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| 1 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 2 | 人免疫球蛋白转基因小鼠自身免疫性重症肌无力模型的建立显示文摘 | 孟繁平 杨康鹃 李芳芳 孙昌元 金权鑫 M. Stassen M. de Baets | 2005 | 中华微生物学和免疫学杂志2005，25，2： | 7 |
| 3 | Taking silicon photonics modulators to a higher performance level: state-of-the-art and a review of new technologies显示文摘Optical links are moving to higher and higher transmission speeds while shrinking to shorter and shorter ranges where optical links are envisaged even at the chip scale.The scaling in data speed and span of the optical links demands modulators to be concurrently performant and cost-effective.Silicon photonics(SiPh),a photonic integrated circuit technology that leverages the fabrication sophistication of complementary metal-oxide-semiconductor technology,is well-positioned to deliver the performance,price,and manufacturing volume for the high-speed modulators of future optical communication links.SiPh has relied on the plasma dispersion effect,either in injection,depletion,or accumulation mode,to demonstrate efficient high-speed modulators.The high-speed plasma dispersion silicon modulators have been commercially deployed and have demonstrated excellent performance.Recent years have seen a paradigm shift where the integration of various electro-refractive and electro-absorptive materials has opened up additional routes toward performant SiPh modulators.These modulators are in the early years of their development.They promise to extend the performance beyond the limits set by the physical properties of silicon.The focus of our study is to provide a comprehensive review of contemporary(i.e.,plasma dispersion modulators)and new modulator implementations that involve the integration of novel materials with SiPh. | Abdul Rahim Artur Hermans Benjamin Wohlfeil Despoina Petousi Bart Kuyken Dries Van Thourhout Roel Baets | 2021 | Advanced Photonics2021，3，2： | 6 |
| 4 | 重症肌无力单链抗体基因的制备显示文摘[目的 ]构建抗人乙酰胆碱受体主要免疫原区单链抗体 .[方法 ]应用多聚酶链反应从抗人乙酰胆碱受体主要免疫原区抗原结合片段扩增重链和轻链可变区基因 ,并克隆到载体噬粒 pHEN2 .将含有单链抗体基因的重组噬粒转化大肠杆菌DH5α ,分离提纯重组噬粒后再经酶切、琼脂糖凝胶电泳检查以确认单链抗体基因的正确性 .[结果 ]电泳检查发现了大小分别为 3 78bp ,3 3 9bp和 762bp的重链可变区、轻链可变区和单链抗体基因 ,且位置正确 .[结论 | 杨康鹃 孟繁平 M.Stassen M.de Baets | 2002 | 延边大学医学学报2002，25，1： | 6 |
| 5 | 抗乙酰胆碱受体单克隆抗体A7诱导实验性自身免疫性重症肌无力作用显示文摘目的探讨抗乙酰胆碱受体单克隆抗体A7(抗-AChR mAb A7)对实验性自身免疫性重症肌无力(EAMG)的作用. 方法经Lewis大鼠腹腔注射5 mL 20倍浓缩的含抗-AChR mAb A7培养上清液,建立EAMG被动转输模型.对照组经腹腔注射同体积的PBS.每8 h监测体重和临床症状评分.48 h后处死实验动物.采用放射免疫法检测AChR,并计算出AChR损失率.结果抗-AChR mAb A7诱导的EAMG模型AChR损失率高达24.3%~45.2%,而且AChR损失率与临床症状评分相关(r=0.74, P<0.01).抗-AChR mAb A7攻击位点在终板的AChR上.结论抗-AChR mAb A7可用于诱导EAMG模型及有关研究. | 张旭 Mario Losen Marc De Baets | 2005 | 中国神经免疫学和神经病学杂志2005，12，2： | 5 |
| 6 | Exertional rhabdomyolysis and heat stroke: Beware of volatile anesthetic sedation显示文摘In view of the enormous popularity of mass sporting events such as half-marathons, the number of patients with exertional rhabdomyolysis or exercise-induced heat stroke admitted to intensive care units(ICUs) has increased over the last decade. Because these patients have been reported to be at risk for malignant hyperthermia during general anesthesia, the intensive care community should bear in mind that the same risk of life-threatening rhabdomyolysis is present when these patients are admitted to an ICU, and volatile anesthetic sedation is chosen as the sedative technique. As illustrated by the three case studies we elaborate upon, a thorough diagnostic work-up is needed to clarify the subsequent risk of strenuous exercise, and the anesthetic exposure to volatile agents in these patients and their families. Other contraindications for the use of volatile intensive care sedation consist of known malignant hyperthermia susceptibility, congenital myopathies, Duchenne muscular dystrophy, and intracranial hypertension. | Karel Heytens Jan De Bleecker Walter Verbrugghe Jonathan Baets Luc Heytens | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 7 | 电鳐乙酰胆碱受体的分离和纯化显示文摘[目的 ]分离和纯化具有活性的电鳐乙酰胆碱受体 .[方法 ]将电鳐电器官肌肉制成匀浆 ,细胞经裂解制备电鳐乙酰胆碱受体粗提液 .经眼镜蛇毒素偶联的Sepharose 4B层析柱亲和吸附 ,得到纯化的电鳐乙酰胆碱受体 .应用酶联免疫吸附试验检查纯化的电鳐乙酰胆碱受体与抗乙酰胆碱受体抗体的结合活性 .[结果 ]分离和纯化的电鳐乙酰胆碱受体能与抗乙酰胆碱受体抗体结合 ,且结合活性高 .[结论 ]从电鳐电器官中分离和纯化的乙酰胆碱受体活性高、特异性强 ,可作为抗原在酶联免疫吸附试验中用于检查抗乙酰胆碱受体抗体 . | 杨康鹃 孟繁平 M.de Baets | 2004 | 延边大学医学学报2004，27，1： | 3 |
| 8 | Widely tunable 2.3μm III-V-on-silicon Vernier lasers for broadband spectroscopic sensing显示文摘Heterogeneously integrating III-V materials on silicon photonic integrated circuits has emerged as a promising approach to make advanced laser sources for optical communication and sensing applications. Tunable semiconductor lasers operating in the 2–2.5 μm range are of great interest for industrial and medical applications since many gases(e.g., CO_2, CO, CH_4) and biomolecules(such as blood glucose) have strong absorption features in this wavelength region. The development of integrated tunable laser sources in this wavelength range enables low-cost and miniature spectroscopic sensors. Here we report heterogeneously integrated widely tunable III-V-on-silicon Vernier lasers using two silicon microring resonators as the wavelength tuning components. The laser has a wavelength tuning range of more than 40 nm near 2.35 μm. By combining two lasers with different distributed Bragg reflectors, a tuning range of more than 70 nm is achieved. Over the whole tuning range, the side-mode suppression ratio is higher than 35 dB. As a proof-of-principle, this III-V-on-silicon Vernier laser is used to measure the absorption lines of CO. The measurement results match very well with the high-resolution transmission molecular absorption(HITRAN) database and indicate that this laser is suitable for broadband spectroscopy. | RUIJUN WANG STEPHAN SPRENGEL ANTON VASILIEV GERHARD BOEHM JORIS VAN CAMPENHOUT GuY LEPAGE PETER VERHEYEN ROEL BAETS MARKUS-CHRISTIAN AMANN GUNTHER ROELKENS | 2018 | Photonics Research2018，6，9： | 3 |
| 9 | Lass calculation and design of arbitrarily curved integrated-optic waveguides显示文摘 | Baets B Lagasse P E | 1983 | J Opt Soc Am1983，73，2： | 2 |
| 10 | 重症肌无力致病性自身抗体的人工构建显示文摘目的构建一株具有致病性的人抗乙酰胆碱受体(AchR)自身抗体,用于诱导猴实验性自身免疫性重症肌无力(EAMG)模型。方法将分离自重症肌无力(MG)患者胸腺的抗AchR抗体的抗原结合片段(Fab637)克隆至含有免疫球蛋白(IgG1)基因的载体pIgG1,构建能在哺乳类细胞表达完整IgG1类抗AchR抗体(IgG1-637)的重组表达载体(pIgG1-637),将pIgG1-637转染CHO-k1细胞系,筛选出稳定表达IgG1-637的细胞株扩大培养。将纯化的IgG1-637注射5只恒河猴,通过检查猴肌肉收缩强度和复合肌肉运动电位(CMAP),判定猴EAMG发病情况,从而鉴定IgG1-637的致病性。结果20μmol/L MSX(L-methionine sulfoxmine)选择的CHO-k1细胞表达最高水平的抗体IgG1-637,表达产量为17.4μg/ml。3只猴(分别接受1.7、1.7和5.0mg/kg的注射剂量)在注射IgG1-637后1周内出现肌肉收缩无力临床症状,并表现出CMAP减弱现象。结论由Fab637构建的完整的IgG1-637是一株致病性抗AchR抗体,可在猴诱导出EAMG。 | 杨康鹃 孟繁平 魏晶 李强 李红花 李英信 M.Stassen M.de Baets | 2006 | 中华微生物学和免疫学杂志2006，26，8： | 2 |
| 11 | PCR扩增抗乙酰胆碱受体单克隆抗体重链可变区基因的反应条件显示文摘应用多聚酶链反应(polymerasechainreaction,PCR)扩增抗乙酰胆碱受体单抗重链可变区的基因,探讨了PCR的反应条件和影响因素。 | 杨康鹃 孟繁平 Y Graus M de Baets | 1995 | 延边医学院学报1995，18，3： | 2 |
| 12 | Properties of poly(butylene terephthatlate) polymerized from cyclic oligomers and its composites显示文摘 | Hilde Parton Joris Baets Pascale Lipnik Bart Goderis Jacques Devaux Ignaas Verpoest | 2005 | Polymer2005，，23： | 2 |
| 13 | 抗乙酰胆碱受体单链抗体在大肠杆菌中的表达显示文摘[目的 ]使构建的抗人乙酰胆碱受体单链抗体基因在大肠杆菌中表达 .[方法 ]将含有单链抗体基因的载体 pHEN2 (含有 pelB引导肽和c myc)转化大肠杆菌HB 2 15 1,在细菌外周质中表达单链抗体 .应用鼠抗c myc单链抗体的斑点杂交试验检查细菌外周质裂解物中单链抗体的表达 .[结果 ]单链抗体表达在细菌外周质中 ,培养液上清及对照大肠杆菌外周质和培养液上清均未发现单链抗体 .[结论 ]已成功地在大肠杆菌中表达了抗人乙酰胆碱受体单链抗体 . | 杨康鹃 孟繁平 M.Stassen M.de Baets | 2002 | 延边大学医学学报2002，25，2： | 2 |
| 14 | 重症肌无力转基因小鼠模型的建立显示文摘[目的]建立人免疫球蛋白转基因小鼠实验性自身免疫性重症肌无力模型.[方法]用电鳐电器官分离纯化的乙酰胆碱受体免疫人免疫球蛋白转基因小鼠,以肌肉收缩力判定病情,以放射免疫测定法测定动物血清中抗乙酰胆碱受体抗体滴度及动物全身肌肉乙酰胆碱受体浓度.[结果]实验动物血清中抗乙酰胆碱受体抗体滴度为6~296nmol,全身肌肉乙酰胆碱受体损失率最高达65%,部分动物出现肌肉收缩无力表现.[结论]成功地建立了人免疫球蛋白转基因小鼠实验性自身免疫性重症肌无力模型. | 李红花 金桂花 孟繁平 李英信 李芳芳 孙昌元 金权鑫 Stassen M de Baets M | 2006 | 延边大学医学学报2006，29，2： | 2 |
| 15 | The tribological behaviour of paper friction plates for wet clutch application investigated on SAE #II and pin-on-disk test rigs 显示文摘 | W Ost P De Baets J Degrieck | 2001 | Wear2001，249，： | 1 |
| 16 | 从TE671细胞株提取人乙酰胆碱受体显示文摘目的 ]分离提取具有活性的人乙酰胆碱受体 .[方法 ]用摇动培养瓶大量培养表达人乙酰胆碱受体的TE 671细胞株 ,细胞经裂解制备人乙酰胆碱受体提取液 .应用放射免疫测定法检测提取的人乙酰胆碱受体与抗人乙酰胆碱受体抗体的结合活性 .[结果 ]提取的人乙酰胆碱受体能与抗人乙酰胆碱受体抗体结合 ,且结合活性很高 ,含量为 1 8× 10 10 个乙酰胆碱受体分子 / 10 0 μL提取液 .[结论 ]从TE 671细胞株提取的人乙酰胆碱受体具有与相应抗体结合的功能 。 | 杨康鹃 孟繁平 M.de Baets | 2003 | 延边大学医学学报2003，26，3： | 1 |
| 17 | Membrane sequencing batch reactor system for the treatment of dairyindustry wastewater 显示文摘 | BAET H HAN S S TA K T M | 2003 | Process Biochemistry2003，39，2： | 1 |
| 18 | Scattering at Sidewall Roughness in Photonic Crystal Slabs显示文摘 | BOGAERTS W BIENSTMAN P BAETS R | 2003 | Opt Lett2003，28，9： | 1 |
| 19 | Root character- istics of representative Mediterranean plant species and their erosion-reducing potential during concentrated runoff显示文摘 | de Baets S Poesen J Knapen A | 2007 | Plant and Soil2007，294，1： | 1 |
| 20 | Inherited peripheral neuropathies: a myriad of genes and complex phenotypes显示文摘 | Baets J Timmerman V | 2011 | Brain2011，134，6： | 1 |
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