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| 1 | MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases显示文摘In spite of the introduction in therapy of highly effective biological agents,glucocorticoids(GCs)are still employed to induce remission in moderate to severe inflammatory bowel diseases(IBD),but considerable inter-individual differences in their efficacy and side effects have been reported.The effectiveness of these drugs is indeed very variable and side effects,particularly severe in pediatric patients,are common and often unpredictable:the understanding of the complex gene regulation mediated by GCs could shed light on the causes of this variability.In this context,microRNAs(miRNAs)represent a new and promising field of research.miRNAs are small non-coding RNA molecules that suppress gene expression at post-transcriptional level,and are fine-tuning regulators of diverse biological processes,including the development and function of the immune system,apoptosis,metabolism and inflammation.Emerging data have implicated the deregulated expression of certain miRNA networks in the pathogenesis of autoimmune and inflammatory diseases,such as IBD.There is a great interest in the identification of the role of miRNAs in the modulation of pharmacological response;however,the association between miRNA and GC response in patients with IBD has not yet been evaluated in a prospective clinical study.The identification of miRNAs differently expressed as a consequence of GC treatment in comparison to diagnosis,represents an important innovative approach that could be translated into clinical practice.In this review we highlight the altered regulation of proteins involved in GC molecular mechanism by miRNAs,and their potential role as molecular markers useful for predicting in advance GC response. | Sara De Iudicibus Marianna Lucafò Stefano Martelossi Chiara Pierobon Alessandro Ventura Giuliana Decorti | 2013 | World Journal of Gastroenterology2013，19，44： | 4 |
| 2 | Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600–Mutant Colorectal Cancer显示文摘 | Corcoran Ryan B. Atreya Chloe E. Falchook Gerald S. Kwak Eunice L. Ryan David P. Bendell Johanna C. Hamid Omid Messersmith Wells A. Daud Adil Kurzrock Razelle Pierobon Mariaelena Sun Peng Cunningham Elizabeth Little Shonda Orford Keith Motwani Monica Bai | 2015 | Journal of Clinical Oncology2015，，34： | 2 |
| 3 | Individualized therapy for metastatic colorectal cancer显示文摘 | A. Silvestri E. Pin A. Huijbers R. Pellicani E. M. Parasido M. Pierobon E. Petricoin L. Liotta C. Belluco | 2013 | J Intern Med2013，，1： | 2 |
| 4 | Bottleneck-induced transitions in a minimal model for intracellular transport 显示文摘 | PIEROBON P MOBILIA M KOUYOS R EREY E | 2006 | Phys Rev E2006，74，03： | 1 |
| 5 | Pneumonia in stroke pa- tients with oropharyngeal dysphagia: a six-month follow-up study显示文摘 | Masiero S Pierobon R Previato C | 2008 | Neurol Sci2008，29，3： | 1 |
| 6 | Pneumonis instroke patients with oroph aryngeal dysphagia; a six follow up study显示文摘 | Masiero S Pierobon R Previato C | 2008 | Neurol Sci2008，29，3： | 1 |
| 7 | A routing framework for energy harvesting wireless nanosensor networks in the Terahertz Band显示文摘 | Pierobon M Jornet J M Akkari N | 2014 | Wireless networks2014，20，5： | 1 |
| 8 | Surface-related drain current dispersion effects in AlGaN-GaN HEMTs显示文摘 | Meneghesso G Verzellesi G Pierobon R | 2004 | IEEE Trans Elec Dev2004，51，10： | 1 |
| 9 | Reliability analysis of GaN-Based LEDs for solid state illumination显示文摘 | MENEGHESSO G LEVADA S PIEROBON R | 2003 | IEICE Trans Electron2003，86，： | 1 |
| 10 | Sur- face-related drain current dispersion effects in AIGaN- GaN HEMTs显示文摘 | Meneghesso G Verzellesi G Pierobon R | 2004 | IEEE Electron Devices2004，51，10： | 1 |
| 11 | Surface-related drain current dispersion effects in AlGaN- GaN HEMTs 显示文摘 | Meneghesso G Verzellesi G Pierobon R | 2004 | IEEE Trans Electron Devices2004，51，10： | 1 |
| 12 | Nanonetworks , a new frontier in communications显示文摘 | Akyildiz IF JornetJ M Pierobon M | 2011 | Communications of the ACM2011，54，11： | 1 |
| 13 | mRNA detection by reverse transcfiption-PCR for monitoring viability over time in an Enterococcus faecalis viable but nonculturable population maintained in a laboratory microcosm 显示文摘 | Leo M M Pierobon S Taft M C | 2000 | App Environ Microbio12000，66，10： | 1 |
| 14 | Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory pheno- type and TREM-1 expression显示文摘 | Pierobon D Bosco MC Blengio F | 2013 | Eur J Immunol2013，43，4： | 1 |
| 15 | Ca^2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations显示文摘 | Brini M Manni S Pierobon N | 2005 | J Biol Chem2005，280，15： | 1 |
| 16 | Pneumonia in strokepatients with oroph aryngeal dysphagia:a six month follow upstudy显示文摘 | Masiero S Pierobon R Previato C | 2008 | Neurol S ci2008，29，3： | 1 |
| 17 | Sur- face-related drain current dispersion effects in AIGaN-GaN HEMTs显示文摘 | Meneghesso G Verzellesi G Pierobon R | 2004 | IEEE Electron Devices2004，51，10： | 1 |
| 18 | Ca^2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations 显示文摘 | Brini M Manni S Pierobon N | 2005 | J Biol Chem2005，280，15： | 1 |
| 19 | Multiplexed Protein Signal Pathway Mapping Identifies Patients With Rectal Cancer That Responds to Neoadjuvant Treatment显示文摘 | Enzo Mammano Francesca Galdi Mariaelena Pierobon Emanuela Tessari Jianghong Deng Salvatore Pucciarelli Marco Agostini Francesco De Marchi Vincenzo Canzonieri Antonino De Paoli Claudio Belluco Lance Liotta Emanuel Petricoin Pierluigi Pilati Donato Nitti | 2012 | Clinical Colorectal Cancer2012，，4： | 1 |
| 20 | Performance e- valuation of bluetooth polling schemes: an analytical approach显示文摘 | Miorandi D Zanella A Pierobon G | 2004 | ACM Mobile Networks and Applica- tions2004，9，1： | 1 |
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