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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Positron emission tomography study of human brain functional development 显示文摘 | Chungani H Phelps M Mazziotta J | 1987 | Ann Neurol1987，22，： | 2 |
| 3 | Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin显示文摘 | Phelps M A Swaan P W | 2003 | J Pharmacol Exp Ther2003，306，： | 1 |
| 4 | Induction of epithelial- mesenchymal transition in alveolar epithelial cells by transforming growth factor -β1, potential role in idiopathic pulmonary fibrosis显示文摘 | WILLIS B C LIEBLER J M LUBY- PHELPS K | 2005 | Am J Pathol2005，166，5： | 1 |
| 5 | Congenital malformation of the ear and cochear implantation in children:Review and Temporal bone report of common cavity显示文摘 | GRAHAM J M PHELPS P D MICHAELS L | 2000 | J Laryngol Otol Suppl2000，25，： | 1 |
| 6 | Elevation of matrix metalloprotei-nases 3 and 9 in cerebrospinal fluid and blood in patients with severetraumatic brain injury显示文摘 | Grosstete M Phelps J Arko L | 2009 | Neurosurgery2009，65，4： | 1 |
| 7 | Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide显示文摘 | P.V O'Donnell L Luznik R.J Jones G.B Vogelsang M.S Leffell M Phelps P Rhubart K Cowan S Piantadosi E.J Fuchs | 2002 | Biology of Blood and Marrow Transplantation2002，，7： | 1 |
| 8 | Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research past, present, and future 显示文摘 | RAUCH S L SHIN L M PHELPS E A | 2006 | Biol Psychiatry2006，60，4： | 1 |
| 9 | The incidence and course of retinopathy of prematuri- ty :findings from the early treatment for retinopathy of prematu- rity study显示文摘 | Good WV Hardy RJ Dobson V Paimer EA Phelps DL Quintos M et cd | 2005 | Pediatrics2005，116，1： | 1 |
| 10 | Nuclear integration of glucocorticoid receptor and nuclear factor-kappa B signaling by CREB-binding protein and steroid receptor coactivator-1显示文摘 | Sheppard K A Phelps K M Williams A J | 1998 | The Journal of Biological Chemistry1998，273，29： | 1 |
| 11 | Interfirm collaboration net- works: The impact of large-scale network structure on firm innovation显示文摘 | Schilling M A Phelps C C | 2007 | Mailagement Science2007，53，7： | 1 |
| 12 | Interfirm collaboration netw- orks: The impact of large-scale network structure on firm innovation显示文摘 | Schilling M A Phelps C C | 2007 | Management Science2007，53，7： | 1 |
| 13 | Overexpression of follistatin in trout stimulates increased muscling显示文摘 | Medeiros E F Phelps M P Fuentes F D | 2009 | American Journal of Physiology-regulatory Integrative and ComparativePhysiology2009，297，： | 1 |
| 14 | The incidence and course of retinopathy of prematurity : Findings from the early treatment for retinopathy of prematurity study 显示文摘 | Good WV Hardy RA Dobson V Palmer EA Phelps DL Quintos M | 2005 | Pediatrics2005，116，1： | 1 |
| 15 | An interactive evolutionary metaheuristic for multiobjective combinatorial optimization显示文摘 | Phelps S Ktksalan M | 2003 | Management Science2003，49，12： | 1 |
| 16 | Interfim/ collabm'ation networks: the impact of large - scale network structure on finn innovation 显示文摘 | SCHILLING M A PHELPS C C | 2007 | Management Science2007，53，7： | 1 |
| 17 | Efficacy of ropivacaine, bupivacaine, and levobupivacaine for labor epidural analgesia显示文摘 | Sah N Vallejo M Phelps A | 2007 | J Clin Anesth2007，19，3： | 1 |
| 18 | Synthesis and structure-activity relationships of chiral allosteric modifiers of hemoglobin显示文摘 | PHELPS GRELLA M DANSO-DANQUAH R SAFO MK | 2000 | J Med Chem2000，43，25： | 1 |
| 19 | Evaluation of an ethylene oxide sterilizer显示文摘 | Babb JR Phelps M Downs J | 1983 | Sterile World1983，5，2： | 1 |
| 20 | Interfirm collaboration net- works: The impact of large-scale network structure on firm innovation显示文摘 | Schilling M A Phelps C C | 2007 | Management Science2007，53，7： | 1 |
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