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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | The cytochrome e maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain -specific insertion sequence element显示文摘 | Viswanathan VK Kurtz S Pedersen LL | 2002 | Infect lmmun2002，70，4： | 1 |
| 3 | Vasopres- sin induces phosphorylation of the thiazide-sensitive sodium chlo- ride cotransporter in the distal convoluted tubule显示文摘 | Pedersen NB Hofmeister MV Rosenbaek LL | 2010 | Kidney Int2010，78，2： | 1 |
| 4 | Temporal Pore formation- mediated egress from maerophages and alveolar epithelial cells by Legionella pneumophila显示文摘 | Alli OA Gao LY Pedersen LL | 1999 | Infect Immu1999，68，11： | 1 |
| 5 | Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila显示文摘 | Gao LY Pedersen LL | 2000 | Infect Immun2000，68，11： | 1 |
| 6 | Producing primate embryonic stem ceils by somatic cell nuclear transfer显示文摘 | Byrne JA Pedersen DA Clepper LL | 2007 | Nature2007，450，7169： | 1 |
| 7 | Effect of specific resistance training on musculoskeletal pain symp- toms: dose-response relationship显示文摘 | Pedersen MT Andersen LL Jorgensen MB | 2013 | J Strength Cond Res2013，27，1： | 1 |
| 8 | Producing primate embryonic stem cells by somatic cell nuclear transfer 显示文摘 | Byrne JA Pedersen DA Clepper LL | 2007 | Nature2007，450，： | 1 |
| 9 | Producing primate embryonic stem cells by somatic cell nuclear transfer 显示文摘 | Byrne JA Pedersen DA Clepper LL | 2007 | Nature2007，450，： | 1 |
| 10 | Producing primate embryonic stem cells by somatic cell nuclear transfer显示文摘 | Pedersen DA Clepper LL | 2007 | Nature2007，450，7169： | 1 |
| 11 | Implementation of neck/shoulder exercises for pain relief among industrial workers:A randomized controlled trial显示文摘 | Zebis MK Andersen LL Pedersen MT | 2011 | BMC Musculoskelet Disord2011，21，12： | 1 |
| 12 | Producing primate embryonic stem cells by somatic cell nuclear transfer 显示文摘 | Byrnel JA Pedersen DA Clepper LL | 2007 | Nature2007，45，022450： | 1 |
| 13 | Implementation of neck/shoulder exercises for pain relief among industrial workers:A randomized controlled trial显示文摘 | Zebis MK Andersen LL Pedersen MT | 2011 | BMC Musculoskelet Disord2011，21，12： | 1 |
| 14 | Producing primate embryonic stem cells by somatic cell nuclear transfer显示文摘 | Byrne JA Pedersen DA Clepper LL | 2007 | Nature2007，450，7169： | 1 |
| 15 | HtrA homologue of Legionella pneumophila:an indispensable element for intracellular infection of mammalian but not protozoan cells显示文摘 | Pedersen LL Radulic M Doric M | 2001 | Infect Immun2001，69，： | 1 |
| 16 | Basal forebrain control of wakefulness and cortical rhythms 显示文摘 | Anaclet C Pedersen NP Ferrari LL | 2015 | Nat Com- mun2015，6，： | 1 |
| 17 | Characteriza- tion of a novel phosphorylation site in the sodium - chloride co- transporter, NCC 显示文摘 | Rosenbaek LL Assentoft M Pedersen NB | 2012 | J Physiol2012，590，23： | 1 |
| 18 | Producing primate embryonic stem cells by somatic cell nuclear transfer显示文摘 | Byrne JA Pedersen DA Clepper LL Nelson M Sanger WG Gokhale S Wolf DP Mitalipov SM | 2007 | Nature2007，450，： | 1 |
| 19 | Producing primate embryonic stem cells by somatic cell nuclear transfer显示文摘 | Byme JA Pedersen DA Clepper LL | | 0，，： | 1 |
| 20 | 乐高之家显示文摘'乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的新世界,并为他们提供使之成为现实的技能。这就是孩子们每天用乐高积木来做的事情,这也是我们今天用真实的砖石在乐高之屋里完成的事情. | Snorre Nash Andreas Klok Pedersen Agne Tamasauskaite Annette Birthe Jensen Ariel Joy Norback Wallner Ask Hvas Birgitte Villadsen Chris Falla Christoffer Gotfredsen Daruisz Duong Vu Hong David Zahle Esben Christoffersen Franck Fdida Ioana Fartadi Scurtu Jakob Andreassen Jakob Ohm Laursen Jakob Sand Jakub Matheus Wlodarczyk Jesper Bo Jensen Jesper Boye Andersen Julia Boromissza Kasper Reimer Hansen Katarzyna Krystyna Siedlecka Katarzyna Stachura Kekoa Charlot Leszek Czaja Lone Fenger Albrechtsen Louise B■geskov Hou Mads Enggaard Stidsen Magnus Algreen Suhr Manon Otto Marta Christensen Mathias Bank Stigsen Michael Kepke Ole Dau Mortensen Ryohei Koike Sergiu Calacean S■ren Askehave Stefan Plugaru Stefan Wolf Thomas Jakobsen Randb■ll Tobias Hjortdal Tommy Bj■rnstrup Iwan Baan Kim Christensen 陈思瑾(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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