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| 1 | Measurement and Interpretation of Connectivity of Chinese Cities in World City Network,2010显示文摘This is an empirical paper that measures and interprets the position of Chinese cities in the world city network in 2010. Building on a specification of the world city network as a′interlocking network′in which business services firms play the crucial role in city network formation, information is gathered about the presence of global service firms in cities. This information is converted into data to provide the′service value′of a city for a firm′s provision of corporate services in a 526(cities)×175(firms) matrix. These data are then used as the input to the interlocking network model in order to measure cities′connectivity and its predominant geographical orientation. Here we focus on the position of some key Chinese cities in this regard, and discuss and interpret results in the context of the urban dimensions of the′opening up′of the Chinese economy. | Ben DERUDDER Peter J TAYLOR Michael HOYLER NI Pengfei LIU Xingjian ZHAO Miaoxi SHEN Wei Frank WITLOX | 2013 | Chinese Geographical Science2013，23，3： | 40 |
| 2 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 3 | Genetics of hepatocellular carcinoma显示文摘The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis. | Andreas Teufel Frank Staib Stephan Kanzler Arndt Weinmann Henning Schulze-Bergkamen Peter R Galle | 2007 | World Journal of Gastroenterology2007，13，16： | 21 |
| 4 | 南海张裂过程及其对晚中生代以来东南亚构造的启示--IODP建议书735-Full介绍显示文摘南海的形成揭示了大陆边缘张裂和盆地形成的复杂模式,尽管已经进行了广泛研究,但是关于基底岩石和深海盆沉积层的精确年代数据还很缺乏,这使得对南海张裂年代的估计存在很大的误差,对张裂机制和历史的各种假设没有得到验证。同时只有对南海的张裂过程有了精确地分析与刻画,才能更好地理解西太平洋边缘海盆地的形成以及它们在印支块体受印度—欧亚板块碰撞而向东南挤出、青藏高原隆升中可能起到的作用。2009年正式提交的国际综合大洋钻探计划(IODP)建议书735-Full建议在南海深海盆内的4个站位上实施钻探。这4个站位分布在南海盆地4个不同的次级构造单元上(南海东北部、西北次海盆、东部次海盆和西南次海盆),这样的站位设计会确保完成本建议书的整体研究目标,即揭示南海的张裂历史和它对晚中生代以来东南亚构造的启示。位于南海盆地最东北部的站位有助于确定该区域地壳的属性和验证古南海是否存在,位于西北次海盆的站位可能会提供南海的最早张裂年代,另外2个分别位于东部次海盆和西南次海盆的站位将重点确定2个次海盆的绝对年龄、基底矿物成分与磁化率以及2个次海盆的相对张裂次序。这些站位的水深大约在2910~4400m,钻探深度预计到海底以下大约700~2200m,总的钻透深度为5959m,其中5359m穿透沉积层,另外600m或400m钻入基底。所有这些站位的位置是由已有的地球物理观测数据所确定,目前计划收集更多的地质与地球物理数据以满足IODP对井位调查数据的要求。 | 李春峰 汪品先 Dieter Franke 李家彪 Randell Stephenson 许树坤 Peter Michael 周祖翼 翦知湣 李前裕 刘志飞 耿建华 木村学 阎贫 丘学林 王嘹亮 解习农 吴时国 吴能友 | 2009 | 地球科学进展2009，24，12： | 20 |
| 5 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 6 | 报告随机对照试验的CONSORT声明修订版:说明与详述(一)显示文摘有充分的证据表明目前随机对照试验(RCT)的报告质量不尽如人意。最近的方法学调查表明,不恰当的报告及试验设计将使治疗措施的效果产生偏倚。这种系统偏差正严重损害RCT本可摒弃系统偏差的特征。RCT中的系统偏差反映出了科学性差,而科学性差会严重影响正确的伦理标准。科学家和编辑们共同制定了CONSORT(试验报告统一标准,ConsolidatedStandardsofReportingTrials,)声明以提高RCT报告质量。CONSORT声明由清单和流程图组成,作者可用来报告RCT。许多优秀期刊和重要国际性编辑组织已经采用CONSORT声明。CONSORT声明为作者提高临床试验报告质量提供指南,使得评价和解释RCT结果更方便。此文旨在增强大家对CONSORT声明的理解、应用和传播,并对每个清单项目的意义和原理进行了说明。很多项目都列出优秀报告的示例,并尽可能参考相关的经验性研究,还列出几个流程图的示例。CONSORT声明的说明和详述文件在以下网址可找到:http://gffzzff905fc352db4ba6h6w0v0vb9fkww6bbb.ffgz.tsg.suse.edu.cn,这是提高随机对照试验报告质量的有益资源。 | Douglas G.Altman Kenneth F.Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C.Gφtzsch Thomas Lang the CONSORT Group 刘雪梅 | 2005 | 中国循证医学杂志2005，5，9： | 19 |
| 7 | 相变材料微胶囊悬浮液在矩形小通道内层流流动传热的实验显示文摘本文进行了对比性的实验,以研究相变材料微胶囊(MEPCM)-水悬浮液在水力直径为2.71mm的矩形小通道内的层流流动传热性能。实验中用的MEPCM颗粒的平均粒径为4.97μm,与蒸馏水混合制备成质量浓度范围为0~20%的MEPCM-水悬浮液。对比性的实验是指,在相同的悬浮液质量流量和热力条件下,使用不同浓度的MEPCM悬浮液进行传热实验。实验发现,MEPCM悬浮液的冷却性能严重依赖于悬浮液的质量流量和悬浮液的质量浓度。质量浓度为5%的悬浮液在在整个质量流量范围内总是表现出比水好的冷却性能,它对应的是更低的壁面温度以及更好的传热系数。而对于更高质量浓度的悬浮液,在低质量流量的情况下,它们具有很好的冷却性能;而在高质量流量的情况下,它们表现出的冷却性能比水更差,它们对应更高的壁面温度以及更低的Nusselt数。 | 饶宇 Frank Dammel Peter Stephan 林贵平 | 2006 | 航空动力学报2006，21，6： | 18 |
| 8 | Characterization and functions of beta defensins in the epididymis显示文摘附睾β - defensins 由重复基因复制和分叉演变编码对病原体提供直接保护并且也在它的主要功能支持男繁殖的道的蛋白质的一个家庭。男道 defensins 也从病原体攻击便于恢复。β - defensins 拥有古老的保存顺序和在多细胞的有机体普遍的结构的特征,在种幸存建议基本角色。首领 SPAG11,二祖先地独立的β - defensin 基因的功能的熔化,生产根据 tissue-specificand 被表示的或者拼接的抄本的一个大家庭种类特定的限制。SPAG11 的复杂性在哺乳动物的进化的不同分支变化。有主人蛋白质的人的 SPAG11D 的相互作用在多重发信号的小径显示参与。 | Susan H. Hall Suresh Yenugu Yashwanth Radhakrishnan Maria Christina W. Avellar Peter Petrusz Frank S. French | 2007 | Asian Journal of Andrology2007，9，4： | 18 |
| 9 | Changing Connectivities of Chinese Cities in the World City Network,2010–2016显示文摘Against the backdrop of the sizable economic growth of China in recent years, this paper uses the most recent data gathering of the Globalization and World Cities(Ga WC) research network to update and supplement earlier research on the shifting global connectivity of Chinese cities. The update consists of an evaluation of the connectivity of Chinese cities in 2016, the supplement of an analysis of the changing position of Chinese cities in the world city network between 2010 and 2016. To this end, we build on a specification of the world city network as an ‘interlocking network' in which producer services firms play the crucial role in city network formation. Information about the presence of leading producer services firms in cities in 2010 and 2016 is used as the input to a bipartite network projection algorithm in order to measure cities' network connectivity. The first set of results discusses the geographies of urban connectivity in the world city network in 2016. The second set of results discusses standardized measures of change to reveal the major dimensions of the transformations between 2010 and 2016. We find that, with the exception of Hong Kong, Macao and Kaohsiung of Taiwan, all Chinese cities record connectivity gains. This wholesale rise in connectivity is nonetheless geographically uneven, with above all Beijing, Chengdu/Chongqing and Changsha/Wuhan becoming more connected. We conclude that the wholesale rise of Chinese cities in the world city network and their changing trajectories in the post-crisis era are embedded in shifting external and internal political economies. | Ben DERUDDER CAO Zhan LIU Xingjian SHEN Wei DAI Liang ZHANG Weiyang Freke CASET Frank WITLOX Peter J.TAYLOR | 2018 | Chinese Geographical Science2018，28，2： | 17 |
| 10 | The vital threat of an upper gastrointestinal bleeding: Risk factor analysis of 121 consecutive patients显示文摘瞄准:在预言死亡的病人风险由于分析重要性上面胃肠(UGI ) 在今天的治疗学的政体下面流血。方法:从 1998 ~ 2001,有 UGI 流血的诊断的 121 个病人在我们的医院里被对待。基于病人的数据,一回顾多变量数据分析与开始,超过 270 个单个因素被执行。随后,下列潜在的风险因素经历了逻辑回归分析:年龄,性,起始的血红素, coumarines ,肝肝硬化,前凝血酶时间(磅),胃溃疡(小弯曲),十二指肠溃疡(灯泡我们背墙),福雷斯特分类,脉管的树桩, variceal 流血, Mallory-Weiss 症候群, RBC 替换,周期性的流血,保守、外科的治疗。结果:七十男性(58%) 和 51 女性(42%) 有 70 的中部的年龄的病人(变化:21-96 ) 年被对待。他们的在里面医院死亡是 14% 。当(11/91 )12% 在保守治疗以后死于病人时,(6/30 )20% 在经历外科的治疗以后死了。流血的 UGI 由于十二指肠溃疡发生了(n = 36;30%) ,胃溃疡(n = 35;29%) ,食道的静脉曲张病(n = 12;10%) , Mallory-Weiss 症候群(n = 8;7%) ,粘膜的腐蚀损害(n = 20;17%) ,癌症(n = 5;4%) , coagulopathy (n = 4;3%) ,淋巴瘤(n = 2;2%) ,良性瘤(n = 2;2%) 并且未知理智(n = 1;1%) 。所有上述的因素的逻辑回归分析揭示了那肝肝硬化和十二指肠溃疡(灯泡我们背墙) 是为在 UGI 流血以后的一堂致命的功课的联系风险因素。在内视镜检查法以前,仅仅肝肝硬化是一个可估价的风险因素。此后,肝肝硬化,流血溃疡的地点(灯泡我们背墙) 并且病人的性(男性) 具有为有流血溃疡的病人的临床的结果(死亡) 的预示的重要性。结论:在今天的临床的常规使用的最预示的参数不在预言一个病人的重要威胁由流血的 UGI 摆姿势是足够可靠的。在另一方面,肝肝硬化更经常显著地与增加的风险被联系在在以后的十二指肠的墙定位的溃疡流血以后死。 | Peter Schemmer Frank Decker Genevieve Dei-Anane Volkmar Henschel Klaus Buhl Christian Herfarth Stefan Riedl | 2006 | World Journal of Gastroenterology2006，12，22： | 16 |
| 11 | 呈现科研数据知识库:re3data.org注册机制显示文摘科研人员在钻研科研问题与分享科研数据的过程中,需要某种基础设施来确保数据最大程度的获取性、稳定性和可用性。这类基础设施可以统称为科研数据知识库(Research Data Repository,RDR)。自2012年启动的re3data.org项目,主要从事科研数据知识库的登记注册,以及为科研人员、科研资助组织、图书馆和出版商等提供有关异构科研数据知识库的全景概述。截至2013年7月,已有400个科研数据知识库向re3data.org登记,其中288个采用re3data.org的信息图标,以协助科研人员遴选合适的知识库,并且存储与重用他们的数据。这篇论文描绘异构RDR的全景,表述机构的、学科的、跨学科的以及项目专业的RDR类型。深入描述re3data.org的特性,以及这套注册系统如何协助科研人员分辨适合存储和搜索科研数据的知识库。 | Heinz Pampel Paul Vierkant Frank Scholze Roland Bertelmann Maxi Kindling Jens Klump Hans-Jürgen Goebelbecker Jens Gundlach Peter Schirmbacher Uwe Dierolf 顾立平 | 2014 | 现代图书情报技术2014，，3： | 15 |
| 12 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 13 | 报告随机对照试验的CONSORT声明修订版:说明与详述(三)显示文摘 | Douglas G.Altman Kenneth F.Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C.GФtzsch Thomas Lang 刘雪梅 | 2005 | 中国循证医学杂志2005，5，11： | 8 |
| 14 | 报告随机对照试验的CONSORT声明修订版:说明与详述(二)显示文摘 | Douglas G. Altman Kenneth F. Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C. Gtzsch Thomas Lang 刘雪梅 | 2005 | 中国循证医学杂志2005，5，10： | 8 |
| 15 | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery显示文摘Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as PTFE.While collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery.Thus,biodegradable GBR membranes made of pure magnesium might be an alternative.In this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective.After implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft tissue.During the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect space.As the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier capabilities.During the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new bone.After the membrane had completely resorbed,only healthy tissue remained.The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane.Overall,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. | Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte | 2022 | Bioactive Materials2022，7，8： | 7 |
| 16 | 报告随机对照试验的CONSORT声明修订版:说明与详述(四)显示文摘Douglas G. Altman1, Kenneth F. Schulz2, David Moher3, Matthias Egger4, Frank Davidoff5, Diana Elbourne6, Peter C. Gtzsch7, Thomas Lang8 for the CONSORT | Douglas G. Altman Kenneth F. Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C. Gtzsch Thomas Lang 刘雪梅 | 2005 | 中国循证医学杂志2005，5，12： | 7 |
| 17 | 报告随机对照试验的CONSORT声明修订版:说明与详述(六)显示文摘 | Douglas G.Altman Kenneth F.Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C.Gφtzsche Thomas Lang 姚巡 | 2006 | 中国循证医学杂志2006，6，2： | 7 |
| 18 | 报告随机对照试验的CONSORT声明修订版:说明与详述(一)显示文摘 | Douglas G. Altman Kenneth F. Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C. Gφtzsch Thomas Lang 刘雪梅 秦莉 林东涛 邓长安 李静 吴泰相 李幼平 | 2006 | 中国实用内科杂志:临床前沿版2006，26，2： | 6 |
| 19 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 20 | Flow frictional characteristics of microencapsulated phase change material suspensions flowing through rectangular minichannels显示文摘An experimental investigation was conducted on the laminar flow frictional characteristics of suspensions with microencapsulated phase change material (MEPCM) in water flowing through rectangular copper minichannels. The MEPCM was provided at an average particle size of 4.97 μm, and was mixed with distilled water to form suspen- sions with various mass concentrations ranging from 0 to 20%. The experiment was per- formed to explore the effect of MEPCM mass concentration on friction factor and pressure drop in the minichannels. The Reynolds number ranged from 200 to 2000 to provide laminar and transitional flows. It was found that the experimental data for the suspensions with 0 and 5% concentration agree well with the existing theoretical data for an incom- pressible, fully developed, laminar Newtonian flow. For the suspensions with mass con- centrations higher than 10%, there is an obvious increase in friction factor and pressure drop in comparison with laminar Newtonian flow. | Frank Dammel Peter Stephan | 2006 | Science China(Technological Sciences)2006，49，4： | 6 |
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