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| 1 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 2 | Abdominal aortic coarctation inducing aortic occlusion and renovascular hypertension显示文摘 | Astuni M Baroni C | 1991 | J Cardiovasc Surg1991，32，6： | 1 |
| 3 | Performance characteris tics and clinical utility of an enzymatic method for the measure' ment of glycated albumin in plasma显示文摘 | Paroni R Ceriotti F Galanello R | 2007 | Clin Biochem2007，40，13： | 1 |
| 4 | Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive dis- order in late life显示文摘 | Seripa D Pilotto A Paroni G | 2015 | J Psychopharmacol2015，29，15： | 1 |
| 5 | Performance characteristics and clinical utility of an enzymatic method for the measurement of glycated albumin in plasma显示文摘 | Paroni R Ceriotti F Galanello R et at | 2007 | Clin Biochem2007，40，： | 1 |
| 6 | Qualification of highrecovery,flocked swabs as compared to traditional rayon swabs for microbiological environmental monitoring of surfaces显示文摘 | Dalmaso G Bini M Paroni R | 2008 | PDA J Pharm Sci Technol2008，62，3： | 1 |
| 7 | Determination of asymmetric and symmetric dimethylarginines in plasma of hyperhomocysteinemic subjects显示文摘 | R. Paroni I. Fermo P. Fiorina G. Cighetti | 2005 | Amino Acids2005，，4： | 1 |
| 8 | High-performance liquid chromatographic determination of ribavirin in serum and urine and of its urinary metabolite 1,2,4-triazole-3-carboxamide显示文摘 | Paroni R Sirtori CR Borghi C Kienle MG | 1987 | J Chromatogr1987，420，： | 1 |
| 9 | Pantethine inhibits cholesterol and fatty acid syntheses and stimulates carbon dioxide formation in isolated rat hepatocytes显示文摘 | CIGHETTI G DEL PUPPO M PARONI R | 1987 | Journal of Lipid Research1987，28，2： | 1 |
| 10 | An asymptotic approach to the torsional problem in thin rec- tangular domains 显示文摘 | Davini C Paroni R Puntle E | 2008 | Meccanica2008，43，4： | 1 |
| 11 | pantethine inhibit cholesterol and fatty acid syntheses and stimulates carbon dioxide formulation in isolatd rat hapotocytes显示文摘 | Cighetti G Delpuppo M Paroni R | 1987 | J Iipid Res1987，28，2： | 1 |
| 12 | Effect of local hyperthermia of the bladder on mitomycin C pharmacokinetics during intravesical chemotherapy for the treatment of superficial transitional cell ear- cinoma显示文摘 | Paroni R Salonia A Lev A et 81 | 2001 | Br J Clin Pharmacol2001，52，3： | 1 |
| 13 | Asymmetric dimethylarginine (ADMA),symmetric dimethylarginine (SDMA) and Larginine in patients with arteriogenic and nonarteriogenic erectile dysfunction显示文摘 | Paroni R Barassi A Ciociola F | 2012 | International Journal of Andrology2012，35，5： | 1 |
| 14 | Quatitative mapping of air pollution density using Earth observations: a new processing method and application to an urban area显示文摘 | SIFAKIS N I SOULAKELLIS N A PARONIS D K | 1998 | International Journal of Remote Sensing1998，19，： | 1 |
| 15 | In vivo growth of Pseudomonas aeruginosa strains PAO1 and PAl4 and the hypervirulent strain LESB58 in a rat model of chronic lung infection 显示文摘 | Kukavica-Ibrulj I Bragonzi A Paroni M Winstanley C Sanschagrin F O'Toole GA Levesque RC | 2008 | J Bacteriol2008，190，8： | 1 |
| 16 | Performance characteristics and clinical utility of an enzymatic method for the measurement of glycated albumin in plasma显示文摘 | Paroni R Cefiotti F Galanello R | 2007 | Clin Biochem2007，40，18： | 1 |
| 17 | Qualification of high-recovery,flocked swabs as compared to traditional rayon swabs for microbiological environmental monitoring of surfaces显示文摘 | Dalmaso G Bini M Paroni R | 2008 | PDA J Pharm Sci Technol2008，62，3： | 1 |
| 18 | Effect of Alginate Lyase on Biofilm-Grown Helicobacter pylori Probed by Atomic Force Microscopy显示文摘 | Alessandro Maiorana Francesca Bugli Massimiliano Papi Riccardo Torelli Gabriele Ciasca Giuseppe Maulucci Valentina Palmieri Margherita Cacaci Francesco Paroni Sterbini Brunella Posteraro Maurizio Sanguinetti Marco De Spirito Miriam Rafailovich | 2015 | International Journal of Polymer Science2015，，： | 1 |
| 19 | Performance characteris- tics and clinical utility of an enzymatic method for the measurement of glyeated albumin in plasma 显示文摘 | Paroni R Ceriotti F Galanello R | 2007 | Clin Biochem2007，40，18： | 1 |
| 20 | CXCL10- ~ path to ~t-celldeath显示文摘 | Paroni F Domsgen E Maedler K | 2009 | Islets2009，1，3： | 1 |
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