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| 1 | Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature显示文摘Lymphoepithelioma-like hepatocellular carcinoma(LELHCC) is a rare form of undifferentiated carcinoma of the liver characterized by the presence of an abundant lymphoid infiltrate. Here,a case of LEL-HCC is described. An 81-year-old woman with a chronic hepatitis C infection was referred to the general surgery department of our hospital in August 2013 with a diagnosis of HCC. A past ultrasound examination had revealed a 60 mm-diameter nodular lesion in the third segment of the liver. After a needle biopsy,the lesion was diagnosed as HCC. The patient underwent surgery with a liver segmentectomy. Two additional nodes on the gastric wall were detected during the surgical operation. The histology of the removed specimen showed a poorly differentiated HCC with significant lymphoid stroma. Immunohistochemical studies revealed that the epithelial component was reactive for CK CAM5.2,CK8,CK18,CEA(polyclonal) and was focally positive for hepar-1 and that the lymphoid infiltrate was positive for CD3,CD4 and CD8. The tumor cells were negative for Epstein-Barr virus. The gastric nodes were ultimately determined to be two small gastrointestinal stromal tumors(GISTs).The synchronous occurrence of HCC and GIST is another very uncommon finding rarely described in the literature. Here,we report the clinicopathological features of our case,along with a review of the few cases present in the literature. | Andrea Cacciato Insilla Pinuccia Faviana Luca Emanuele Pollina Paolo De Simone Laura Coletti Franco Filipponi Daniela Campani | 2015 | World Journal of Gastroenterology2015，21，36： | 5 |
| 2 | Mitogenic Effects of the Up-Regulation of Minichromosome Maintenance Proteins in Anaplastic Thyroid Carcinoma显示文摘 | Teresa Guida Giuliana Salvatore Pinuccia Faviana Riccardo Giannini Ginesa Garcia-Rostan Livia Provitera Fulvio Basolo Alfredo Fusco Francesca Carlomagno Massimo Santoro | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，8： | 1 |
| 3 | Combined chemotherapy-radiotherapy approach in locally advanced (T3b-T4) breast cancer显示文摘 | Mario Lena Roberto Zucali Giovanni Viganotti Pinuccia Valagussa Gianni Bonadonna | 1978 | Cancer Chemotherapy and Pharmacology1978，，1： | 1 |
| 4 | Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness显示文摘 | Valentina G Pinuccia F Giuliana S | 2005 | Clin Endocrinol Metab2005，90，9： | 1 |
| 5 | Surgical Treatment of Low- and Intermediate-Risk Papillary Thyroid Cancer with Minimally Invasive Video-Assisted Thyroidectomy显示文摘 | Paolo Miccoli Aldo Pinchera Gabriele Materazzi Agnese Biagini Piero Berti Pinuccia Faviana Eleonora Molinaro David Viola Rossella Elisei | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，5： | 1 |
| 6 | Osteopontin is overexpressed in human papillary thyroid carcinomas and enhancer thyroid carcinoma cell invasiveness显示文摘 | Valentina G Pinuccia F Giuliana S | 2005 | J Clin Endocrinol Metab2005，90，9： | 1 |
| 7 | 可手术乳腺癌CMF辅助化疗随机研究的30年随访:队列研究显示文摘目的根据1973年6月至1980年12月期间的3项连续随机试验和1项观察研究,评价有复发风险的可手术乳腺癌患者使用环磷酰胺、甲氨蝶呤和氟尿嘧啶(CMF)辅助治疗的长期有效性。设计队列研究。地点意大利米兰国家肿瘤研究所。主要结局指标无复发生存和总生存,采用单变量和多变量分析。结果在首项研究随访平均28.5年后,发现辅助CMF能显著降低复发的相对危险度(危险比为0.71,95%可信区间0.56~0.91,P=0.005)并减少死亡(0.79,0.63~0.98,P=0.04)。12个周期的CMF似乎并不优于6个周期的相对短期治疗。在淋巴结和雌激素受体阴性的研究中,平均随访20年后,静脉使用CMF能显著降低疾病复发的相对危险度(0.65,0.47~0.90,P=0.009)以及死亡的相对危险度(0.65,0.470.92,P=0.01)。结论如应用适当,CMF方案能使具有远处复发风险的患者获益,没有证据显示它对任何研究亚组有不良影响。 | Gianni Bonadonna Angela Moliterni Milvia Zambetti Maria Grazia Daidone Silvana Pilotti Luca Gianni Pinuccia Valagussa 樊英 | 2005 | 英国医学杂志中文版2005，8，3： | 0 |
| 8 | Robotically assisted removal of pelvic splenosis fifty-six years after splenectomy: A case report显示文摘BACKGROUND‘Splenosis’is defined as the autotransplantation of splenic tissue following trauma or surgery,usually in the form of intraperitoneal nodules.The proliferation of imaging techniques has resulted in increased unexpected discoveries of splenosis nodules,and achieving a differential diagnosis can be challenging.Nuclear medicine studies have been playing an increasingly important role in this process,but the clinical significance of asymptomatic nodules remains uncertain.CASE SUMMARY We present a case of pelvic splenosis in a 73-year-old man diagnosed 56 years after a splenectomy during a computed tomography(CT)follow-up for B-cell lymphoma,presenting intense contrast enhancement of an 18 mm nodule in the right recto-vesical space.18F-fluorodeoxyglucose demonstrated weak metabolic activity.Since histological diagnosis was deemed necessary,the nodule was easily removed with robotically assisted laparoscopy,together with another 6 mm left a paracolic lesion.The latter was previously undiagnosed but retrospectively visible on the CT scan.CONCLUSION In a patient requiring differential diagnosis of splenosis nodules from lymphomarecurrence, the robotic approach provided a safe en bloc removal with shorthospitalization. The Da Vinci Xi robot was particularly helpful because its opticscan be introduced from all ports, facilitating visualization and lysis of multipleintra-abdominal adhesions. | Alessio Tognarelli Lorenzo Faggioni Anna Paola Erba Pinuccia Faviana Jacopo Durante Francesca Manassero Cesare Selli | 2021 | World Journal of Clinical Cases2021，9，12： | 0 |
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