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| 1 | Evolution of systemic therapy of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) commonly occurs in hepatitis B endemic areas, especially in Asian countries. HCC is highly refractory to cytotoxic chemotherapy. This resistance is partly related to its tumor biology, pharmacokinetic properties, and both intrinsic and acquired drug resistance. There is no convincing evidence thus far that systemic chemotherapy improves overall survival in advanced HCC patients. Other systemic approaches, such as hormonal therapy and immunotherapy, have also disappointing results. Recently, encouraging results have been shown in using sorafenib in the treatment of advanced HCC patients. In this review, we concisely summarize the evolution of developments in the systemic therapy of advanced HCC. | Thomas Yau Pierre Chan Richard Epstein Ronnie T Poon | 2008 | World Journal of Gastroenterology2008，14，42： | 23 |
| 2 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 3 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 4 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 5 | Splenic and portal venous obstruction in chronic pancreatitis显示文摘 | Pr. Pierre Bernades André Baetz Philippe Lévy Jacques Belghiti Yves Menu Fran?ois Fékété | 1992 | Digestive Diseases and Sciences1992，，3： | 2 |
| 6 | Estimating EGARCH-M Models:Science or Art?显示文摘 | Eileen F Pierre S T | 1998 | The Quarterly Revi-ew of Economics and Finance1998，38，： | 1 |
| 7 | Arterial emboliz-ation for massive hematuria following transurethral prostatectomy显示文摘 | Michel F Dubruille T Jean- Pierre C | 2002 | J Urol2002，168，： | 1 |
| 8 | Relief of BPO or improvement in quality of life显示文摘 | Pierre T | 1998 | Eur urol1998，，： | 1 |
| 9 | Deformylase as a target for new generation,broad spectrum antimicrobial agents 显示文摘 | Giglione C Pierre M Meinnel T | 2000 | Mol Microbiol2000，36，6： | 1 |
| 10 | Optimal Path Planning for UCAV to Defeat Radar Tracking 显示文摘 | Pierre T K Semyou M M Frederick H Z | 2006 | Journal of Guidance Control and Dynamics March-April2006，29，2： | 1 |
| 11 | Molecular characterization of two functional domains of CLIP-170 in vivo显示文摘 | Pierre P Pepperkok R Kreis T E | 1994 | Journal of Cell Science1994，107，7： | 1 |
| 12 | RnKSN, a floral repressor, forms protein complexes with RoFD and RoFT to regulate vegetative and reproductive development in rose 显示文摘 | RANDOUX M DAVIERE J M JEAUFFRE J THOUROUDE T PIERRE S TOUALBIA Y PERROTTE J REYNO1RD J P JAMMES M J HIBRAND-SAINT OYANT L FOUCHER F | 2014 | New Phytologist2014，202，1： | 1 |
| 13 | Electrowinning of zinc from alkaline solutions at high current densities显示文摘 | Pierre J S T Piron D L | 1990 | Journal of Applied Electrochemistry1990，20，1： | 1 |
| 14 | Localization phenomena in mistuned assemblies with cyclic symmetry part 2: forced vibrations 显示文摘 | Wei S T Pierre C | 1988 | ASME Journal of Vibration Acoustics Stress and Reliability in Design1988，110，4： | 1 |
| 15 | Influence of key parameters on drying shrinkage of cementitious materials显示文摘 | Beno?t Bissonnette Pascale Pierre Michel Pigeon | 1999 | Cement and Concrete Research1999，29，： | 1 |
| 16 | Insulin-like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing显示文摘 | PIERRE EJ REGINO PEREZ-POLO J ALFRED T | 1997 | J Burn Care Rehabil1997，18，： | 1 |
| 17 | Employment branding in the knowledge economy显示文摘 | Michael T Ewing Leyland F Pitt Nigel M de Bussy and Pierre Berthon | 2002 | International Journal of Advertising2002，21，1： | 1 |
| 18 | Dilatation as a marker of pulmonary veins initiating atrial fibrillation显示文摘 | Yamane T Shah DC Pierre JA | 2002 | J Interv Card Electrophysiol2002，6，3： | 1 |
| 19 | Isolation and expression of cold specific genes in potato (Solanum sogarandinum)显示文摘 | Rorat T Wojciech J G Pierre B | 1998 | Plant Science1998，133，1： | 1 |
| 20 | Optimal path planning for unmanned combat aerial vehi- cles to defeat radar tracking 显示文摘 | Pierre T Kabamba Semyon Meerkov Frederick H Zeitz | 2006 | Journal of Guidance Control and Dynamics2006，29，2： | 1 |
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