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| 1 | Recent high-resolution glaciochemical record from a Dasuopu firn core of middle Himalayas显示文摘A 16.8 m firn core of middle Himalayas was recovered on the col of Dasuopu glacier in August 2006,being 7000 m above sea level.A total of 317 samples were measured for stable oxygen isotope ratios(δ18O)and major ion concentrations(Na+,NH4+,K+,Mg2+,Ca2+,Cl?,SO42?,and NO3?).The firn core dating and seasonal partitioning were carried out based on the marked seasonal variations along the stable oxygen isotopes and crustal species(Ca2+,Mg2+)profiles.The multi-parameters and high-resolution glaciochemical data set of Dasuopu firn core recorded the detailed chemical characteristics of pre-cipitation in high-elevation region,middle Himalayas,since 1991 A.D.,which mainly originated from the crustal and anthropogenic sources,while the sea-salt contribution was minor.The seasonal variability of major ion concentrations was dominated by the seasonal alternation of the prevalent air mass,at-mospheric circulation situation and precipitation regime.Linear regression analysis indicated that most of the variance in annual ionic fluxes can be explained by a linear dependence on snow accumu-lation rate. | WANG PengLing YAO TanDong TIAN LiDe WU GuangJian LI Zhen YANG Wei | 2008 | Chinese Science Bulletin2008，53，3： | 4 |
| 2 | Scenario-based approach for project portfolio selection in army engineering and manufacturing development显示文摘The decisions concerning portfolio selection for army engineering and manufacturing development projects determine the benefit of those projects to the country concerned.Projects are typically selected based on ex ante estimates of future return values,which are usually difficult to specify or only generated after project launch.A scenario-based approach is presented here to address the problem of selecting a project portfolio under incomplete scenario information and interdependency constraints.In the first stage,the relevant dominance concepts of scenario analysis are studied to handle the incomplete information.Then,a scenario-based programming approach is proposed to handle the interdependencies to obtain the projects,whose return values are multi-criteria with interval data.Finally,an illustrative example of army engineering and manufacturing development shows the feasibility and advantages of the scenario-based multi-objective programming approach. | Pengle Zhang Kewei Yang Yajie Dou Jiang Jiang | 2016 | Journal of Systems Engineering and Electronics2016，27，1： | 2 |
| 3 | Preparation of highly dispersed Pt-SnO x nanoparticles supported on multi-walled carbon nanotubes for methanol oxidation显示文摘 | Chuangang Hu Yanxia Cao Lin Yang Zhengyu Bai Yuming Guo Kui Wang Pengle Xu Jianguo zhou | 2011 | Applied Surface Science2011，，18： | 1 |
| 4 | Boundary Element Analysis on Flow Problem around Cascades with smallAngle of Attack显示文摘 | Yang Dequan Xing Pengling Ba Yanyan | 2004 | Procceding of Joint conference ICCP6 and CCP2003 Rinton Press Corporation (USA)2004，1，2： | 1 |
| 5 | Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels显示文摘Objective: Heat shock factor 1(HSF1), a transcriptional regulator of heat shock proteins(HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far.Methods: The mRNA and protein levels of HSF1, HSPs, cleaved PARP, and phosphorylated HSF1 were examined by real-time PCR and Western blot. Forced expression, RNA interference, and immunofluorescence assay were used for mechanistic studies.Cell viability and apoptosis were measured by WST-8 assay and flow cytometry, respectively. Xenograft studies were performed in nude mice to evaluate the effect of dorsomorphin and an HSP90 inhibitor on tumor growth.Results: Dorsomorphin suppressed multiple stimuli-induced and constitutive HSPs expression in cancer cells. Mechanistic studies revealed that dorsomorphin reduced heat-induced HSP expression independent of adenosine monophosphate activated protein kinase. Dorsomorphin reduced heat-stimulated HSF1 Ser320 phosphorylation and nuclear translocation, as well as resting nuclear HSF1 levels in cancer cells. Dorsomorphin induced cancer cell apoptosis by inhibiting HSF1 expression. A structure-activity study revealed that the 4-pyridyl at the 3-site of the pyrazolo [1, 5-a]pyrimidine ring is critical for the anti-HSF1 activities of dorsomorphin. Dorsomorphin sensitized cancer cells to HSP90 and proteasome inhibitors and inhibited HSP70 expression induced by these inhibitors in vitro. In tumor-bearing nude mice, dorsomorphin enhanced HSP90 inhibitor-induced cancer cell apoptosis, tumor growth inhibition, and HSP70 expression.Conclusions: Dorsomorphin is an HSF1 inhibitor. It induces cancer cell apoptosis, sensitizes cancer cells to both HSP90 and proteasome inhibitors, and suppresses HSP upregulation by these drugs, which may prevent the development of drug resistance.Hence, dorsomorphin and its derivates may serve as potential precursors for developing drugs against cancer. | Na Li Ting Wang Zongmeng Li Xiaoli Ye Bo Deng Shu Zhuo Pengle Yao Mengmei Yang Hong Mei Xiaofang Chen Tengfei Zhu Shiting Chen Hui Wang Jiming Wang Yingying Le | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 6 | Clinical Significance and Functional Studies of Myeloid-Derived Suppressor Cells in Chronic Hepatitis C Patients显示文摘 | Weiping Cai Aiping Qin Pengle Guo Dehong Yan Fengyu Hu Qiong Yang Min Xu Yongshui Fu Jie Zhou Xiaoping Tang | 2013 | Journal of Clinical Immunology2013，，4： | 1 |
| 7 | Laser-induced damage thresholds of ultrathin targets and their constraint on laser contrast in laser-driven ion acceleration experiments显示文摘Single-shot laser-induced damage threshold(LIDT)measurements of multi-type free-standing ultrathin foils were performed in a vacuum environment for 800 nm laser pulses with durationsτranging from 50 fs to 200 ps.The results show that the laser damage threshold fluences(DTFs)of the ultrathin foils are significantly lower than those of corresponding bulk materials.Wide band gap dielectric targets such as SiN and formvar have larger DTFs than semiconductive and conductive targets by 1–3 orders of magnitude depending on the pulse duration.The damage mechanisms for different types of targets are studied.Based on the measurement,the constrain of the LIDTs on the laser contrast is discussed. | Dahui Wang Yinren Shou Pengjie Wang Jianbo Liu Zhusong Mei Zhengxuan Cao Jianmin Zhang Pengling Yang Guobin Feng Shiyou Chen Yanying Zhao Joerg Schreiber Wenjun Ma | 2020 | High Power Laser Science and Engineering2020，8，4： | 1 |
| 8 | Boundary Element Analysis on Flow Problem around Cascades with small Angle of Attack显示文摘 | Yang Dequan Xing Pengling Ba Yanyan | 2004 | Procceding of Joint conference ICCP6 and CCP2003 Rinton Press Corporation(USA)2004，1，2： | 1 |
| 9 | Allicin Inhibits Microbial Growth and Oxidative Browning of Fresh-Cut Lettuce ( Lactuca sativa ) During Refrigerated Storage显示文摘 | Xiaoli Peng Ren Li Rong Zou Jun Chen Qiang Zhang Pengle Cui Fuli Chen Yu Fu Jingpeng Yang Xiaodong Xia | 2014 | Food and Bioprocess Technology2014，，6： | 1 |
| 10 | COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors显示文摘Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie nts.Mecha nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid metabolism.Furthermore,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin resistance.Taken together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications. | Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 11 | Improving endotracheal tube tolerance with intracufflidocaine: a meta-analysis of randomized controlled trials显示文摘Objective: The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine(in different forms) with air and/or normal saline(NS) during general anesthesia with tracheal intubation.Methods: Cochrane Central Register of Controlled Trials, PubMed and Embase were searched for relevant studies. Thirteen randomized, controlled trials involving 1 010 patients were ultimately identified. A meta-analysis of all randomized controlled trials fulfilling the predefined criteria was performed. Random-effect model and subgroup studies were used when significant heterogeneity existed among those trials. Results: Compared with air and NS, intracufflidocaine could significantly alleviate the severity of sore throat at different time points(15min, 30min, 1h, 2h, 3h, 6h, 12h and 24h after extubation) and the occurrence of cough, restlessness,postoperative nausea and vomiting, dysphonia and hoarseness. Besides intracufflidocaine brought about a significant prolongation of spontaneous ventilation time. It was worth mentioning that, compared withlidocaine or its hydrochloride form, alkalinized lidocainewas much more efficient in reducing the severity of sore throat and prolonging spontaneous ventilation time. Conclusion: The present meta-analysis indicates that intracufflidocaine can significantly improve endotracheal tube tolerance and this improvement can be strengthened by alkalinization of lidocaine. | CHEN Wei SUN Pengling YANG Liye PU Jun YUAN Hongbin TIAN Mouli | 2013 | Journal of Medical Colleges of PLA(China)2013，28，5： | 0 |
| 12 | High-Quality de novo Genome Assembly of Huajingxian 74, a Receptor Parent of Single Segment Substitution Lines显示文摘Rice(Oryza sativa L.)is grown nearly worldwide and provides the staple food for more than half of the global population(Luo et al,2017).The genomes of several cultivated rice varieties including Nipponbare(NPB)(Kawahara et al,2013;Sakai et al,2013),IR64(Tanaka et al,2020),93-11(Zhang et al,2018)and R498(Du et al,2017)at chromosome level,and Minghui 63 and Zhenshan 97(Zhang et al,2016)at scaffold level have been assembled,annotated and released,among which the R498 and NPB genomes are widely used as reference genomes in rice research.However,there are thousands of rice cultivars,landraces and wild rice varieties in the world with dramatically different genetic backgrounds,and the genomes of native rice varieties in South China,which is one of the major rice production areas in China,have not been de novo assembled.Huajingxian 74(HJX74)is an indica rice variety bred in South China Agricultural University,Guangdong Province with widely environmental adaptability and high yield(www.ricedata.cn/variety/varis/602548.htm).HJX74 exhibits significant phenotypic and genetic differences from those varieties whose whole genomes have been properly sequenced and assembled(Fig.1). | LI Fangping GAO Yanhao WU Bingqi CAI Qingpei ZHAN Pengling YANG Weifeng SHI Wanxuan LI Xiaohua YANG Zifeng TAN Quanya LUAN Xin ZHANG Guiquan WANG Shaokui | 2021 | Rice science2021，28，2： | 0 |
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