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| 1 | Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy显示文摘Background The purposes of this study were to confirm the changes in myocardial collagen level after left ventricular assist device (LVAD) support in dilated cardiomyopathy (DCM), find the relation between these changes and prognosis, an d test a practical method to assess the level of myocardial collagen.Methods Left ventricular samples were collected from DCM patients with different prognosis (transplanted group n=8, weaning group n=10) at the time when the LV ADs were implanted and again during cardiac transplantation (n=8). The level of neutral salt soluble collagen (NSC) and acid soluble collagen (ASC) was measured by Sircol collagen assay, and that of total collagen and insoluble collagen (ISC) by quantification of hydroxyproline (Hyp). Serum samples were collected from a portion of these patients (transplanted group, n=6; weaning group n=7) at the time the LVADs were implanted, 1 month after implantation and on explantation. Circulating concentration of carboxy-terminal propeptide of type Ⅰ procollagen (PⅠCP), amino-terminal propeptide of type Ⅰ procollagen (PⅠNP), amino-terminal propeptide of type Ⅲ procollagen (PⅢNP) and type Ⅰ collagen telopeptide (ⅠCTP) were measured by the equilibrium type radioimmunoassay. Results Before LVAD implantation the level of NSC and ISC in th e weaning group was higher but ASC in the transplanted group was lower than in the control s (P<0.05). After LVAD support, the level of total collagen was higher, but ASC was also lower in the transplanted group than in the controls (P<0.05). In comparison of the pre- and po st-LVAD subgroups of the transplanted and weaning groups, all collagen fraction levels before LVAD implantation were lower in the transplanted group than in the weaning group (P<0.05); but this difference disappeared after LVAD support. Comparison of the pre- and post-LVAD subgroups of the transplanted group showed increased le vel of NSC and total collagen after LVAD support. The changes of serum p eptide concentration showed that PⅢNP increased constantly in the transplanted group, but PⅠCP and PⅠNP increased in the weaning group after LVAD implantation. Conclusions The changes in myocardial collagen level as a sign of myocardial interstitial remodeling in DCM are not involved with total collagen b ut invalved with collagen fractions, and they are related to prognosis. The changes of myocardial c ollagen content and serum procollagen peptide after LVAD support can be regarded as an expression of the reverse of maladaptive myocardial interstitial remodeling. | 梁红 Johannes Müller 翁渝国 Gerd Wallukat 付平 林汉生 Sabina Bartel Christoph Knosalla Reinhard Pregla Roland Hetzer | 2004 | Chinese Medical Journal2004，，3： | 3 |
| 2 | A new technique for the analysis of the dispersion characteristics of planar waveguides显示文摘 | Schulz U Pregla R | 1980 | Arch Electron and Uebertragang Band1980，34，： | 2 |
| 3 | RGD-containing fibrillin-1 fragments upregulatc matrix metalloproteinase expression in cell culture: a potential factor in the pathogenesis of the Marfan syndrome 显示文摘 | Booms P Pregla R Ney A | 2005 | Hum Genet2005，116，12： | 1 |
| 4 | Numerical techniques for modeling guided-wave photonics devices 显示文摘 | Gopinath A Pregla A | 2000 | IEEE J Selected Topics in Quantum Electronics2000，6，1： | 1 |
| 5 | Numerical techniques for modeling guided-wave photonic devices 显示文摘 | Scarmozzino R Gopinath A Pregla R | 2000 | IEEE J Selected Topics in Quantum Electronics2000，6，1： | 1 |
| 6 | Lipid peroxidation and the expressional regulation of lhe heat- shock response during ischemia - reperfusion of rat kidney显示文摘 | A kcetin Z Pregla R Busch A | 2000 | Urol lnt2000，65，1： | 1 |
| 7 | Plasma levels and cardiovascular gene expression of urotensin Ⅱ in human heart failure显示文摘 | Dschiezig T Bartach C Pregla R | 2002 | Regal Pept2002，110，1： | 1 |
| 8 | Inflammatory cells as source of tachykinin - induced mucus secretion in chronic bronchitis 显示文摘 | Springer J Groneber D A Pregla R | 2005 | Regul Peptides2005，124，3： | 1 |
| 9 | Lipid Peroxidation and the Expressional Regulation of the Heat - Shock Response during Ischemia - Reperfusion of Rat Kidney显示文摘 | Ziya Akcetin Reinhard Pregla Alexander Busch | 2000 | Urol Int2000，65，： | 1 |
| 10 | A new technique for the analysis of the dispersion characteristics of planar waveguides and its application to microstrips with tuning septums 显示文摘 | Schulz U Pregla R | 1981 | Rad/o Science1981，16，6： | 1 |
| 11 | Differential expression of heat shock proteins 70-1 and 70-2 mRNA after ischemia-reperfusion injury of rat kidney 显示文摘 | Akcetin Z Pregla R Darmer D | 1999 | Urol Res1999，27，5： | 1 |
| 12 | A new technique for the analysis of the dispersion characteristics of planar waveguides 显示文摘 | Schulz U Pregla R | 1980 | AEU Band1980，34，4： | 1 |
| 13 | A new technique for the analysis of the dispersion characteristics of planar waveguides显示文摘 | SCHULZ U PREGLA R | 1980 | Arch Electron and Uebertragang(AEU):Band1980，34，： | 1 |
| 14 | Hybrid mode analysis of arbitrarily shaped planar microwave structures by the method of lines显示文摘 | WORM S B PREGLA R | 1984 | IEEE Trans MTT1984，32，： | 1 |
| 15 | Bragg waveguide grating as a 1d photonic band gap structure: COST 268 modelling task显示文摘 | J. ?tyroky S. Helfert R. Pregla P. Bienstman R. Baets R. Ridder R. Stoffer G. Klaasse J. Petrá?ek P. Lalanne J. P. Hugonin R. M. LaRue | 2002 | Optical and Quantum Electronics (-)2002，，5： | 1 |
| 16 | 显示文摘 | Dschietzig T Bartsch C Pregla R | 2002 | Regul Pept2002，110，1： | 1 |
| 17 | The method of lines for the anal- ysis of planar waveguides with magnetized ferrite substrate 显示文摘 | PREGLA R WORM S B | 1984 | IEEE MTF-S 1984 Int Microwave Symp Dig1984，2，： | 1 |
| 18 | Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure显示文摘 | Fielitz J Dendorfer A Pregla R | 2002 | Circulation2002，105，3： | 1 |
| 19 | Numerical techniques for modehng guided - wave photonic devices 显示文摘 | SCARMOZZINO R GOPINATH A PREGLA R | 2000 | IEEE Journal of Selected Topics in Quantum Electonics2000，6，1： | 1 |
| 20 | Bragg waveguide gratingas a ID photonic band gap structure: COST 268 model-ling task 显示文摘 | Ctyrok J Helfert S Pregla R | 2002 | Optical and Quantum Electronics2002，34，： | 1 |
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