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| 1 | Lessons from “real life experience” of rifaximin use in the management of recurrent hepatic encephalopathy显示文摘BACKGROUND Hepatic encephalopathy(HE)is a major complication of cirrhosis with independent prognostic significance.The current management of HE is mainly based on lactulose.Rifaximin has been shown to decrease the risk of HE recurrence in patients with episodic forms.HE can also be persistent.However,there is no drug support recommendation for rifaximin use in this setting.AIM To assess the effectiveness of rifaximin in the management of recurrent episodes of HE and recurrent acute exacerbations on persistent HE,in“real life conditions”.METHODS In this retrospective study,using a within-subjects design,we collected data of patients treated with rifaximin for HE in two liver diseases centers,during the six-month period before and during the six-month period after the initiation of rifaximin.The primary effectiveness endpoint was the total number of HE events involving hospitalization.RESULTS Rifaximin was introduced for prevention of recurrent HE episodes in 29 out of 62 patients with normal mental status between episodes and for prevention of recurrent acute exacerbations on persistent HE in 33 out of 62 patients.In the“prevention of recurrent HE episodes”group,fewer HE events(0.79 vs 1.78;P=0.013)were reported during the period of time when rifaximin was used.In the“prevention of recurrent acute exacerbations on persistent HE”group,there was no significant difference in the number of HE-events(1.48 vs 1.77;P=0.582).CONCLUSION In this real-life experience,the effectiveness of rifaximin was confirmed in the prevention of HE episodes recurrence but was not proved in the prevention of acute exacerbations recurrence on persistent HE. | Fiona Chautant Maeva Guillaume Marie-Angèle Robic Jean-François Cadranel Jean-Marie Peron Hortensia Lison Charlène Cool Christophe Bureau Véronique Duhalde | 2020 | World Journal of Hepatology2020，12，1： | 3 |
| 2 | Synthesis and hydrolytic degradation of graft copolymers containing poly ( lactic acid) side chains : in vitro release studies of bioactive molecules显示文摘 | Langlois V Vallee- Rebel K Peron J J | 2002 | Polymer Degradation and Stability2002，76，3： | 1 |
| 3 | Effect of different cooking methods on lipid oxidation and formation of free cholesterol oxidation products (COPs) in Latissimus dorsi muscle of Iberian pigs显示文摘 | BRONCANO J M PERON M J PARRA V | 2009 | Meat Science2009，83，3： | 1 |
| 4 | Transvaginal tape lysis for urinary obstruction after tension-free vaginal tape placement显示文摘 | Croak AJ Schulte V Peron S | 2003 | J Urol2003，69，6： | 1 |
| 5 | Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine 显示文摘 | Boudry G Peron V Huerou-Luron I | 2004 | Journal of Nutrition2004，134，： | 1 |
| 6 | Weaning in- duces both transient and long- lasting modifications of ab?sorptive, secretory, and barrier properties of piglet intestine显示文摘 | Boudry G V Peron 1 Le Huerou+Luron | 2004 | Journal of Nutrition2004，134，9： | 1 |
| 7 | hFLT3-ligand administration inhibits liver metastases:role of NK cells显示文摘 | Peron J M Esche C Subbotin V M | 1998 | J Immunol1998，161，11： | 1 |
| 8 | Weaning induces both transient and long-lasting modifications of ab- sorptive, secretory, and barrier properties of piglet in- testine 显示文摘 | Boudry G Peron V Le H L | 2004 | J Nutr2004，134，9： | 1 |
| 9 | Weaning induces both transient and long-losting modifications of absorptive,secretory,and barrier properties of piglet intestine显示文摘 | Boudry G Peron V Le Huerou-Luron l | 2004 | J Nutr2004，134，： | 1 |
| 10 | Partial purification and kinetics caracterization of enzyme polyphenol oxidase of stunded banana (Musa acuminata)显示文摘 | PERONE C A S QUEIROZ A S DALOSSO V M | 2007 | Rev Inst Cienc SaOde2007，25，3： | 1 |
| 11 | Weaning induces both transient and long - lasting modifications of absorptive, secretory, and barrier properties of piglet intestine 显示文摘 | Boudry G Peron V Le Huerou - Luron I | 2004 | J Nutr2004，134，22： | 1 |
| 12 | Weaninginctuces both transient and long lasting modifications of absorptive, se cretory, and barrier properties of piglet intestine显示文摘 | Boudry G Peron V Huerou Luron I | 2004 | Journal of Nutrition2004，134，： | 1 |
| 13 | Weaning induces both transient and long-lasting modifications of absorptive, secretory,and barrier properties of piglet intestine 显示文摘 | Boudry G Peron V Le Huerou Luron I | 2004 | J Nutr2004，134，： | 1 |
| 14 | Weaning induces both transient and long-laating modifications of absorptive,secretory,and barrier properties of piglet intestine显示文摘 | Boudry G Peron V Le Huerou-Luron I | 2004 | J Nutr2004，134，： | 1 |
| 15 | Molecular analysis of the PROP1 and HESX1 genes in patients with septo-optic dysplasia and/or pituitary hormone deficiency显示文摘 | Cruz J B Nunes V S Clara S A Perone D Kopp P Nogueira C R | | 0，，： | 1 |
| 16 | Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine 显示文摘 | Boudry G Peron V Le Huerou-Luron I | 2004 | J Nutr2004，134，： | 1 |
| 17 | Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine 显示文摘 | Boudry G Peron V Le Huerou-Luron I | 2004 | Journal of Nutrition2004，134，： | 1 |
| 18 | Weaning induces both transient and long-lastingmodifications of absorptive,secre tory,and barrier properties of piglet intestine 显示文摘 | Boudry G Peron V Le Huerou Luron I | 2004 | J Nutr2004，134，： | 1 |
| 19 | Decrease of Prefrontal Metabolism After Subthalamic Stimulation in Obsessive-Compulsive Disorder: A Positron Emission Tomography Study显示文摘 | Florence Le Jeune Marc Vérin Karim N’Diaye Dominique Drapier Emmanuelle Leray Sophie Tezenas Du Montcel Nicolas Baup Antoine Pelissolo Mircea Polosan Luc Mallet Jérome Yelnik Bertrand Devaux Denys Fontaine Isabelle Chereau Aurélie Bourguignon Julie Peron | 2010 | Biological Psychiatry2010，，11： | 1 |
| 20 | Weaning induces both transient and long-lasting modifications of absorptive, secre- tory, and barrier properties of piglet intestine 显示文摘 | Boudry G Peron V Le Huerou-Luron I et o!1 | 2004 | J Nutr2004，134，： | 1 |
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