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| 1 | 饮用水中甲羟孕酮的臭氧氧化降解研究显示文摘以饮用水中内分泌干扰物孕激素类甲羟孕酮(MPA)为目标物,采用臭氧氧化工艺对其进行降解,对臭氧降解过程动力学进行了研究,并考察液相臭氧浓度、pH、羟基自由基(.OH)清除剂(HCO3-)对降解过程的影响.结果表明,臭氧在合适条件下能够有效降解水溶液中的MPA,MPA初始浓度为3、5、10 mg.L-1,采用连续臭氧曝气方式降解时,降解过程遵守一级反应动力学模型;采用序批式臭氧投加方式进行降解时,降解过程符合二级反应动力学模型.pH的升高和HCO3-的添加都会对降解效果产生负面影响.在反应温度为20℃,采用序批式臭氧投加方式,MPA的去除率从pH=3.10时的89.8%下降到pH=9.02时的74.6%.相同反应条件下,添加羟基自由基清除剂HCO3-后,降解反应速率常数由0.146 3 L.(mg.min)-1下降到0.049 5 L.(mg.min)-1,去除率下降了22.2个百分点. | 岳婵媛 缪恒锋 任洪艳 阮文权 | 2012 | 环境科学2012,33,4: | 8 |
| 2 | Effect of Combined Oral Contraceptive Use on Bone Mineral Density in Adolescent Females显示文摘Objective To compare adolescents'bone mineral density (BMD) between users of combined oral contraceptive (Marvelon, desogestrel/ethinylestradiol) and nonhormonal control subjects. Methods The study included 127 women who aged between 16 and 18 years using Marvelon for 24 months and 115 women who aged between 16 and 18 years using nonhormonal contraception as control subjects. BMD of the lumbar spine and femoral neck were obtained using dual energy X-ray absorptiometry. Results After 24 months of Marvelon use, as compared with baseline, the mean BMD in lumbar spine and femoral neck were decreased by 0.30% and 0.61%, respectively. While in the nonusers group, the mean BMD were increased by 1.88% and 1.10%, respectively. Lumbar spine and femoral neck BMD in women who used Marvelon were not significantly different compared with the subjects who used nonhormonal contraception (P>0.05). Conclusion Two years of Marvelon use had no significant effect on BMD, but it remains unknown whether longer than 2 years of use has a significant adverse effect on the attainment of peak bone mass. | Ling GAI Xia LIU Ping GAI Ai-dong ZHANG Ping JIANG Wei ZHANG | 2012 | Journal of Reproduction and Contraception2012,23,3: | 2 |
| 3 | 1424例老年妇女骨健康状况分析显示文摘目的探讨老年妇女的骨健康状况。方法实施双能X线骨密度仪测定骨密度检查的1 424例老年妇女,以10岁为一阶梯,分为A、B、C、D四个年龄组,对不同年龄阶梯妇女髋部骨密度、腰椎骨密度以及骨折发生率、骨转换标志物水平进行对比。结果 A组大转子部位骨密度、全髋部位骨密度、华氏三角区部位骨密度、股骨颈部位骨密度明显高于B、C、D组;L2~4部位骨密度大小顺序为D>C>A>B,D组最高,且各组间均有统计学差异(P<0.05)。A组N-Mid BGP明显高于其他组,NTX/Cr、CTX/Cr中A组、B组结果明显高于C组、D组。发生一次及以上骨折次数中,C组高于B组,B组高于A组。结论随着年龄增长,老年妇女发生骨折可能性增大,骨代谢逐渐降低,临床诊断中采用髋部骨密度对老年妇女骨质疏松诊断更加准确。 | 娄英 李英 | 2014 | 中国老年学杂志2014,34,4: | 0 |
| 4 | Effect of depot medroxyprogesterone acetate(DMPA) on bone mineral density(BMD) and evaluating changes in BMD after discontinuation of DMPA in adolescent women显示文摘Objective To compare bone mineral density(BMD) between users of intramuscular depot medroxyprogesterone acetate(DMPA) and nonhormonal subjects and evaluated the changes in BMD after discontinuation of DMPA.Methods The study included 102 women aged 16-18 years using DMPA for 24 months and 97 same-age nonusers. BMD of the lumbar spine and femoral neck were measured using dual-energy X-ray absorptiometry. The mean BMD values were compared between DMPA users(DMPA group) and nonusers(control group) and the changes of BMD during 36 months after discontinuation of DMPA were observed.Results Mean BMD at the spine and femoral neck did not differ significantly between DMPA group and control group over 12 months, but the BMD values at both anatomical sites were significantly lower in DMPA group than in control group after 24 months treatment. After DMPA discontinuation, the mean BMD values in DMPA users increased substantially. At 24 months after DMPA discontinuation, there were no significant differences between DMPA group and control group. But the values of the lumbar spine and femoral neck BMD in DMPA group were still 1.70% and 1.87%, respectively,below nonusers at 36 months after DMPA discontinuation.Conclusion The use of DMPA for short-term(≤12 months) had no significant effects on BMD at spine and femoral neck, but long-term exposure to DMPA had significantloss in BMD in adolescents. Bone loss occurring with DMPA use is reversible after DMPA discontinuation. | Cheng-wu SHEN Ling GAI Li-hong ZHANG Lin-lin WANG Hai-qing DING Hui JIANG | 2015 | Journal of Reproduction and Contraception2015,26,3: | 0 |
| 5 | Changes in bone mineral density among women aged 19-24 years using injectable contraceptive depot medroxyprogesterone acetate显示文摘Objective To compare bone mineral density(BMD) between users of intramuscular depot medroxyprogesterone acetate(DMPA) and nonhormonal control subjects.Methods The study included 87 women aged between 19 and 24 years using DMPA(DMPA group) for 24 months and 83 same-age women using nonhormonal contraception as control group. BMD of the lumbar spine and femoral neck were measured using dual-energy X-ray absorptiometry, comparing mean BMD changes in DMPA group with the control.Results After 24 months of DMPA treatment, as compared with baseline, the mean BMD in lumbar spine and femoral neck were decreased by 2.67% and 2.71%, respectively.The mean lumbar spine and femoral neck BMD in DMPA group at 24 months were not significantly different compared with baseline(P=0.080 and P=0.076, respectively). In comparison, in control group, there was a trend toward increasing BMD. After 24 months of observation, the mean percentage changes from baseline in lumbar spine and femoral neck BMD were increased by 1.24% and 1.30%, respectively. There was no significantly difference compared with baseline(P=0.436 and P=0.373, respectively).Mean BMD at the spine and femoral neck did not differ significantly between DMPA users and nonusers over 12 months(P=0.153 and P=0.140, respectively), but the BMD at both anatomical sites was significantly lower in DMPA group than in the controlafter 24 months of treatment(P=0.012 and P=0.008, respectively).Conclusion The use of DMPA for short-term(≤12-month) had no significant effects on BMD at spine and femoral neck, but long-term exposure to DMPA had significant loss in BMD in women aged between 19 and 24 years. | Ling GAI Li-hong ZHANG Xue-mei LV Bin WEI Hai-qing DING Jin-yun LIU Hui JIANG | 2015 | Journal of Reproduction and Contraception2015,26,2: | 0 |
| 6 | 金华市868名健康女性骨质疏松发生情况调查显示文摘目的:探讨金华市健康女性骨密度(BMD)状态、骨质疏松(OP)的发生情况,以及生活习惯与骨质疏松关系,为临床治疗骨质疏松提供参考。方法:选取金华市2011年10月-2013年6月868名健康体检女性,以10岁为年龄阶梯对比不同年龄层女性BMD及OP发生率,并分析OP患者生活习惯的差异。结果:BMD与年龄呈负相关,年龄越大BMD越低,40岁后下降更显著,不同年龄层间对比差异有统计学意义(P〈0.05);共检出OP 75例,检出率为8.64%,年龄越大检出率越高,70岁及以上女性人群检出30例,检出率为20.27%,不同年龄层间对比,差异有统计学意义(P〈0.05);从不摄取奶制品、钙剂等OP检出率最高,检出51例。酗酒、吸烟、长期室内工作均是OP高检出人群,其中长期室内工作检出38例。结论:20-30岁年轻女性BMD最高,OP发生率随着年龄增大而增高,且与生活习惯关系密切,加强早期干预有助于预防OP的发生。 | 王卫萍 马秋爱 | 2015 | 中国妇幼保健2015,30,1: | 0 |