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| 1 | Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma:A Rare Cancer Network study显示文摘Objective: Primary uterine leiomyosarcomas(ULMS) are rare,and the optimal treatment is controversial.We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS.Methods: We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network(RCN).Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS,aged 18–80 years,complete International Federation of Gynecology and Obstetrics(FIGO) stage information,complete information on treatment,and a minimum follow-up of 6 months.Local control(LC) and locoregional control(LRC),overall survival(OS) and disease-free survival(DFS) rates were computed using the Kaplan-Meier method.Univariate analysis was implemented using the log rank test,and multivariate analysis using the Cox model.Results: All patients underwent surgery.Seventy-five patients(68%) received adjuvant radiotherapy(RT),including brachytherapy in 18(16%).Seventeen patients(15%) received adjuvant chemotherapy.Median follow-up was 58(range,6–240) months.Five-year OS and DFS rates were 50% and 34%,and LC and LRC rates were 88%and 72%,respectively.On multivariate analysis,independent favorable prognostic factors were younger age,FIGO stage I,small tumor size,previous uterine disease,and no vascular invasion for OS and DFS.FIGO stage was the only favorable factor influencing LRC.Adjuvant local or systemic treatments did not improve the outcomes.Eight patients treated with RT presented a grade 3 acute toxicity,and only one patient with grade 3 late toxicity.Conclusions: In this large population of primary ULMS patients,we found good results in terms of LC and LRC.Nevertheless,OS remains poor,mainly due to the occurrence of distant metastases.An early diagnosis seemed to improve the prognosis of the patients.Adjuvant local or systemic treatments,or more aggressive surgicalprocedures such as the Wertheim procedure,did not seem to impact the outcome. | Alessandra Franzetti Pellanda Berardino De Bari Elisabeth Deniaud-Alexandre MarcoKrengli Paul Van Houtte Antonella Riehetti Salvador Villa Hadassah Goldberg EwaSzutowiez-Zielifiska Michel Bolla Heidi Rutten Marc Van Eijkeren Philip Poortmans Guido Henke Yavuz Anaeak Steve Chan Christine Landmann Carine Kirkove LueianoScandolaro Jacques Bernier Rene-Olivier Mirimanof Mahmut Ozsahin | 2017 | Chinese Journal of Cancer Research2017，29，6： | 2 |
| 2 | C-reactive protein in acute coronary syndrome:association with 3-year outcomes显示文摘 | Schaan BD Pellanda LC Maciel PT | 2009 | Braz J Med Biol Res2009，42，12： | 1 |
| 3 | C-reactive protein in acute coronary syndrome:association with 3-year outcomes显示文摘 | Schaan BD Pellanda LC Maciel PT | 2009 | Braz J Med Biol Res2009，42，12： | 1 |
| 4 | C-reactive protein in acute coronary syndrome:association with 3-year outcomes显示文摘 | Schaan B D Pellanda L C Maciel P T | | 0，，12： | 1 |
| 5 | Fumonisin B1treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3-and H4-histone methylation patterns in fetuses显示文摘 | PELLANDA H FORGES T BRESSENOT A | 2012 | Mol Nutr Food Res2012，56，6： | 1 |
| 6 | Stimulus Parameters for Goldmann Kinetic Perimetry in Nonorganic Visual Loss显示文摘 | Ebneter Andreas Pellanda Niccolo Kunz Andrea Mojon Stefania Mojon Daniel S | 2010 | Ophthalmologica2010，，3： | 1 |
| 7 | Pharmacokinetics of antifungal agents显示文摘 | Fabris A Pellanda M V Gardin C | 1993 | Perit Dial Int1993，13，2： | 1 |
| 8 | The ' Happy Heart' educational program for changes in health habits in children and their families:protocol for a randomized clinical trial 显示文摘 | Minossi V Pellanda LC | 2015 | BMC Pediatr2015，15，1： | 1 |
| 9 | I I guidelines of prevention of atherosclerosis in childhood and adolescence] 显示文摘 | Back Giuliano Ide C Caramelli B Pellanda L Duncan B Mattos S Fonseca F H Sociedade Brasileira de Cardiologia | 2005 | Arq Bras Cardiol2005，856，： | 1 |
| 10 | Fumonisin Bl treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses 显示文摘 | Pellanda H Forges T Bressenot A | 2012 | Molecular Nutrition and Food Research2012，56，6： | 1 |
| 11 | C-reactive protein in acute coronary syndrome; association with 3-year outcomes显示文摘 | Schaan BD Pellanda LC Maciel PT | 2009 | Braz J Med Biol Res2009，42，12： | 1 |
| 12 | Topical bioavailability of triamcinolone acetonide: effect of dose and application frequency显示文摘 | Carolina Pellanda Evelyne Ottiker Christoph Strub Verena Figueiredo Theo Rufli Georgios Imanidis Christian Surber | 2006 | Archives of Dermatological Research2006，，5： | 1 |
| 13 | Topical bioavailability of triamcinolone acetonide: effect of dose and application frequency 显示文摘 | PELLANDA C OTTIKER E STRUB C | 2006 | Arch Dermatol Res2006，298，5： | 1 |
| 14 | Glycemia and inflamma tory markers in acute coronary syndrome:association with late post hospital outcomes 显示文摘 | Maciel PT Pellanda LC Portal VL | 2007 | Diabetes Research & Clinical Practice2007，78，2： | 1 |
| 15 | Morel-Lavallée lesion in the knee:A case report显示文摘 | Pitrez EH Pellanda RC Silva ME | 2010 | Radiologia Brasileira2010，43，5： | 1 |
| 16 | Inflammatory markers of cardiovascular disease in the elderly 显示文摘 | Adriane M Ramos Lucia Campos Pellanda | 2009 | Arq Bras Cardiol2009，92，3： | 1 |
| 17 | Fumonisin FBItreatment acts synergistically with methyl donor deficiency duringrat pregnancy to produce alterations of H3- and H4-histonemethylation patterns in fetuses显示文摘 | Pellanda H Forges T Bressenot A | 2012 | Mol Nutr Food Res2012，56，6： | 1 |
| 18 | C-reactive protein in acute coronary syndrome:as-sociation with3-year outcomes显示文摘 | SCHAAN B D PELLANDA L C MACIEL P T | 2009 | Braz J Med Biol Res2009，42，： | 1 |
| 19 | Glycemia and inflammatory markers in acute coronary syndrome:association with late post-hospital outcomes显示文摘 | Maciel PT Pellanda LC Portal VL | 2007 | Diabetes Res Clin Pract2007，78，： | 1 |
| 20 | Mixed H2/H∞ multi-channel linear parameter-varying control in discrete time 显示文摘 | APKARIAN P PELLANDA P C TUAN H D | 2000 | Systems & Control Letters2000，41，5： | 1 |
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