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| 1 | Behavioral Abnormality along with NMDAR-related CREB Suppression in Rat Hippocampus after Shortwave Exposure显示文摘Objective To estimate the detrimental effects of shortwave exposure on rat hippocampal structure and function and explore the underlying mechanisms. Methods One hundred Wistar rats were randomly divided into four groups(25 rats per group) and exposed to 27 MHz continuous shortwave at a power density of 5, 10, or 30 m W/cm^2 for 6 min once only or underwent sham exposure for the control. The spatial learning and memory, electroencephalogram(EEG), hippocampal structure and Nissl bodies were analysed. Furthermore, the expressions of N-methyl-D-aspartate receptor(NMDAR) subunits(NR1, NR2 A, and NR2 B), c AMP responsive element-binding protein(CREB) and phosphorylated CREB(p-CREB) in hippocampal tissue were analysed on 1, 7, and 14 days after exposure. Results The rats in the 10 and 30 m W/cm^2 groups had poor learning and memory, disrupted EEG oscillations, and injured hippocampal structures, including hippocampal neurons degeneration, mitochondria cavitation and blood capillaries swelling. The Nissl body content was also reduced in the exposure groups. Moreover, the hippocampal tissue in the 30 m W/cm^2 group had increased expressions of NR2 A and NR2 B and decreased levels of CREB and p-CREB. Conclusion Shortwave exposure(27 MHz, with an average power density of 10 and 30 m W/cm^2) impaired rats' spatial learning and memory and caused a series of dose-dependent pathophysiological changes. Moreover, NMDAR-related CREB pathway suppression might be involved in shortwave-induced structural and functional impairments in the rat hippocampus. | YU Chao BAI Yan Xin XU Xin Ping GAO Ya Bing HAO Yan Hui WANG Hui TAN Sheng Zhi LI Wen Chao ZHANG Jing YAO Bin Wei DONG Ji ZHAO Li PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019,32,3: | 7 |
| 2 | 微波辐射对女性生殖系统的影响显示文摘微波是非电离性电磁辐射。通常指波长为1mm~1m、频率为300MHz~300GHz的电磁波。微波技术近年来在国防、通讯、广播和医疗等领域广泛应用,如雷达、手机、电脑、微波炉等,在给人们工作和生活带来便利的同时也对人们的健康造成了潜在危害。 | 孙志辉 李亚里 王德文 | 2017 | 中华劳动卫生职业病杂志2017,35,12: | 2 |
| 3 | 微波辐射对学习记忆及海马内神经递质的影响显示文摘中枢神经系统是对微波辐射最敏感的重要靶器官系统之一。微波辐射可引起空间学习记忆能力的改变及神经信息传递异常,目前关于微波辐射对海马相关神经递质的影响及其机制尚未明确。本文主要从微波辐射对学习记忆、神经递质的效应及对神经递质的作用机理3个方面进行综述。旨在为这一领域的未来研究提供科学依据。 | 杜丹 尚梦娟 林加金 苗霞 晏雨铭 徐胜龙 孙娜 李静 | 2023 | 中国辐射卫生2023,32,2: | 1 |
| 4 | 1.8GHz微波对小鼠下丘脑组织结构的影响显示文摘旨在研究1.8 GHz的电磁辐射是否对性成熟前小鼠的下丘脑细胞产生形态学影响。试验选用90只昆白雌鼠,随机平均分为三组,从母鼠怀孕当天至小鼠出生后30 d采用1.8 GHz的电磁辐射,强度分别为0(对照组)、1(低剂量试验组)和2 mw·cm^-2(高剂量试验组)。观察仔鼠的精神状态,30、45、60日龄时取材,记录体重和脑质量,用组织学方法观察下丘脑组织结构的变化,采用高效液相色谱仪检测下丘脑中神经递质谷氨酸(Glu)、天门冬氨酸(Asp)、γ-氨基丁酸(GABA)和甘氨酸(Gly)的含量。结果显示,(1)30日龄时两试验组小鼠的体重、脑质量均显著减小(P<0.05),下丘脑细胞出现空泡化,细胞内线粒体水肿,血管间隙扩张,小鼠脑内Asp、Glu、Gly、GABA的含量均增加。(2)45日龄时,低剂量试验组细胞形态基本恢复,线粒体肿胀现象仍然存在,但脑内Asp、Gly、Glu、GABA的含量与对照组相比无明显差异(P>0.05);高剂量试验组细胞萎缩仍较多,细胞内线粒体肿胀,小鼠脑内Asp、Glu、Gly、GABA的含量显著增加(P<0.05)。(3)60日龄时,低剂量组细胞形态基本恢复,线粒体恢复正常,小鼠脑内Asp、Glu、Gly和GABA的含量与对照组相比无明显差异(P>0.05);高剂量组细胞基本恢复,细胞内线粒体肿胀基本恢复,细胞核恢复正常形态,脑内Asp、Glu、GABA的含量与对照组相比无明显差异(P>0.05),但Gly的含量与对照组相比显著增加(P<0.05)。结果表明,1.8 GHz微波辐射处理可对小鼠下丘脑的细胞形态和功能产生一定损害,但停止辐射后,下丘脑的细胞形态和功能可逐渐恢复。 | 安秀秀 刘琳 徐玉薇 吴亚琳 罗梦芸 魏学良 | 2020 | 畜牧兽医学报2020,51,3: | 0 |