|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection显示文摘AIM:To investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H. pylori ) infection. METHODS:This open randomized trial recruited 234 H. pylori positive gastritis patients from seven local centers. The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid , clarithromycin 500 mg bid , and amoxicillin 1000 mg bid ; OCA group, n = 79); two weeks of pre-treatment with probiotics, containing 3 × 107 Lactobacillus acidophilus per day, prior to one week of triple therapy (POCA group, n = 78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group, n = 77). Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy. Patients were asked to report associated symptoms at baseline and during follow-up, and side effects related to therapy were recorded. Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods. RESULTS:PP analysis involved 228 patients, 78 in the OCA, 76 in the POCA and 74 in the OCAP group. Successful eradication was observed in 171 patients; by PP analysis, the eradication rates were significantly higher (P = 0.007 each) in the POCA (62/76; 81.6%, 95% CI 72.8%-90.4%) and OCAP (61/74; 82.4%, 95% CI 73.6%-91.2%) groups than in the OCA group (48/78; 61.5%, 95% CI 50.6%-72.4%). ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5%, 95% CI 70.4%-88.6%) and OCAP (61/77; 79.2%, 95% CI 70%-88.4%) groups than in the OCA group (48/79; 60.8%, 95% CI 49.9%-71.7%), (P = 0.014 and P = 0.015). The symptom relieving rates in the POCA, OCAP and OCA groups were 85.5%, 89.2% and 87.2%, respectively. Only one of the 228 patients experienced an adverse reaction. CONCLUSION:Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates. | Yi-Qi Du Tun Su Jian-Gao Fan Yu-Xia Lu Ping Zheng Xing-Hua Li Chuan-Yong Guo Ping Xu Yan-Fang Gong Zhao-Shen Li | 2012 | World Journal of Gastroenterology2012，18，43： | 54 |
| 2 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 3 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 4 | Emerging in-plane anisotropic two-dimensional materials显示文摘Black phosphorus(BP)is a rapidly up and coming star in two-dimensional(2D)materials.The unique characteristic of BP is its in-plane anisotropy.This characteristic of BP ignites a new type of 2D materials that have low-symmetry structures and in-plane anisotropic properties.On this basis,they offer richer and more unique low-dimensional physics compared to isotropic 2D materials,thus providing a fertile ground for novel applications including electronics,optoelectronics,molecular detection,thermoelectric,piezoelectric,and ferroelectric with respect to in-plane anisotropy.This article reviews the recent advance in characterization and applications of in-plane anisotropic 2D materials. | Liang Li Wei Han Lejing Pi Ping Niu Junbo Han Chengliang Wang Bin Su Huiqiao Li Jie Xiong Yoshio Bando Tianyou Zhai | 2019 | InfoMat2019，1，1： | 16 |
| 5 | Serum levels of microRNAs can specifically predict liver injury of chronic hepatitis B显示文摘AIM:To investigate whether circulating microRNAs (miRNAs) can serve as molecular markers to predict liver injury resulted from chronic hepatitis B (CHB). METHODS:The profiles of serum miRNA expression were first generated with serum samples collected from 10 patients with CHB and 10 healthy donors (Ctrls) by microarray analysis. The levels of several miRNAs were further quantitated by real-time reverse transcriptionpolymerase chain reaction with serum samples from another 24 CHB patients and 24 Ctrls. Serum samples of 20 patients with nonalcohlic steatohepatitis (NASH) were also included for comparison. The comparison in the levels of miRNAs between groups (CHB, NASH and Ctrl) was analyzed with Mann-Whitney Utest. The correlation between miRNAs and clinical pathoparameters was analyzed using Spearman correlation analysis or canonical correlation analysis. The receiver-operator characteristic (ROC) curves were also generated to determine the specificity and sensitivity of each individual miRNA in distinguishing patients with CHB from Ctrls. RESULTS:miRNA profile analysis showed that 34 miRNAs were differentially expressed between CHB and Ctrl subjects, in which 12 were up-regulated and 22 down-regulated in CHB subject (fold change > 2.0 and P < 0.01). The median levels of miR-122, -572, -575 and -638 were significantly higher (P < 1.00 × 10 -5 ) while miR-744 significantly lower (P < 1.00 × 10 -6 ) in CHB compared with the Ctrl. The levels of miR-122, -572 and -638 were also higher (P < 1.00 × 10 -3 ) while the level of miR-744 lower in CHB (P < 0.05) than in NASH, although the difference between them was not as significant as that between CHB and Ctrl. ROC curve analysis revealed that the levels of miR-122, -572, -575, -638 and -744 in serum were sensitive and specific enough to distinguish CHB, NASH and Ctrl. Multivariate analysis further showed that the levels of these miRNAs were correlated with the liver function parameters. Most significantly, it was the scatter plot of principal component with the levels of these miRNAs, but not the parameters of liver function, which clearly distinguished CHB, NASH and Ctrl subjects. CONCLUSION:Serum levels of miR-122, -572, -575, -638 and -744 are deregulated in patients with CHB or NASH. The levels of these miRNAs may serve as potential biomarkers for liver injury caused by CHB and NASH. | Hui Zhang Qing-Ya Li Zhi-Zhong Guo Yan Guan Jia Du Yi-Yu Lu Yi-Yang Hu Ping Liu Shuang Huang Shi-Bing Su | 2012 | World Journal of Gastroenterology2012，18，37： | 15 |
| 6 | Chinese herbal formula Fuzheng Huayu alleviates CCl4-induced liver fibrosis in rats: a transcriptomic and proteomic analysis显示文摘 | Shu DONG Fei-fei CAI Qi-long CHEN Ya-nan SONG Yang SUN Bin WEI Xiao-yan LI Yi-yang HU Ping LIU Shi-bing SU | 2018 | Acta Pharmacologica Sinica2018，39，6： | 15 |
| 7 | Microstructure and Properties of Cu-Cr-Zr Alloy after Rapidly Solidified Aging and Solid Solution Aging显示文摘The structure and properties of Cu-Cr-Zr alloy were studied after rapidly solidified aging and solid solution aging.At the early stage of aging (500℃ for 15 min), the hardness and the conductivity of the alloy rapidly solidified are 143 HV and 72% IACS, respectively. Under the same aging condition, the hardness and electrical conductivity of the alloy solid solution treated can reach 86 HV and 47% lACS, respectively. The microstructure was analyzed, and the grain size after rapid solidification is much smaller than that after solid solution treatment. By rapidly solidified aging the fine precipitates distribute inside the grains and along the grain boundary, while by solid solution aging there are large Cr particles along the grain boundary. | Ping LIU Juanhua SU Qiming DONG Hejun LI | 2005 | Journal of Materials Science & Technology2005，21，4： | 14 |
| 8 | Long-term efectiveness of infancy low-dose hepatitis B vaccine immunization in Zhuang minority area in China显示文摘METHODSTwoepidemiologicmethods,acrosssectionalfolowupstudyandacasecontrolstudy,wereusedfortheevaluationoftheserologicalef... | LI Hui 1, LI Rong Cheng 2, LIAO Su Su 1, GONG Jian 2, ZENG Xian Jia 1 and LI Yan Ping 2 | 1999 | World Journal of Gastroenterology1999，5，2： | 14 |
| 9 | Expression of interleukin 1β converting enzyme in 5-FU induced apoptosis in esophageal carcinoma cells显示文摘NTRODUCTIONApoptosisisanimportantphysiologicalformofceldeath.Itisstrictlycontroledbygenes.Ithasbeenshowninexperimentsthatexte... | DENG Li Ying 1, ZHANG Yun Han 2, XU Ping 2, YANG Su Min 1 and YUAN Xue Bin 1 | 1999 | World Journal of Gastroenterology1999，5，1： | 13 |
| 10 | Two new terpenoids from fruits of Ziziphus jujuba显示文摘一新 ceanothane 类型 triterpene 和一新 sesquiterpene,和二,已知的 triterpenes 从 Ziziphus jujuba 米尔的水果被孤立。(Rhamnaceae ) 。基于光谱分析,二新混合物的结构作为 2 α 被阐明; -aldehydo-A(1)-norlup-20(29)-en-27,28-dioic 酸(zizyberanal 酸)(1 ) ,和 zizyberanone (2 ) 。当二已知的 triterpenes 作为 zizyberanalic 酸(3 ) 和 ursolic 酸(4 ) 被识别时。 | Sheng Guo Yu Ping Tang Jin Ao Duan Shu Lan Su An Wei Ding | 2009 | Chinese Chemical Letters2009，20，2： | 13 |
| 11 | STUDIES ON SOLUBILIZATION AND TRANSFORMATION OF SPECIES OF Cu,Pb.Zn AND Cr IN SIMULANT ACID RAIN显示文摘STUDIESONSOLUBILIZATIONANDTRANSFORMATIONOFSPECIESOFCu,Pb.ZnANDCrINSIMULANTACIDRAINGuiHuaHE;LianCunGAO;ShuRenWANG(Ensironmenta... | Gui Hua HE Lian Cun GAO Shu Ren WANG (Ensironmental Science Center Shandong University, Jinan 250100)Su Ping FANG (Experimectal Center, Shandong University) | 1994 | Chinese Chemical Letters1994，5，1： | 13 |
| 12 | Terrestrial water variations in the North China Plain revealed by the GRACE mission显示文摘Using eight years of time-variant gravity measurements from the GRACE gravity satellite mission, we estimate monthly terrestrial water storage variations in the North China Plain between August 2002 and August 2010. We find that during this period, the water storage is not constant but accelerate at a rate of -1.1 cm/yr over time. The study confirms that the relatively long-term trend of water storage in the North China Plain (by 13-point moving average) is consistent well with that by linear fitting. Two hydrological models, CPC and GLDAS, are adopted in calculating surface water variations, with results indicating that they agree with those of GRACE. Furthermore, rates of -0.6 cm/yr for surface water variations and -0.5 cm/yr for groundwater variations are found in the North China Plain during the study period. Decrease of rainfall and the groundwater over-exploitation are possibly the main causes for groundwater depletion in the North China Plain. The results will be helpful for better understanding climatic changes and provide reference for the management of water resources and the establishment of policies on preventing and alleviating natural hazards. | SU XiaoLi PING JinSong YE QiXin | 2011 | Science China Earth Sciences2011，54，12： | 13 |
| 13 | A metabolic mechanism analysis of Fuzheng-Huayu formula for improving liver cirrhosis with traditional Chinese medicine syndromes显示文摘 | Ya-nan SONG Jian CHEN Fei-fei CAI Yi-yu LU Qi-long CHEN Yong-yu ZHANG Ping LIU Shi-bing SU | 2018 | Acta Pharmacologica Sinica2018，39，6： | 13 |
| 14 | The Effects of Demographic Features on Differences in Sensitivity between PCL-C and SCL-90 Scores in a Follow-up Study in Secondary School Students in the Wenchuan Earthquake Region显示文摘Objective To analyze the sensitivity of effect factors between the PCL‐C and the SCL‐90,to provide evidence for social psychological crisis screening and post‐trauma interventions.Methods We administered the PCL‐C and SCL‐90 to screen for PTSD and other psychological problems among students who survived the disaster and continued their school studies.The surveys were carried out 3,6,9,and 12 months after the earthquake.A bivariate 2‐level logistic model was used to explore the different levels of sensitivity among students.The factors influencing the relationships between PTSD and depression,and between PTSD and anxiety were examined.Results We analyzed data from 1 677 students,revealing that female students in higher grades were more likely to exhibit symptoms of depression,rather than PTSD,compared with the control group (males in lower grades),and the difference was significant (P<0.05).In contrast,ethnic minorities were more likely to exhibit PTSD symptoms compared to the others.In addition,female students were more likely to exhibit symptoms of anxiety than PTSD.Other effects that did not reach statistical significance were suggested to have a similar influence on PTSD,depression,and anxiety.Conclusion After a natural disaster,specific aspects of depression and anxiety should be examined,avoiding an overemphasis on PTSD in social psychological crisis interventions. | HOU Feng Su LI Ting LI Juan HU Xiao Qin LIU Zhi Yue YUAN Ping | 2011 | Biomedical and Environmental Sciences2011，24，6： | 11 |
| 15 | Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males显示文摘AIM:To evaluate the impact of alcohol dehydrogenase-2(ADH2) and aldehyde dehydrogenase-2(ALDH2) polymorphisms on esophageal cancer susceptibility in Southeast Chinese males.METHODS:Two hundred and twenty-one esophageal cancer patients and 191 healthy controls from Taixing city in Jiangsu Province were enrolled in this study.ADH2 and ALDH2 genotypes were examined by polymerase chain reaction and denaturing high-performance liquid chromatography.Unconditional logistic regression was used to calculate the odds ratios(OR) and 95% confi dence interval(CI) .RESULTS:The ADH G allele carriers were more susceptible to esophageal cancer,but no association was found between ADH2 genotypes and risk of esophageal cancer when disregarding alcohol drinking status.Regardless of ADH2 genotype,ALDH2G/A or A/A carriers had significantly increased risk of developing esophageal cancer,with homozygous individuals showing higher esophageal cancer risk than those who were heterozygous.A signif icant interaction between ALDH2 and drinking was detected regarding esophageal cancer risk;the OR was 3.05(95% CI:1.49-6.25) .Compared with non-drinkers carrying both ALDH2 G/G and ADH2 A/A,drinkers carrying both ALDH2 A allele and ADH2 G allele showed a signif icantly higher risk of developing esophageal cancer(OR = 8.36,95% CI:2.98-23.46) .CONCLUSION:Both ADH2 G allele and ALDH2 A allele significantly increase the risk of esophageal cancer development in Southeast Chinese males.ALDH2 A allele significantly increases the risk of esophageal cancer development especially in alcohol drinkers.Alcohol drinkers carrying both ADH2 G allele and ALDH2 A allele have a higher risk of developing esophageal cancer. | Jian-Hua Ding Su-Ping Li Hai-Xia Cao Jian-Zhong Wu Chang-Ming Gao Ping Su Yan-Ting Liu Jian-Nong Zhou Jun Chang Gen-Hong Yao | 2009 | World Journal of Gastroenterology2009，15，19： | 10 |
| 16 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 17 | Two adaptive detectors for range-spread targets in non-Gaussian clutter显示文摘This paper addresses adaptive detection of range-spread target in spherically invariant random vector clutter. Based on the nonadaptive detectors of NSDD-GLRT and SDD-GLRT, two adaptive detectors named ANSDD-GLRT and ASDD-GLRT are devised by replacing the unknown normalized clutter covariance matrix with the sample covariance matrix based on the secondary data. The formulas of detection probability and false alarm probability are deduced. Moreover, the constant false alarm rate properties of both adaptive detectors are assessed and the inffuence of mismatched steering vector on detection probability is analyzed. The experimental results show that the adaptive detectors have an acceptable loss with respect to the nonadaptive counterparts. Furthermore, the ANSDD-GLRT converges much faster than the ASDD-GLRT, however, the latter rejects the misaligned signals more effectively. Both detectors perform well for the uniformly-distributedenergy target, but degenerate for the fluctuating targets. In addition, the correlation between target scatterers results in an additional gain for low signal-to-clutter power ratio. | HE You JIAN Tao SU Feng PING DianFa | 2011 | Science China(Information Sciences)2011，54，2： | 10 |
| 18 | Effect of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease显示文摘OBJECTIVE:To observe the effects of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease.METHODS:Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group(n=45) treated with Liandouqingmai Recipe and a standard treatment group(control group,n=56).A normal group of 16 healthy persons was additionally set up.Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire(SAQ) was adopted in studying life quality before and after treatment for two weeks.The data were analyzed with SPSS 16.0 statistic software.RESULTS:The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease.There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation(PL),pngina stability(AS),apngina frequency(AF),treatment satisfaction(TS) and disease perception(DP)] between the two groups before treatment(P>0.05).But after treatment,the scores of SAQ(PL,AS,AF,TS,DP) and NO level were higher than those in the control group,and ET-1 average level in the treatment group was lower than that in the control group.The negative relations between PL and ET-1 and between AF and ET-1 were found in this study.CONCLUSION:Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment,thus improving vascular endothelial function and life quality.Life quality is related to vascular endothelial function. | Hongjun Zhu Shu Lu Wei Su Shaoyu Gong Zhibin Zhang Ping Li | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 10 |
| 19 | Idiopathic pulmonary fibrosis will increase the risk of lung cancer显示文摘 | Li Junyao Yang Ming Li Ping Su Zhenzhong Gao Peng Zhang Jie | 2014 | Chinese Medical Journal2014，，17： | 10 |
| 20 | Long-term eficacy of plasma-derived hepatitis B vaccine among Chinese children:a 12-year folow-up study显示文摘INTRODUCTIONToevaluatelongtermeficacyofaplasmaderivedhepatitisBvaccineandprovideevidencefordecisionmakingonthevaccineboost... | LIAO Su Su 1, LI Rong Cheng 2, LI Hui 1, YANG Jin Ye 2, ZENG Xian Jia 1, GONG Jian 2, WANG Shu Sheng 2, LI Yan Ping 2 and ZHANG Kong Lai 1 | 1999 | World Journal of Gastroenterology1999，5，2： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员