|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 3 | Nonalcoholic steatohepatitis显示文摘 | Shiva KK Peter FM | 2000 | Mayo Clinic Proceedings2000，75，： | 1 |
| 4 | Apolipoprotein E genotyping using the polymerase chain reaction and allele specific oligouncleotide primers显示文摘 | Blair FM Peter JH Jones | 1991 | J Lipid Res1991，32，： | 1 |
| 5 | Azole cross-resistance to ketoconazole,fluconazole,itraconazole and voriconazole in clinical Candida albicans isolates from HIV-infected children with oropharyngeal candidosis显示文摘 | Muller FM Weig M Peter J | 2000 | J Antimicrob Chemother2000，46，2： | 1 |
| 6 | Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: a systematic review of randomised controlled trials显示文摘 | Elisabeth M Hodson Cheryl A Jones Angela C Webster Giovanni FM Strippoli Peter G Barclay Kathy Kable Dushyanthi Vimalachandra Jonathan C Craig | 2005 | The Lancet2005，，9477： | 1 |
| 7 | Visfatin/pre-B- cell colony-enhancing factor (PBEF), aproinflammatory and cell motility-changing factor inrheumatoid arthritis显示文摘 | Meier FM Frommer KW Peters MA | 2012 | J Biol Chem2012，287，28： | 1 |
| 8 | Antibiot- ic prescribing and C-reactive protein testing for pulmonary infections in patients with intellectual disabilities 显示文摘 | Peters CM Schouwenaars FM Haagsma E | 2013 | Br J Gen Pract2013，63，610： | 1 |
| 9 | Visfatialpre -B - cell colony - enhancing factor ( PBEF ), a proinflammatory and eell motility -ehanging factor in rheumatoid arthritis 显示文摘 | Meier FM Frommer KW Peters MA | 2012 | J Biol Chem2012，287，28： | 1 |
| 10 | Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: a systematic review of randomised controlled trials显示文摘 | Elisabeth M Hodson Cheryl A Jones Angela C Webster Giovanni FM Strippoli Peter G Barclay Kathy Kable Dushyanthi Vimalachandra Jonathan C Craig | 2005 | The Lancet . 2005 (9477)2005，，9477： | 1 |
| 11 | Comparison of sbcutaneous siluble human insulin and insulin analogues ( AspB9, GluB27, AspB10, AspB28 ) on meal - related plasma glucose excursions in type 1 diabetic subjects 显示文摘 | Kang S Creagh FM Peter JR | 1991 | Diabetes Care1991，14，： | 1 |
| 12 | Review of fullerene toxicity andexposure-appraisal of a human health risk assessment, based on open literature 显示文摘 | Aschberger K Johnston HJ Stone V Aitken RJ Tran CL HankinSM Peters SAK Christensen FM | 2010 | Regul Toxicol Pharm2010，58，3： | 1 |
| 13 | Role of laparoscopic salpingostomy in the treatment of hydrosalpinx显示文摘 | Rebecca CT Jonathan B Peter FM | 2001 | Fertil Steril2001，75，3： | 1 |
| 14 | Role of laparoscopic salpingostomy in the treatment of hydrosalpinx显示文摘 | Rebecca CT Jonathan B Peter FM | 2001 | Fertil Steril2001，75，3： | 1 |
| 15 | Comparison of Subcutaneous Siluble Human Insulin and Insulin Analogues (AspB9 Glu B27,Asp B10,Asp B28)on Meal-related Plasma Glucose Excursions in Type 1 Diabetic Subjects显示文摘 | Kang S Creagh FM Peter JR | 1991 | Diabetes Care1991，14，： | 1 |
| 16 | isfatin/pre-B-ceU col- ony-enhancing factor (PBEF), a proinfiammatory and cell motili- ty-changing factor in rheumatoid arthritis 显示文摘 | Meier FM Frommer KW Peters MA | 2012 | J Biol Chem2012，287，28： | 1 |
| 17 | Nonalcoholic steatohepatitis显示文摘 | Peter FM | 2000 | Mayo Clinic Proceedings2000，75，7： | 1 |
| 18 | Comparison of subcutaneous siluble human insulin and insulin analogues(Asp B9 Glu B27,Asp B10,Asp B28) on meal-related plasma glucose excursions in type 1 diabetic subjects显示文摘 | Kang S Creagh FM Peter JR | 1991 | Diabetes Care1991，14，： | 1 |
| 19 | Health-related quality of life: a comparison of outcomes after lumbar fusion for degenerative spondy- lolisthesis with large joint replacement surgery and population norms显示文摘 | Sabarul AM Peter FM Owen DW | 2010 | The Spine Journal2010，10，4： | 1 |
| 20 | Venous air embolism and intracardiac thrombus after pressurized fibrin glue during liver surgery显示文摘 | Ebner FM Paul A Peters J | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员