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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 3 | Genetic analysis and fine mapping of an enclosed panicle mutant esp2 in rice (Oryza sativa L.)显示文摘The phenomenon of panicle enclosure in rice is mainly caused by the shortening of uppermost internode.Elucidating the molecular mechanism of panicle enclosure will be helpful for solving the problem of panicle enclosure in male sterile lines and creating new germplasms in rice.We acquired a monogenic recessive enclosed panicle mutant,named as esp2 (enclosed shorter panicle 2),from the tissue culture progeny of indica rice cultivar Minghui-86.In the mutant,panicles were entirely enclosed by flag leaf sheaths and the uppermost internode was almost completely degenerated,but the other internodes did not have obvious changes in length.Genetic analysis indicated that the mutant phenotype was controlled by a recessive gene,which could be steadily inherited and was not affected by genetic background.Apparently,ESP2 is a key gene for the development of uppermost internode in rice.Using an F 2 population of a cross between esp2 and a japonica rice cultivar Xiushui-13 as well as SSR and InDel markers,we fine mapped ESP2 to a 14-kb region on the end of the short arm of chromosome 1.According to the rice genome sequence annotation,only one intact gene exists in this region,namely,a putative phosphatidylserine synthase gene.Sequencing analysis on the mutant and the wild type indicated that this gene was inserted by a 5287-bp retrotransposon sequence.Hence,we took this gene as a candidate of ESP2.The results of this study will facilitate the cloning and functional analysis of ESP2 gene. | GUAN HuaZhong DUAN YuanLin LIU HuaQing CHEN ZhiWei ZHUO Ming ZHUANG LiJun QI WenMing PAN RunSen MAO DaMei ZHOU YuanChang WANG Feng WU WeiRen | 2011 | Chinese Science Bulletin2011，56，14： | 6 |
| 4 | Upregulation of annexin A5 affects the biological behaviors of lung squamous carcinoma cells in vitro显示文摘Annexin A5 is a Ca2?-dependent phospholipidbinding protein and protein kinase C inhibitory protein. It has a potential role in cellular signal transduction, inflammation, growth and differentiation. In this study, we evaluated the expression of this protein in lung tumor tissues and subsequently established a NCI-H520 cell line that stably expresses the wild-type ANXA5 gene to determine the effects of annexin A5 upregulation on the cell morphology, proliferation and metastasis potential in vitro.The effects of annexin A5 on NCI-H520 cells were tested by crystal violet staining, CCK-8 assay, scratch wound assay, and Transwell assay. The expressions of Akt,PCNA, vimentin, and E-cadherin were examined by Western blot assay. In this study, we demonstrated that annexin A5 is expressed at lower levels in tumor tissues compared with normal tissues. Additionally, the upregulation of this protein may inhibit the proliferation, migration, and invasion abilities of NCI-H520 cells in vitro. The transfected cells were arrested in the G1/S phase of the cell cycle, and the expression levels of Akt, PCNA and Vimentin were downregulated, while E-cadherin was upregulated. | Linlin Gong Haoqi Zhao Lan Wang Bing Sun Lijun Yu Xiaoyu Qi Xin Zhou Liyuan Zhang Hongwei Guan Shujuan Shao | 2014 | Chinese Science Bulletin2014，59，28： | 6 |
| 5 | TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-αpathway显示文摘Background:Inflammation is a complex physiological and pathological process.Although many types of inflammation are well characterized,their physiological func-tions are largely unknown.tRNA aspartic acid methyltransferase 1(TRDMT1)has been implicated as a stress-related protein,but its intrinsic biological role is unclear.Methods:We constructed a Trdmt1 knockout rat and adopted the LPS-induced sepsis model.Survival curve,histopathological examination,expression of inflammatory fac-tors,and protein level of TLR4 pathway were analyzed.Results:Trdmt1 deletion had no obvious impact on development and growth.Trdmt1 de-letion slightly increased the mortality during aging.Our data showed that Trdmt1 strongly responded in LPS-treated rats,and Trdmt1 knockout rats were vulnerable to LPS treat-ment with declined survival rate.We also observed more aggravated tissue damage and more cumulative functional cell degeneration in LPS-treated knockout rats compared with control rats.Further studies showed upregulated TNF-αlevel in liver,spleen,lung,and serum tissues,which may be explained by enhanced p65 and p38 phosphorylation.Conclusions:Our data demonstrated that Trdmt1 plays a protective role in inflamma-tion by regulating the TLR4-NF-κB/MAPK-TNF-αpathway.This work provides useful information to understand the TRDMT1 function in inflammation. | Zhengguang Li Xiaolong Qi Xu Zhang Lei Yu Lijuan Gao Weining Kong Wei Chen Wei Dong Lijun Luo Dan Lu Lianfeng Zhang Yuanwu Ma | 2022 | Animal Models and Experimental Medicine2022，5，2： | 5 |
| 6 | Effects of slow-release urea fertilizers on urease activity, microbial biomass, and nematode communities in an aquic brown soil显示文摘A field experiment was carried out at the Shenyang Experimental Station of Ecology (CAS) in order to study the effects of slow-release urea fertilizers high polymer-coated urea (SRU1), SRU1 mixed with dicyandiamide DCD (SRU2), and SRU1 mixed with calcium carbide CaC2 (SRU3) on urease activity, microbial biomass C and N, and nematode communities in an aquic brown soil during the maize growth period. The results demonstrated that the application of slow-release urea fertilizers inhibits soil urease activity and increases the soil NH4+-N content.Soil available N increment could promote its immobilization by microorganisms. Determination of soil microbial biomass N indicated that a combined application of coated urea and nitrification inhibitors increased the soil active N pool. The population of predators/omnivores indicated that treatment with SRU2 could provide enough soil NH4+-N to promote maize growth and increased the food resource for the soil fauna compared with the other treatments. | JIAO Xiaoguang, LIANG Wenju, CHEN Lijun, ZHANG Haijun, LI Qi, WANG Peng & WEN Dazhong Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Shenyang Experimental Station of Ecology, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China(Life Sciences)2005，48，z1： | 5 |
| 7 | Short-term Exposure to Fine Particles and Risk of Cause-Specific Mortality--China,2013-2018显示文摘What is already known about this topic?Short-term exposure to PM2.5 has been associated with population excess death.This issue is of critical concern in China given its high level of exposure to PM2.5 compared to that of the rest of the world.What is added by this report?Existing studies were conducted from 2013-2015 and have failed to capture the full effects of China’s actions towards cleaner air in recent years,such as the first Action Plan for Air Pollution Prevention and Control issued in 2013.This study uses the longest time series data to date from 2013-2018,provides the latest evidence on PM2.5 and cause-specific death nationwide,and identifies regional patterns of PM2.5-related effects as well as PM2.5-related susceptible populations.What are the implications for public health practice?This study suggests that the development of standards and the implementation of actions to clean the air and protect public health should be tailored to PM2.5-related sensitive diseases,susceptible populations,and regional patterns. | Chen Chen Tiantian Li Lijun Wang Jinlei Qi Wangying Shi Mike Z He Qinghua Sun Jiaonan Wang Huanhuan Zhu Xiaoming Shi | 2019 | China CDC weekly2019，1，1： | 5 |
| 8 | Clinical curative effect of fuzi-cake-separated moxibustion for preventing dysuria after operation for lower limb fracture显示文摘OBJECTIVE: To assess the clinical curative effect of fuzi-cake-separated moxibustion at Zhongji(CV 3)and Guanyuan(CV 4) for preventing dysuria after internal fixation of lower limb fractures.METHODS: Sixty patients conforming to the inclusion standards were randomly divided into a treatment group(n=30) and a control group(n=30).Fuzi-cake-separated moxibustion was performed at Guanyuan(CV 4) and Zhongji(CV 3), 20 min at a time, twice a day, for 3 days before operation in the treatment group. No fuzi-cake-separated moxibustion was performed in the control group. After treatment, the score for symptoms of first urination, urinary time, urinary volume, 24 h remaining urinary volume, incidence of uroschesis, and rate of controlling dysuria were compared to evaluate the curative effect of preventing post-operative dysuria.RESULTS: The score for symptoms of first urination,24 h remaining urinary volume(maximum 120 m L vs 250 m L, and less than 10 m L in 24 cases vs 15 cases), and the rate of controlling dysuria(83.34% vs30%) were significantly better(P<0.05, P<0.05, and P<0.001, respectively) in the treatment compared with the control group. There was no statistical difference(P>0.05) between the two groups in first post-operative urinary time, urinary volume, or incidence of 24 h uroschesis.CONCLUSION: Fuzi-cake-separated moxibustion at Zhongji(CV 3) and Guanyuan(CV 4) can better prevent post-operative dysuria, effectively promote the functional restoration of the urinary bladder,and control the incidence of post-operative dysuria. | Yan Yue Lijun Tao Jianqiao Fang Qi Xie Shaofeng He Chunxia Huang Xueming Yang | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 4 |
| 9 | Application of waste frying oils in the biosynthesis of biodemulsifier by a demulsifying strain Alcaligenes sp.S-XJ-1显示文摘Exploration of biodemulsifiers has become a new research aspect.Using waste frying oils(WFOs) as carbon source to synthesize biodemulsifiers has a potential prospect to decrease production cost and to improve the application of biodemulsifiers in the oilfield.In this study,a demulsifying strain,Alcaligenes sp.S-XJ-1,was investigated to synthesize a biodemulsifier using waste frying oils as carbon source.It was found that the increase of initial pH of culture medium could increase the biodemulsifier yield but decrease the demulsification ratio compared to that using paraffin as carbon source.In addition,a biodemulsifier produced by waste frying oils and paraffin as mixed carbon source had a lower demulsification capability compared with that produced by paraffin or waste frying oil as sole carbon source.Fed-batch fermentation of biodemulsifier using waste frying oils as supplementary carbon source was found to be a suitable method.Mechanism of waste frying oils utilization was studied by using tripalmitin,olein and tristearin as sole carbon sources to synthesize biodemulsifier.The results showed saturated long-chain fatty acid was diffcult for S-XJ-1 to utilize but could effectively enhance the demulsification ability of the produced biodemulsifier.Moreover,FT-IR result showed that the demulsification capability of biodemulsifiers was associated with the content of C=O group and nitrogen element. | Jia Liu Kaiming Peng Xiangfeng Huang Lijun Lu Hang Cheng Dianhai Yang Qi Zhou Huiping Deng | 2011 | Journal of Environmental Sciences2011，23，6： | 4 |
| 10 | Groundwater evapotranspiration under psammophilous vegetation covers in the Mu Us Sandy Land, northern China显示文摘Groundwater is a significant component of the hydrological cycle in arid and semi-arid areas. Its evapotranspiration is an important part of the water budget because many plants are groundwater-dependent. To restore the degraded ecosystems, the need is pressing to further our understanding of the groundwater evapotranspiration(ET_g) in arid and semi-arid areas. This study employed the White method to estimate ET_g at four sites in the Mu Us Sandy Land in northern China, and the four sites are covered by Salix psammophila(SP site), Artemisia ordosica(AO site), Poplar alba(PA site), and Carex enervis(CE site), respectively. The depth of groundwater table and the duration of drainage were taken into account in calculating the specific yield(S_y) to improve the accuracy of the ET_g estimats. Our results showed that from late May to early November 2013 the ET_g were 361.87(SP site), 372.53(AO site), 597.86(PA site) and 700.76 mm(CE site), respectively. The estimated ET_g rate was also species-dependent and the descending order of the ET_g rate for the four vegetation was: C. enervis, P. alba, A. ordosica, and S. psammophila. In addition, the depth of groundwater table has an obvious effect on the ET_g rate and the effect varied with the vegetation types. Furthermore, the evapotranspiration for the vegetation solely relying on the water supply from unsaturated layers above the groundwater table was much less than that for the vegetation heavily relying on the water supply from shallow aquifers. | CHENG Donghui DUAN Jibo QIAN Kang QI Lijun Yang Hongbin CHEN Xunhong | 2017 | Journal of Arid Land2017，9，1： | 4 |
| 11 | Quality metrology of carbon nanotube thin films and its application for carbon nanotube-based electronics显示文摘Large area,highly uniform,and density controllable carbon nanotube(CNT)films,either well-aligned or random network,are required for practical application of CNT-based electronics.Mass production methods for such CNT films and corresponding quality metrology,which are critical for pushing the CNT-based transistor technology to manufacturing,should be developed in advance.Much progress has been made on fabrication of CNT films;however,there still lacks a metrology for thoroughly quantifying their quality until now.In this paper,through comparing study of CNT films fabricated by dip-coating(DC)and direct deposition(DD)methods,local anisotropy in the film is revealed to impact the performance uniformity of devices so fabricated in a spatial scale dependent manner.The anisotropy effect should be taken into account for the quality characterization of CNT films,which was not noticed in previous studies.Based on these findings,we propose a four-parameter metrology to quantify the overall quality of the CNT films,which includes the local tube density(DL),global density uniformity(Cv),local degree of order(OL),and the relative tube proportion in a certain orientation(Pθ)at a location.The four-parameter characterization and corresponding device performance confirm DC films are superior to DD films for practical application.The four-parameter metrology is not only powerful for overall quality evaluation of CNT films,but also able to predict the fluctuation of devices’performance.Therefore,this material metrology is important for devices and circuits design and valuable for pushing the CNT-based transistor technology forward. | Jie Zhao Lijun Shen Fang Liu Pan Zhao Qi Huang Hua Han Lianmao Peng Xuelei Liang | 2020 | Nano Research2020，13，6： | 4 |
| 12 | Large-area and highly uniform carbon nanotube film for nigh-performance thin film transistors显示文摘 | Guodong Dong Jie Zhao Lijun Shen Jiye Xia Hu Meng Wenhuan Yu Qi Huang Hua Han Xuelei Liang Lianmao Peng | 2018 | Nano Research2018，11，8： | 3 |
| 13 | Changes in Life Expectancy of Respiratory Diseases from Attaining Daily PM_(2.5) Standard in China: A Nationwide Observational Study显示文摘Although exposure to air pollution increases the risk of premature mortality and years of life lost(YLL),the effects of daily air quality improvement to the life expectancy of respiratory diseases remained unclear.We applied a generalized additive model(GAM)to assess the associations between daily PM_(2.5) exposure and YLL from respiratory diseases in 96 Chinese cities during 2013–2016.We further estimated the avoidable YLL,potential gains in life expectancy,and the attributable fraction by assuming dailyPM_(2.5) concentration decrease to the air quality standards of China and World Health Organization.Regional and national results were generated by random-effects meta-analysis.A total of 861,494 total respiratory diseases and 586,962 chronic obstructive pulmonary disease(COPD)caused death from 96 Chinese cities were recorded during study period.Each 10 mg/m3 increase of PM_(2.5) in 3-day moving average(lag02)was associated with 0.16(95%CI:0.08,0.24)years increment in life expectancy from total respiratory diseases.The highest effect was observed in Southwest region with 0.42(95%CI:0.22,0.62)years increase in life expectancy.By attaining the WHO's Air Quality Guidelines,we estimated that an average of 782.09(95%CI:438.29,1125.89)YLLs caused by total respiratory death in each city could be avoided,which corresponded to 1.15%(95%CI:0.67%,1.64%)of the overall YLLs,and 0.12(95%CI:0.07,0.17)years increment in life expectancy.The results of COPD were generally consistent with total respiratory diseases.Our findings indicate that reduction in daily PM_(2.5) concentrations might lead to longer life expectancy from respiratory death. | Yin Yang Jinlei Qi Zengliang Ruan Peng Yin Shiyu Zhang Jiangmei Liu Yunning Liu Rui Li Lijun Wang Hualiang Lin | 2020 | The Innovation2020，1，3： | 3 |
| 14 | Mortality of Common Gastrointestinal Tract Cancers--Huai River Basin, 2008–2018显示文摘What is already known on this topic?Gastrointestinal(GI)tract cancer is a leading cause of death and produces a heavy disease burden.GI tract cancer in the Huai River Basin was reportedly higher than the national level during 2004–2006,while current mortality rates and variations have not been reported recently.What is added by this report?During 2008 to 2018,significant decreases were observed in the rates of esophageal cancer(from 28.5 to 13.2 per 100,000)and stomach cancer(from 32.1 to 16.5 per 100,000).There was no statistical difference for the mortality rates of colorectal cancer,which actually showed a significant increase among men aged 45 to 54 years and women aged below 55 years.Substantial disparities exist among different sexes,age groups,and geographical regions.What are the implications for public health practice?These results highlight that the mortality of GI tract cancers in the Huai River Basin in 2018 are similar to national levels and still produce a heavy disease burden.More attention is needed to provide important evidence for evaluating the improvement and remaining gaps in cancer prevention and control strategies in the Huai River Basin. | Jinlei Qi Lijun Wang Maigeng Zhou Baohua Wang Peng Yin Wei Wang Jiangmei Liu Yunning Liu Jing Wu | 2020 | China CDC weekly2020，2，16： | 3 |
| 15 | Screening and verification of ssDNA aptamers targeting human hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 是在世界上的最恶意的癌症之一。能认出为 HCC 特定的 biomarkers 的分子的探针着急地被需要改进早诊断的敏感和特性。最近的研究由指数的丰富使用了 ligands 的系统的进化的方法并且生产了能明确地绑在老鼠肝癌症房间和纸巾的几 aptamers。然而,与人的肝癌症的有约束力的亲密关系充分没被识别。用导出人的 hepatoma,房间线 HepG2 同样积极的目标房间线和正常 hepatocyte 房间作为否定的衬里 HL-7702,我们获得了能明确地在 nanomolar 范围与 Kd 绑在人的肝癌症房间并且认出嵌入石蜡的人的 HCC 纸巾的 aptamer HA09。这 aptamer 可以便于新奇 biomarkers 的发现并且与诊断、治疗学的含意为细胞内部的交货用作一根理想的分子的探针。 | Bin Lu Jiucun Wang Jun Zhang Xiaojiao Zhang Dongqin Yang Lijun Wu Zhongguang Luo Yanyun Ma Qi Zhang Yunfang Ma Xiaoyu Pei Hua Yu Jie Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 3 |
| 16 | Incidence,Prevalence,and Mortality of Four Major Chronic Non-communicable Diseases—China,1990-2017显示文摘Introduction Chronic and non-communicable diseases(NCDs)have become an important public health concern in China.We aimed to estimate the incidence,prevalence,and mortality of four major NCDs including cardiovascular disease(CVD),cancer,chronic respiratory diseases(CRD),and diabetes in China during 1990-2017.Methods The general analytic framework of Global Burden of Diseases Study 2017(GBD 2017)was applied.Data from Disease Surveillance Point System,censuses,and Chinese Center for Disease Control and Prevention Cause-of-Death Reporting System were used for mortality estimates.National surveys,cancer registries,and published studies were used for incidence and prevalence estimates.Results In 2017,new cases for CVD,cancer,and diabetes were 13.5,4.6,and 3.3 million,an increase of 120.4%,159.7%,and 57.3%respectively compared with 1990.There were 9.6 million incident cases for CRD in 2017,a 4.9%decrease compared with 1990.A total of 8.1 million people died from cancer,CVD,CRD,and diabetes in China in 2017.There was a substantial decline in age-standardized mortality rate for CRD and a steady but slow decline for CVD and cancer.During 1990-2017,the age-standardized prevalence rate increased by 7.4%,135.2%,and 17.0%for CVD,cancer,and diabetes respectively.Conclusions and Implications for Public Health Practice The accumulated prevalence of the four major NCDs are increasing but the age-standardized mortality rate for CVD,cancer,and CRD has been on a decline during 1990-2017.More effective intervention strategies should be developed to deal with the continuously increasing burden caused by NCDs in China. | Peng Yin Jinlei Qi Yunning Liu Jiangmei Liu Jinling You Lijun Wang Maigeng Zhou | 2019 | China CDC weekly2019，1，3： | 2 |
| 17 | Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development显示文摘Objective:Hepatocellular carcinoma(HCC)is a severely lethal cancer that usually originates from chronic liver injury and inflammation.Although progress on diagnosis and treatment is obvious,the cause of HCC remains unclear.In this study,we sought to determine key genes in HCC development.Methods:To identify key regulators during HCC progression,we performed transcriptome sequencing to obtain time series gene expression data from a mouse model with diethylnitrosamine-induced liver tumors and further verified gene expression and function in vitro and in vivo.Results:Among the differentially expressed genes,Cyp2c29 was continuously downregulated during HCC progression.Overexpression of Cyp2c29 suppressed N F-kB activation and proinflammatory cytokine production by increasing the production o f 14,15-epoxyeicosatrienoic acid in vitro.Furthermore,overexpression of Cyp2c29 in vivo protected against liver inflammation in mouse models of liver injury induced by both acetaminophen and CC14.Two human homologs of mouse Cyp2c29,CYP2C8 and CYP2C9,were found to be downregulated in human HCC progression,and their expression was positively correlated with overall survival in patients with HCC(significance:P=0.046 and 0.0097,respectively).Conclusions:Collectively,through systematic analysis and verification,we determined that C yp2c29 is a novel gene involved in liver injury and inflammation,which may be a potential biomarker for HCC prevention and prognosis determination. | Qi Wang Qin Tang Lijun Zhao Qiong Zhang Yuxin Wu Hui Hu Lanlan Liu Xiang Liu Yanhong Zhu Anyuan Guo Xiangliang Yang | 2020 | Cancer Biology & Medicine2020，17，2： | 2 |
| 18 | ABNORMAL SHOOT 6 interacts with KATANIN 1 and SHADE AVOIDANCE 4 to promote cortical microtubule severing and ordering in Arabidopsis显示文摘Plant interphase cortical microtubules(cMTs)mediate anisotropic cell expansion in response to environmental and developmental cues.In Arabidopsis thaliana,KATANIN 1(KTN1),the p60 catalytic subunit of the conserved MT-severing enzyme katanin,is essential for cMT ordering and anisotropic cell expansion.However,the regulation of KTN1-mediated cMT severing and ordering remains unclear.In this work,we report that the Arabidopsis IQ67 DOMAIN(IQD)family gene ABNORMAL SHOOT 6(ABS6)encodes a MT-associated protein.Overexpression of ABS6 leads to elongated cotyledons,directional pavement cell expansion,and highly ordered transverse cMT arrays.Genetic suppressor analysis revealed that ABS6-mediated cMT ordering is dependent on KTN1 and SHADE AVOIDANCE 4(SAV4).Live imaging of cMT dynamics showed that both ABS6 and SAV4 function as positive regulators of cMT severing.Furthermore,ABS6 directly interacts with KTN1 and SAV4 and promotes their recruitment to the cMTs.Finally,analysis of loss-of-function mutant combinations showed that ABS6,SAV4,and KTN1 work together to ensure the robust ethylene response in the apical hook of dark-grown seedlings.Together,our findings establish ABS6 and SAV4 as positive regulators of cMT severing and ordering,and highlight the role of cMT dynamics in fine-tuning differential growth in plants. | Yuanfeng Li Meng Deng Haofeng Liu Yan Li Yu Chen Min Jia Hui Xue Jingxia Shao Jun Zhao Yafei Qi Lijun An Fei Yu Xiayan Liu | 2021 | Journal of Integrative Plant Biology2021，63，4： | 2 |
| 19 | Trends of Mortality in End-Stage Liver Disease—China,2008–2020显示文摘Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics. | Xiaoxiao Wang Huixin Liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng Liu Hongbo Li Yunning Liu Jiangmei Liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou | 2023 | China CDC weekly2023，5，30： | 1 |
| 20 | Stress- dependent Electrical Resistance Model for Fatigue Lifetime Calculation of 48MnV Steel显示文摘 | Binxiang Sun Qiuwei Yang Lijun Yang Qi Liu | 2012 | IJACT2012，，4： | 1 |
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