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| 1 | Laparoscopic surgery for benign and malign diseases of the digestive system:Indications,limitations,and evidence显示文摘The laparoscopic technique was introduced in gastrointestinal surgery in the mid 1980s.Since then,the development of this technique has been extraordinary.Triggered by technical innovations(stapling devices or coagulation/dissecting devices),nowadays any type of gastrointestinal resection has been successfully performed laparoscopically and can be performed laparoscopically dependent on the patient’s condition.This summary gives an overview over 30 years of laparoscopic surgery with focus on today’s indications and evidence.Main indications remain the more common procedures,e.g.,appendectomy,cholecystectomy,bariatric procedures or colorectal resections.For all these indications,the laparoscopic approach has become the gold standard with less perioperative morbidity.Regarding oncological outcome there have been several highquality randomized controlled trials which demonstrated equivalency between laparoscopic and open colorectal resections.Less common procedures like esophagectomy,oncological gastrectomy,liver and pancreatic resections can be performed successfully as well by anexperienced surgeon.However,the evidence for these special indications is poor and a general recommendation cannot be given.In conclusion,laparoscopic surgery has revolutionized the field of gastrointestinal surgery by reducing perioperative morbidity without disregarding surgical principles especially in oncological surgery. | Markus Alexander Küper Friederike Eisner Alfred K?nigsrainer J?rg Glatzle | 2014 | World Journal of Gastroenterology2014，20，17： | 9 |
| 2 | Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males显示文摘瞄准:如果总数与煽动性的肠疾病(IBD ) 在病人血小板 P-selectin (tP-selectin ) 总计,观察与疾病实体或活动有关, 5-aminosalicylic 酸(5-ASA ) 药或性。方法:tP-selectin 被免疫分析在十七个 IBD 病人和 12 健康控制测量。结果:比作控制,没有在与疾病实体或活动和 5-ASA 药有关的病人的 tP-selectin 的差别。当这些组根据性被切开时,男耐心的组与男控制相比显示出 tP-selectin 的高水平(153 ng/mL 对 94 ng/mL, P<0.05 ) 。结论:增加的 tP-selectin 层次可以改变煽动性的反应和危险性到 thromboembolic 疾病。当以前与可溶的 P-selectin 出现, tP-selectin 显示重要的性依赖者差别在未来研究考虑。 | J Patrik Fgerstam Per A Whiss | 2006 | World Journal of Gastroenterology2006，12，8： | 8 |
| 3 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 4 | Incorporating novelty and novel ecosystems into restoration planning and practice in the 21st century显示文摘Novelty pervades the biosphere.In some cases,potentially irreversible abiotic and/or biotic changes have led to the crossing of thresholds and thus the formation of“novel ecosystems.”Their widespread emergence(particularly on land)and the presence of continued environmental change challenge a traditional restoration goal of restoring an historical ecosystem.Instead,we argue that restoration could broaden its frame of reference to consider how novel ecosystems might be used to maintain global biodiversity and provide ecosystem services and,in doing so,save potentially wasted efforts in attempting to fulfil traditional goals.Here we explore this contention in more depth by addressing:Are novel ecosystems innovative planning or lowering the bar?We show that novel ecosystems were not innovative planning in their original conception.On the contrary,they were recognized as ecosystems that were recalcitrant to traditional restoration approaches,coupled with an awareness that they had arisen inadvertently through deliberate human activity,either on-or off-site.Their recalcitrance to traditional restoration suggests that alternative goals may exist for these ecosystems using sometimes innovative intervention.This management may include biodiversity conservation or restoration for ecological function.We elucidate the latter aspect with reference to an experiment in the wheatbelt of Western Australia—The Ridgefield Multiple Ecosystem Services Experiment—the design of which has been informed by ecological theory and the acceptance of novelty as an ecosystem component.Although novel ecosystems do provide opportunities to broaden restoration planning and practice,and ultimately maintain and conserve global biodiversity in this era of environmental change,they necessarily“lower the bar”in restoration if the bar is considered to be the historical ecosystem.However,in these times of flux,such a bar is increasingly untenable.Instead,careful and appropriate interventions are required at local,regional,and global scales.These interventions need to take history into account,use ecological and evolutionary theory to inform their design,and be mindful of valid concerns such as hubris.Careful interventions thus provide an opportunity for broadening restoration’s framework to focus on maintaining global biodiversity and delivering ecosystem services as well as the traditional goals of restoring historical ecosystems. | Michael P Perring Rachel J Standish Richard J Hobbs | 2013 | Ecological Processes2013，2，1： | 6 |
| 5 | Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China显示文摘Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been recognised.Methods: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli complex.Results: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler L.montis and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed morphologically.Conclusions: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou provinces.The taxonomic status of the other allopatric populations is less clear. However, as they differ to a degree comparable with that of the sympatric L. mandelli and the new species, we elevate L. idonea to species status, and retain L. seebohmi and L. montis as separate species, the latter with timorensis as a subspecies. Further research should focus on different populations of L. montis and the Mt Victoria population of L. mandelli. | Per Alstrom Canwei Xia Pamela C Rasmussen Urban Olsson Bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei | 2015 | Chinese Birds2015，，2： | 4 |
| 6 | Life cycle stages of heterophyid trematodes in Vietnamese freshwater fishes traced by molecular and morphometric methods显示文摘 | Jakob Skov Per W. Kania Anders Dalsgaard Thomas R. J?rgensen Kurt Buchmann | 2008 | Veterinary Parasitology2008，，1： | 2 |
| 7 | TIMESAT—a program for analyzing time-series of satellite sensor data显示文摘 | Per J?nsson Lars Eklundh | 2004 | Computers and Geosciences2004，，8： | 2 |
| 8 | Empirical Analysis of Business Growth Factors Using Swedish Data显示文摘 | Per Davidsson Bruce Kirehhojf Abdulnasser Hatemi- J Helena Gustavsson | 2002 | Journal of Small Business Management2002，40，4： | 1 |
| 9 | Effects of zucchini yellow mosaic virus on colonization and feeding behavior of Aphis gossypii (Homoptera: Aphididae) alatae显示文摘 | BLUA M J PERRING T M | 1992 | Environ Entomol1992，21，3： | 1 |
| 10 | Design of PID-type controllers using multiobjective genetic algorithms显示文摘 | Herreros A Baeyens E Perán J R | 2002 | Isa Transactions2002，41，4： | 1 |
| 11 | lnterIeukins in ather oscler o2sis: molecular pathways and therapeutic potential显示文摘 | Vonder Thusen jH Kui per J van Berkel TJ | 2003 | Phar macol Rev2003，55，13： | 1 |
| 12 | Association of the nucleic acid of squash leaf curl geminivirus with the whitefly Bemisia tabaci显示文摘 | Polston J E A1-Musa A Perring T M Dodds J A | | 0，，： | 1 |
| 13 | Determination of platinum and rhodium in dust and plant samples using microwave-assisted sample digestion and ICP-MS显示文摘 | NIEMEL魧M PER魧M魧KI P PIISPANEN J | 2004 | Analytica Chimica Acta2004，，521： | 1 |
| 14 | Microbial community structure and denitrification in a wetland mitigation bank 显示文摘 | electrophoresis analysis of electrophoresis ( TGGE ) in Per'alta A L Matthews J W Kent A D | 2010 | Appl Environ Microbiol2010，76，13： | 1 |
| 15 | Courtship behavior of Bemisia argentifolii (Hemiptera:Aleyrodidae) and whitefly mate recognition显示文摘 | Perring T M Symmes E J | | 0，，： | 1 |
| 16 | Factors affecting the measurement of energy expenditure during energy balance studies in preterm infants 显示文摘 | Perring J Henderson M Cooke RJ | 2000 | Pediatr Res2000，48，： | 1 |
| 17 | Pulsed odors from maize or spinach elicit orientation in European corn borer neonate larvae 显示文摘 | Piesik D Rochat D van der Pers J | 2009 | Journal of Chemical Ecology2009，35，9： | 1 |
| 18 | 查看详情显示文摘 | Schuch R Garibian A Nygaard P Raymond S Araik G Hans H S Patrick J P Per N | | 0，，： | 1 |
| 19 | Synthesis of new Gemini surfaetants显示文摘 | Oystein Rist Per H J Carlsen | 1999 | Synthetic Commun1999，29，5： | 1 |
| 20 | Osteoclast differentia-tion and recruitment during early stages of experimental tooth mo-vement in rats显示文摘 | Xie R Kuij pers - J agtman AM Maltha JC | 2009 | Eur J Oral Sci2009，117，1： | 1 |
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