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| 1 | Scorpion toxin BmKI directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats显示文摘在主要感觉神经原的电压门钠隧道(VGSC ) 在把疼痛信号传给中央神经系统起一个关键作用。BmK 我, site-3 钠从蝎子 Buthus martensi Karsch 的隧道特定的毒素,在老鼠导致疼痛行为。然而,我不是的 BmK 指向的 VGSC 的子类型完全变清。我们因此调查了 BmK 的效果我在当前的振幅, gating 和 Na 在 DRG 神经原与 neuronal hyperexcitability 被联系的 v 1.8, 。它被发现我 dose-dependently 增加了的那 BmK Na v 1.8 电流在小型(< 25 ? m ) 尖锐地分裂的 DRG 神经原,它在快、慢的 inactivation 上与它的抑制相关。而且,电压依赖者激活和不变的 inactivation Na v 1.8 在一个 hyperpolarized 方向被转移。因此, BmK 我减少了 neuronal 易兴奋性的阀值并且增加了在 DRG 神经原开火的行动潜力。在结论,我们的数据清楚地表明了我调制了的那 BmK Na v 1.8 显著地,建议我为学习 Na v 1.8。并且 Nav1.8 是与 BmK 我唤起疼痛有关的一个重要目标。 | Pin Ye Yunlu Jiao Zhenwei Li Liming Hua Jin Fu Feng Jiang Tong Liu Yonghua Ji | 2015 | Protein & Cell2015，6，6： | 10 |
| 2 | Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain显示文摘BmK 我,从蝎子 Buthus martensi Karsch (BmK ) 的毒液净化了,是电压门钠隧道(VGSC ) 的一个受体 site-3-specific 调节的人并且能在老鼠导致疼痛相关的行为。tetrodotoxin 抵抗(TTX-R ) 钠隧道 Nav1.8 贡献大多数在背面的根 ganglia (DRG ) 位于行动潜力向上的一击下面的钠水流神经原并且可以用作 BmK 指向的一条批评离子隧道我。此处,使用 electrophysiological,分子、行为的途径,我们调查了在 DRG 的 Nav1.8 的异常表示是否贡献 BmK 导致的疼痛的产生我。Nav1.8 的表示被发现显著地在跟随 BmK 的 intraplantar 注射的 mRNA 和蛋白质层次被增加我在老鼠。另外, TTX-R Nav1.8 钠隧道的当前的密度显著地被增加, Nav1.8 的 gating 动力学也从 BmK 我对待老鼠在 DRG 神经原被改变。而且,自发的疼痛和机械 allodynia,然而并非热痛觉过敏由 BmK 导致了我,被它的选择 blocker A-803467 显著地通过 Nav1.8 钠隧道的任何一个封锁减轻或在由在老鼠指向 Nav1.8 的 antisense oligodeoxynucleotide (AS-ODN ) 的 DRG 的 Nav1.8 表示击倒。最后,我被给看导致的 BmK 提高了疼痛行为在里面完全的 freund 的助手(CFA ) 在 DRG 由于 Nav1.8 的在表示上部分煽动了老鼠,它是。我们的结果建议 DRG 神经原上的 Nav1.8 隧道的功能的起来规定在老鼠贡献 BmK 我导致疼痛的发展。 | Pin Ye Liming Hua Yunlu Jiao Zhenwei Li Shichao Qin Jin Fu Feng Jiang Tong Liu Yonghua Ji | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 3 |
| 3 | SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration显示文摘SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals.However,it remains undear whether and how SARS-CoV-2 crosses the blood-brain barrier(BBB).Herein,SARS-CoV-2 RNA was occasionally detected in the vascular wall and perivascular space,as well as in brain microvascular endothelial cells(BMECs)in the infected K18-hACE2 transgenic mice.Moreover,the permeability of the infected vessel was in creased.Furthermore,disin tegrity of BBB was discovered in the infected hamsters by administration of Evans blue.Interestingly,the expression of claudin5,ZO-1,occludin and the ultrastructure of tight junctions(TJs)showed unchanged,whereas,the basement membrane was disrupted in the infected animals.Using an in vitro BBB model that comprises primary BMECs with astrocytes,SARS-CoV-2 was found to infect and cross through the BMECs.Consistent with in vivo experiments,the expression of MMP9 was increased and collagen IV was decreased while the markers for TJs were not altered in the SARS-CoV-2-infected BMECs.Besides,inflammatory responses including vasculitis,glial activation,and upregulated inflammatory factors occurred after SARS-CoV-2 infection.Overall,our results provide evidence supporting that SARS-CoV-2 can cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of TJs. | Ling Zhang Li Zhou Linlin Bao Jiangning Liu Hua Zhu Qi Lv Ruixue Liu Wei Chen Wei Tong Qiang Wei Yanfeng Xu Wei Deng-Hong Gao Jing Xue Zhiqi Song Pin Yu Yunlin Han Yu Zhang Xiuping Sun Xuan Yu Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 4 | Qingfei Paidu Decoction for COVID-19: A Bibliometric Analysis显示文摘Traditional Chinese medicine(TCM)has been used for thousands of years in fighting epidemics and has achieved remarkable therapeutic effects[1].The coronavirus disease 2019(COVID-19)pandemic has been effectively controlled in China under a series of policies. | LIU Si Hong MA Yan SHI Nan Nan TONG Lin ZHANG Lei CHEN Ren Bo FAN Yi Pin JI Xin Yu GE You Wen ZHANG Hua Min WANG Yan Ping WANG Yong Yan | 2021 | Biomedical and Environmental Sciences2021，34，9： | 2 |
| 5 | Occupational Health Risk Assessment of Benzene,Toluene,and Xylene in Shanghai显示文摘Objective This study was designed to conduct a retrospective and systematic occupational health risk assessment(OHRA)of enterprises that used benzene,toluene,and xylene(BTX)in Shanghai,China.Methods All data for the study were obtained from 1,705 occupational health examination and evaluation reports from 2013 to 2017,and a semiquantitative model following Chinese OHRA guidelines(GBZ/T 298-2017)was applied for the assessment.Results The selected enterprises using BTX were mainly involved in manufacturing of products.Using the exposure level method,health risk levels associated with exposure to BTX were classified as medium,negligible,or low.However,the risk levels associated with benzene and toluene were significantly different according to job types,with gluers and inkers exhibiting greater health risks.For the same job type,the health risk levels assessed using the comprehensive index method were higher than those using the exposure level method.Conclusion Our OHRA reveals that workers who are exposed to BTX still face excessive health risk.Additionally,the risk level varied depending on job categories and exposure to specific chemicals.Therefore,additional control measures recommended by OHRA guidelines are essential to reduce worker exposure levels. | WANG Tong Shuai SONG Bo SUN Qing Hua LIN Yong Xin SUN Yuan SUN Pin JIA Xiao Dong William W.Au MEI Can Hua XIA Zhao Lin | 2021 | Biomedical and Environmental Sciences2021，34，4： | 2 |
| 6 | Onset of Multiple Site Damage and Widespread Fatigue Damage in Ag- ing airplanes显示文摘 | DAVID Y JEONG PIN TONG | 1997 | International Journal of Fracture1997，85，： | 1 |
| 7 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 8 | Linear electro-elastic analysis of a cavity or a crack in a piezoelectric material显示文摘 | ZHANG Tong-yi QIAN Cai-fu TONG Pin | 1998 | Int J Solids Structures1998，35，： | 1 |
| 9 | Linear electro-elastic analysis of a cavity or a crack in a piezoelectric material显示文摘 | ZHANG Tong-yi QIAN Cai-fu TONG Pin | 1998 | Internat J Solids Structures1998，35，17： | 1 |
| 10 | A hybrid- element approach to crack problems in plane elasticity显示文摘 | TONG Pin PIAN T H H LASRY S J | 1973 | International Journal for Numerical Methods in Engineering1973，7，3： | 1 |
| 11 | Fracture mechanics for a mode III crack in a piezoelectric material显示文摘 | Tong-Yi Zhang Pin Tong | 1995 | International Journal of Solids and Structures1995，，3： | 1 |
| 12 | Fracture of piezoelectric ceramics显示文摘 | Zhang Tong-Yi Zhao Minghao Tong Pin | 2001 | Adv Appl Mech2001，38，： | 1 |
| 13 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 14 | Equivalent Transverse Shear Stiffness of Honeycomb Cores 显示文摘 | Shi Guangyu Tong Pin | 1995 | Solid Structures1995，32，10： | 1 |
| 15 | Equivalent transverse shear stiffness of honeycomb cores显示文摘 | Shi Guangyu Tong Pin | 1995 | Solid Structures1995，32，10： | 1 |
| 16 | Local and global energy release rates for an electrically yielded crack in a piezoelectric ceramic显示文摘 | Gao Hua-jian Zhang Tong-yi Tong Pin | | 0，，04： | 1 |
| 17 | Effects of bonding force on contact pressure and frictional energy in wire bonding显示文摘 | Yong Ding Jang-Kyo Kim Pin Tong | 2005 | Microelectronics Reliability2005，，7： | 1 |
| 18 | Numerical analysis of ultrasonic wire bonding: Effects of bonding parameters on contact pressure and frictional energy 显示文摘 | Yong Ding Jang - Kyo Kim Pin Tong | 2006 | Mechanics of material2006，38，： | 1 |
| 19 | Effects of bonding force on contact pressure and frictional energy in wire bonding显示文摘 | DING Yong KIM J K TONG Pin | 2006 | Microelectronics Reliability2006，46，7： | 1 |
| 20 | Novel(Ni, Fe)S2/(Ni, Fe)3S4 solid solution hybrid: an efficient electrocatalyst with robust oxygen-evolving performance显示文摘Fabrication of high-activity electrocatalysts with operational stability is desperately needed to achieve efficient energy conversion.Herein,for the first time,we highlight a novel electrocatalyst based on binary nickel iron sulfide solid solution hybrids on carbon cloth for oxygen evolution reaction.Benefitting from the synergistic effect of varied phases and the interfacial connection between(Ni,Fe)S2 and(Ni,Fe)3S4 to accelerate the charge transport,the Ni incorporation to optimize the electronic structure of the hybrids and the downshift of the d-band center to facilitate the desorption of oxygen intermediates,the partial charge-transfer between Fe and Ni to boost the generation of catalytically active Ni3+as well as the unique nanosphere structure to offer enough buffer area for the volume changes during constant redox reactions,the obtained binary nickel iron sulfide hybrids((Ni,Fe)S2/(Ni,Fe)3S4)display high catalytic reactivity with a low overpotential of 210 mV to reach the current density of 10 mA cm-2,and excellent stability with negligible activity deterioration,making the hybrid a promising candidate for electrocatalytic alkaline water oxidation. | Pin Hao Ying Xin Jian Tian Liyi Li Junfeng Xie Fengcai Lei Lili Tong Hong Liu Bo Tang | 2020 | Science China Chemistry2020，63，8： | 0 |
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