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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 显示文摘 | Hatley ME Patrick DM Garcia MR | 2010 | Cancer Cell2010，18，3： | 1 |
| 3 | Web-based surveillance and global Salmonella distribution ,2000- 2002 显示文摘 | Galanis E Lo Fo Wong DM Patrick ME | 2006 | Emerg Infect Dis2006，12，3： | 1 |
| 4 | Web-based surveil- lance and global Sahnonella distribution, 2000-2002显示文摘 | GALANIS E WONG DM PATRICK ME | 2006 | Emerg Infect Dis2006，12，3： | 1 |
| 5 | The use of financial incentives in promoting smoking eessation 显示文摘 | Sigmon SC Patrick ME | 2012 | Preventive Medicine2012，，： | 1 |
| 6 | Web-based surveillance and global Sahnonella distribution, 2000 2002 显示文摘 | Galanis E Lo Fo Wong DM Patrick ME | 2006 | Emerging Infect Dis2006，12，3： | 1 |
| 7 | Structural determinants of the high thermal stability of SsoPox from the hyperthermophilic archaeon Sulfolobus solfataricus显示文摘 | Pompea Vecchio Mikael Elias Luigia Merone Giuseppe Graziano Jér?me Dupuy Luigi Mandrich Paola Carullo Bertrand Fournier Daniel Rochu Mosè Rossi Patrick Masson Eric Chabriere Giuseppe Manco | 2009 | Extremophiles2009，，3： | 1 |
| 8 | Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21显示文摘 | Hatley ME Patrick DM Garcia MR | 2010 | Cancer Cell2010，18，3： | 1 |
| 9 | Human infections withnew subspecies of Campylobacter fetus显示文摘 | Patrick ME Gilbert MJ’Blaser MJ | 2013 | Emerg Infect Dis2013，19，10： | 1 |
| 10 | Modulation of K-Ras- dependent lung tumorigenesis by MicroRNA-21 显示文摘 | Hatley ME Patrick DM Garcia MR | 2010 | Cancer Cell2010，18，3： | 1 |
| 11 | ModuJation of K-Ras-de- pendent lung tumorigenesis by MicroRNA-21显示文摘 | Hariey ME Patrick DM Garcia MB | 2010 | Cancer Cell2010，18，3： | 1 |
| 12 | A Comparativestudy of dexmedetomidine with midazolam and midazolam alone for se-dation during elective awake fiberoptic intubation 显示文摘 | Bergese SD Patrick Bender S Me Sweeney TD | 2010 | Clin Anesth2010，22，1： | 1 |
| 13 | Web-based surveillance and global Salmonella distribution, 2000-2002显示文摘 | Galanis E Lo Fo Wong DM Patrick ME | 2006 | Emerg Infect Dis2006，12，3： | 1 |
| 14 | Iron isotope composition of the bulk waters and sediments from the Amazon River Basin显示文摘 | Franck Poitrasson Lucieth Cruz Vieira Patrick Seyler Giana Márcia dos Santos Pinheiro Daniel Santos Mulholland Marie-Paule Bonnet Jean-Michel Martinez Barbara Alcantara Lima Geraldo Resende Boaventura Jér?me Chmeleff Elton Luiz Dantas Jean-Loup Guyot Luiz | 2014 | Chemical Geology2014，，： | 1 |
| 15 | Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 显示文摘 | Hatley ME Patrick DM Garcia MR | 2010 | Cancer Cell2010，18，3： | 1 |
| 16 | IBQS:A synthetic index of soil quality based on soil macro-invertebrate communities显示文摘 | Nuria R Jér?me M Léonide C Christine R Gérard H Etienne I Patrick L | | 0，，： | 1 |
| 17 | Modulation ofK-Ras-dependent lung tumorigenesis by MicroRNA-21显示文摘 | Hatley ME Patrick DM Garcia MR | 2010 | Cancer Cell2010，18，3： | 1 |
| 18 | Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21显示文摘 | Hatley ME Patrick DM Garcia MR | 2010 | Cancer Cell2010，18，3： | 1 |
| 19 | Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 显示文摘 | Hatley ME Patrick DM Garcia MR | 2010 | Cancer Cell2010，18，3： | 1 |
| 20 | Human infections with new subspecies of Campylobacterfetus显示文摘 | Patrick ME Gilbert MJ Blaser M J | 2013 | Emerg Infect Dis2013，9，10： | 1 |
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