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| 1 | PDX1.1-dependent biosynthesis of vitamin B6 protects roots from ammonium-induced oxidative stress显示文摘Despite serving as a major inorganic nitrogen source for plants,ammonium causes toxicity at elevated con-centrations,inhibiting root elongation early on.While previous studies have shown that ammonium-inhibited root development relates to ammonium uptake and formation of reactive oxygen species(ROS)in roots,it remains unclear about the mechanisms underlying the repression of root growth and how plants cope with this inhibitory effect of ammonium.In this study,we demonstrate that ammonium-induced apo-plastic acidification co-localizes with Fe precipitation and hydrogen peroxide(H_(2)O_(2))accumulation along the stele of the elongation and differentiation zone in root tips,indicating Fe-dependent ROS formation.By screening ammonium sensitivity in T-DNA insertion lines of ammonium-responsive genes,we identified PDX1.1,which is upregulated by ammonium in the root stele and whose product catalyzes de novo biosyn-thesis of vitamin B6.Root growth of pdx1.1 mutants is hypersensitive to ammonium,while chemical complementation or overexpression of PDX1.1 restores root elongation.This salvage strategy requires non-phosphorylated forms of vitamin B6 that are able to quench ROS and rescue root growth from ammo-nium inhibition.Collectively,these results suggest that PDX1.1-mediated synthesis of non-phosphorylated B6 vitamers acts as a primary strategy to protect roots from ammonium-dependent ROS formation. | Ying Liu Rodolfo A.Maniero Ricardo F.H.Giehl Michael Melzer Priscille Steensma Gabriel Krouk Teresa B.Fitzpatrick Nicolaus von Wirén | 2022 | Molecular Plant2022，15，5： | 3 |
| 2 | High-content imaging of Mycobacterium tuberculosis -infected macrophages: an in vitro model for tuberculosis drug discovery显示文摘 | Thierry Christophe Fanny Ewann Hee Kyoung Jeon Jonathan Cechetto Priscille Brodin | 2010 | Future Med. Chem2010，，： | 1 |
| 3 | Culture Fil trate Protein and ESAT-6 Independently of a 10- Kilodalton RI)I Immunogenicity tuberculosis mycobacterium contributes to cell envelope proteinPPE68 显示文摘 | Caroline Demangel Priscille Brodin Paul J | 2004 | Infect Immune2004，72，4： | 1 |
| 4 | Dissection of ESAT- 6 System 1 of Mycobacterium tuberculosis and Impact on Im- munogenicity and Virulence显示文摘 | Priscille B Laleh M Laurent M | 2006 | Infection and Immunity2006，74，1： | 1 |
| 5 | Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence显示文摘 | Priscille Brodin Laleh Majlessi Laurent Marsollier | 2012 | Infection and Immunity2012，74，1： | 1 |
| 6 | A Truncated HIV- 1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus显示文摘 | Eric Vives Priscille Brodin Bernard Lebleu | 1997 | Thejournal of Biological Chemistry1997，272，16： | 1 |
| 7 | Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors显示文摘 | Julien Maruotti Marta Mu?oz Severine A. Degrelle Enrique Gómez Claire Louet Carmen Díez Monforte Priscille Huot de Longchamp Vincent Brochard Isabelle Hue José Nestor Caama?o Alice Jouneau | 2012 | Mol Reprod Dev2012，，7： | 1 |
| 8 | ESAT-6 proteins: protective antigens and virulence faetors?显示文摘 | PRISCILLE B IDA R PETER A | 2004 | Trends in Microbiology2004，12，11： | 1 |
| 9 | Rapid correction of hyperglycemia:A necessity but at what price?A brief report of a patient living with type 1 diabetes显示文摘BACKGROUND The correction and control of chronic hyperglycemia are the management goals of patients living with diabetes.Chronic hyperglycemia is the main factor inducing diabetes-related complications.However,in certain situations,the rapid and intense correction of chronic hyperglycemia can paradoxically favor the onset of microvascular complications.CASE SUMMARY In this case report,we describe the case of a 25-year-old woman living with type 1 diabetes since the age of 9 years.Her diabetes was chronic and unstable but without complications.During an unplanned pregnancy,her diabetes was intensely managed with the rapid correction of her hyperglycemia.However,over the following 2 years,she developed numerous degenerative microvascular complications:Charcot neuroarthropathy with multiple joint involvement,severe proliferative diabetic retinopathy,gastroparesis,bladder voiding disorders,and end-stage renal failure requiring hemodialysis.CONCLUSION In the literature to date,the occurrence of multiple microvascular complications following the rapid correction of chronic hyperglycemia has been rarely described in the same individual. | Priscille Huret Philippe Lopes Randa Dardari Alfred Penfornis Claire Thomas Dured Dardari | 2023 | World Journal of Diabetes2023，14，11： | 1 |
| 10 | Cell envelope proteinPPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a lO-kilodalton culture Filtrate protein and ESAT-6 显示文摘 | Caroline D Priscille B Paul JC | 2004 | Infect Immun2004，72，4： | 1 |
| 11 | In vitro gastrointestinal bioavailability of arsenic in soils collected near CCA-treated utility poles 显示文摘 | PRISCILL A P GERALDJ Z | 2006 | Environmental Science & Technology2006，40，： | 1 |
| 12 | Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti显示文摘 | Alexander S Pym Priscille Brodin Roland Brosch | 2002 | Molecular Microbiology2002，46，3： | 1 |
| 13 | ESAT-6 proteins: protective antigens and virulence factors?显示文摘 | Priscille Brodin Ida Rosenkrands Peter Andersen Stewart T. Cole Roland Brosch | 2004 | Trends in Microbiology2004，，11： | 1 |
| 14 | Imaging in pulmonary hypertension: Focus on the role of echocardiography显示文摘 | Pamela Moceri Delphine Baudouy Olivier Chiche Pierre Cerboni Priscille Bouvier Claire Chaussade Emile Ferrari | 2014 | Archives of Cardiovascular Diseases2014，，： | 1 |
| 15 | Cell envelope pro- tein PPE68 contributes to mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodahon culture filtrate protein and ESAT 6显示文摘 | Caroline D Priscille B Paul JC | 2004 | linfection and im munity2004，72，4： | 1 |
| 16 | Transduction of full-length TAT fusion proteins into mammalian cells显示文摘 | Eric V Priscille B | 1995 | Nat Med1995，4，12： | 1 |
| 17 | Spray drying and sintering of zirconia based hollow powders 显示文摘 | Priscille Roy Ghislaine Bertrand Christian Coddet | 2005 | Powder Technology2005，，157： | 1 |
| 18 | Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis显示文摘 | ALEXANDER SP PRISCILLE B LALEH M | 2003 | Nature Medicine2003，9，： | 1 |
| 19 | Spray Drying and Sintering of Zirconia Based Hollow Powders显示文摘 | Ghislaine Bertrand Christian Coddet | 2005 | Powder Technology2005，157，： | 1 |
| 20 | Science:研究人员利用小分子SMARt-420逆转结核分枝杆菌的抗生素耐药性显示文摘在一项新的研究中,来自瑞典、法国、比利时和瑞士的一个研究团队发现一种方法逆转对一种用于治疗肺结核的抗生素药物产生的耐药性。在他们发表在Science期刊上的论文中.该团队描述了他们如何筛选激活用于活化ethionaide的不同通路的化合物。Ethionaide是一种被用来治疗肺结核的前体分子。在体内经过代谢后产生一种真正有疗效的药物。 | Nicolas Blondiaux Vanessa Mathys Karine Soetaert Mehdi Kiass Vincent Delorme Kamel Djaout Vincent Trebosc Christian Kemmer René Wintjens Alexandre Wohlkönig Rudy Antoine Ludovic Huot David Hot Mireia Coscolla Julia Feldmann Sebastien Gagneux Camille Locht Priscille Brodin Marc Gitzinger Benoit Déprez | 2017 | 现代生物医学进展2017，17，15： | 0 |
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