactors显示文摘 | Buyuan Guan Tao Wang Shangjing Zeng Xue Wang Dong An Dongmei Wang Yu Cao Dingxuan Ma Yunling Liu Qisheng Huo | 2014 | Nano Research2014，7，2： | 12 |
| 6 | Risk analysis for the highly pathogenic avian influenza in China's Mainland using meta-modeling显示文摘A logistic model was employed to correlate the outbreak of highly pathogenic avian influenza (HPAI) with related environmental factors and the migration of birds. Based on MODIS data of the normalized difference vegetation index, environmental factors were considered in generating a probability map with the aid of logistic regression. A Bayesian maximum entropy model was employed to explore the spatial and temporal correlations of HPAI incidence. The results show that proximity to water bodies and national highways was statistically relevant to the occurrence of HPAI. Migratory birds, mainly waterfowl, were important infection sources in HPAI transmission. In addition, the HPAI outbreaks had high spatiotemporal autocorrelation. This epidemic spatial range fluctuated 45 km owing to different distribution patterns of cities and water bodies. Furthermore, two outbreaks were likely to occur with a period of 22 d. The potential risk of occurrence of HPAI in China's Mainland for the period from January 23 to February 17, 2004 was simulated based on these findings, providing a useful meta-model framework for the application of environmental factors in the prediction of HPAI risk. | CAO ChunXiang XU Min CHANG ChaoYi XUE Yong ZHONG ShaoBo FANG LiQun CAO WuChun ZHANG Hao GAO MengXu HE QiSheng ZHAO Jian CHEN Wei ZHENG Sheng LI XiaoWen | 2010 | Chinese Science Bulletin2010，55，36： | 9 |
| 7 | Miocene Tectonic Evolution from Dextral-Slip Thrusting to Extension in the Nyainqentanglha Region of the Tibetan Plateau显示文摘在西藏的 Nyainqentanglha 区域的右滑倒导致了 obliqueunderthrusting 和花岗石产生在对中间早中新世,但是在时代底高举并且紧张的指责统治了的前。东方西方右滑倒 Gangdise 差错系统合并进东北趋势东方,转动东方更远的北方进右滑倒北方 Damxung 剪碎带和 Jiali 的蘸东南的 Nyainqentanglha 戳系统指责。这些差错是形成了由当西方的块不到东方的开车了,早, Miocene,和大 Nyainqentanglha 花岗石的底盘在 18.3-11.0 妈形成了戳系统。Thedextral 滑倒运动在~ 1 结束了 1 个妈和底盘玫瑰,由在 8.6-8.3 妈的重力的砍标记,一个新差错系统发展了。西北趋势右滑倒差错形成了到 raisen 底盘的西北,而有某左首滑倒的东北趋势南方 Damxung 上投断层形成了到东南。后者被 thewest-northwest-trending Lhiinzhub 上投断层被右滑倒远代替到东方。这相对本地高举让存款保存了的 Eocene 和 Miocene 邻近那被区域抬升和一个系统的开始跟随通常纵贯抓住 ens 在在~ 6 .5 晚中新世妈。Theregional 高举南部的西藏的高原因此看起来发生在 8.3 妈和 6.5Ma 之间。Gulu, Damxung-Yangbajain 和 Angan 在 NyainqentanglhaMountains 的通行证东方被更早的东北趋势差错局部地控制的系统抓住。这些抓住 ens 统治随后的构造运动并且山向西北作为西北趋势右滑倒差错仍然很活跃。Miocene 是迎来了现代构造政体的大构造变化的一时间。 | WU Zhenhan Patrick J. BAROSH ZHAO Xun WU Zhonghai HU Daogong LIU Qisheng | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 8 |
| 8 | Current status of cell-mediated regenerative therapies for human spinal cord injury显示文摘During the past decade, significant advances have been made in refinements for regenerative therapies following human spinal cord injury(SCI).Positive results have been achieved with different types of cells in various clinical studies of SCI.In this review, we summarize recently-completed clinical trials using cellmediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells.Specifically, clinical studies published in Chinese journals are included.These studies show that current transplantation therapies are relatively safe, and have provided varying degrees of neurological recovery.However, many obstacles exist, hindering the introduction of a specifi c clinical therapy, including complications and their causes, selection of the target population, and optimization of transplantation material.Despite these and other challenges, with the collaboration of research groups and strong support from various organizations, cell-mediated regenerative therapies will open new perspectives for SCI treatment. | Tongming Zhu Qisheng Tang Huasong Gao Yiwen Shen Luping Chen Jianhong Zhu | 2014 | Neuroscience Bulletin2014，30，4： | 7 |
| 9 | Overexpression of Dickkopf-3 induces apoptosis through mitochondrial pathway in human colon cancer显示文摘AIM:To investigate the mechanisms of the biological roles of Dickkopf-3(Dkk-3) in cell invasion,survival and apoptosis in colon cancer cells.METHODS:Three human colon cancer cell lines,i.e.,HT-29,LoVo and SW480,were used.Overexpression of Dkk-3 induced by pEGFP-N1-Dkk-3-GFP plasmid in LoVo cells was performed using Lipofectamine 2000 reagent.Reverse transcription polymerase chain reaction and Western blotting were performed to determine the mRNA and protein expression levels of Dkk-3,respectively.Cell proliferation assay,cell cycle analysis,hoechst 33258 assay and Matrigel invasion assay were performed on Dkk-3 overexpressing transfectants.RESULTS:The mRNA and protein expressions of Dkk-3 in HT-29(mRNA:0.06 ± 0.02,protein:0.06 ± 0.01) and LoVo(mRNA:0.07 ± 0.02,protein:0.07 ± 0.02) cells were significantly lower than that in SW480 cells(mRNA:0.92 ± 0.04,protein:0.69 ± 0.13;all P < 0.05),and the greatest levels of invasiveness wasin LoVo cells.Dkk-3 overexpression inhibited the proliferation and invasion of LoVo cells and induced cell cycle arrest at G0/G1 phase and subsequent apoptosis,as indicated by increased chromatin condensation and fragments,upregulated Bax and cytochrome c protein,downregulated survivin and Bcl-2 protein,and the activation of caspase-3 and caspase-9.Furthermore,Dkk-3 overexpression reduced the accumulation of cytosolic fraction of β-catenin.CONCLUSION:Dkk-3 overexpression induced apoptosis in human colon cancer possibly through the mitochondrial pathway.Dkk-3 may be involved in the Wnt/β-catenin signaling pathways in colon cancer. | Zi-Rong Yang Wei-Guo Dong Xiao-Fei Lei Meng Liu QiSheng Liu | 2012 | World Journal of Gastroenterology2012，18，14： | 7 |
| 10 | A new MODIS daily cloud free snow cover mapping algorithm on the Tibetan Plateau显示文摘Because of similar reflective characteristics of snow and cloud,the weather status seriously affects snow monitoring using optical remote sensing data.Cloud amount analysis during 2010 to 2011 snow seasons shows that cloud cover is the major limitation for snow cover monitoring using MOD10A1 and MYD10A1.By use of MODIS daily snow cover products and AMSR-E snow water equivalent products(SWE),several cloud elimination methods were integrated to produce a new daily cloud free snow cover product,and information of snow depth from 85 climate stations in Tibetan Plateau area(TP)were used to validate the accuracy of the new composite snow cover product.The results indicate that snow classification accuracy of the new daily snow cover product reaches 91.7% when snow depth is over 3 cm.This suggests that the new daily snow cover mapping algorithm is suitable for monitoring snow cover dynamic changes in TP. | XiaoDong Huang XiaoHua Hao QiSheng Feng Wei Wang TianGang Liang | 2014 | Research in Cold and Arid Regions2014，6，2： | 7 |
| 11 | A novel deletion mutation, c.1296delT in the BCOR gene, is associated with oculo-facio-cardio-dental syndrome显示文摘The purpose of the present study was to analyze the clinical phenotypes of a girl with oculo-facio-cardio-dental(OFCD)syndrome and to identify the potential pathogenic mutation responsible for her disease. The patient underwent detailed clinical examinations and phenotype data were collected over a follow-up period of 9 years. Mutation analysis of the candidate gene BCOR was performed with polymerase chain reaction and Sanger sequencing. BCOR of 60 unrelated normal individuals were also sequenced as a control group. Clinical phenotyping and follow-up study results indicate that this patient had multiple system anomalies including ocular, facial, cardiac, dental, and limb malformations. In addition, papilloma of the choroid plexus was identified, which represents the first report of this phenotype in an OFCD patient. A novel deletion mutation, c.1296 delT in exon4 of the BCOR gene, was identified in this patient and was not found in her parents or in 60 normal unrelated individuals. This deletion was a frameshift mutation and is proposed to encode a premature stop codon, thus producing a truncated protein. Our patient fitted the diagnostic criteria for OFCD syndrome and we report the first papilloma of the choroid plexus in an OFCD patient, expanding the recognized phenotypic spectrum of this disease. Meanwhile, we identified a novel deletion mutation that may cause OFCD syndrome. | Jingshang Zhang Hongyan Jia Jinda Wang Ying Xiong Jing Li Xiaoxia Li Jing Zhao Xiaohui Zhang Qisheng You Guyu Zhu Frank F.Tsai Mark Espina Xiuhua Wan | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 12 | New approach to multiple attribute decision making with interval numbers显示文摘In an ambiguous decision domain, the evaluation values of alternatives against attributes would be interval numbers because of the inherent, uncertain property of the problems. By using a number of linear program-ming models, Bryson and Mobolurin propose an approach to compute attribute weights and overall values of the alternatives in the form of interval numbers. The intervals of the overall values of alternatives are then transformed into points or crisp values for comparisons among the alternatives. However, the attribute weights are different because of the use of linear programming models in Bryson and Mobolurin's approach. Thus, the alternatives are not comparable because different attribute weights are employed to calculate the overall values of the alternatives. A new approach is proposed to overcome the drawbacks of Bryson and Mobolurin's approach. By transforming the decision matrix with intervals into the one with crisp values, a new linear programming model is proposed, to calculate the attribute weights for conducting alternative ranking. | Zhang Quan Gao Qisheng Geng Jinhua | 2008 | Journal of Systems Engineering and Electronics2008，19，2： | 6 |
| 13 | The novel H1N1 Influenza A global airline transmission and early warning without travel containments显示文摘A novel influenza A (H1N1) has been spreading worldwide. Early studies implied that international air travels might be key cause of a severe potential pandemic without appropriate containments. In this study, early outbreaks in Mexico and some cities of United States were used to estimate the preliminary epidemic parameters by applying adjusted SEIR epidemiological model, indicating transmissibility infectivity of the virus. According to the findings, a new spatial allocation model totally based on the real-time airline data was established to assess the potential spreading of H1N1 from Mexico to the world. Our estimates find the basic reproductive number R0 of H1N1 is around 3.4, and the effective reproductive number fall sharply by effective containment strategies. The finding also implies Spain, Canada, France, Panama, Peru are the most possible country to be involved in severe endemic H1N1 spreading. | CHANG ChaoYi CAO ChunXiang WANG Qiao CHEN Yu CAO ZhiDong ZHANG Hao DONG Lei ZHAO Jian XU Min GAO MengXu ZHONG ShaoBo HE QiSheng WANG JinFeng LI XiaoWen | 2010 | Chinese Science Bulletin2010，55，26： | 6 |
| 14 | Application of SVM in Feather and Down Category Recognition显示文摘 | Qisheng Yan Xiaofei Yan | 2006 | 通讯和计算机(中英文版)2006，3，1： | 5 |
| 15 | Copper-ceria sheets catalysts: Effect of copper species on catalytic activity in CO oxidation reaction显示文摘Copper-ceria sheets catalysts with different loadings of copper(2 wt.%, 5 wt.% and 10 wt.%) supported on ceria nanosheets were synthesized via a depositioneprecipitation(DP) method. The prepared catalysts were systematically characterized with various structural and textural detections including X-ray diffraction(XRD), Raman spectra, transmission electron microscopy(TEM), X-ray absorption fine structure(XAFS), and temperature-programmed reduction by hydrogen(H_2-TPR), and tested for the CO oxidation reaction. Notably, the sample containing 5 wt.% of Cu exhibited the best catalytic performance as a result of the highest number of active CuO species on the catalyst surface. Further increase of copper content strongly affects the dispersion of copper and thus leads to the formation of less active bulk CuO phase, which was verified by XRD and H_2-TPR analysis. Moreover, on the basis of in-situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS) results, the surface Cu^+ species, which are derived from the reduction of Cu^(2+), are likely to play a crucial role in the catalyzing CO oxidation.Consequently, the superior catalytic performance of the copper-ceria sheets is mainly attributed to the highly dispersed CuO_x cluster rather than Cu-[O_x]-Ce structure, while the bulk CuO phase is adverse to the catalytic activity of CO oxidation. | Linying Du Weiwei Wang Han Yan Xu Wang Zhao Jin Qisheng Song Rui Si Chunjiang Jia | 2017 | Journal of Rare Earths2017，35，12： | 5 |
| 16 | Remote sensing based shrub above-ground biomass and carbon storage mapping in Mu Us desert,China显示文摘The estimation of above-ground biomass(AGB) and carbon storage is very important for arid and semi-arid ecosystems.HJ-1A/B satellite data combined with field measurement data was used for the estimation of shrub AGB and carbon storage in the Mu Us desert,China.The correlations of shrub AGB and spectral reflectance of four bands as well as their combined vegetation indexes were respectively analyzed and stepwise regression analysis was employed to establish AGB prediction equation.The prediction equation based on ratio vegetation index(RVI)was proved to be more suitable for shrub AGB estimation in the Mu Us desert than others.Shrub AGB and carbon storage were mapped using the RVI based prediction model in final.The statistics showed the western Mu Us desert has relatively high AGB and carbon storage,and that the gross shrub carton storage in Mu Us desert reaches 16 799 200 t,which has greatly contributed to the carbon fixation in northern China. | XU Min 1,2,CAO ChunXiang 1,TONG QingXi 1,LI ZengYuan 3,ZHANG Hao 1,HE QiSheng 1,2,GAO MengXu 1,2,ZHAO Jian 1,2,ZHENG Sheng 1,2,CHEN Wei 1,2 & ZHENG LanFen 1 1State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China 2 Graduate School of the Chinese Academy of Sciences,Beijing 100049,China 3 Research Institute of Forest Resources and Information Techniques,Chinese Academy of Forestry,Beijing 10009,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 5 |
| 17 | Inductive heat property of Fe_3O_4 nanoparticles in AC magnetic field for local hyperthermia显示文摘Magnetite (Fe3O4) nanoparticles with different magnetic properties were prepared by coprecipitation of Fe3+ and Fe2+ with aqueous NaOH solution. The inductive heat properties of Fe3O4 nanoparticles in an alternating current (AC) magnetic field were investigated for local hyperthermia. The maximum saturation magnetization Ms of Fe3O4 nanoparticles is 65.53 emu·g-1 under the optimum conditions of Fe3+: Fe2+ molar ratio at 1.8:1. The Ms of Fe3O4 nanoparticles decreased as the Fe3+/Fe2+ molar ratio increased. But the coercivity Hc increases with the increasing of Fe3+/Fe2+ molar ratio. Exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspension containing Fe3O4 nanoparticles were 42-97.5 ℃. The inductive heat property of Fe3O4 nanoparticles in AC magnetic field decreases as Hc increases, but increases with the increasing of Ms. The Fe3O4 nanoparticles would be useful as good thermoseeds for localized hyperthermia treatment of cancers. | ZHAO Donglin ZENG Xianwei XIA Qisheng TANG Jintian | 2006 | Rare Metals2006，25，z1： | 5 |
| 18 | Research on key techniques of expendable conductivity temperature depth measuring system显示文摘This paper analysis the developing of expendable conductivity temperature depth measuring system(XCTD)and introduce its principle of measuring about temperature,salinity and depth of ocean.Some key techniques are put forward.According to the real needs of XCTD,conductivity sensor with high sensitivity is designed by principle of electromagnetic induce,the ocean conductivity from induced electromotive force has been calculated.Adding temperature correction circuit would help to reduce error of conductivity measurement because of sharply changing temperature.Advanced temperature measuring circuit of high precision and the constant current source is used to weaken effect of self-heating of resistance and fluctuation of the source.On respect of remote data transmission,LVDS is a good choice for the purpose of guarantee the quality of data transmitted and the transmission distance is reaching to thousand meters in the seawater.Modular programming method is also brought into this research aimed at improve the stability,reliability and maintainability of the whole measuring system.In February,2015,the trials in South China Sea demonstrate that the developed XCTD realize effective measurement at a speed of 6 knots and detection depth at 800 m.The consistency coefficient of the acquired data is greater than 0.99 and the success rate of probe launching is above 90%. | CHEN Guangyuan DU Libin HE Haijing LEI Zhuo ZHANG Qisheng WU Chengxuan | 2015 | Instrumentation2015，2，2： | 5 |
| 19 | In vitro effects of sodium hyaluronate on the proliferation and the apoptosis in chondrocytes from patients with Kashin-Beck disease and osteoarthritis显示文摘Objective:To identify the in vitro effects of sodium hyaluronate(HA) on the proliferation and the apoptosis of chondrocytes from patients with Kashin-Beck disease(KBD) and osteoarthritis(OA). Methods:Samples of articular cartilages from KBD and OA patients, as well as healthy volunteers(6 subjects in each of the 3 groups) were dissected, digested with collagenase and the cells cultured in monolayers. Chondrocytes from each sample were assigned to an untreated group and two HA-treated groups: H0(no HA), H100(HA, 0.1 g/L) and H500(HA, 0.5 g/L). The first passage chondrocytes were used to observe proliferation using the MTT assay, and apoptosis by flow cytometry through Annexin V/PI staining. Results:HA promoted proliferation of chondrocytes in all the three groups, and in KBD and OA groups, for cells cultured for 4 and 6 days, H500 significantly promoted the cell proliferation. The apoptotic rates of both KBD and OA group chondrocytes were in the order H500 < HA100 < H0. Conclusion:Sodium hyaluronate administration has a dose-dependent in vitro effect to promote proliferation and inhibit apoptosis of chondrocytes from patients with KBD and OA. | Zongqiang Gao Xiong Guo Chen Duan Weijuan Ma Peng Xu Ruiyu Liu Qisheng Gu Junchang Chen | 2009 | Journal of Nanjing Medical University2009，23，2： | 5 |
| 20 | MicroRNA-135a Modulates Hepatitis C Virus Genome Replication through Downregulation of Host Antiviral Factors显示文摘Cellular microRNAs(miRNAs) have been shown to modulate HCV infection via directly acting on the viral genome or indirectly through targeting the virus-associated host factors. Recently we generated a comprehensive map of HCV–miRNA interactions through genome-wide miRNA functional screens and transcriptomics analyses. Many previously unappreciated cellular miRNAs were identified to be involved in HCV infection, including miR-135a, a human cancerrelated miRNA. In the present study, we investigated the role of miR-135a in regulating HCV life cycle and showed that it preferentially enhances viral genome replication. Bioinformatics-based integrative analyses and subsequent functional assays revealed three antiviral host factors, including receptor interacting serine/threonine kinase 2(RIPK2), myeloid differentiation primary response 88(MYD88), and C-X-C motif chemokine ligand 12(CXCL12), as bona fide targets of miR-135a. These genes have been shown to inhibit HCV infection at the RNA replication stage. Our data demonstrated that repression of key host restriction factors mediated the proviral effect of miR-135a on HCV propagation. In addition,miR-135a hepatic abundance is upregulated by HCV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HCV-induced liver malignancy.These results provide novel insights into HCV–host interactions and unveil molecular pathways linking miRNA biology to HCV pathogenesis. | Catherine Sodroski Brianna Lowey Laura Hertz T.Jake Liang Qisheng Li | 2019 | Virologica Sinica2019，34，2： | 5 |
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