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| 1 | Polymorphism Analyses of Hepatitis B Virus X Gene in Hepatocellular Carcinoma Patients from Southern China显示文摘长期的肝炎 B 病毒( HBV )感染是主要原因 ofhepatocellular 癌( HCC )之一,并且 HBV X ( HBx )基因在HBV相关的 HCC.We 的分子的致病起一个关键作用调查了是否有特别 HBx 基因变化,从南部的中国在病人与 HCC 联系。HBx 基因被嵌套的聚合酶链反应(PCR ) 从 HBVcarrier 与 HCC 和 25 件浆液样品从病人在 51paraffin-embedded 肿瘤织物样品检验,搁浅单人赛的 conformational 多型性 andheteroduplex 分析。有从肿瘤织物样品的潜在地重要的变化的 HBx 基因被克隆,在肿瘤织物样品与出版 HBx 基因 sequence.HBV 遗传型定序并且排列被在肿瘤织物的31.3% HBx 基因碎片取样的基因多型性显示出的 HBx 的嵌套的 PCR.Analyses 分析有特殊 pattern.A 在 29 点突变伴随的 HBxgene 的 nt 382-400 的普通删除随机在四被检测有在 HBx 开的读物引起了框架移动的这个模式的选择肿瘤织物样品在 atnt 上与一条新站鳕鱼装裱 1818 ,导致 HBx 多肽链在这些情况中在 C 结束截断了。在四件随机选择的样品之中,三是 HBV 遗传型 B ,并且一个人没被我们的现在的 assay.Inanother 肿瘤织物样品检测,全身的 HBx 基因的扩大产出揭示的这碎片的 shorterfragment.Sequencing 在 1577 HBVgene.These 和 1840 结果建议的 nt 之间的 264 bp 删除那个 HBx 基因变化在 HCC 样品经常发生,并且在 HBx 基因的 nt 382-400 的删除可能在南部的中国在 HCC 的 carcinogenesis 起一个作用。 | Ping'an ZHU Deming TAN Zhongtian PENG Fei LIU Lin SONG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 29 |
| 2 | PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia显示文摘Prion 疾病是人和动物的一组能递送的致命的 neurodegenerative 混乱,包括牛的海绵状的 encephalopathy, scrapie,和 CreutzfeldtJakob 疾病。Microglia,中央神经系统的居民巨噬细胞,对病理学的织物改变精致地敏感,改变他们的形态学和显型采用一个所谓的激活的状态并且执行免疫学的响应 pathophysiological 大脑侮辱工作。尽管最近的调查结果提供了珍贵卓见进角色 microglia,在在 prion 观察的 proinflammatory 事件玩,为这些回答的开始负责的细胞内部的发信号分子尚待被阐明。看起来 microglial 激活包含 PrP106126 绑定和象 CD36 和 integrins 那样的房间表面免疫者和粘附分子的激活与象 Fyn 那样的 Src 家庭酷氨酸 kinases 的随后的招募, Lyn,和 Syk kinases。在现在的学习,我们证明 CD36 涉及导致 PrP106126 的 microglial 激活并且 PP2 和 piceatannol (照片) 能废除毒害神经的 prion 在 microglia 的导致肽的可诱导的氮的氧化物 synthase 激活。这些调查结果作为 Src 家庭 kinase Fyn 和涉及毒害神经的 prion peptidesmicroglia 相互作用的酷氨酸 kinase Syk 禁止者揭开 PP2 和照片的一个以前未被认出的角色,因此提供新卓见进由毒害神经的 prion 肽位于 microglia 的激活下面的机制。 | Siming Zhang Lifeng Yang Mohammed Kouadir Rongrong Tan Yun Lu Jiaxin Chang Binrui Xu Xiaomin Yin Xiangmei Zhou Deming Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
| 3 | Efficacy and safety of entecavir compared to lamivudine in nucleoside-na?ve patients with chronic hepatitis B: a randomized double-blind trial in China显示文摘 | Guangbi Yao Chengwei Chen Weilun Lu Hong Ren Deming Tan Yuming Wang Daozheng Xu Zhengrong Jiang Jessica Liu Dong Xu Laurie MacDonald | 2007 | Hepatology International2007，，3： | 1 |
| 4 | Virologic, serologic, and biochemical outcomes through 2?years of treatment with entecavir and lamivudine in nucleoside-na?ve Chinese patients with chronic hepatitis B: a randomized, multicenter study显示文摘 | Guangbi Yao ChengWei Chen WeiLun Lu Hong Ren DeMing Tan YuMing Wang DaoZheng Xu Jessica Liu Dong Xu Cyril Llamoso | 2008 | Hepatology International2008，，4： | 1 |
| 5 | A High-Performance RSA Coprocessor Based on Half-Carry-Save and Dual-Core MAC Architecture显示文摘This research focuses on the methods to improve the throughput and lower the power for low cost RSA coprocessors. We proposed the following optimized methods: 1. A fast half-carry-save Montgomery modular multiplication algorithm suitable for hardware implementation; 2. A high-speed dual-core multiplier accumulator architecture to optimize the critical path; 3. Several lowpower optimization schemes for the RSA coprocessor. The design has been implemented with TSMC 90 nm technology, and the experimental results show that the critical path is 2.71 ns, the power consumption is just 9.76 m W and the throughput can reach 381.57 kbps. Compared with relative works, our design is featured by the minimal power and the best overall performance, thus it is most suitable for applications in low-power systems. | DING Yanyu HU Jianguo WANG Deming TAN Hongzhou | 2018 | Chinese Journal of Electronics2018，27，1： | 0 |
| 6 | Design of hollow core step-index antiresonant fiber with stepped refractive indices cladding显示文摘With the benefits of low latency,wide transmission bandwidth,and large mode field area,hollow-core antiresonant fiber(HC-ARF)has been a research hotspot in the past decade.In this paper,a hollow core step-index antiresonant fiber(HC-SARF),with stepped refractive indices cladding,is proposed and numerically demonstrated with the benefits of loss reduction and bending improvement.Glass-based capil-laries with both high(n=1.45)and low(as low as n=1.36)refractive indices layers are introduced and formatted in the cladding air holes.Using the finite element method to perform numerical analysis of the designed fiber,results show that at the laser wavelengths of 980 and 1064 nm,the confinement loss is favorably reduced by about 6 dB/km compared with the conventional uniform cladding HC-ARF.The bending loss,around 15 cm bending radius of this fiber,is also reduced by 2 dB/km.The cladding air hole radius in this fiber is further investigated to optimize the confinement loss and the mode field diameter with single-mode transmission behavior.This proposed HC-SARF has great potential in optical fiber transmission and high energy delivery. | Botao DENG Chaotan SIMA Hongyu TAN Xiaohang ZHANG Zhenggang LIAN Guoqun CHEN Qianqing YU Jianghe XU Deming LIU | 2021 | Frontiers of Optoelectronics2021，14，4： | 0 |
| 7 | Built-in ESD Protection for RFID Tag ICs显示文摘The built-in Electro-Static discharge(ESD) protection circuits for Radio frequency identification(RFID) tag ICs are proposed. The ESD protection function is built into the rectifier and amplitude limiter.The rectifier and limiter are connected directly to the RF interface, and some transistors can discharge the larger current. These transistors can be used to build ESD protection circuits, through the redesign and optimization. The built-in ESD protection circuits can improve the ESD protection level and reduce the layout area. The circuits have been fabricated in 0.18μm CMOS process. The test results show that the built-in ESD protection circuits work well under 4kV ESD pressure and save as much as 72% of the layout area compare with foundry standard ESD protection cells. | DING Yi HU Jianguo DUAN Zhikui WANG Deming DING Yanyu TAN Hongzhou | 2016 | Chinese Journal of Electronics2016，25，6： | 0 |
| 8 | RELATIONSHIP BETWEEN THE CLINICAL USE OF ANTIBIOTIC AND PRODUCTION OF ESBLS显示文摘Objective:To determine the relationship between the application of antibiotic and the production of extended spectrum β-lactamases (ESBLs).Methods:ESBLs were detected by the double disc diffusion method among 161 gram-negative bacilli isolated from clinical specimens.The use of antibiotic in the patients was investigated before ESBLs were detected. Results:The rate of ESBLs-producing strains was 35.4% (57/161). In the patients with ESBLs-producing strains, the utilization rates of antibiotic and the third-generation cephalosprin were 96.4% (55/57) and 42.1% (24/57) respectively, which were significantly higher than those without ESBLs-producing strains [80.6% (84/104) and 16.3% (17/104), respectively].There were significant differences ( P <0.05 and P <0.005,respectively) between the two groups of patients.The duration of the third-generation cephalosprins therapy was significantly longer in the patients with ESBLs-producing strains [(7.5 ± 5.4)d] than those without ESBLs-producing strains [(2.7±2.6)d, P <0.05].Conclusion:The application of antibiotic, especially the third-generation cephalosprins, is the risk factor for the production of ESBLs. | Liu Wenen, Tang Yin, Wang Lange,Tan Deming Xiangya Hospital, Central South University, Changsha 410008 | 2003 | 中国现代医学杂志2003，13，8： | 0 |
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