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| 1 | Polymorphism Analyses of Hepatitis B Virus X Gene in Hepatocellular Carcinoma Patients from Southern China显示文摘长期的肝炎 B 病毒( HBV )感染是主要原因 ofhepatocellular 癌( HCC )之一,并且 HBV X ( HBx )基因在HBV相关的 HCC.We 的分子的致病起一个关键作用调查了是否有特别 HBx 基因变化,从南部的中国在病人与 HCC 联系。HBx 基因被嵌套的聚合酶链反应(PCR ) 从 HBVcarrier 与 HCC 和 25 件浆液样品从病人在 51paraffin-embedded 肿瘤织物样品检验,搁浅单人赛的 conformational 多型性 andheteroduplex 分析。有从肿瘤织物样品的潜在地重要的变化的 HBx 基因被克隆,在肿瘤织物样品与出版 HBx 基因 sequence.HBV 遗传型定序并且排列被在肿瘤织物的31.3% HBx 基因碎片取样的基因多型性显示出的 HBx 的嵌套的 PCR.Analyses 分析有特殊 pattern.A 在 29 点突变伴随的 HBxgene 的 nt 382-400 的普通删除随机在四被检测有在 HBx 开的读物引起了框架移动的这个模式的选择肿瘤织物样品在 atnt 上与一条新站鳕鱼装裱 1818 ,导致 HBx 多肽链在这些情况中在 C 结束截断了。在四件随机选择的样品之中,三是 HBV 遗传型 B ,并且一个人没被我们的现在的 assay.Inanother 肿瘤织物样品检测,全身的 HBx 基因的扩大产出揭示的这碎片的 shorterfragment.Sequencing 在 1577 HBVgene.These 和 1840 结果建议的 nt 之间的 264 bp 删除那个 HBx 基因变化在 HCC 样品经常发生,并且在 HBx 基因的 nt 382-400 的删除可能在南部的中国在 HCC 的 carcinogenesis 起一个作用。 | Ping'an ZHU Deming TAN Zhongtian PENG Fei LIU Lin SONG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 29 |
| 2 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 3 | Intraoperative endoscopic sphincterotomy for common bile duct stones during laparoscopic cholecystectomy显示文摘INTRODUCTION The advent of laparoscopic cholecystectomy(LC)inthe late 1980s gained widespread acceptance withina short period of time and has become the preferredtreatment for symptomatic gallstones,but themanagement of coexisting gallbladder and commonbile duct(CBD)stones has remained controversialbecause the various strategies proposed have theirlimitations.In fact,choledocholithiasis | De Fei Hong Ming Gao Urs Bryner Xiu Jun Cai Yi Ping Mou | 2000 | World Journal of Gastroenterology2000，6，3： | 19 |
| 4 | Effects of Honghua preserved amniotic membrane on scar healing in experimental glaucoma surgery显示文摘AIM:To investigate the efficacy and safety of Honghua preserved amniotic membrane(AM)for preventing scar formation of the filtering bleb in a rabbit model of glaucoma trabeculectomy surgery.METHODS:Totally 36 rabbits(36 eyes)were randomly divided into 3 groups:the experimental group(ocular trabeculectomy in combination with Honghua preserved AM transplantation),the control group(ocular trabeculectomy surgery in combination with AM implantation),and the blank group(single trabeculectomy).Clinical observations[including intraocular pressure(IOP),filtering blebs and complications],MassonTrichrome staining,real-time quantitative reverse transcription-polymerase chain reaction(real-time PCR),Western blot were performed on different time points(D1,D7,D14,D21 and D56)after the surgery.RESULTS:After operated for 14d,there were statistically significant differences in the filtering blebs compared to the situation before operation(P<0.05),whereas no statistically difference on that among three groups(P>0.05).After 21d,the IOP of experimental group was lowest(P<0.05).There was significant difference between control group and blank group(P<0.05).On postoperative D14,the mean number of fibroblasts in the experimental group was significantlylower(40.6±10.2)compared to those in the control group(54.4±10.8)and blank group(68.2±11.6)(P<0.05,respectively).The mean numbers of the macrophage in the experimental and control groups were respcitively significantly lower versus the blank group(P<0.05,P<0.05,respectively).Compared to that in blank group,the level of transforming growth factor-β(TGF-β1)expression in sclera and conjunctival areas was reduced in the experimental and control groups on protein and mRNA level(P<0.05),but not significant difference between these two groups(P>0.05).CONCLUSION:The trabeculectory surgery with Honghua preserved AM can control IOP,sustain the functional filtration bleb,inhibit the proliferation of fibroblasts and open the filtrating pathway on the rabbit glaucoma models. | Yi Shao Yao Yu Qiu-Ping Liu Jing-Ming Li Fei Dong Xin Huang Chong-Gang Pei Ping Tu Hen-Hui Li Gui-Ping Gao | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 16 |
| 5 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 6 | Laparoscopic cystogastrostomy for the treatment of pancreatic pseudocysts: A case report显示文摘Pancreatic pseudocysts(PPs) are collections o pancreatic secretions that are lined by fibrous tissue and may contain necrotic debris or blood. The interventions including percutaneous, endoscopic o surgical approaches are based on the size, location symptoms and complications of a pseudocyst With the availability of advanced imaging system and cameras, better hemostatic equipments and excellent laparoscopic techniques, most pseudocyst can be found and managed by laparoscopy. We describe a case of a 30-year-old male patient with a pancreatic pseudocyst amenable to laparoscopi cystogastrostomy. An incision was made through the anterior gastric wall to expose the posterior gastri wall in close contact with the pseudocyst using an ultrasonically activated scalpel. Then, another incision was made for cystogastrostomy to obtain complete and unobstructed drainage. The patient recovered well after operation and was symptom-free during a 6-mo follow-up, suggesting that laparoscopi cystogastrostomy is a safe and effective alternative to open cystogastrostomy for minimally invasive management of PPs. | Qin-song Sheng Da-Zhi Chen Ren Lang Zhong-Kui Jin Dong-Dong Han Li-Xin Li Yong-Jiu Yang Ping Li Fei Pan Dong Zhang Zhao-Wei Qu Qiang He | 2008 | World Journal of Gastroenterology2008，14，30： | 15 |
| 7 | Liver Enzymes Concentrations Are Closely Related to Pre-diabetes:Findings of the Shanghai Diabetes Study Ⅱ (SHDS Ⅱ)显示文摘Objective To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.Methods A total of 3 756 participants were enrolled.Each participant underwent an oral glucose tolerance test and completed a questionnaire.Anthropometric indices were recorded and serum samples were collected for measurement.Results Liver enzymes concentrations were independently associated with i-IGT,IFG+IGT,and diabetes.With the increase of ALT and GGT concentrations,ORs for i-IGT,IFG+IGT,and diabetes increased gradually.By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1),ORs for i-IGT,IFG+IGT,or diabetes was significant after adjustment.Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI):2.56 (1.51-4.34) P=0.00;GGT OR (95% CI):2.66 (1.53-4.65) P=0.00].Conclusion Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance. | GAO Fei PAN Jie Min HOU Xu Hong FANG Qi Chen LU Hui Juan TANG Jun Ling GU Hui Lin PAN Zhi Jian YAO You Hua SHEN Wei Zhen JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 15 |
| 8 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 9 | Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo显示文摘Dihydrotanshinone 我(DI ) ,从鼠尾草植物 miltiorrhiza Bunge 提取的自然地发生的混合物,被报导了有 cytotoxicity 到许多肿瘤房间。在这研究,我们在人的脐的静脉 endothelial 房间调查了它的 anti-angiogenic 能力。DI 导致了有势力 cytotoxicity 到人的脐的静脉 endothelial 房间,与约 1.28 亩 g/ml 的 IC50 价值。在 0.25-1 亩 g/ml, DI dose-dependently 压制了分别地愈合弯屈, Transwell 侵略和 Matrigel 试管形成试金检测的人的脐的静脉 endothelial 房间移植,侵略,和试管形成。而且,在在小鸡胚胎 chorioallantoic 的 vivo anti-angiogenic 活动重要的显示出的 DI 膜试金。DI 在 0.2 亩 g/egg 导致了微容器密度的 61.1% 禁止的率。总起来说,我们的结果证明 DI 能通过压制 endothelial 房间增长,移植,侵略和试管形成禁止 angio 开始,显示 DI 有一个潜力作为一个新奇 anti-angiogenic 代理人被发展。 | Weipeng Bian Fei Chen Ling Bai Ping Zhang Wenxin Qin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 13 |
| 10 | Vegetation dynamics induced by groundwater fluctuations in the lower Heihe River Basin,northwestern China显示文摘Aims Since 2000,the environmental flow controls project has been implemented in the lower Heihe River Basin,a typical arid inland river basin in northwest China,to restore the deteriorated ecological environment in this region.The aim of this study was to explore the impacts of groundwater fluctuations on vegetation dynamics.Our results can be used as a reference for water resources planning and management to maintain proper environmental flows in arid areas.Methods The location(by Global Positioning System)and depth of the monitoring wells,as well as groundwater table depth and salinity were measured in situ at each site from July to August 2009.Based on the measurements of the groundwater table depth and salinity following the implementation of environmental flow controls project(EFCP)in the lower Heihe River Basin,the groundwater fluctuations during the period from 2001 to 2009 were analyzed.Descriptive statistics and Pearson’s correlation were used to analyze the relationship between vegetation changes and groundwater table fluctuations.Additionally,the spatial distributions of the groundwater table depth and salinity were interpolated using the simple kriging method.Trend analysis was applied to the time series of integrated Moderate Resolution Imaging Spectroradiometer normalized difference vegetation index data to identify interannual vegetation dynamics.The relationship between vegetation status and groundwater environment was investigated at different spatial scales by analyzing and comparing the time series and trends.Important Findings(i)The groundwater table and salinity increased significantly in most of the study area with spatial heterogeneity.On average,the groundwater table rose;0.5 and 1.5 m in the upper and lower Ejina Basin,respectively,and the groundwater salinity increased across the study area by 0–4%.(ii)A notable correlation between the vegetation status and the groundwater table was revealed when the groundwater table depth fluctuated between 1.8 and 3.5 m,whereas the vegetation did not show an obvious response to groundwater table changes when the groundwater table depth was more than 5–6 m.(iii)Vegetation restoration mainly occurred in riparian areas within 500–1000 m of from natural rivers,where the groundwater table depth varied from 2 to 4 m,and salinity was<5%,whereas vegetation degradation appeared at some locations where groundwater environment had deteriorated. | Ping Wang Yichi Zhang Jingjie Yu Guobin Fu Fei Ao | 2011 | Journal of Plant Ecology2011，4，1： | 10 |
| 11 | Effects of different free fatty acids on insulin resistance in rats显示文摘BACKGROUND: Much evidence demonstrates that elevated free fatty acids (FFAs) are associated with insulin resistance. However, it is not clear whether different FFAs can cause different degrees of peripheral insulin resistance. This study aimed to investigate the effects of short-term elevation of FFAs on hepatic and peripheral insulin action, and determine whether FFAs with different degrees of saturation have differential effects on hepatic insulin resistance. METHODS: Intralipid+heparin (IH, polyunsaturated fatty acids), oleate (OLE), lard oil+heparin (LOH), and saline (SAL) were separately infused intravenously for 7 hours in normal Wistar rats. During the last 2 hours of the fat/saline infusion, a hyperinsulinemic-euglycemic clamping was performed with [6-3H] glucose tracer. Plasma glucose was measured using the glucose oxygenase method. Plasma insulin and C-peptide were determined by radioimmunoassays. Plasma FFAs were measured using a colorimetric method. RESULTS: Compared with infusion of SAL, plasma FFA levels were significantly elevated by infusions of IH, OLE, and LOH (P<0.001). All three fat infusions caused remarkably higher hepatic glucose production (HGP) than SAL (P<0.001). OLE and LOH infusions induced much higher HGP than IH (P<0.01). Glucose utilization (GU) was decreased with all three fat infusions relative to SAL (P<0.001), but GU did not differ among the three types of fat infusions.CONCLUSIONS: Short-term elevation of FFAs can induce hepatic and peripheral insulin resistance. Polyunsaturated fatty acids induced less hepatic insulin resistance than monounsaturated or saturated fatty acids. However, IH, OLE, and LOH infusions induced similar peripheral insulin resistance. | Han, Ping Zhang, Yong-Yan Lu, Yan He, Bing Zhang, Wei Xia, Fei | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 10 |
| 12 | Autoimmune pancreatitis:report of two cases and literature review显示文摘BACKGROUND:Autoimmune pancreatitis(AIP)is a unique chronic inflammation of the pancreas in which autoimmune mechanisms are involved in the pathogenesis.It is characterized by clinical,histopathological,radiographic,serologic and therapeutic features.Since it was first described in 1995,increasing numbers of AIP patients have been diagnosed.METHODS:In this study,the data from 2 patients with AIP who had elevation of serum immunoglobulin G,positive autoantibody,swelling of the pancreas and narrowing of the main pancreatic duct on imaging were analyzed retrospectively.RESULTS:With the initial diagnosis of AIP,both patients underwent regular prednisone therapy,which was initiated at a dose of 40 mg per day with a tapering schedule of 5 mg every 2 weeks.The patients responded very well to treatment with prednisone.CONCLUSIONS:AIP is a relatively new disease entity.Although it is diagnosed by distinct characteristics of the clinical,radiologic,histopathologic,and serologic findings,many questions require further clarification,including its relationship to other autoimmune diseases and misdiagnosis as pancreaticobiliary malignancies. | Sheng, Qin-Song Chen, Da-Zhi Lang, Ren He, Qiang Han, Dong-Dong Pan, Fei Li, Ping Qu, Zhao-Wei | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 13 | A novel phenylpropanoid glycoside from Callicarpa kwangtungensis Chun显示文摘新奇 phenylpropanoid glycoside, Callicarposide A 从 Callicarpa kwangtungensis Chun 的天线部分被孤立。化学结构被阐明根据光谱分析。 | Er Lei Xie Guo Ping Zhou Teng Fei Ji Jun Wu Gui Ping Yuan | 2009 | Chinese Chemical Letters2009，20，7： | 8 |
| 14 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
| 15 | Tunable and scalable broadband metamaterial absorber involving VO2-based phase transition显示文摘Optical absorbers with dynamic tuning features are able to flexibly control the absorption performance, which offers a good platform for realizing optical switching, filtering, modulating, etc. Here, we propose a thermally tunable broadband absorber applying a patterned plasmonic metasurface with thermo-chromic vanadium dioxide (VO2) spacers. An actively tunable absorption bandwidth and peak resonant wavelength in the region from the near-to mid-infrared (NMIR) are simultaneously achieved with the insulating.metallic phase transition ofVO2·Moreover, the scalable unit cell,which is composed of multi-width sub-cells, provides a new freedom to further manipulate (i.e., broaden or narrow) the absorption bandwidth while maintaining a high relative absorption bandwidth and efficient absorbance at the same time. For both transverse-electric and transverse-magnetic polarizations, the proposed nanostructure exhibits a high absorption over a wide angular range up to 60°.This method holds a promising potential for versatile utilizations in optical integrated devices,NMIR photodetection, thermal emitters, smart temperature control systems,and so fbrth. | Lei Lei Fei Lou Keyu Tao Haixuan Huang Xin Cheng Ping Xu | 2019 | Photonics Research2019，7，7： | 8 |
| 16 | Monitoring Computer Numerical Control Machining Progress Based on Information Fusion显示文摘To cope with the market demand dynamically,enterprise needs to obtain the production status of work in process real-timely,but the information of machining progress has feature of uncertainty and can not reflect the status of production field effectively.In this work,to overcome the ineffectiveness of computer numerical control(CNC) machining progress information extraction and its application restriction in practice because of heterogeneous system of CNC machine,based on information fusion by analyzing multi-sources information,estimating CNC machining status and predicting the machining progress through tracking tool coordinates,a CNC machining progress monitoring method is presented.The multi-sources heterogeneous information includes machining path,real-time spindle power information,manual input data and tool position.On the method of obtaining this multi-sources heterogeneous information,the method which helps explore numerical control(NC) program,monitor spindle power of CNC,collect human-computer interaction(HCI) information,obtain real-time tool coordinates and express the knowledge concerned in this field is analyzed;The decision rule of CNC machining status in the way of fusing multi-sources information in manufacturing process is summarized,as well as the machining progress tracking method in accordance with real-time tool coordinates and machining path is presented.Finally,the method discussed is proved feasible by the verification of machining progress tracking through simulation experiment.The proposed research realizes the effective integration of CNC machining progress information,and enables enterprises an efficient way to share CNC information and configure CNC resources optimally. | TONG Liang YAN Ping LIU Fei | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 7 |
| 17 | Tissue plasminogen activator-assisted vitrectomy in the early treatment of acute massive suprachoroidal hemorrhage complicating cataract surgery显示文摘Dear Editor,I am Dr.Zhao PQ,from the Department of Ophthalmology,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China.I write to present a case report of tissue plasminogen activator(tP A)-assisted vitrectomy in the early treatment of acute massive | Ping Fei Hai-Ying Jin Qi Zhang Xin Li Pei-Quan Zhao | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 7 |
| 18 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 19 | Grease film evolution in rolling elastohydrodynamic lubrication contacts显示文摘Although most rolling element bearings are grease lubricated,the underlying mechanisms of grease lubrication has not been fully explored.This study investigates grease film evolution with glass disc revolutions in rolling elastohydrodynamic lubrication(EHL)contacts.The evolution patterns of the grease films were highly related to the speed ranges and grease structures.The transference of thickener lumps,film thickness decay induced by starvation,and residual layer were recognized.The formation of an equilibrium film determined by the balance of lubricant loss and replenishment was analyzed.The primary mechanisms that dominate grease film formation in different lubricated contacts were clarified. | Xinming LI Feng GUO Gerhard POLL Yang FEI Ping YANG | 2021 | Friction2021，9，1： | 7 |
| 20 | Enhanced Hall-Petch strengthening in graphene/Cu nanocomposites显示文摘Grain size dependent strength,known as Hall-Petch relation,has been approved to be valid in crystalline metals and alloys.However,softening would eventually occur as grain size reduced into nanoscale that below a critical value.Hence,it is essential to find a way to break the strength limitation by avoiding the deformation mechanism transition from dislocation-mediated to grain-boundary-mediated processes.By replacing grain boundary(GB)of nanocrystalline Cu with graphene,in the present study,molecular dynamics simulations show that graphene-boundary(GrB)embedded GrB/Cu nanocomposites exhibit enhanced enlarged Hall-Petch slope with decreasing grain size.The absence of inverse-Hall-Petch relation and the extremely high strength derived at the GrB/Cu nanocomposites were interpreted by the high back stress and abundant dislocation activity that attributed from the high-degree of heterogeneous structure of the nanocomposites. | Shuang Zhang Fei Wang Ping Huang | 2021 | Journal of Materials Science & Technology2021，，28： | 7 |
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