|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Involvement of the cyclin2 dependent kinase inhibitaor p16 INK4a in replieative senescence of normal human fibroblasts显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 3 | Involvement of the cyclin-de- pendent kinase inhibitor p 16 (INK4a) in replicative senescence of normal human fibroblasts显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 4 | Involvement of the cyclin-dependent kinase inhibitor p16(INK4a)in replicative senescence of normal human fibroblasts显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 5 | Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci U S A1996，93，13： | 1 |
| 6 | Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC-or N-MYC-regulated protein expression 显示文摘 | Pawlik CA Krull EJ Phelps DA Burger RA Harris LC Potter PM Danks MK | 2001 | Cancer Res2001，61，7： | 1 |
| 7 | Involvement of the cyclin dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts显示文摘 | Alcorta DA Xiong Y Phelps D et cd | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 8 | Involvement of thecyclindependent kinas inhibitor pl61NK4a in replicati,,'e senescence of normal human fibroblasts 显示文摘 | Alcorla DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 9 | Involvement of the cyclin-dependent kinase inhibitor p16(INK4a)in replicative senescence of normal human fibroblasts显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci U S A1996，93，13： | 1 |
| 10 | ICAM-2 Expression Mediates a Membrane-Actin Link,Confers a Nonmetastatic Phenotype and Reflects Favorable Tumor Stage or Histology in Neuroblastoma显示文摘 | Yoon KJ Phelps DA Bush RA | 2008 | PLoSONE2008，3，11： | 1 |
| 11 | Involvement of the cyclin - de- pendent kinase inhibitor p16(INK4a) in replicative sensecence of nor- mal human fibroblasts 显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proe Natl Acad Sci USA1996，93，13： | 1 |
| 12 | Polydactyly of the foot显示文摘 | Phelps DA Groqan DP | 1985 | J Pediatr Orthop1985，5，4： | 1 |
| 13 | The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis显示文摘 | Precht TA Phelps RA Linseman DA | 2005 | Cell Death Differ2005，12，1： | 1 |
| 14 | Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 15 | Insulin- like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons显示文摘 | Linseman DA Phelps RA Bouchard R J | 2002 | J Neumsci2002，22，： | 1 |
| 16 | The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis显示文摘 | Precht TA Phelps RA Linseman DA | 2005 | Cell Death Differ2005，12，3： | 1 |
| 17 | Involvement of the cyclindependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts 显示文摘 | Alcorta DA Xiong Y Phelps D | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 18 | Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death ( Bim ) induc- tion and intrinsic death signaling in cerebellar granule neurons 显示文摘 | Linseman DA Phelps RA Bouchard R J | 2002 | J Neurosci2002，22，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员