|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 2 | An approach to the explanation of cellmembrane alteration in primary hypertension 显示文摘 | Postnov YV | 1990 | Hypertens1990，15，3： | 1 |
| 3 | Reduction of Ring Artifacts in High Resolution Micro-CT Reconstructions显示文摘 | Sijbers J Postnov A | 2004 | Physics in Medicine and Biology2004，49，14： | 1 |
| 4 | Study of the genetic markers of thrombosis in hypertensive patients of the native population in the Republic of Mordovia显示文摘 | Postnov AI Goncharova LN Khasanova ZB | | 0，，04： | 1 |
| 5 | High resolution micro-CT scanning as an innovatory tool for evaluation of the surgical positioning of cochlear implant electrodes显示文摘 | A. Postnov A. Zarowski N. De Clerck F. Vanpoucke F.E. Offeciers D. Van Dyck S. Peeters | 2006 | Acta Oto-Laryngologica2006，，5： | 1 |
| 6 | PET imaging shows loss of striatal PDE10A in patients with Huntington disease显示文摘 | Abroad R Bourgeois S Postnov A | 2014 | Neurology2014，82，3： | 1 |
| 7 | Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks显示文摘 | Postnov DE Koreshkov RN Brazhe NA Brazhe AR Sosnovtseva OV | 2009 | J Biol Phys2009，35，4： | 1 |
| 8 | Decreased ATP-synthe- sis ability of brain mitochondria in spontaneously hypertensive rats显示文摘 | Doroshchuk A Postnov A Manasyeva G | 2004 | Kardiologiya2004，44，3： | 1 |
| 9 | Vascular calcification is associated with cortical bone loss in chronic renal failure rats with and without ovariectomy:the calcification paradox显示文摘 | De Schutter TM Neven E Persy VP Behets GJ Postnov AA De Clerck NM D'Haese PC | | 0，，： | 1 |
| 10 | Reduction of ring artifacts in high resolution micro-CT reconstructions显示文摘 | AIJBERS J POSTNOV A | 2004 | Physics in Medicine and Biology2004，49，14： | 1 |
| 11 | phase-transfer catalyzed synthesis of α-ferrocenylmethylenecycloalkanones显示文摘 | Puciova M Postnov U N | 1990 | Chem Papers1990，44，： | 1 |
| 12 | Synchronization of chaos显示文摘 | Anishchenko V S Vadivasova T E Postnov D E | 1992 | International Journal of Bi- furcation and Chaos1992，2，3： | 1 |
| 13 | Vascular Calcification Is Associated with Cortical Bone Loss in Chronic Renal Failure Rats with and without Ovariectomy: The Calcification Paradox显示文摘 | De Schutter Tineke M Neven Ellen Persy Veerle P Behets Geert J Postnov Andrei A De Clerck Nora M D’haese Patrick C | 2011 | EN2011，，4： | 1 |
| 14 | Interacting coherence resonance oscillators显示文摘 | Han S K Yim T G Postnov D E etal | 1999 | Phys Rev Lett1999，83，： | 1 |
| 15 | Synchronization of chaos 显示文摘 | ANISCHENKO V S VADIVASOVA T E POSTNOV D E | 1992 | Int J of Bifurcation and Chaos1992，2，3： | 1 |
| 16 | Reduction of ring artifacts in high resolution micro-CT reconstructions 显示文摘 | SIJBERS J POSTNOV A | 2004 | Phys- ics in Medicine and Biology2004，49，14： | 1 |
| 17 | Reduction of ring artefacts in high resolution micro-CT reconstructions 显示文摘 | Sijbers J Postnov A | 2004 | Phys Med Biol2004，49，14： | 1 |
| 18 | Experimental observation of coherence resonance in cascaded excitable systems显示文摘 | Postnov D E Han S K Yim T G | 1999 | Phys Rev E1999，59，： | 1 |
| 19 | Study of the genetic markers of thrombosis in hypertensive patients of the native population in the Republic of Mordovia显示文摘 | Postnov A Goncharova L N Khasanova Z B | 2009 | Arkh Patol2009，71，4： | 1 |
| 20 | phase-transfer catalyzed synthesis of a-ferrocenylmethylenecycloalkanoes 显示文摘 | Salisova M Puciova M Postnov U N | 1990 | Chem Papers1990，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员