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| 1 | QUADAS的制定:用于系统评价中评价诊断性研究质量的工具显示文摘背景在以系统评价为基石的循证医学时代,需要有恰当的质量评价工具。对诊断性研究的评价目前尚缺乏系统开发且经过验证的评价工具。本研究的目的是采用共识决策法整合经验证据和专家意见,制定在系统评价时用于评价原始诊断性研究质量的工具。方法按照循证原则,我们在之前发表的3篇诊断性研究文献的综述的基础上,初选出一些条目形成列表,然后通过Delphi流程逐步调整列表,形成质量评价工具。参与Delphi流程的都是诊断性研究领域的专家。结果共有9位诊断学领域的专家参与Delphi流程。经过4轮Delphi流程后,专家们对哪些条目应纳入评价工具达成共识,我们把这个评价工具命名为QUADAS。纳入条目从最初的28个减少到14个,涵盖了疾病谱、金标准、疾病进展偏倚(disease progression bias)、证实偏倚(verification bias)、评价偏倚、临床评价偏倚、合并偏倚、试验的实施、病例退出以及不确定结果。QUADAS工具中的每个条目都配有评分细则。结论本研究项目开发出了用于诊断性试验系统评价的循证质量评价工具。下一步工作是确定其适用性和有效性。 | Penny Whiting Anne WS Rutjes Johannes B Reitsma Patrick MM Bossuyt Jos Kleijnen 刁骧(译) 艾昌林(译) 秦莉(审校) 姚巡(审校) | 2007 | 中国循证医学杂志2007，7，4： | 67 |
| 2 | QUADAS评价:一种用于诊断性研究的质量评价工具(修订版)显示文摘背景 QUADAS是一种新近发展起来的诊断性研究的质量评价工具。虽然已有系统评价采用了QUADAS,但尚未得以正式确证。本研究的目的是评价QUADAS的有效性和实用性。方法3位评价者采用QUADAS独立评价30项研究的质量。比较每位评价者的评分与最终结论之间的意见一致度。这主要是通过比较所有QUADAS条目的总分和每个单项的得分来实现的。20位曾在其系统评价中使用过QUADAS的评价者就其使用经验完成一份简短的问卷。结果就所有条目而言,每位评价者的评分与最终结论之间的意见一致度分别达到了91%、90%和85%。就单项QUADAS条目而言,一致度在50%至100%之间,中位值是90%。与难以解释的试验结果和退出病例相关的条目,评分结果差异最大。有关QUADAS内容的反馈意见普遍较好,仅少数评价者提出了有关QUADAS涵盖面、使用便利性、评分说明的清晰度及有效性方面的问题。结论QUADAS内容本身无需作大的修改。评价过程的主要困难出现在难以解释的试验结果和退出病例这2个条目的评分上。对这些条目的评分指南提出了修改意见。评价者必需根据其系统评价制定相应的评分指南,并确保所有评价者都清楚如何评分。评价者还应考虑是否所有的QUADAS条目都与其系统评价相关,以及其他质量条目是否应作为其系统评价的评价部分。 | Penny F Whiting Marie E Weswood Anne WS Rutjes Johannes B Reitsma Patrick NM Bossuyt Jos Kleijnen 马章淳 钱楠 | 2007 | 中国循证医学杂志2007，7，7： | 64 |
| 3 | CO_2和H_2O在活性炭上的吸附平衡和吸附动力学研究显示文摘活性炭是应用在变压吸附分离CO2工艺中的常用吸附剂,而工业废气中一般都含有一定量的饱和水蒸气.通过吸附等温线和穿透曲线分别研究了单/双组份的CO2和H2O在活性炭上的吸附平衡和吸附动力学.结果表明,活性炭对二氧化碳具有较高的吸附量,并具有较好的CO2/N2吸附选择性.由于吸水官能团的存在,活性炭在较高分压下表现出较大的水蒸气吸附量.不过由于吸附机理不同,水蒸气在活性炭上的吸附几乎不会影响活性炭对CO2的吸附.动力学研究表明,CO2在活性炭上的吸附速率远大于H2O的吸附速率. | 徐冬 张军 李刚 XIAO Penny WEBLEY Paul 翟玉春 | 2012 | 无机材料学报2012，27，2： | 13 |
| 4 | Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future. | Penny L Jeffery Michael A McGuckin Sara K Linden | 2011 | World Journal of Gastroenterology2011，17，10： | 12 |
| 5 | Preemptive mechanical ventilation can block progressive acute lung injury显示文摘Mortality from acute respiratory distress syndrome(ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation(APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury(ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS. | Benjamin Sadowitz Sumeet Jain Michaela Kollisch-Singule Joshua Satalin Penny Andrews Nader Habashi Louis A Gatto Gary Nieman | 2016 | World Journal of Critical Care Medicine2016，5，1： | 9 |
| 6 | 电厂废气中饱和水蒸气对活性炭变压吸附捕集CO_2的影响显示文摘由于热电厂废气中含有高湿饱和水蒸气,选用疏水材料活性炭为吸附剂,利用真空变压吸附技术研究了活性炭分离电厂废气中水蒸气和二氧化碳的可行性和优越性,研究了水对CO2捕集的影响。实验分析表明,水在活性炭上的'S'型等温吸附曲线有利于真空条件下被解吸。同时,圆锥模型描述了水蒸气在吸附床内的浓度分布。结果表明,即使水蒸气可以被活性炭吸附,但它的存在不影响CO2的捕集。每个循环操作可在相对较短的解吸时间和较高的解吸压力下完成。实验中单床三步变压吸附工艺可以使CO2回收率高达80%,CO2纯度达43%。 | 徐冬 张军 李刚 Penny Xiao Paul Webley 翟玉春 | 2011 | 燃料化学学报2011，39，3： | 8 |
| 7 | 澳大利亚的精神卫生服务简介显示文摘 | 李明 Penny Li 马渝汉 刘晓璋 | 2007 | 中国医刊2007，42，1： | 6 |
| 8 | 早产儿母亲使用手动吸奶器与电动吸奶器效率的比较显示文摘目的母乳对早产儿的益处众所周知,但是挤奶技术却有待提高。我们将一种新式手动吸乳器MP(MP;Avent)和英国94%新生儿中心使用的标准电吸乳器(EP;Egell)进行比较。方法我们选择了145例35w前早产产妇,随意化分配使用MP或EP,测量每一产妇在婴儿住院期间使用吸乳器后总泌乳量,第2周试验一段时间内乳汁输出模式和乳脂比率,对孕妇问卷调查了解吸乳器的特点。结果使用EP的产妇频繁双侧挤奶,较之使用MP的产妇,挤乳时间短但泌乳量却并不多。连续使用吸乳器20m in以上,MP组产妇的泌乳总量及流速远远大于EP组产妇。MP在各方面优于EP。乳脂比率不受吸奶器种类影响。结论相同参数条件(连续抽吸)下,使用MP的产妇泌乳量更大,这显示其设计更符合生理标准。使用EP的产妇即使双侧吸乳也不能给她们的孩子提供更多的母乳。这种新型有效的吸乳器MP受到广大产妇的欢迎,而价格也较便宜,它体现了高危婴儿母乳哺育技术的重大进步。 | Mary S.Fewtrell Penny Lucas | 2006 | 中国优生与遗传杂志2006，14，1： | 3 |
| 9 | Ecosystem service delivery in Karst landscapes: anthropogenic perturbation and recovery显示文摘Covering extensive parts of China, Karst landscapes are exceptional because rapid and intensive land use change has caused severe ecosystem degradation within only the last 50 years. The twentieth century intensification in food production through agriculture has led to a rapid deterioration of soil quality, evidenced in reduced crop production and rapid loss of soil. In many areas, a tipping point appears to have been passed as basement rock is exposed and 'rocky desertification' dominates. Through the establishment of the 'Soil processes and ecological services in the karst critical zone of SW China'(SPECTRA)Critical Zone Observatory(CZO) we will endevaour to understand the fundmental processes involved in soil production and erosion, and investigate the integrated geophysical-geochemical-ecological responses of the CZ to perturbations. The CZ spans a gradient from undisturbed natural vegetation through human perturbed landscapes.We seek to understand the importance of heterogeneity insurface and below-ground morphology and flow pathways in determining the spatial distribution of key stocks(soil,C, vegetation, etc.) and their control on ecosystem service delivery. We will assess the extent to which the highly heterogeneous critical zone resources can be restored to enable sustainable delivery of ecosystem services. This paper presents the CZO design and initial assessment of soil and soil organic carbon stocks and evidence for their stability based on caesium-137(^(137) Cs) data. | Timothy Quine Dali Guo Sophie M.Green Chenglong Tu Iain Hartley Xinyu Zhang Jennifer Dungait Xuefa Wen Zhaoliang Song Hongyan Liu Heather Buss Timothy Barrows Richard Evershed Penny Johnes Jeroen Meersmans | 2017 | Acta Geochimica2017，36，3： | 3 |
| 10 | Outcomes of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding显示文摘AIM:To evaluate weight loss and surgical outcomes of Roux-en-Y gastric bypass(RYGB)and laparoscopic adjustable gastric band(LAGB).METHODS:Data relating to changes in body mass index(BMI)and procedural complications after RYGB(1995-2009;n=609;116M:493F;42.4±0.4 years)or LAGB(2004-2009;n=686;131M:555F;37.2±0.4years)were extracted from prospective databases.RESULTS:Pre-operative BMI was higher in RYGB than LAGB patients(46.8±7.1 kg/m2vs 40.4±4.2 kg/m2,P<001);more patients with BMI<35 kg/m2underwent LAGB than RYGB(17.1%vs 4.1%,P<0.0001).BMI decrease was greater after RYGB.There were direct relationships between weight loss and pre-operative BMI(P<0.001).Although there was no difference in weight loss between genders during the first 3-year post-surgery,male LAGB patients had greater BMI reduction than females(-8.2±4.3 kg/m2vs-3.9±1.9kg/m2,P=0.02).Peri-operative complications occurred more frequently following RYGB than LAGB(8.0%vs0.5%,P<0.001);majority related to wound infection.LAGB had more long-term complications requiring corrective procedures than RYGB(8.9%vs 2.1%,P<0.001).Conversion to RYGB resulted in greater BMI reduction(-9.5±3.8 kg/m2)compared to removal and replacement of the band(-6.0±3.0 kg/m2).Twelve months post-surgery,fasting glucose,total cholesterol and low density lipoprotein levels were significantly lower with the magnitude of reduction greater in RYGB patients.CONCLUSION:RYGB produces substantially greater weight loss than LAGB.Whilst peri-operative complications are greater after RYGB,long-term complication rate is higher following LAGB. | Nam Q Nguyen Philip Game Justin Bessell Tamara L Debreceni Melissa Neo Carly M Burgstad Pennie Taylor Gary A Wittert | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 11 | Minimal volume vitrification of epididymal spermatozoa results in successful in vitro fertilization and embryo development in mice显示文摘这研究在精子功能, IVF 结果,和胚胎开发上比较了三个 cryopreservation 协议。Epididymal 精子 cryopreserved 用慢凉下来(18% w/v 棉白糖, RS-C ) 与用 0.25 M 蔗糖(SV ) 或 18% w/v 棉白糖(RV ) 使成玻璃的精子相比。新鲜控制(FC ) 的活动性,活力,和 DNA 损坏(TUNEL 试金) 精子与 thawed 以后相比或温暖了 RS-C, RV,和 SV 样品。老鼠卵母细胞(n = 267 ) 随机为授精被分配进三个组:RV (n = 102 ) , RS-C (n = 86 ) ,并且 FC (n = 79 ) 。数字和从每个处理的二房间的胚胎和胚囊的比例被估计。精子活动性(P <0.01 ) 并且活力(P <0.05 ) 显著地与慢凉下来的精子相比在玻璃化以后被减少。然而, DNA 破碎显著地在用蔗糖使成玻璃的精子被减少(15 ±1.8%[SV ] 对 26 ±2.8%[RV ] 并且 27 ±1.2%[RS-C ] ;P <0.01 ) 。尽管 RS-C, RV,和 FC 精子生产的二房间的胚胎的数字不是显著地不同的,胚囊的数字用 RV 精子从二房间的胚胎生产了比 FC 精子显著地高(P = 0.0053 ) 。这个简单、小体积玻璃化协议和标准授精方法从 epididymal 精子的小数字允许成功的胚胎生产并且可以临床上被使用为 ICSI 围绕需要,它有绕过精子的劣势选择。 | Fabrizzio Horta Hamida Alzobi Sutthipat Jitanantawittaya Sally Catt Penny Chen Mulyoto Pangestu Peter Temple-Smith | 2017 | Asian Journal of Andrology2017，19，1： | 3 |
| 12 | Managing the co-creation of value显示文摘 | Adrian F. Payne Kaj Storbacka Pennie Frow | 2008 | Journal of the Academy of Marketing Science2008，，1： | 2 |
| 13 | Virology, epidemiology, pathogenesis, and control of enterovirus 71显示文摘 | Tom Solomon Penny Lewthwaite David Perera Mary Jane Cardosa Peter McMinn Mong How Ooi | 2010 | The Lancet Infectious Diseases2010，，11： | 2 |
| 14 | Preparation of zeolite NaA for CO_2 capture from nickel laterite residue显示文摘Zeolite NaA was successfully prepared from nickel laterite residue for the first time via a fusion–hydrothermal procedure. The structure and morphology of the as-synthesized zeolite NaA were characterized with a range of experimental techniques, such as X-ray diffraction, scanning electronic microscopy, and infrared spectroscopy. It was revealed that the structures of the produced zeolites were dependent on the molar ratios of the reactants and hydrothermal reaction conditions, so the synthesis conditions were optimized to obtain pure zeolite NaA. Adsorption of nitrogen and carbon dioxide on the prepared zeolite NaA was also measured and analyzed. The results showed that zeolite NaA could be prepared with reasonable purity, it had physicochemical properties comparable with zeolite NaA made from other methods, and it had excellent gas adsorption properties, thus demonstrating that zeolite NaA could be prepared from nickel laterite residue. | Tao Du Li-ying Liu Penny Xiao Shuai Che He-ming Wang | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，8： | 2 |
| 15 | Softlifting: A model of motivating factors显示文摘 | Penny M. Simpson Debasish Banerjee Claude L. Simpson | 1994 | Journal of Business Ethics1994，，6： | 2 |
| 16 | 生物神经反馈干预训练:培养运动员训练和比赛心理的技术显示文摘从运动心理学文献中了解到,运动员适当地关注和有效地管理焦虑情绪的能力是在比赛中取得优秀成绩的两大关键技能。生物/神经反馈是一种以加强培养这两项技能为目标的训练工具。该训练旨在培养运动员对身体的生理活动和大脑的神经活动进行自我认识和自我调节的能力。注意力训练(神经反馈)有助于培养运动员的警觉和精力集中能力, | Penny Werthner 邹文华 | 2011 | 中国体育教练员2011，19，1： | 2 |
| 17 | 马来西亚视神经萎缩的临床特点及病因(英文)显示文摘目的:研究在马来西亚非青光眼视神经萎缩的病因及临床特点。方法:一系列回顾性的研究分析马来西亚理科大学校医院眼诊所在2007/2011年间被诊断为非青光眼视神经萎缩的患者。至少随访1a。评估这些患者的医疗记录及汇编调查结果。结果:100例患者符合选择标准,56%的患者双眼都参与研究。主要症状为视力模糊(61%),除了视力模糊外还出现神经方面病症(18%),视野狭窄(9%)。大多数患者(63%)患眼视力下降到3/60以下。主要的病因是颅内占位性病变(26%),先天性疾病(13%),脑积水(12%),创伤(12%)及血管因素(12%)。对大多数患者(67%)采用保守治疗。不管其病因,视神经萎缩都伴有不同程度的视功能障碍。随访1a后,50%的患者出现不同程度的视觉障碍。结论:视神经萎缩主要的病因是颅内占位性病变,其次分别是先天性疾病,创伤和血管疾病。在诊断之前常常就出现视觉和神经上的症状,而疾病显著地影响着视力的变化。为了早期诊断视神经萎缩,当视力模糊的主诉为非特异性时,应该高度怀疑本病。 | Evelyn Tai Li Min Jessica Mani Penny Tevara Zunaina Embong Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam | 2014 | 国际眼科杂志2014，14，2： | 2 |
| 18 | 铁铝共生矿绿色化综合利用显示文摘采用硫酸铵焙烧铁铝共生矿,共生矿中的铝和铁与硫酸铵反应生成可溶的硫酸盐,加水溶出后与二氧化硅分离,过滤得到硫酸盐溶液和硅渣。硅渣采用氢氧化钠浸出制取硅酸钠溶液和尾渣,硅酸钠溶液经苛化和碳分分别制取硅酸钙和白炭黑。采用黄铵铁矾法沉铁,生成的黄铵铁矾经水解制取氧化铁。硫酸铝溶液沉铝得到硫酸铵溶液和粗氢氧化铝,粗氢氧化铝经碱溶和种分制取氢氧化铝。整个过程综合提取利用铁铝共生矿中的有价组元,硫酸铵、氢氧化钠和水循环利用。 | 田丁 申晓毅 辛海霞 翟玉春 Penny Xiao Paul Webley | 2018 | 轻金属2018，，9： | 2 |
| 19 | Airbome laser hydrography in Australia 显示文摘 | PENNY M F ABBOT R H PHILLIPS D M | 1986 | App Opt1986，25，13： | 2 |
| 20 | The I nhibitor of wax 1 locus ( I w1 ) prevents formation of β‐ and OH ‐β‐diketones in wheat cuticular waxes and maps to a sub‐c M interval on chromosome arm 2 BS显示文摘 | Nikolai M. Adamski Maxwell S. Bush James Simmonds Adrian S. Turner Sarah G. Mugford Alan Jones Kim Findlay Nikolai Pedentchouk Penny Wettstein‐Knowles Cristobal Uauy | 2013 | Plant J2013，，6： | 2 |
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