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| 1 | Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit;a critical review显示文摘The emergence of antibiotic resistant bacteria in the healthcare is a serious concern.In the Healthcare premises precisely intensive care unit are major sources of microbial diversity.Recent findings have demonstrated not only microbial diversity but also drug resistant microbes largely habitat in ICU.Pseudomonas aeruginosa found as a part of normal intestinal flora and a significant pathogen responsible for wide range of ICU acquired infection in critically ill patients.Nosocomial infection associated with this organism including gastrointestinal infection,urinary tract infections and blood stream infection.Infection caused by this organism are difficult to treat because of the presence of its innate resistance to many antibiotics(b-lactam and penem group of antibiotics),and its ability to acquire further resistance mechanism to multiple class of antibiotics,including Beta-lactams,aminoglycosides and fluoroquinolones.In the molecular evolution microbes adopted several mechanism to maintain genomic plasticity.The tool microbe use for its survival is mainly biofilm formation,quorum sensing,and horizontal gene transfer and enzyme promiscuity.Such genomic plasticity provide an ideal habitat to grow and survive in hearse environment mainly antibiotics pressure.This review focus on infection caused by Pseudomonas aeruginosa,its mechanisms of resistance and available treatment options.The present study provides a systemic review on major source of Pseudomonas aeruginosa in ICU.Further,study also emphasizes virulence gene/s associated with Pseudomonas aeruginosa genome for extended drug resistance.Study gives detailed overview of antibiotic drug resistance mechanism. | Preeti Pachori Ragini Gothalwal Puneet Gandhi | 2019 | Genes & Diseases2019，6，2： | 20 |
| 2 | 三种根管糊剂用于一次性根管治疗术后的评价显示文摘目的:对AH Plus,Vitapex及Cortisomol糊剂在一次性根管治疗术后,对疼痛及远期疗效评价。方法:180颗患牙随机分为三组,分别以AH Plus,Vitapex和Cortisomol糊剂配合牙胶尖充填根管,对术后1周、3、6、12个月的疼痛及远期疗效进行评估。结果:术后1周随访,AH Plus、Cortisomol糊剂与Vitapex疼痛发生率有显著性差异,前两者之间无显著性差异;经3、6、12个月复查,在根尖周炎病例的治疗中,Vitapex与AH Plus和Cortisomol糊剂远期愈合率有显著性差异,后两者之间无显著性差异。结论:AH Plus和Cortisomol糊剂对一次性根管治疗术后疼痛的缓解有较好的效果,而Vitapex糊剂在促进根尖周组织的愈合方面,更具有优越性。 | 郑晓丹 赵佳佳 徐静 陈雪芬 Preeti Mandal 刘加荣 | 2012 | 临床口腔医学杂志2012，28，11： | 11 |
| 3 | MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα显示文摘In human adipose tissue and obesity,miR-99a expression is negatively correlated with inflammation.Therefore,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes.Phenotype-switching experiments established an association between upregulated miR-99a expression and the M2 phenotype.Overexpression of miR-99a prevented M1 phenotype activation and attenuated bactericidal activity.Likewise,knockdown of miR-99a abolished M2 phenotype activation.By means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of miR-99a.Knockdown of TNFαrecapitulated the effect of miR-99a overexpression in M1 BMDMs.In a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+ATMs.Systemic overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 immunostaining.Flow cytometry analysis also showed an increased M2 and a reduced M1 macrophage population.Mimics of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the liver.Furthermore,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and liver.The present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity. | Anant Jaiswal Sukka Santosh Reddy Mohita Maurya Preeti Maurya Manoj Kumar Barthwal | 2019 | Cellular & Molecular Immunology2019，16，5： | 7 |
| 4 | 英国全科医生的一天显示文摘在英国,全科医生(英文简称GP)与居民建立的是注册关系,这与我国目前探索建立的签约关系有所不同,那么,英国全科医生要为注册居民做些什么?近日,英国国王基金会网站以全科医生日记的形式向人们展示了一个很好的案例。7:30~8:15:行政工作我的一天开始于45分钟的案头工作:查看信件、病人出院小结、相关报告和检查、检验结果。有很多医院转诊信件都要求GP对病人采取一些特定的干预措施,比如,跟踪病情或者是对病人做进一步检查等。注: | Anna Charles Preety Das | 2016 | 中国卫生2016，，7： | 3 |
| 5 | Cytomegalovirus infection in the bone marrow transplant patient显示文摘Cytomegalovirus(CMV) infection is an important contributor to the morbidity and mortality associated with bone marrow transplantation(BMT). Infection may lead to CMV disease involving multiple organs such as pneumonia, gastroenteritis, retinitis, central nervus system involvement and others. CMV seropositivity is an important risk factor and approximately half of BMT recipients will develop clinically significant infection most commonly in the first 100 d post-transplant. The commonly used tests to diagnose CMV infection in these patients include the pp65 antigenemia test and the CMV DNA polymerase chain reaction(PCR) assay. Because of its greater sensitivity and lesser turnaround time, the CMV PCR is nowadays the preferred test and serves as a main guide for pre-emptive therapy. Methods of CMV prevention include use of blood products from seronegative donors or leukodepleted products. Prophylaxis or pre-emptive therapy strategies for CMV prevention may be used post-transplant with the latter becoming more common. The commonly used antivirals for pre-emptive therapy and CMV disease management include intravenous gancyclovir and foscarnet. The role of intravenous immunoglobulin, although used commonly in CMV pneumonia is not clear. | Vivek Bhat Amit Joshi Rahul Sarode Preeti Chavan | 2015 | World Journal of Transplantation2015，5，4： | 3 |
| 6 | Integrated preclinical and clinical development of S- trans, trans -farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer显示文摘 | Daniel Laheru Preeti Shah N. V. Rajeshkumar Florencia McAllister Gretchen Taylor Howard Goldsweig Dung T. Le Ross Donehower Antonio Jimeno Sheila Linden Ming Zhao Dongweon Song Michelle A. Rudek Manuel Hidalgo | 2012 | Investigational New Drugs2012，，6： | 2 |
| 7 | Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus显示文摘Objective: To investigate the antibacterial activity of SHHextracted with either water or ethanol against methicillin-resistant Staphylococcus aureus(MRSA) and combinatory antimicrobial effect with ciprofloxacin(CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan(SHH) water extract(SHHW) and SHH ethanol extract(SHHE) ranged from 250 to 2000 μg/m L and 125 to 1000 μg/m L against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections. | Jang-Gi Choi Ji-Young Choi Su-Hyun Mun Ok-Hwa Kang Preeti Bharaj Dong-Won Shin Myong-Soo Chong Dong-Yeul Kwon | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 2 |
| 8 | Prospects for 3D bioprinting of organoids显示文摘Three-dimensional(3D)organoids derived from pluripotent or adult tissue stem cells seem to possess excellent potential for studying development and disease mechanisms alongside having a myriad of applications in regenerative therapies.However,lack of precise architectures and large-scale tissue sizes are some of the key limitations of current organoid technologies.3D bioprinting of organoids has recently emerged to address some of these impediments.In this review,we discuss 3D bioprinting with respect to the use of bioinks and bioprinting methods and highlight recent studies that have shown success in bioprinting of stem cells and organoids.We also summarize the use of several vascularization strategies for the bioprinted organoids,that are critical for a complex tissue organization.To fully realize the translational applications of organoids in disease modeling and regenerative medicine,these areas in 3D bioprinting need to be appropriately harnessed and channelized. | Preety Rawal Dinesh M.Tripathi Seeram Ramakrishna Savneet Kaur | 2021 | Bio-Design and Manufacturing2021，4，3： | 2 |
| 9 | Changes in species composition, diversity and biomass of herbaceous plant traits due to N amendment in a dry tropical environment of India显示文摘Aim European and North american studies have suggested that nitrogen(N)depositions reduce plant diversity and increase primary pro-ductivity due to changes in plant traits.To predict the vegetation response to future global change,experimental validations from other regions are widely needed.We assessed the effects of N treat-ment by urea fertilization on the diversity and biomass of the her-baceous plant traits(HPTs)in a dry tropical environment of India.Methods Diversity and biomass of different HPTs were determined on the basis of data collected in year 2010,from 135,1 m×1 m plots dis-tributed over 15 locations.The plots were treated with urea fertilizer in different doses(Control,60 kgNha−1 yr−1 and 120 kg N ha−1yr−1)since 1st January 2007.The plots were ordinated and data were subjected to appropriate statistical analyses.Important Findings Correspondence analysis(Ca)suggested uniqueness of species composition due to N amendment.species number and biomass of the trait categories varied due to N fertilization and traits.all studied trait categories(except N-fixers)yielded maximum mean species number at moderate level of N fertilization.Different levels of N fer-tilization exhibited different species diversity-primary productivity(D-P)relationships.Further,study showed reduction in plant diver-sity due to increase in biomass at high rates of N addition.Conclusions Tall,erect,non N-fixers,annuals,grasses HPTs were favoured by N enrichment.N dose above 60 kg enhanced the biomass of fast grow-ing,erect,annuals,non N-fixers,nitrophilic HPTs.The changes in traits with N addition,especially the increase in annuals and grasses and decrease in typically N-rich N-fixers,have implications for sus-tainable cattle production. | Punita Verma R.Sagar Hariom Verma Preeti Verma Dharmendra K.Singh | 2015 | Journal of Plant Ecology2015，8，3： | 2 |
| 10 | lpxA/lpxC/lpxD基因突变致鲍曼不动杆菌耐多黏菌素作用机制显示文摘目的探讨细胞膜脂质A生物合成基因lpxA/lpxC/lpxD突变导致鲍曼不动杆菌临床株对多黏菌素耐药的机制。方法用透射电子显微镜(TEM)观察细菌细胞壁、细胞内外膜的变化;用气相色谱(GC)法定量测定脂肪酸含量观察脂多糖(LPS)的变化。此外,用分子生物学方法确定菌株编码细胞膜脂质生物合成的lpxA/lpxC/lpxD基因突变。结果 TEM显示多黏菌素耐药鲍曼不动杆菌细胞外膜和内膜完整性降低,失去细胞壁膜间隙的均一性。GC结果表明短碳链饱和脂肪酸和脂肪酸醇有下降趋势,且几乎失去了所有的未知脂肪酸,但长碳链饱和、不饱和脂肪酸和脂肪酸醇的量都增加了。参与细胞膜脂质生物合成的lpx、lpxC和lpxD基因发现有缺失、点突变和插入等改变。结论多黏菌素耐药鲍曼不动杆菌存在lpxA/lpxC/lpxD基因突变及细胞内外膜改变。 | 张文利 Joan-Miquel Balada-Llasat Vijay Pancholi Bhowmik Aurosree Bhavani Gopalakrishnan Preeti Pancholi | 2015 | 中国感染与化疗杂志2015，15，6： | 2 |
| 11 | Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice显示文摘 | Rui Kang Qiuhong Zhang Wen Hou Zhenwen Yan Ruochan Chen Jillian Bonaroti Preeti Bansal Timothy R. Billiar Allan Tsung Qingde Wang David L. Bartlett David C. Whitcomb Eugene B. Chang Xiaorong Zhu Haichao Wang Ben Lu Kevin J. Tracey Lizhi Cao Xue-Gong Fan M | 2013 | Gastroenterology2013，，： | 2 |
| 12 | CEACAM-1 Induced CSF3-receptor Downregulation in Bone Marrow Associated With Refractory Neutropenia in Advanced Cirrhosis显示文摘Background and Aims:Cirrhosis patients exhibit cyto-penia,and,at times refractory neutropenia to granulocyte colony-stimulating factor(G-CSF),which acts through the CSF3-receptor(CSF3R),and changes in CSF3R can affect the response.We conducted this study to assess the CSF3R status and its relevance in cirrhotic patients.Methods:Cirrhotic patients(n=127)and controls(n=26)with clini-cally indicated bone marrow(BM)examination were stud-ied.BM assessment was done by qRT-PCR and immunohis-tochemistry(IHC)for CSF3R.Circulating G-CSF,CSF3R,and carcinoembryonic antigen cell adhesion molecule-1(CEACAM1)were measured.BM hematopoietic precursor cells and their alterations were examined by flow cytom-etry.The findings were validated in liver cirrhosis patients who received G-CSF for severe neutropenia.Results:The mean age was 48.6±13.4 years,and 80.3%were men.Circulatory CSF3R reduction was noted with the advance-ment of cirrhosis,and confirmed by qRT-PCR and IHC in BM.CSF3R decline was related to decreased hematopoietic stem cells(HSCs)and downregulation of CSF3R in the re-maining HSCs.Cocultures confirmed that CEACAM1 led to CSF3R downregulation in BM cells by possible lysosomal degradation.Baseline low peripheral blood-(PB)-CSF3R also predisposed development of infections on follow-up.Decreased CSF3R was also associated with nonresponse to exogenous G-CSF treatment of neutropenia.Conclu-sions:Advanced liver cirrhosis was associated with low CSF3R and high CEACAM1 levels in the BM and circula-tion,making patients prone to infection and inadequate response to exogenous G-CSF. | Chhagan Bihari Sukriti Baweja Seggere Murlaikrishna Shasthry Deepika Lal Preeti Negi Swati Thangariyal Dinesh Mani Tripathi Shiv Kumar Sarin | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 2 |
| 13 | Design of reaction conditions for the enhancement of microbial degradation of dyes in sequential cycles显示文摘The present study evaluated the potential of white-rot fungal strain Coriolus versicolor to decolorize five structurally different dyes in sequential batch reactors under optimized conditions. The experiments were run continuously for seven cycles of 8 d each. High decolorizing activity was observed even during the repeated reuse of the fungus, especially when the old medium was replaced with fresh medium after every cycle. Biodegradation was the dominating factor as the fungus was able to produce the enzyme laccase mainly, to mineralize synthetic dyes. The nutrients and composition of the medium played important roles in sustaining the decolorisation potential of the fungus. Corncob was found be an easy and cheap substitute for carbon source for the fungus. Glucose consumption by the fungus was in accordance to its decolorisation activity and chemical oxygen demand (COD) reduction. | Rashmi Sanghi Awantika Dixit Preeti Verma Sadhna Puri | 2009 | Journal of Environmental Sciences2009，21，12： | 2 |
| 14 | Development of Non-enzymatic Cholesterol Electrochemical Sensor Based on Polyindole/Tungsten Carbide Nanocomposite显示文摘Non-enzymatic electrochemical sensor was developed for estimation of low-level cholesterol.Polyindole/tungsten carbide(PIN/WC)nanocomposite was synthesized and used as an electroactive material to develop low-cost modified stainless steel plate electrode(SSPE).Surface morphology of developed electrode was characterized by scanning electron microscopy.Electrochemical behavior of cholesterol was investigated through electron impedance spectroscopy,potentiodynamic polarization and cyclic voltammetry in 1-M KOH electrolytic solution.The quantification of cholesterol was studied by square wave voltammetry and differential pulse voltammetry.The calibration plots between the cholesterol concentration and peak current were in linear relation with limit of detection of 1.23×10^(−6) mol L^(−1).The overall result reveals that developed PIN/WC/SSPE electrode has excellent performance for trace-level cholesterol estimation and can be further employed for cholesterol monitoring in blood serum samples. | Shubham Sharma Preeti Joshi Sameena Mehtab Md.Ghulam Haider Zaidi Kavita Singhal Tanveer Irshad Siddiqi | 2020 | Journal of Analysis and Testing2020，4，1： | 2 |
| 15 | 糖尿病酮症酸中毒患者发生胃肠道出血的预测因素:一项回顾性的观察研究显示文摘背景酮症酸中毒(DKA)是糖尿病一种常见的急性并发症,需要积极的药物治疗。我们旨在研究DKA患者急性胃肠道出血(AGIB)和急性上消化道出血(AUGIB)的发生率及其相关危险因素。方法:我们对本中心2010年1月至2015年12月间收治的DKA病例进行回顾性分析,通过电子病历库收集其人口统计学、临床、实验室、内镜及住院资料。根据有无发生胃肠道出血将患者分为两组。结果:共计234例DKA患者纳入研究,其中27例(11.5%)有AGIB的记录。除2例直肠出血和3例隐匿性出血外,22例(9.4%)表现为呕血。AGIB组与非AGIB组患者年龄、性别和种族的分布无显著差异。两组患者电解质水平、阴离子间隙、pH值及糖化血红蛋白HbA1c的差异亦无统计学意义。然而,AGIB组患者初始血糖水平显著高于非AGIB组(738 mg/dL vs 613 mg/dL,P=0.014)。AGIB组患者病死率也有所升高(7.4%vs 4.8%),尽管差异未达到统计学意义。结论:初始高血糖水平会增加DKA患者发生AGIB的风险。我们还注意到发生AGIB的DKA患者病死率增加,尽管这个增加未达到统计学意义。临床上应更加积极地纠正DKA患者的血糖水平以降低AGIB发生率,从而降低住院病死率。 | Kanthi Rekha Badipatla Preeti Jadhav Sushma Vaddigiri Bharat Bajantri Amandeep Singh Chaitanya Chandrala Vijay S Are Suresh Kumar Nayudu | 2017 | Gastroenterology Report2017，5，4： | 2 |
| 16 | Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin显示文摘 | Preeti Shah Yael Gau Gauri Sabnis | 2014 | Breast Cancer Research and Treatment2014，，： | 2 |
| 17 | Primary Myeloid Sarcoma Masquerading as an Obstructing Duodenal Carcinoma显示文摘 | Preeti Narayan Vijayashree Murthy Mu Su Rosemonde Woel I. Robert Grossman Ronald S. Chamberlain G. Feher Y. Shiozawa | 2012 | Case Reports in Hematology2012，，： | 2 |
| 18 | Hopf bifurcation and chaos in a Leslie–Gower prey–predator model with discrete delays显示文摘In this work,a Leslie–Gower prey-predator model with two discrete delays has been investigated.The positivity,boundedness and persistence of the delayed system have been discussed.The system exhibits the phenomenon of Hopf bifurcation with respect to both delays.The conditions for occurrence of Hopf bifurcation are obtained for different combinations of delays.It is shown that delay induces the complexity in the system and brings the periodic oscillations,quasi-periodic oscillations and chaos.The properties of periodic solution have been determined using central manifold and normal form theory.Further,the global stability of the system has been established for different cases of discrete delays.The numerical computation has also been performed to verify analytical results. | Anuraj Singh Preeti Pradeep Malik | 2020 | International Journal of Biomathematics2020，13，6： | 2 |
| 19 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 20 | Interaction of aliphatic cap group in inhibition ofhistone deacetylases by cyclic tetrapeptides显示文摘 | Norikazu Nishino Gururaj M Shivashimpi Preeti B Soni | 2008 | Bioorg Med Chem2008，16，： | 1 |
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