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| 1 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 2 | Changes in Life Expectancy of Respiratory Diseases from Attaining Daily PM_(2.5) Standard in China: A Nationwide Observational Study显示文摘Although exposure to air pollution increases the risk of premature mortality and years of life lost(YLL),the effects of daily air quality improvement to the life expectancy of respiratory diseases remained unclear.We applied a generalized additive model(GAM)to assess the associations between daily PM_(2.5) exposure and YLL from respiratory diseases in 96 Chinese cities during 2013–2016.We further estimated the avoidable YLL,potential gains in life expectancy,and the attributable fraction by assuming dailyPM_(2.5) concentration decrease to the air quality standards of China and World Health Organization.Regional and national results were generated by random-effects meta-analysis.A total of 861,494 total respiratory diseases and 586,962 chronic obstructive pulmonary disease(COPD)caused death from 96 Chinese cities were recorded during study period.Each 10 mg/m3 increase of PM_(2.5) in 3-day moving average(lag02)was associated with 0.16(95%CI:0.08,0.24)years increment in life expectancy from total respiratory diseases.The highest effect was observed in Southwest region with 0.42(95%CI:0.22,0.62)years increase in life expectancy.By attaining the WHO's Air Quality Guidelines,we estimated that an average of 782.09(95%CI:438.29,1125.89)YLLs caused by total respiratory death in each city could be avoided,which corresponded to 1.15%(95%CI:0.67%,1.64%)of the overall YLLs,and 0.12(95%CI:0.07,0.17)years increment in life expectancy.The results of COPD were generally consistent with total respiratory diseases.Our findings indicate that reduction in daily PM_(2.5) concentrations might lead to longer life expectancy from respiratory death. | Yin Yang Jinlei Qi Zengliang Ruan Peng Yin Shiyu Zhang Jiangmei Liu Yunning Liu Rui Li Lijun Wang Hualiang Lin | 2020 | The Innovation2020，1，3： | 3 |
| 3 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 4 | Ambient air pollution and low temperature associated with case fatality of COVID-19: A nationwide retrospective cohort study in China显示文摘The evidence for the effects of environmental factors on COVID-19 case fatality remains controversial,and it is crucial to understand the role of preventable environmental factors in driving COVID-19 fatality.We thus conducted a nationwide cohort study to estimate the effects of environmental factors(temperature,particulate matter[PM2.5,PM10],sulfur dioxide[SO2],nitrogen dioxide[NO2],and ozone[O3])on COVID-19 case fatality.A total of 71,808 confirmed COVID-19 cases were identified and followed up for their vital status through April 25,2020.Exposures to ambient air pollution and temperature were estimated by linking the city-and county-level monitoring data to the residential community of each participant.For each participant,two windows were defined:the period from symptom onset to diagnosis(exposure window I)and the period from diagnosis date to date of death/recovery or end of the study period(exposure window II).Cox proportional hazards models were used to estimate the associations between these environmental factors and COVID-19 case fatality.COVID-19 case fatality increased in association with environmental factors for the two exposure windows.For example,each 10 mg/m^(3) increase in PM2.5,PM10,O3,and NO2 in window I was associated with a hazard ratio of 1.11(95%CI 1.09,1.13),1.10(95%CI 1.08,1.13),1.09(95 CI 1.03,1.14),and 1.27(95%CI 1.19,1.35)for COVID-19 fatality,respectively.A significant effect was also observed for low temperature,with a hazard ratio of 1.03(95%CI 1.01,1.04)for COVID-19 case fatality per 1C decrease.Subgroup analysis indicated that these effects were stronger in the elderly,as well as in those with mild symptoms and living in Wuhan or Hubei.Overall,the sensitivity analyses also yielded consistent estimates.Short-term exposure to ambient air pollution and low temperature during the illness would play a nonnegligible part in causing case fatality due to COVID-19.Reduced exposures to high concentrations of PM2.5,PM10,O3,SO2,and NO2 and low temperature would help improve the prognosis and reduce public health burden. | Fei Tian Xiaobo Liu Qingchen Chao Zhengmin(Min)Qian Siqi Zhang Li Qi Yanlin Niu Lauren DArnold Shiyu Zhang Huan Li Hualiang Lin Qiyong Liu | 2021 | The Innovation2021，2，3： | 2 |
| 5 | Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches显示文摘Artificial intelligence(AI)models usually require large amounts of high-quality training data,which is in striking contrast to the situation of small and biased data faced by current drug discovery pipelines.The concept of federated learning has been proposed to utilize distributed data from different sources without leaking sensitive information of the data.This emerging decentralized machine learning paradigm is expected to dramatically improve the success rate of AI-powered drug discovery.Here,we simulated the federated learning process with different property and activity datasets from different sources,among which overlapping molecules with high or low biases exist in the recorded values.Beyond the benefit of gaining more data,we also demonstrated that federated training has a regularization effect superior to centralized training on the pooled datasets with high biases.Moreover,different network architectures for clients and aggregation algorithms for coordinators have been compared on the performance of federated learning,where personalized federated learning shows promising results.Our work demonstrates the applicability of federated learning in predicting drug-related properties and highlights its promising role in addressing the small and biased data dilemma in drug discovery. | Zhaoping Xiong Ziqiang Cheng Xinyuan Lin Chi Xu Xiaohong Liu Dingyan Wang Xiaomin Luo Yong Zhang Hualiang Jiang Nan Qiao Mingyue Zheng | 2022 | Science China(Life Sciences)2022，65，3： | 1 |
| 6 | Theoretical studies on cation-π interactions (I)—Densityfunctional theory investigation on the configurations and interaction for ammonium cation-benzene complex显示文摘 | Hualiang Jiang Weiliang Zhu Xiaojian Tan Jiande Gu Jianzhong Chen Maowei Lin Kaixian Chen Ruyun Ji | 1998 | Science in China Series B: Chemistry1998，，5： | 1 |
| 7 | Association Between Ambient Temperature and Years of Life Lost from Stroke—30 PLADs,China,2013–2016显示文摘What is already known about this topic?Previous studies have mainly focused on the relationship between temperature and mortality from stroke,but analysis on the effects on years of life lost(YLL)is limited.What is added by this report?YLLs were used as the health outcome,and cold and hot weather were found to be significantly associated with an increase in YLLs from stroke and for different groups,with a stronger effect found to be associated with low temperature.What are the implications for public health practice?These findings could help identify vulnerable regions and populations that have a more serious temperaturerelated burden and to guide the practical and effective measures for stroke control from a YLL perspective. | Jinlei Qi Fei Tian Siqi Ai Peng Yin Maigeng Zhou Lijun Wang Hualiang Lin | 2021 | China CDC weekly2021，3，23： | 1 |
| 8 | Short-term effects of meteorological factors on children hand,foot and mouth disease in Guangzhou,China显示文摘 | Chun Chen Hualiang Lin Xiaoquan Li | 2014 | International Journal of Biometeorology2014，58，7： | 1 |
| 9 | Holographic fabrication of octagon graded photonic supercrystal and potential applications in topological photonics显示文摘Novel optical properties in graded photonic super-crystals can be further explored if new types of graded photonic super-crystals are fabricated.In this paper,we report holographic fabrication of graded photonic super-crystal with eight graded lattice clusters surrounding the central non-gradient lattices through pixel-by-pixel phase engineering in a spatial light modulator.The prospect of applications of octagon graded photonic super-crystal in topological photonics is discussed through photonic band gap engineering and coupled ring resonators. | Oliver SALE Safaa HASSAN Noah HURLEY Khadijah ALNASSER Usha PHILIPOSE Hualiang ZHANG Yuankun LIN | 2020 | Frontiers of Optoelectronics2020，13，1： | 0 |
| 10 | Release of Exogenous Growth Factors from Small Intestinal Submucosa during Bladder Regeneration in Rat显示文摘 | Maohu Lin Hualiang Yu Rui Miao Wanchang Qin Ning Jia | 2006 | Journal of US-China Medical Science2006，3，3： | 0 |
| 11 | Wide field-of-view metalens: a tutorial显示文摘Wide field-of-view(FOV)optics are essential components in many optical systems,with applications spanning imaging,display,sensing,and beam steering.Conventional refractive wide FOV optics often involve multiple stacked lenses,resulting in large size and weight as well as high cost.Metasurface lenses or metalenses promise a viable solution to realizing wide FOV optics without complex lens assembly.We review the various architectures of wide FOV metalenses,elucidate their fundamental operating principles and design trade-offs,and quantitatively evaluate and contrast their imaging performances.Emerging applications enabled by wide FOV metasurface optics are also discussed. | Fan Yang Mikhail YShalaginov Hung-I Lin Sensong An Anu Agarwal Hualiang Zhang Clara Rivero-Baleine Tian Gu Juejun Hu | 2023 | Advanced Photonics2023，5，3： | 0 |
| 12 | Temporal trend of mortality from major cancers in Xuanwei, China显示文摘尽管很多研究在 Xuanwei 县检验了肺癌症的病原学,中国,在这个县的癌症的另外的类型没系统地被报导。这研究试图从三死亡调查(19731975, 19901992,和 20042005 ) 用数据在 Xuanwei 县调查八主要癌症的时间的趋势。在 1990 的中国人口被用作一张标准人口计算 agestandardized 死亡率。肺,肝,胸,大脑,食管,白血病,直肠,和胃的癌症以死亡率在这个县作为领先的癌症被识别。在三次经期期间,肺癌症作为癌症的最普通的类型留下了。为癌症的所有另外的类型的死亡率是比国家一般水准的那些低的,但是一个增加的趋势为所有癌症被观察,特别地从 19901992 ~ 20042005。时间的趋势能被变化部分在风险因素解释,但是它可能也由于在癌症诊断的改进并且屏蔽。进一步流行病学的研究被保证系统地在 Xuanwei 县为主要癌症的时间的趋势检验内在的原因。 | Hualiang Lin Bofu Ning Jihua Li Guangqiang Zhao Yunchao Huang Linwei Tian | 2015 | Frontiers of Medicine2015，9，4： | 0 |
| 13 | A New Format of Single Chain Tri-specific Antibody with Diminished Molecular Size Efficiently Induces Ovarian Tumor Cell Killing显示文摘 | Jing Liu Qi Zhao Baofeng Zhao Julong Cheng Xiangbin Wang Liping Song Zhang Zhong Qing Lin Hualiang Huang | 2006 | 中国生物学文摘2006，20，1： | 0 |
| 14 | Improved synthesis of rupintrivir显示文摘An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (L-glutamic acid, D-4-fluorophenylalanine, and L-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps. | LIN DaiZong QIAN WangKe HILGENFELD Rolf JIANG HuaLiang CHEN KaiXian LIU Hong | 2012 | Science China Chemistry2012，55，6： | 0 |
| 15 | Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3显示文摘The TEA domain(TEAD)family proteins(TEAD1-4)are essential transcription factors that control cell differentiation and organ size in the Hippo pathway.Although the sequences and structures of TEAD family proteins are highly conserved,each TEAD isoform has unique physiological and pathological functions.Therefore,the development and discovery of subtype selective inhibitors for TEAD protein will provide important chemical probes for the TEAD-related function studies in development and diseases.Here,we identified a novel TEAD 1/3 covalent inhibitor(DC-TEADin1072)with biochemical IC50 values of 0.61±0.02 and 0.58±0.12μmol/L against TEAD1 and TEAD3,respectively.Further chemical optimization based on DC-TEAD in 1072 yielded a selective TEAD3 inhibitor DCTEAD3 in03 with the IC_(50) value of 0.16±0.03μmol/L,which shows 100-fold selectivity over other TEAD isoforms in activity-based protein profiling(ABPP)assays.In cells,DC-TEAD3 in03 showed selective inhibitory effect on TEAD3 in GAL4-TEAD(1-4)reporter assays with the IC50 value of1.15μmol/L.When administered to zebrafish juveniles,experiments showed that DC-TEAD3 in03 reduced the growth rate of zebrafish caudal fins,indicating the importance of TEAD3 activity in controlling proportional growth of vertebrate appendages. | Tian Lu Yong Li Wenchao Lu TWGM Spitters Xueyu Fang Jun Wang Simian Cai Jing Gao Yanting Zhou Zhe Duan Huan Xiong Liping Liu Qi Li Hualiang Jiang Kaixian Chen Hu Zhou Hua Lin Huijin Feng Bing Zhou Christopher L.Antos Cheng Luo | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 0 |
| 16 | Predictive Model and Risk Factors for Case Fatality of COVID-19: A Cohort of 21,392 Cases in Hubei, China显示文摘An increasing number of patients are being killed by coronavirus disease 2019(COVID-19),however,risk factors for the fatality of COVID-19 remain unclear.A total of 21,392 COVID-19 cases were recruited in the Hubei Province of China between December 2019 and February 2020,and followed up until March 18,2020.We adopted Cox regression models to investigate the risk factors for case fatality and predicted the death probability under specific combinations of key predictors.Among the 21,392 patients,1,020(4.77%)died of COVID-19.Multivariable analyses showed that factors,including age(R60 versus<45 years,hazard ratio[HR]=7.32;95%confidence interval[CI],5.42,9.89),sex(male versus female,HR=1.31;95%CI,1.15,1.50),severity of the disease(critical versus mild,HR=39.98;95%CI,29.52,48.86),comorbidity(HR=1.40;95%CI,1.23,1.60),highest body temperature(>39C versus<39C,HR=1.28;95%CI,1.09,1.49),white blood cell counts(>103109/L versus(4–10)3109/L,HR=1.69;95%CI,1.35,2.13),and lymphocyte counts(<0.83109/L versus(0.8–4)3109/L,HR=1.26;95%CI,1.06,1.50)were significantly associated with case fatality of COVID-19 patients.Individuals of an older age,who were male,with comorbidities,and had a critical illness had the highest death probability,with 21%,36%,46%,and 54%within 1–4 weeks after the symptom onset.Risk factors,including demographic characteristics,clinical symptoms,and laboratory factors were confirmed to be important determinants of fatality of COVID-19.Our predictive model can provide scientific evidence for a more rational,evidence-driven allocation of scarce medical resources to reduce the fatality of COVID-19. | Ran Wu Siqi Ai Jing Cai Shiyu Zhang Zhengmin(Min)Qian Yunquan Zhang Yinglin Wu Lan Chen Fei Tian Huan Li Mingyan Li Hualiang Lin | 2020 | The Innovation2020，1，2： | 0 |
| 17 | PanGu Drug Model: learn a molecule like a human显示文摘Dear Editor,Recent achievements in large-scale pre-trained models like GPT-3 and PanGu-α have demonstrated astounding performances in many downstream tasks of natural language processing (NLP),confirming AI to be user-oriented for even industrial applications.Deep learning has been recognized as the most promising technology for pharmaceuticals,a powerful molecule pre-trained model that could economize researchers’tons of time.For the strategic application of AI capabilities to the drug discovery field,we pre-trained a model called PanGu Drug Model with 1.7 billion small molecules from ZINC20 (Irwin et al.,2020),DrugSpaceX(Yang et al.,2021),and UniChem (Chambers et al.,2013). | Xinyuan Lin Chi Xu Zhaoping Xiong Xinfeng Zhang Ningxi Ni Bolin Ni Jianlong Chang Ruiqing Pan Zidong Wang Fan Yu Qi Tian Hualiang Jiang Mingyue Zheng Nan Qiao | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 18 | Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis显示文摘丰满的酸生合成(船边交货) 是在房间的一个重要过程。丰满的酸为房间汇编和细胞的新陈代谢是必要的。反常船边交货直接与房间生长延期和人的疾病相关,例如新陈代谢的症候群和各种各样的癌症。船边交货系统是利用酰搬运人蛋白质(ACP ) 稳定的 transporter 和梭变得丰满在整个为逐步的催化作用的酶的模块的酸链。因此,学习在酶的模块和 ACP 之间的相互作用为理解 FAS 系统的生物函数是批评的。然而,信息由于有酶的模块的 ACP 和它的弱相互作用的高灵活性仍然保持不清楚。我们在场这里 2.55?在有 holo-ACP 的建筑群的类型 II 船边交货 dehydratase FabZ 的水晶结构,它与每 ACP 绑定展出高度对称的 FabZ hexamer-ACP 3 stoichiometry 到一个 FabZ 更暗淡的子单元。和生物物理、计算的结果,进一步结构的分析在船边交货系统为 dehydratase 模块揭示新奇动态像跷跷板的 ACP 绑定和催化作用机制,它被操作表层的运动的批评看门人残余(在 FabZ 的 Tyr100 ) 调整。这些调查结果在 FAS 系统改进脱水进程的一般理解并且将潜在地为在船边交货与畸形联系的疾病便于药和治疗学的设计。 | Lin Zhang Jianfeng Xiao Jianrong Xu Tianran Fu Zhiwei Cao Liang Zhu Hong-Zhuan Chen Xu Shen Hualiang Jiang Liang Zhang | 2016 | Cell Research2016，26，12： | 0 |
| 19 | The impact of EV71 vaccination program on hand,foot and mouth disease in Zhejiang Province,China:A negative control study显示文摘Objective:To estimate the potential causal impact of Enterovirus A71(EV71)vaccination program on the reduction of EV71-infected hand,foot,and mouth disease(HFMD)in Zhejiang Province.Methods:We utilized the longitudinal surveillance dataset of HFMD and EV71 vaccination in Zhejiang Province during 2010-2019.We estimated vaccine efficacy using a Bayesian structured time series(BSTS)model,and employed a negative control outcome(NCO)model to detect unmeasured confounding and reveal potential causal association.Results:We estimated that 20,132 EV71 cases(95%CI:16,733,23,532)were prevented by vaccination program during 2017-2019,corresponding to a reduction of 29%(95%CI:24%,34%).The effectiveness of vaccination increased annually,with reductions of 11%(95%CI:6%,16%)in 2017 and 66%(95%CI:61%,71%)in 2019.Children under 5 years old obtained greater benefits compared to those over 5 years.Cities with higher vaccination coverage experienced a sharper EV71 reduction compared to those with lower coverage.The NCO model detected no confounding factors in the association between vaccination and EV71 cases reduction. | Dashan Zheng Lingzhi Shen Wanqi Wen Feng Ling Ziping Miao Jimin Sun Hualiang Lin | 2023 | Infectious Disease Modelling2023，8，4： | 0 |
| 20 | Physical Activity and Different Recommendations Associated with the Dynamic Trajectory of Cardiometabolic Diseases-UK,2006-2021显示文摘What is already known about this topic?Previous studies have illustrated the benefits of physical activity on cardiometabolic multimorbidity(CMM),while limited studies have concentrated on the trajectory of CMM progression.What is added by this report?Through multi-stage regression analysis,we found that physical activity could reduce the risk of CMM incidence.Participants initially free of cardiometabolic diseases(CMDs)may benefit more from engaging in recommended physical activity.What are the implications for public health practice?Adults,especially those initially free of CMDs,should engage in WHO-recommended physical activity as early as possible to prevent CMD incidence and further progression. | Lan Chen Miao Cai Hongtao Zou Shiyu Zhang Xiaojie Wang Haitao Li Hualiang Lin Zilong Zhang | 2022 | China CDC weekly2022，4，51： | 0 |
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