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| 1 | Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection显示文摘 | Nezam Afdhal Stefan Zeuzem Paul Kwo Mario Chojkier Norman Gitlin Massimo Puoti Manuel Romero-Gomez Jean-Pierre Zarski Kosh Agarwal Peter Buggisch Graham R. Foster Norbert Br?u Maria Buti Ira M. Jacobson G. Mani Subramanian Xiao Ding Hongmei Mo Jenny C. Ya | 2014 | The New England Journal of Medicine2014，，： | 6 |
| 2 | Review of Cellulose Nanocrystal-based Fluorophore Materials and Their Application in Metal Ion Detection显示文摘Cellulose nanocrystals(CNCs), a unique and promising natural material extracted from native cellulose, have attracted considerable attention owing to their physical properties and special surface chemistry. This review focuses on chemical conjugation strategies that can be used for preparation of fluorescent-molecule labeled CNCs and the development of biomaterials.Furthermore, their application in the detection of metal ions and future development prospects are discussed. We hope to provide a clear view of the strategies for surface fluorescent modification of CNCs and their application in detection of metal ions. | Ya Wang Alain Dufresne Peter R. Chang XiaoZhou Ma Jin Huang | 2018 | Paper And Biomaterials2018，3，4： | 2 |
| 3 | Treatment of dye wastewater containing acid orange Ⅱ using a cell with three-phase three-dimensional electrode 显示文摘 | Xiong Ya Strunk Peter J | 2001 | Water Research2001，35，17： | 1 |
| 4 | Facile biosynthesis, separa- tion and conjugation of gold nanoparticles to doxorubicin 显示文摘 | Kumar SA Peter YA Nadeau JL | 2008 | Nanotechnology2008，10，49： | 1 |
| 5 | Methods of decision making in fuzzy environment and their applications显示文摘 | Peter Ya Ekel | 2001 | Third World Congress of Nonlinear Analysis2001，47，： | 1 |
| 6 | Treatment of dye wastewater containing acid orange Ⅱ using a cell with three-phase three--dimensional electrode显示文摘 | Xiong Ya Strunk Peter J Xia Hongyun | 2001 | Water Research2001，35，17： | 1 |
| 7 | Asmptotic normality of the maximum-likelihood estimator for general hidden Markov models 显示文摘 | Peter J Bickel Ya'acov Ritov Tobias Ryden | 1998 | The Annals of Statistics1998，26，4： | 1 |
| 8 | Treatment of dye wastewater containing acid orange II using a cell with three-phase three-dimensional electrode显示文摘 | Ya Xiong Peter J. Strunk Hongyun Xia Xihai Zhu Hans T. Karlsson | 2001 | Water Research2001，，17： | 1 |
| 9 | Treatment of dye wastewater containing acid orange Ⅱ using a cell with three-phase three-dimensional electrode显示文摘 | Xiong Ya Peter J Strunk Xia Hongyun | 2001 | Water Research2001，35，17： | 1 |
| 10 | Treatment of dye wastewater containing acid orangeⅡ using a cell with three-phase three-dimensional electrode显示文摘 | Ya Xiong Peter J S Hong Xin | 2001 | Water Research2001，35，7： | 1 |
| 11 | Hannun regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation显示文摘 | Feng X Becker KP Stribling SD Peters KG Hannun YA | 2000 | Biol Chem2000，275，17： | 1 |
| 12 | Mechanisms of cycloheximide-induced apoptosis in liver cells显示文摘 | Alice V Alessenko Peter Ya Boikov Galina N Filippova Alexey V Khrenov Anatoliy S Loginov Elena D Makarieva | 1997 | FEBS Letters1997，，1： | 1 |
| 13 | NEC1, a novel gene, highly expressed in nectary tissue of Petunia hybrida显示文摘 | Ya‐XinGe Gerco C.Angenent Peter E.Wittich JeroenPeters JohnFranken MarcoBusscher Le‐MinZhang EllenDahlhaus Martin M.Kater George J.Wullems TinekeCreemers‐Molenaar | 2008 | The Plant Journal2008，，6： | 1 |
| 14 | First detection of viruses in Africanized honey bees from Peru显示文摘Dear Editor,The ability of the Western honey bee,Apis mellifera,to adapt to most climates of the world and the ongoing standardization of colony management has made this species of honey bees the most important species for crop pollination.In recent years,Peru emerged as a main exporter of industrial crops.This industry is mainly concentrated in the Peruvian coastal region,because the local climate permits off-season | Orlando Yaez Graciano Tejada Peter Neumann | 2014 | Virologica Sinica2014，29，5： | 0 |
| 15 | Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain显示文摘Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor(GABAAR)mediated inhibition is essential for brain functioning;and its imbalance contributes to the pathogenesis of many brain disorders including neurodegenerative diseases and mental illnesses.Here we identify a novel glutamate-GABAAR interaction mediated by a direct glutamate binding of the GABAAR.In HEK293 cells overexpressing recombinant GABAARs,glutamate and its analog ligands,while producing no current on their own,potentiate GABA-evoked currents.This potentiation is mediated by a direct binding at a novel glutamate binding pocket located at theα+/β−subunit interface of the GABAAR.Moreover,the potentiation does not require the presence of aγsubunit,and in fact,the presence ofγsubunit significantly reduces the potency of the glutamate potentiation.In addition,the glutamate-mediated allosteric potentiation occurs on native GABAARs in rat neurons maintained in culture,as evidenced by the potentiation of GABAAR-mediated inhibitory postsynaptic currents and tonic currents.Most importantly,we found that genetic impairment of this glutamate potentiation in knock-in mice resulted in phenotypes of increased neuronal excitability,including decreased thresholds to noxious stimuli and increased seizure susceptibility.These results demonstrate a novel cross-talk between excitatory transmitter glutamate and inhibitory GABAAR.Such a rapid and short feedback loop between the two principal excitatory and inhibitory neurotransmission systems may play a critical homeostatic role in fine-tuning the excitation-inhibition balance(E/I balance),thereby maintaining neuronal excitability in the mammalian brain under both physiological and pathological conditions. | Ya Wen Zhifang Dong Jun Liu Peter Axerio-Cilies Yehong Du Junjie Li Long Chen Lu Zhang Lidong Liu Jie Lu Ning Zhou Dong Chuan Wu Yu Tian Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
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