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| 1 | 动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛的介入治疗显示文摘本临床实践标准述及动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛(post—hemorrhagiccerebralvasospasm,PHCV)的介入治疗。这些结论基于神经介入外科学学会的标准委员会的评估,包括使用由美国心脏协会卒中委员会和牛津大学循证医学中心提出的循证医学指南进行的文献回顾。特别关注现有介入治疗方法的安全性和有效性,包括腔内球囊血管成形术(transluminalballoonangioplasty,TBA)和动脉内血管扩张药物输注治疗(intra-arterialvasodilatorinfusiontherapy,IAVT)。评估结果显示,这些侵袭性介入治疗可能有益,并可考虑用于PHCV,如伴有脑缺血症状和最佳的药物治疗无效的患者的治疗。概括起来,IAVT对累及近端和(或)远端颅内脑循环的PHCV可能有益,而TBA则可能对累及近端颅内脑循环的PHCV有益。评估结果显示,对于上述适应证,根据美国心脏协会指南可将TBA和IAVT归为IIb级推荐和B级证据,根据牛津大学循证医学中心指南则可归为4级推荐和C级证据。 | Todd Abruzzo Christopher Moran Kristine A Blacldaam Clifford J Eskey Raisa Lev Philip Meyers Sandra Narayanan Charles Joseph Prestigjacol~ 黄凯滨(译) 吴永明(译) | 2013 | 国际脑血管病杂志2013，21，1： | 4 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Identification of influential spreaders in complex networks显示文摘 | Kitsak Maksim Gallos Lazaros K Havlin Shlomo Liljeros Fredrik Muchnik Lev Stanley H Eugene Makse Hernán A | 2010 | Nature Physics2010，，11： | 2 |
| 4 | Identification of influential spreaders in complex networks显示文摘 | Kitsak Maksim Gallos Lazaros K Havlin Shlomo Liljeros Fredrik Muchnik Lev Stanley H Eugene Makse Hernán A | 2010 | Nature Physics2010，，11： | 2 |
| 5 | Desmoid tumor: a disease opportune for molecular insights 显示文摘 | Kotiligam D Lazar A J Pollock R E Lev D | 2008 | Histol Histopathol2008，23，： | 1 |
| 6 | Pleuropneumonia as the sole manifestation of Epstein-Barr virus-associated Infectious mononucleosis 显示文摘 | Miron D Merzel Y Lev A | 2002 | Israel Medical Association Journal Imaj2002，4，9： | 1 |
| 7 | Should laparoscopy be a man- datory component of the infertility evaluation in infertile women with normal hysterosalpingogram or suspected unilateral distal tubal pathol- ogy? 显示文摘 | Lavy Y Lev - Sagie A Hohzer H | 2004 | Eur J Obstet Gyneeol Reprod Biol2004，14，1： | 1 |
| 8 | Effects of temperature on biological degradation of phenols,benzoates and phthalates under methanogenic conditions显示文摘 | Levén L Sehnürer A | | 0，，： | 1 |
| 9 | 显示文摘 | Saccardo P A Erysipheae Lev | 1902 | Sylloge Fungorum1902，16，： | 1 |
| 10 | Recombinant antibodies with MHC-restricted,peptide-specific,T-cell receptor-like specificity:new tools to study antigen presentation and TCR-peptide-MHC interactions显示文摘 | Cohen CJ Denkberg G Lev A | 2003 | J Mol Recognit2003，16，5： | 1 |
| 11 | Pathways mediating the interaction between endothelial progenitor cells (EPCs) and platelets显示文摘 | Raz O Lev DL Battler A | 2014 | PLoS One2014，9，95： | 1 |
| 12 | The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases a meta-analysis显示文摘 | LEV A S JOS L | 1996 | Ann Intern Med1996，124，： | 1 |
| 13 | Generation of oscillation by the p53-Mdm2 feedback loop: a theoretical and experimental study 显示文摘 | LEV B R MAYA R SEGEL L A | 2000 | Proceedings of the National Academy of Sciences USA2000，97，11： | 1 |
| 14 | An application of relaxation methods to edge reinforcement 显示文摘 | Schachter B J Lev A Zucher S W | 1977 | IEEE Trans Systems Man and Cybernetics1977，7，5： | 1 |
| 15 | An inventory model with finite horizon and price change 显示文摘 | Soyster A L | 1979 | Journal of the Operations Research Society1979，30，1： | 1 |
| 16 | CY angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke显示文摘 | Ezzeddine M A Lev M H Mc Donald C T | 2002 | Stroke2002，33，2： | 1 |
| 17 | Treatment of Aspirin- Resistant Patients With Omega-3 Fatty Acids Versus As- pirin Dose Escalation显示文摘 | Lev EI Solodky A Harel N | 2010 | J Am Coll Cardiol2010，55，： | 1 |
| 18 | The allosteric activation of mammalian alpha-amylase by chloride显示文摘 | LEV(I)TZKI A STEER M L | 1974 | European Journal of Biochemistry1974，41，： | 1 |
| 19 | Sol-gelprocessing of titaniumcontaining thin coatings partЩXPS studies 显示文摘 | Trapalis C Modestov A D Lev O | 1993 | J Mater Sci1993，28，： | 1 |
| 20 | N-Terminal pro-B-type natriuretic peptide concentrations in mothers just before Delivery, in Cord Blood, and in Newborns显示文摘 | BAR OZ B LEV SAGIE A ARAD I | 2005 | Clin Chem2005，51，5： | 1 |
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