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| 1 | Correlation between KCNQ1 and KCNJ11 gene polymorphisms and type 2 and posttransplant diabetes mellitus in the Asian Indian population显示文摘Type 2 diabetes mellitus(T2DM)and post-transplant diabetes mellitus(PTDM)share a common pathophysiology.However,diabetes mellitus is a complex disease,and T2DM and PTDM have different etiologies.T2DM is a metabolic disorder,characterized by persistent hyperglycemia,whereas PTDM is a condition of abnormal glucose tolerance,with variable onset after organ transplant.The KCNQ1 and KCNJ11 gene encode potassium channels,which mediate insulin secretion from pancreatic b-cells,and KCN gene mutations are correlated with the development of diabetes.However,no studies have been carried out to establish an association between KCNQ1 and KCNJ11 gene polymorphisms and T2DM and PTDM.Therefore,our study was aimed at the identification of the role of KCNQ1 and KCNJ11 gene polymorphisms associated with T2DM and the risk of developing PTDM in the Asian Indian population.We have carried out a caseecontrol study including 250 patients with T2DM,250 control subjects,42 patients with PTDM and 98 subjects with non-PTDM.PCR-RFLP analysis was carried out following the isolation of genomic DNA from EDTA-blood samples.The results of the present study reveal that two single nucleotide polymorphisms(rs2283228 and rs5210,of the KCNQ1 and KCNJ11 genes,respectively)are associated with both T2DM and PTDM.The results of our study suggest a role of KCNQ1 and KCNJ11 gene variants in the increased risk of T2DM and PTDM in the Asian Indian population. | Imran Ali Khan Kiran Kumar Vattam Parveen Jahan Kamal Kiran Mukkavali Qurratulain Hasan Pragna Rao | 2015 | Genes & Diseases2015，2，3： | 6 |
| 2 | Role of angiogenesis and angiogenic factors in acute and chronic wound healing显示文摘Angiogenesis plays a crucial role in wound healing by forming new blood vessels from preexisting vessels by invading the wound clot and organizing into a microvascular network throughout the granulation tissue.This dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix environment.Vascular endothelial growth factor,angiopoietin,fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound angiogenesis.Specific endothelial cell ECM receptors are critical for morphogenetic changes in blood vessels during wound repair.In particular integrin(αvβ3)receptors for fibrin and fibronectin,appear to be required for wound angiogenesis:αvβ3 is focally expressed at the tips of angiogenic capillary sprouts invading the wound clot,and any functional inhibitors ofαvβ3 such as monoclonal antibodies,cyclic RGD peptide antagonists,and peptidomimetics rapidly inhibit granulation tissue formation.In spite of clear knowledge about influence of many angiogenic factors on wound healing,little progress has been made in defining the source of these factors,the regulatory events involved in wound angiogenesis and in the clinical use of angiogenic stimulants to promote repair. | Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Echalasara Govindarama Padmanabha Udupa Sudesh Kumar Udaya Kumar Pragna Rao | 2015 | Plastic and Aesthetic Research2015，2，1： | 3 |
| 3 | Correlation of Serum Homocysteine Levels with the Severity of Coronary Artery Disease显示文摘 | Vijetha Shenoy Veena Mehendale Krishnananda Prabhu Ranjan Shetty Pragna Rao | 2014 | Indian Journal of Clinical Biochemistry2014，，3： | 1 |
| 4 | Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections显示文摘 | Kate Buchacz Pragna Patel Melanie Taylor Peter R Kerndt Robert H Byers Scott D Holmberg Jeffrey D Klausner | 2004 | AIDS2004，，15： | 1 |
| 5 | Syphilis increases HIV viral load and decreases CD4 cell count in HIV-infected patients with new syphilis infections 显示文摘 | Kate Buchacz Pragna Patel Melanie Taylor | 2004 | AIDS2004，18，： | 1 |
| 6 | Solid state thermochromic materials显示文摘 | Pragna Kiri | 2010 | Adv Mater Lett2010，1，2： | 1 |
| 7 | Thin Solid Films显示文摘 | Pragna Kiri Michael E A Warwick | 2011 | 520(4):13632011，520，4： | 1 |
| 8 | Heap Bio-oxidation and Gold Recovery at Newmont Mining:First-Year Results显示文摘 | Pragna Bhakta Brian Arthur | | 0，，： | 1 |
| 9 | Fluorine doped vanadium dioxide thin films for smart windows显示文摘 | Pragna Kiri Michael E.A. Warwick Ian Ridley Russell Binions | 2011 | Thin Solid Films2011，，4： | 1 |
| 10 | Heap Bio-oxidation and Gold Recovery at Newmont Mining:First-Year Results显示文摘 | Pragna Bhakta Brian Arthur | 2002 | Metal and Materials Society2002，54，10： | 1 |
| 11 | Evaluation of the performance of the Abbott ARCHITECT HIV Ag/Ab Combo Assay显示文摘 | Pollyanna Chavez Laura Wesolowski Pragna Patel Kevin Delaney S. Michele Owen | 2011 | Journal of Clinical Virology2011，，： | 1 |
| 12 | Detecting acute human immunodeficiency virus infection using 3 different screening immunoassays and nucleic acid amplification testing for human immunodeficiency virus RNA, 2006-2008 显示文摘 | Pragna P Duncan M Pat S | 2010 | Arch Intern Med2010，170，1： | 1 |
| 13 | A comparative study to evaluate the effect of limited access dressing on diabetic ulcers显示文摘Aim:Emerging evidence favors the important role of antioxidants,matrix metalloproteinases(MMPs),and nitric oxide(NO)in the healing of diabetic wounds.There is a lack of substantial evidence regarding the effects of negative pressure on antioxidants,MMPs and NO in chronic wounds associated with diabetes.Methods:A total of 55 type 2 diabetic patients with leg ulcers were divided into 2 groups:a limited access dressing(LAD)group(n=27)and a conventional dressing group(n=28).Levels of hydroxyproline,total protein,MMP-2 and MMP-9,NO and antioxidants including reduced glutathione(GSH)and the oxidative biomarker malondialdehyde(MDA)were measured in the granulation tissue at days 0 and 10.Changes in levels between the LAD and conventional groups were determined by the Student’s t-test.Results:After 10 days of treatment,the LAD vs.conventional dressing group showed increase in the levels of hydroxyproline(mean±standard deviation=55.2±25.1 vs.29.2±1,P<0.05),total protein(12.8±6.5 vs.8.34±3.2,P<0.05),NO(1.13±0.52 vs.0.66±0.43,P<0.05),GSH(7.0±2.4 vs.6.6±2.2,P<0.05)and decrease in MMP-2(0.47±0.33 vs.0.62±0.30,P<0.05),MMP-9(0.32±0.20 vs.0.53±0.39,P<0.05)and MDA(6.8±2.3 vs.10.4±3.4,P<0.05).Conclusion:When compared to conventional dressings,LAD induces biochemical changes by significantly increasing the levels of hydroxyproline,total protein,NO and antioxidants levels,and significantly reducing MMPs(MMP-2 and MMP-9)and an oxidative biomarker in diabetic wounds.These biochemical changes are thought to favor diabetic wound healing. | Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Krishnananda Prabhu Ashwini Kumar Pragna Rao E.G.Padmanabha Udupa Shobha Kamath Antony Sylvan D’Souza Krishna Kishore Mahato | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
| 14 | Histopathological study of chronic wounds modulated by intermittent negative pressure therapy under limited access dressing显示文摘Aim:Negative pressure wound therapy(NPWT)has achieved widespread success in the treatment of chronic wounds.However,its effects have been only partially explored,and investigations have generally concentrated on the wound-dressing interface;a detailed histopathological description of the evolution of wounds under NPWT is still lacking.The present study was performed to investigate the effect of a limited access dressing(LAD)which exerts intermittent NPWT in a moist environment on chronic wounds.Methods:A total of 140 patients were randomized into 2 groups:LAD group(n=64)and conventional dressing group(n=76).By histopathological analysis of the granulation tissue,the amount of inflammatory infiltrate,necrotic tissue,angiogenesis,and extracellular matrix(ECM)deposition was studied and compared to determine healing between the 2 groups.Results:After 10 days of treatment,histopathological analysis showed a significant decrease in necrotic tissue with LAD compared to the conventional dressing group(mean±standard error,11.5±0.48 vs.10.1±0.30,P=0.007),the number of inflammatory cells(12.6±0.60 vs.8.63±0.35,P=0.018),a significant increase in new blood vessels(12.8±0.58 vs.9.3±0.29,P=0.005)and ECM deposit(13.3±0.50 vs.9.6±0.24,P=0.001).Conclusion:LAD exerts its beneficial effects on chronic wound healing by decreasing the amount of necrotic tissue and inflammatory cells while increasing the amount of ECM deposition and angiogenesis. | Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Rekha Singh Swarna Shivakumar Pragna Rao Hemanth K.Prasad Sudesh Kumar Udaya Kumar Echalasara Govindarama Padmanabha Udupa | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
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