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| 1 | Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature显示文摘Lymphoepithelioma-like hepatocellular carcinoma(LELHCC) is a rare form of undifferentiated carcinoma of the liver characterized by the presence of an abundant lymphoid infiltrate. Here,a case of LEL-HCC is described. An 81-year-old woman with a chronic hepatitis C infection was referred to the general surgery department of our hospital in August 2013 with a diagnosis of HCC. A past ultrasound examination had revealed a 60 mm-diameter nodular lesion in the third segment of the liver. After a needle biopsy,the lesion was diagnosed as HCC. The patient underwent surgery with a liver segmentectomy. Two additional nodes on the gastric wall were detected during the surgical operation. The histology of the removed specimen showed a poorly differentiated HCC with significant lymphoid stroma. Immunohistochemical studies revealed that the epithelial component was reactive for CK CAM5.2,CK8,CK18,CEA(polyclonal) and was focally positive for hepar-1 and that the lymphoid infiltrate was positive for CD3,CD4 and CD8. The tumor cells were negative for Epstein-Barr virus. The gastric nodes were ultimately determined to be two small gastrointestinal stromal tumors(GISTs).The synchronous occurrence of HCC and GIST is another very uncommon finding rarely described in the literature. Here,we report the clinicopathological features of our case,along with a review of the few cases present in the literature. | Andrea Cacciato Insilla Pinuccia Faviana Luca Emanuele Pollina Paolo De Simone Laura Coletti Franco Filipponi Daniela Campani | 2015 | World Journal of Gastroenterology2015，21，36： | 5 |
| 2 | Efficacy and Safety of Combination Therapy With Everolimus and Sorafenib for Recurrence of Hepatocellular Carcinoma After Liver Transplantation显示文摘 | P. De Simone L. Crocetti D. Pezzati I. Bargellini D. Ghinolfi P. Carrai G. Leonardi C. Della Pina D. Cioni L. Pollina D. Campani C. Bartolozzi R. Lencioni F. Filipponi | 2014 | Transplantation Proceedings2014，，1： | 2 |
| 3 | Relation between the presence of inhibitors and deposit morphology in nickel deposition 显示文摘 | VALLéS E POLLINA R GóMEZ E | 1993 | Journal of Applied Electrochemistry1993，23，5： | 1 |
| 4 | “Tailored”organometallics as precursors for the chemicalvapor deposition of high-purity palladium and platinum thinfilms显示文摘 | John E Gozum Deborah M Pollina James A Jensen | 1988 | J Am Chem Soc1988，110，： | 1 |
| 5 | Modified RECIST to assess tumor response after Transarterial Chemoembolization of Hepatocellular Carcinoma: CT-pathologic correlation in 178 liver explants显示文摘 | Irene Bargellini Elena Bozzi Daniela Campani Paola Carrai Paolo De Simone Luca Pollina Roberto Cioni Franco Filipponi Carlo Bartolozzi | 2012 | European Journal of Radiology2012，，： | 1 |
| 6 | Critical role of lasermicrodissection for genetic,epigenetic and proteomic analysesin pancreatic cancer显示文摘 | Funel N Giovannetti E Pollina LE | 2011 | Expert Rev Mol Diagn2011，11，7： | 1 |
| 7 | Evaluation of PTEN expression in colorectal cancer (CRC) metastases (mets) and in primary tumors as predictors of activity of cetuximab plus irinotecan treatment 显示文摘 | Loupakis F Pollina L Stasi I | 2008 | J Clin Oncol2008，，： | 1 |
| 8 | PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for pa- tients with metastatic colorectal cancer显示文摘 | Loupakis F Pollina L Stasi I | 2009 | J Clin Oncol2009，27，16： | 1 |
| 9 | PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer显示文摘 | LOUPAKIS F POLLINA L STASI I | 2009 | J Clin Oncol2009，27，16： | 1 |
| 10 | Studies of eleetrodeposition of nickel: different nickel(11) and sulphonated additive concentrations 显示文摘 | GOMEZ E MOLLER C POLLINA R | 1992 | Journal of Electroanalytical Chemistry1992，333，12： | 1 |
| 11 | Regulating the angiogenic balance in tissues显示文摘 | Pollina EA Legesse-Miller A Haley EM | 2008 | Cell Cycle2008，7，13： | 1 |
| 12 | Must we change the surgical treatment of gallstones?显示文摘 | Elías Pollina J Delgado Alvira R Martínez-Pardo NG | 2008 | Cir Pediatr2008，21，2： | 1 |
| 13 | Evaluation of PTEN expression in colorectal cancer (CRC) metastases (mets) and in primary tumors as predictors of activity of cetuximab plus irinotecan treatment 显示文摘 | Loupakis F Pollina L Stasi I et at | 2008 | J Clin Oncol2008，26，： | 1 |
| 14 | Tissue microarray-chip featuring computerized immunophenotypical characterization more accurately subtypes ampullary adenocarcinoma than routine histology显示文摘BACKGROUND Ampullary adenocarcinomas(AACs)are heterogeneous tumors currently classified into three important sub-classes(SC):Intestinal(INT),Pancreato-Biliary(PB)and Mixed-Type(MT).The different subgroups have similar clinical presentation and are treated by pancreatoduodenectomy with curative intent.However,they respond differently to chemotherapy and have different prognostic outcomes.The SC are often difficult to identify with conventional histology alone.The clinical outcome of all three remains unclear,particularly for MT.AIM To identify two main subtypes of AACs,using an immunohistochemical(IHC)score based on CDX2,CK7 and CK20.METHODS Tissue samples from 21 patients who had undergone resection of AAC were classified by HE histology and IHC expression of CDX2,CK7 and CK 20.An IHC score was obtained for each marker by counting the number of positive cells(0=no stained cells;1<25%;2<50%and 3>50%)and their intensity(1=weak;2=moderate and 3=strong).A global score(GS)was then obtained by summation of the IHC scores of each marker.The MT tumors were grouped either with the INT or PB group based on the predominant immuno-molecular phenotype,obtaining only two AACs subtypes.The overall survival in INT and PB patients was obtained by Kaplan-Meier methods.RESULTS Histological parameters defined the AACs subtypes as follows:15%INT,45%PB and 40%MT.Using IHC expression and the GS,75%and 25%of MT samples were assigned to either the INT or the PB group.The mean value of the GS was 9.5(range 4-16).All INT samples had a GS above the average,distinct from the PB samples which had a GS score significantly below the average(P=0.0011).The INT samples were identified by high expression of CDX2 and CK20,whereas PB samples exhibited high expression of CK7 and no expression of CK20(P=0.0008).The INT group had a statistically significant higher overall survival than in the PB group(85.7 mo vs 20.3 mo,HR:8.39;95%CI:1.38 to 18.90;P=0.0152).CONCLUSION The combination of histopathological and molecular criteria enables the classification of AACs into two clinically relevant histo-molecular phenotypes,which appear to represent distinct disorders with potentially significant changes to the current therapeutic strategies. | Matteo Palmeri Niccola Funel Gregorio Di Franco Niccolo Furbetta Desiree Gianardi Simone Guadagni Matteo Bianchini Luca E Pollina Claudio Ricci Marco Del Chiaro Giulio Di Candio Luca Morelli | 2020 | World Journal of Gastroenterology2020，26，43： | 1 |
| 15 | Evaluation of PTEN expression in colorectal cancer (CRC) metastases (mets) and in primary tumors as prediction of cetuximab plus irinotecan treatment 显示文摘 | Loupakis F Pollina L Stasi I | 2008 | J Clin Oncol2008，，： | 1 |
| 16 | Life-span attachment:relations between attachment and socio-emotional functioning in adult women显示文摘 | Barnas MV Pollina L Cummings EM | | 0，，： | 1 |
| 17 | Long - term outcome of initially unresectable metastatic colorectal cancer patients treated with 5 - fluorouracil/leucovofin, oxaliplatin, and irinotecan ( FOLFOXIRI ) followed by radical surgery of metastases显示文摘 | Masi G Loupakis F Pollina L | 2009 | Ann Surg2009，249，3： | 1 |
| 18 | Extracellular calcium-sensing receptor distribution in osmoregulatory and endocrine tissues of the tilapia显示文摘 | Loretz CA Pollina C Hyodo S | 2009 | Gen Comp Endocrinol2009，，2： | 1 |
| 19 | Evaluation of PTEN expression in colorectal cancer (CRC) metastases (mets) and in primary tumors as predictors of activity of cetuximab plus irinotecan treatment显示文摘 | Loupakis F Pollina L Stasi I | | 0，，： | 1 |
| 20 | Apoptosis and proliferation in thyroid carcinoma: correlation with bcl-2 and p53 protein expression显示文摘 | Basolo F Pollina L Fontenini G | 1997 | Br J Cancer1997，75，4： | 1 |
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