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| 1 | Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization显示文摘Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell viability.Although direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical practice.Previous reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial ischemia.In this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics technology.The results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the exosomes.In addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1αpathway.In brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization. | Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen | 2022 | Bioactive Materials2022，7，8： | 2 |
| 2 | A heat - sensitive TRP chan- nel expressed in keratinocytes 显示文摘 | Peier AM Reeve AJ Andersson DA | 2002 | Science2002，296，5575： | 1 |
| 3 | Thermo TRP channels and beyond:mechanisms of temperature sensation显示文摘 | Patapoutian A Peier AM Story GM | 2003 | Nat Rev Neurosci2003，4，7： | 1 |
| 4 | A heat - sensitive TRP channel expressed in keratinocytes 显示文摘 | Peier AM Reeve AJ Andersson DA | 2002 | Science2002，296，： | 1 |
| 5 | ANKTM1,a TRP-like channel expressed in nociceptive neurons,is activated by cold temperatures显示文摘 | Story GM Peier AM Reeve AJ | 2003 | Cell2003，112，6： | 1 |
| 6 | ANKTM1, a TRP - like channel expressed in nociceptive neurons, is activated by cold temper- atures 显示文摘 | Story GM Peier AM Reeve AJ | 2003 | Cell2003，112，6： | 1 |
| 7 | A TRP channel that senses cold stimuli and menthol显示文摘 | Peier AM Moqrich A Hergarden AC | 2002 | Cell2002，108，5： | 1 |
| 8 | A TRP Channel that Senses Cold Stimuli and Menthol 显示文摘 | Peier AM Moqrich A Hergarden AC | 2002 | Cell2002，108，5： | 1 |
| 9 | A TRP channel that senses cold stimuli and menthol显示文摘 | Peier A M Moqrich A Hergarden A C | 2002 | Cell2002，108，5： | 1 |
| 10 | ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures显示文摘 | Story GM Peier AM Reeve A J | 2003 | Cell2003，112，6： | 1 |
| 11 | ThermoTRP tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons显示文摘 | Patapoutian A Peier A M Story G M | | The J oumal of neuroscience0，12，6： | 1 |
| 12 | Intervention and Price Leader Ship:A Deeper View of the Microstructure of the Foreign Exchange Market 显示文摘 | Bettina Peiers Informed Traders | 1997 | The Journal of Finance1997，52，4： | 1 |
| 13 | Imprint lithcgraphy with 25 nanometer resolution显示文摘 | STEPHEN Y CHOU PEIER R KRAUSS PRESTON J RENSTROM | 1996 | Science1996，272，5258： | 1 |
| 14 | ANKTM1,a TRP-like channel expressed in nociceptive neurons,is activated by cold temperatures显示文摘 | Story G M Peier A M Reeve A J | | 0，，06： | 1 |
| 15 | ANKTM1,a TRP-like channel expressed in nociceptive neurons,is activated by cold temperatures显示文摘 | Story G M Peier A M Reeve A J | 2003 | Cell2003，112，6： | 1 |
| 16 | PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes显示文摘 | Paolo Ingallinella Andrea M. Peier Alessandro Pocai Annalise Di Marco Kunal Desai Karolina Zytko Ying Qian Xiaobing Du Antonella Cellucci Edith Monteagudo Ralph Laufer Elisabetta Bianchi Donald J. Marsh Antonello Pessi | 2012 | Bioorganic & Medicinal Chemistry2012，，15： | 1 |
| 17 | ANKTM1,a TRP-like channel expressed in nociceptive neurons,is activated by cold temperatures显示文摘 | STORY G M PEIER A M REEVE A J | 2003 | Cell2003，112，6： | 1 |
| 18 | ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures显示文摘 | Story GM Peier AM Reeve AJ | 2003 | Cell2003，112，6： | 1 |
| 19 | 查看详情显示文摘 | R E Peiers | 1993 | Zeitschrift für Physik1993，，： | 1 |
| 20 | ThermoTRP channels and beyond:mechanisms of temperature sensation显示文摘 | PATAPOUTIAN A PEIER A M STORY G M | 2003 | Nature Rev Neurosci2003，4，7： | 1 |
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