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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Inpatient health care utilization in the United States among children, adolescents, and young adults with nephrotic syndrome显示文摘 | Gipson DS Messer KL Tran CL | 2013 | Am J Kidney Dis2013，61，6： | 1 |
| 3 | Evaluation of safety of increased time interval between chemoradiation and resection for rectal cancer显示文摘 | Tran CL Udani S Holt A | 2006 | AmJ Surg2006，192，6： | 1 |
| 4 | Tumor necrosis factor genetic polymo rphisms correlate with infections after liver transplantation显示文摘 | Freeman RBJ Tran CL Mattoli J | | 0，，： | 1 |
| 5 | Membranous nephropathy associa- ted with angiomatoid fibrms histiocytoma in a pediatric patient 显示文摘 | Kohorst MA Tran CL Folpe AL | 2014 | Pediatr Nephrol2014，29，11： | 1 |
| 6 | Nanotoxicology显示文摘 | Donaldson K Stone V Tran CL | 2004 | Toxicology2004，61，： | 1 |
| 7 | Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CIM + T cells and concomitantly impairs survival and proliferation 显示文摘 | Gaber T Tran CL Sehellmann S | 2013 | Eur J Immunol2013，43，6： | 1 |
| 8 | Evaluation of safety of increased time interval between chemoradiation and resection for rectal cancer显示文摘 | Tran CL Udani S Holt A | 2006 | Am J Surg2006，192，6： | 1 |
| 9 | Evaluation of safety of in- creased time interval between chemoradiation and resection for rectal cancer 显示文摘 | Tran CL Udani S Holt A | 2006 | Am J Surg2006，192，6： | 1 |
| 10 | LASIK flap revision using the IntraLase femtosecond laser 显示文摘 | Tran DB Binder PS Brame CL | 2008 | Int Ophthalmol Clin2008，48，1： | 1 |
| 11 | Does reoperation pre- dispose to postoperative wound infection in women undergoing opera- tion for breast cancer显示文摘 | Tran CL Langer S Brodefick-Villa G | 2003 | Am Surg2003，69，10： | 1 |
| 12 | Tumor necrosis factor genetic polymorphisms correlate with infections after liver transplantation 显示文摘 | Freeman RB Tran CL Mattoli J | 1999 | Transplantation1999，67，： | 1 |
| 13 | Instituting a conservative management protocol for pediatric blunt renal trauma: evaluation of a prospectively maintained patient registry显示文摘 | Fitzgerald CL Tran P Burnell J | 2011 | J Urol2011，185，3： | 1 |
| 14 | Pinl induction in the fi- brotic liver and its roles in TGF - β1 expression and Smad2/3 phosphorylation 显示文摘 | Jin WY Tran TH Sung CL | 2013 | Journal of Hepatology2013，60，6： | 1 |
| 15 | LASIK flap revision using the In- traLase femtoseeond laser 显示文摘 | Tran DB Binder PS Brame CL | 2008 | Int Ophthalmol Clin2008，48，1： | 1 |
| 16 | Factors associated with inconsistent condom use among female sex workers in Nha Trang, Vietnam 显示文摘 | Tran Tr Le CL Nguyen TL | 2008 | Asia Pac J Public Health2008，20，4： | 1 |
| 17 | Brain and behavior changes in 12- month-old Tg2576 and nontransgenic mice exposed to anesthetics 显示文摘 | Bianchi SL Tran T Liu CL | 2007 | Neurobiol Aging2007，29，7： | 1 |
| 18 | Review of fullerene toxicity andexposure-appraisal of a human health risk assessment, based on open literature 显示文摘 | Aschberger K Johnston HJ Stone V Aitken RJ Tran CL HankinSM Peters SAK Christensen FM | 2010 | Regul Toxicol Pharm2010，58，3： | 1 |
| 19 | Occupational and Environmental Medicine Nanotoxieology 显示文摘 | Donaldson K Stone V Tran CL | 2004 | 619:727 -7282004，619，： | 1 |
| 20 | Nanotoxicology显示文摘 | Donldson K Stone V Tran CL | 2004 | Occup Environ Med2004，61，： | 1 |
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