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6篇 您的检索式：作者名="T.Jake Liang"

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		题名	作者	年代	出处	被引量
	1	MicroRNA-135a Modulates Hepatitis C Virus Genome Replication through Downregulation of Host Antiviral Factors显示文摘Cellular microRNAs(miRNAs) have been shown to modulate HCV infection via directly acting on the viral genome or indirectly through targeting the virus-associated host factors. Recently we generated a comprehensive map of HCV–miRNA interactions through genome-wide miRNA functional screens and transcriptomics analyses. Many previously unappreciated cellular miRNAs were identified to be involved in HCV infection, including miR-135a, a human cancerrelated miRNA. In the present study, we investigated the role of miR-135a in regulating HCV life cycle and showed that it preferentially enhances viral genome replication. Bioinformatics-based integrative analyses and subsequent functional assays revealed three antiviral host factors, including receptor interacting serine/threonine kinase 2(RIPK2), myeloid differentiation primary response 88(MYD88), and C-X-C motif chemokine ligand 12(CXCL12), as bona fide targets of miR-135a. These genes have been shown to inhibit HCV infection at the RNA replication stage. Our data demonstrated that repression of key host restriction factors mediated the proviral effect of miR-135a on HCV propagation. In addition,miR-135a hepatic abundance is upregulated by HCV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HCV-induced liver malignancy.These results provide novel insights into HCV–host interactions and unveil molecular pathways linking miRNA biology to HCV pathogenesis.	Catherine Sodroski Brianna Lowey Laura Hertz T.Jake Liang Qisheng Li	2019	Virologica Sinica2019，34，2：	5
	2	Renal tubular dysfunction during long‐term adefovir or tenofovir therapy in chronic hepatitis B显示文摘	X.Zhao W. H.Chong T.Jake Liang J. H.Hoofnagle	2012	Aliment Pharmacol Ther2012，，11：	2
	3	Renal tubular dysfunction during long‐term adefovir or tenofovir therapy in chronic hepatitis B显示文摘	X.Zhao W. H.Chong T.Jake Liang J. H.Hoofnagle	2012	Aliment Pharmacol Ther2012，，11：	1
	4	Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate显示文摘	Thomas F. Baumert John Vergalla Jujin Satoi Michael Thomson Martin Lechmann David Herion Harry B. Greenberg Susumu Ito T.Jake Liang	1999	Gastroenterology1999，，6：	1
	5	Progression of fibrosis in chronic hepatitis C显示文摘	Marc G. Ghany David E. Kleiner Harvey Alter Edward Doo Farooq Khokar Kittichai Promrat David Herion Yoon Park T.Jake Liang Jay H. Hoofnagle	2003	Gastroenterology2003，，1：	1
	6	Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C显示文摘	Kittichai Promrat David H. McDermott Carlos M. Gonzalez David E. Kleiner Deloris E. Koziol Matthew Lessie Maya Merrell Alejandro Soza Theo Heller Marc Ghany Yoon Park Harvey J. Alter Jay H. Hoofnagle Philip M. Murphy T.Jake Liang	2003	Gastroenterology2003，，2：	1

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