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| 1 | Computed tomography angiography-guided percutaneous coronary intervention in chronic total occlusion显示文摘Objective:The aim of this study is to investigate if dual-source computed tomography(DSCT) could guide the percutaneous coronary intervention(PCI) of chronic total occlusion(CTO).Methods:We enrolled patients who were confirmed to have at least one native coronary artery CTO by DSCT before they underwent selective PCI in the period from December 2007 to October 2008.A CTO was defined as an obstruction of a native coronary artery with no luminal continuity.The CT-guided PCI procedure involved placing CT and fluoroscopic images side-by-side on the screen.DSCT images were analyzed for location,segment,plaque characteristics,calcification,and proximal lumen diameter of the CTO before PCI.The guidewire was advanced and manipulated under CT guidance.The PCI was carried out and the results were compared.Results:Seventy-four CTOs were assessed.PCI was successful in 57 cases of CTOs(77.0%).According to the results,CTOs were divided into two groups:successful-PCI and failed-PCI.All coronary artery paths of CTOs were clearly recognized by DSCT.In the successful-PCI group,soft plaques were detected much more often than those in the failed-PCI group,but fibrous and calcified plaques were seen more often in the failed-PCI group.Calcification severity in CTO segments showed a significant difference between the groups(P=0.014).Calcified plaques were detected in 20(35.1%) lesions in the successful-PCI group.More than 70% of the failures were calcified plaques,of which there were two arc-calcified and one circular-calcified lesions.Occlusions were longer in the failed-PCI group than those in the successful-PCI group [(38.8±25.0) vs.(18.0±15.3) mm,respectively,P<0.01].Fewer guidewires were used in the successful-PCI group compared with the failed-PCI group(1.7±1.0 vs.2.5±0.9,respectively,P<0.01).The logistic regression analysis indicated that predictors of recanalization of CTOs included occlusion length(P=0.0035,risk ratio(RR)=0.93) and calcification severity(P=0.05,RR=0.27).Multi-linear trends analysis showed that the factors affecting procedural time were CTO location(P=0.0141) and occlusion length(P=0.0035).Conclusions:DSCT could delineate the path of CTOs and characterize plaques.The outcomes of PCI were related to thrombolysis in myocardial infarction(TIMI) flow grade,CTO characteristics,severity of calcified plaques,and the length of occlusive segments.Occlusion length and calcification severity were independent predictors of CTOs.Occlusion length and CTO segments could also help to estimate the duration of interventional procedures. | Ping LI Lu-yue GAI Xia YANG Zhi-jun SUN Qin-hua JIN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，8： | 7 |
| 2 | Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study显示文摘Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.Method We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups.Results The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained infertility.Conclusions Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population. | GAI Xiao Yan CHI Hong Bin ZENG Lin CAO Wen Li CHEN Li Xue ZHANG Chen LU Ming NING Lan Ding CHANG Chun ZHANG Wei Xia LIU Ping LI Rong SUN Yong Chang QIAO Jie | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 3 | Effect of Depot Medroxyprogesterone Acetate (DMPA) on Bone Mineral Density in Women of Reproductive Age显示文摘Objective To compare bone mineral density (BMD) between users of intramuscular depot medroxyprogesterone acetate(DMPA) and nonhormonal control subjects. Methods The study included 68 women aged between 25 and 40 years using depot medroxyprogesterone acetate for 24 months and 59 women aged between 25 and 40 years using nonhormonal contraception as control subjects. BMD of the lumbar spine and femoral neck were obtained using dual energy X-ray absorptiometry. Results At 24 months of treatment, as compared with baseline, the mean BMD in lumbar spine and femoral neck was decreased by 5.5% and 5.9%, respectively. Lumbar spine and femoral neck BMD in women who used DMPA were significantly decreased compared with the subjects in nonuser (P<0.001). Conclusion These results show BMD declined during using DMPA in women aged 25-40 years old. | Ling GAI Jing-lu ZHANG Hui-zhen ZHANG Ping GAI Yong-hong LIU | 2009 | Journal of Reproduction and Contraception2009，20，1： | 6 |
| 4 | The Conceptual Design Method for a Pumping Unit Based on QFD and TRIZ显示文摘优秀功能推广(QFD ) 是一个优秀系统,那能帮助设计满足顾客的需要的新奇产品。有创造力的解决问题(TRIZ ) 的理论是在帮助解决在设计过程遇到的困难的技术问题的一个很强大的工具。介绍 QFD 和 TRIZ 进抽的单位的概念的设计联合这二个理论的优点,不同用户的因此相遇的不同要求。它能告诉我们“什么我们应该做它”与 QFD 并且“怎么我们应该做它”与 TRIZ。概念的设计方法,基于 QFD 和 TRIZ,被介绍并且过去常分析并且评估抽的概念的设计工程联合起来。 | Zhang Peng Gai Feng Guan Hongxiang Li Ping | 2005 | Petroleum Science2005，2，4： | 4 |
| 5 | Effect of Two Kinds of Different Combined Oral Contraceptives Used on Bone Mineral Density in Women of Reproductive Age显示文摘Objective To compare bone mineral density (BMD) among users of ethinylestradiol/desogestrel, ethinylestradiol/cyproterone acetate and nonhormonal control subjects. Methods The study included 154 women aged 25-40 years. Forty-six women were using ethinylestradiol/desogestrel (group A) and 55 women using ethinylestradiol/cyproterone acetate (group B) for 24 months and 53 women using nonhormonal contraception as control subjects (group C). BMD of the lumbar spine and femoral neck were obtained using dual energy X-ray absorptiometry, comparing mean BMD changes in combined oral contraceptives (COCs) users with nonusers. Results For 24 months of treatment, lumbar spine and femoral neck BMD values in women who used ethinylestradiol/desogestrel and ethinylestradiol/cyproterone acetate were not significantly different compared with the baseline and the values of subjects in nonuser (P>0.05). Conclusion There was no statistical difference in BMD between the users of ethinylestradiol/desogestrel or ethinylestradiol/cyproterone acetate and nonusers. | Rui-jian LIU Ling GAI Yi-fang JIA Ping GAI Xiao-jie YU | 2011 | Journal of Reproduction and Contraception2011，22，3： | 3 |
| 6 | Effect of Combined Oral Contraceptive Use on Bone Mineral Density in Adolescent Females显示文摘Objective To compare adolescents'bone mineral density (BMD) between users of combined oral contraceptive (Marvelon, desogestrel/ethinylestradiol) and nonhormonal control subjects. Methods The study included 127 women who aged between 16 and 18 years using Marvelon for 24 months and 115 women who aged between 16 and 18 years using nonhormonal contraception as control subjects. BMD of the lumbar spine and femoral neck were obtained using dual energy X-ray absorptiometry. Results After 24 months of Marvelon use, as compared with baseline, the mean BMD in lumbar spine and femoral neck were decreased by 0.30% and 0.61%, respectively. While in the nonusers group, the mean BMD were increased by 1.88% and 1.10%, respectively. Lumbar spine and femoral neck BMD in women who used Marvelon were not significantly different compared with the subjects who used nonhormonal contraception (P>0.05). Conclusion Two years of Marvelon use had no significant effect on BMD, but it remains unknown whether longer than 2 years of use has a significant adverse effect on the attainment of peak bone mass. | Ling GAI Xia LIU Ping GAI Ai-dong ZHANG Ping JIANG Wei ZHANG | 2012 | Journal of Reproduction and Contraception2012，23，3： | 2 |
| 7 | Fusarielin E,a new antifungal antibiotic from Fusarium sp.显示文摘新抗真菌的抗菌素, fusarielin E,从导出水兵的真菌镰刀霉 sp 被孤立。它的结构根据各种各样的 NMR 分光镜的分析和 HR-FAB-MS 被建立。Fusarielin E 对 Pyricularia oryzae 显示了重要生物效能。 | Yue Gai Ling Ling Zhao Chang Qi Hu Hui Ping Zhang | 2007 | Chinese Chemical Letters2007，18，8： | 2 |
| 8 | Correlation between Acute Coronary Syndrome Classification and Multi-detector CT Characterization of Plaque显示文摘Objective To determine if multi-detector CT (MDCT) characterization of plaque is corre-lated with the classification of acute coronary syndrome (ACS). Methods Altogether 1900 patients were examined by MDCT from December 2007 to May 2009, of whom 95 patients fulfilled the criteria of ACS. Those patients were divided into the discrete plaque group (n=61) and diffuse plaque group (n=34) based on the findings in MDCT. The clinical diagnosis of ACS and CT results were analyzed, including segment stenosis score, segment involvement score, 3-vessel plaque score, left main score, calcification score, and re-modeling index. The incidences of major adverse cardiac events in follow-up period were also recorded. Results The patients of the diffuse plaque group were older than those of the discrete plaque group (P<0.0001). The diffuse plaque group presented more cases of hypertension, pe-ripheral artery disease, diabetes, and heart failure than discrete plaque group (all P<0.05). All the 5 patients with ST-segment elevation myocardial infarction were found in discrete plaque group. The segment stenosis score of the discrete plaque group was lower than that of the diffuse plaque group (5.15±3.55 vs. 14.91±5.37, P<0.001). The other four scores demonstrated significant inter-group difference as well (all P<0.05). The remodeling index of the discrete plaque group was higher (1.12±0.16 vs. 0.97±0.20, P<0.05). Follow-up data showed that major adverse cardiac events occurred more frequently in diffuse plaque group than in discrete group (29.41% vs. 11.48%, P=0.0288). Conclusions Characteristics of discrete and diffuse plaques may be significantly different among different classes of ACS. The diffuse plaque may present higher risk, correlated to higher mortality. The diagnosis of discrete and diffuse plaques by MDCT would provide a new insight into the prognosis and treatment of ACS. | Zhi-guo Wang Lu-yue Gai Jing-jing Gai Ping Li Xia Yang Qin-hua Jin Yun-dai Chen Zhi-jun Sun Zhi-wei Guan | 2011 | Chinese Medical Sciences Journal2011，26，2： | 1 |
| 9 | Brain edema after intracerebral hemorrhage in rats: the role of Iron overload and aquaporin 4 显示文摘 | QING Wang - gai DONG Yang - qi PING Tang - qing | 2009 | J Neurosurg2009，110，3： | 1 |
| 10 | Age Differences in Clinical Characteristics, Health care, and Outcomes after Ischemic Stroke in China显示文摘 | Ya‐Xian Deng Yi‐Long Wang Bao‐Qin Gao Chun‐Xue Wang Xing‐Quan Zhao Li‐Ping Liu An‐Xin Wang Yong Zhou Gai‐Fen Liu Wan‐Liang Du Ning Zhang Jing Jing Xia Meng Jie Xu Lin‐Yu Wang Yong‐Jun Wang | 2012 | CNS Neurosci Ther2012，，10： | 1 |
| 11 | 5′-Hydroxyzearalenol,a new β-resorcylic macrolide from Fusarium sp. 05ABR26显示文摘新尾 - resorcylic macrolide, 5 鈥 ? hydroxyzearalenol (1 ) ,从导出水兵的真菌镰刀霉 sp 的文化肉汤被孤立。05ABR26。三已知的混合物, zearalenone (2 ) , 8 鈥 ? hydroxyzearalenone (3 ) 和 zearalenol (4 ) 也被孤立。结构和 1 的相对立体化学根据分光镜的数据和单个水晶的 X 光检查衍射数据被阐明。化合物 2 显示的有势力对有 6.25 渭 g /mL 的 MIC 价值的 Pyricularia oryzae 的禁止的活动,当化合物 3 是更不活跃的时;然而, 1 和 4 没显示出明显的活动。 | Ling Ling Zhao Yue Gai Hisayoshi Kobayashi Chang Qi Hu Hui Ping Zhang | 2008 | Chinese Chemical Letters2008，19，9： | 1 |
| 12 | Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n显示文摘The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron Source.Promptγ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) detectors.The pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data analysis.Background deductions,normalization,and corrections were carefully considered to obtain reliable measurement results.The multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 keV.The experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and URR.The TALYS code was used to describe the average cross sections in the URR.The astrophysical Maxwell average cross sections(MACSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron energies.At a thermal energy of kT=30 keV,the MACS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended value.By contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value. | Gao‑Le Yang Zhen‑Dong An Wei Jiang Xian‑Kai Li Wei‑Wei Qiu Zheng‑Fa Liao Zi‑Yue Zhuang Xiao‑Ping Zhang Sheng‑Li Chen Chen‑Chen Guo Er‑Xi Xiao Xiao Fang Xin‑Xiang Li Xin‑Rong Hu Bing Jiang Jin‑Cheng Wang Jie Ren Wen Luo Zhi‑Chao Zhu Hao‑Yang Lan Zong‑Wei Cao Xu Ma Ying‑Du Liu Pu‑Sen Wang Yi Yang Ping Su Xian‑Gai Deng Wan‑Bing He Chun‑Wang Ma Yu‑Ting Wang Zhi‑Tao Dai Peng‑Qin He Ren‑Guang Tang Tao Zhou Jing Wang Han Yi Yue Zhang Yong‑Hao Chen Rui‑Rui Fan Ke‑Qing Gao Qiang Li Kang Sun Zhi‑Xin Tan Min‑Hao Gu Han‑Tao Jing Jing‑Yu Tang | 2023 | Nuclear Science and Techniques2023，34，11： | 0 |
| 13 | EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma显示文摘Platelet-derived growth subunit A(PDGFA)plays critical roles in development of glioblastoma(GBM)with substantial evidence from TCGA database analyses and in vivo mouse models.So far,only platelet-derived growth receptor a(PDGFRA)has been identified as receptor for PDGFA.However,PDGFA and PDGFRA are categorized into different molecular subtypes of GBM in TCGA_GBM database. | Qu-Jing Gai Zhen Fu Jiang He Min Mao Xiao-Xue Yao Yan Qin Xi Lan Lin Zhang Jing-Ya Miao Yan-Xia Wang Jiang Zhu Fei-Cheng Yang Hui-Min Lu Ze-Xuan Yan Fang-Lin Chen Yu Shi Yi-Fang Ping You-Hong Cui Xia Zhang Xindong Liu Xiao-Hong Yao Sheng-Qing Lv Xiu-Wu Bian Yan Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
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